JP2009539378A5 - - Google Patents
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- JP2009539378A5 JP2009539378A5 JP2009514393A JP2009514393A JP2009539378A5 JP 2009539378 A5 JP2009539378 A5 JP 2009539378A5 JP 2009514393 A JP2009514393 A JP 2009514393A JP 2009514393 A JP2009514393 A JP 2009514393A JP 2009539378 A5 JP2009539378 A5 JP 2009539378A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- stem cells
- collagen biofabric
- stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims 53
- 102000008186 Collagen Human genes 0.000 claims 30
- 108010035532 Collagen Proteins 0.000 claims 30
- 229920001436 collagen Polymers 0.000 claims 30
- 210000004027 cell Anatomy 0.000 claims 29
- 210000000130 stem cell Anatomy 0.000 claims 27
- 230000014509 gene expression Effects 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 10
- 238000012258 culturing Methods 0.000 claims 9
- 230000004069 differentiation Effects 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 8
- 102000004877 Insulin Human genes 0.000 claims 4
- 108090001061 Insulin Proteins 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 4
- 229960003957 dexamethasone Drugs 0.000 claims 4
- 210000003494 hepatocyte Anatomy 0.000 claims 4
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 4
- 229940125396 insulin Drugs 0.000 claims 4
- 210000001988 somatic stem cell Anatomy 0.000 claims 4
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 3
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 3
- 210000002449 bone cell Anatomy 0.000 claims 3
- 230000000747 cardiac effect Effects 0.000 claims 3
- 210000001612 chondrocyte Anatomy 0.000 claims 3
- 210000004993 mammalian placenta Anatomy 0.000 claims 3
- 210000002569 neuron Anatomy 0.000 claims 3
- 210000002826 placenta Anatomy 0.000 claims 3
- 210000004991 placental stem cell Anatomy 0.000 claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- APIXJSLKIYYUKG-UHFFFAOYSA-N 3 Isobutyl 1 methylxanthine Chemical compound O=C1N(C)C(=O)N(CC(C)C)C2=C1N=CN2 APIXJSLKIYYUKG-UHFFFAOYSA-N 0.000 claims 2
- 102000007469 Actins Human genes 0.000 claims 2
- 108010085238 Actins Proteins 0.000 claims 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 2
- 101800003838 Epidermal growth factor Proteins 0.000 claims 2
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 2
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 2
- 101001111338 Homo sapiens Neurofilament heavy polypeptide Proteins 0.000 claims 2
- MIJPAVRNWPDMOR-ZAFYKAAXSA-N L-ascorbic acid 2-phosphate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(OP(O)(O)=O)=C1O MIJPAVRNWPDMOR-ZAFYKAAXSA-N 0.000 claims 2
- 102000004882 Lipase Human genes 0.000 claims 2
- 108090001060 Lipase Proteins 0.000 claims 2
- 239000004367 Lipase Substances 0.000 claims 2
- 102100024007 Neurofilament heavy polypeptide Human genes 0.000 claims 2
- 102000004264 Osteopontin Human genes 0.000 claims 2
- 108010081689 Osteopontin Proteins 0.000 claims 2
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims 2
- 108010009583 Transforming Growth Factors Proteins 0.000 claims 2
- 102000009618 Transforming Growth Factors Human genes 0.000 claims 2
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims 2
- 102000056172 Transforming growth factor beta-3 Human genes 0.000 claims 2
- 108090000097 Transforming growth factor beta-3 Proteins 0.000 claims 2
- 210000001789 adipocyte Anatomy 0.000 claims 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 2
- 210000001691 amnion Anatomy 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 2
- 230000030833 cell death Effects 0.000 claims 2
- 210000001136 chorion Anatomy 0.000 claims 2
- 230000003511 endothelial effect Effects 0.000 claims 2
- 229940116977 epidermal growth factor Drugs 0.000 claims 2
- 210000004700 fetal blood Anatomy 0.000 claims 2
- 210000002064 heart cell Anatomy 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 229960000905 indomethacin Drugs 0.000 claims 2
- 235000019421 lipase Nutrition 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 210000001665 muscle stem cell Anatomy 0.000 claims 2
- 230000017074 necrotic cell death Effects 0.000 claims 2
- 210000001178 neural stem cell Anatomy 0.000 claims 2
- 230000003169 placental effect Effects 0.000 claims 2
- 229930002330 retinoic acid Natural products 0.000 claims 2
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims 2
- 210000001082 somatic cell Anatomy 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 229940099456 transforming growth factor beta 1 Drugs 0.000 claims 2
- 229960001727 tretinoin Drugs 0.000 claims 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 2
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 1
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 1
- 102000015336 Nerve Growth Factor Human genes 0.000 claims 1
- 102000007339 Nerve Growth Factor Receptors Human genes 0.000 claims 1
- 108010032605 Nerve Growth Factor Receptors Proteins 0.000 claims 1
- 102000008730 Nestin Human genes 0.000 claims 1
- 108010088225 Nestin Proteins 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 239000003636 conditioned culture medium Substances 0.000 claims 1
- 230000003583 cytomorphological effect Effects 0.000 claims 1
- 229940126864 fibroblast growth factor Drugs 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 229940053128 nerve growth factor Drugs 0.000 claims 1
- 210000005055 nestin Anatomy 0.000 claims 1
- 210000003061 neural cell Anatomy 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000010349 pulsation Effects 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 230000014616 translation Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81236606P | 2006-06-09 | 2006-06-09 | |
| PCT/US2007/013507 WO2007146123A2 (en) | 2006-06-09 | 2007-06-08 | Placental niche and use thereof to culture stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009539378A JP2009539378A (ja) | 2009-11-19 |
| JP2009539378A5 true JP2009539378A5 (https=) | 2010-07-29 |
Family
ID=38832407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009514393A Pending JP2009539378A (ja) | 2006-06-09 | 2007-06-08 | 胎盤環境及び幹細胞を培養するためのその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20080044848A1 (https=) |
| EP (1) | EP2035552A2 (https=) |
| JP (1) | JP2009539378A (https=) |
| KR (1) | KR20090031895A (https=) |
| CN (1) | CN101501185A (https=) |
| AU (1) | AU2007258514A1 (https=) |
| CA (1) | CA2654716A1 (https=) |
| IL (1) | IL195826A0 (https=) |
| MX (1) | MX2008015645A (https=) |
| WO (1) | WO2007146123A2 (https=) |
| ZA (1) | ZA200810412B (https=) |
Families Citing this family (86)
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|---|---|---|---|---|
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| DK1349918T3 (da) * | 2000-12-06 | 2014-11-10 | Anthrogenesis Corp | Fremgangsmåde til indsamling af stamceller fra moderkagen |
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| EP3246396B1 (en) | 2001-02-14 | 2020-01-29 | Celularity, Inc. | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
| US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| AU2003298775B2 (en) * | 2002-11-26 | 2008-07-17 | Anthrogenesis Corporation | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
| GB0321337D0 (en) * | 2003-09-11 | 2003-10-15 | Massone Mobile Advertising Sys | Method and system for distributing advertisements |
| KR20060109979A (ko) * | 2003-12-02 | 2006-10-23 | 셀진 코포레이션 | 혈색소병증 및 빈혈의 치료 및 관리를 위한 방법및 조성물 |
| CN1961283A (zh) * | 2004-03-26 | 2007-05-09 | 细胞基因公司 | 建立干细胞库的系统和方法 |
| DK1957633T3 (en) | 2005-10-13 | 2014-03-17 | Anthrogenesis Corp | Immunomodulation USING PLACE SPEECH STEM CELLS |
| CN101326281A (zh) * | 2005-10-13 | 2008-12-17 | 人类起源公司 | 用源自胎盘的干细胞制备少突胶质细胞 |
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| JP6104896B2 (ja) | 2011-06-01 | 2017-03-29 | アントフロゲネシス コーポレーション | 胎盤幹細胞を使用する疼痛の治療 |
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| TWI419971B (zh) * | 2011-09-28 | 2013-12-21 | Tissue Decomposition, Cell Adhesion and Extraction and Culture of Adult Stem Cells. | |
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2007
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- 2007-06-08 US US11/811,447 patent/US20080044848A1/en not_active Abandoned
- 2007-06-08 CA CA002654716A patent/CA2654716A1/en not_active Abandoned
- 2007-06-08 WO PCT/US2007/013507 patent/WO2007146123A2/en not_active Ceased
- 2007-06-08 AU AU2007258514A patent/AU2007258514A1/en not_active Abandoned
- 2007-06-08 JP JP2009514393A patent/JP2009539378A/ja active Pending
- 2007-06-08 KR KR1020097000342A patent/KR20090031895A/ko not_active Withdrawn
- 2007-06-08 ZA ZA200810412A patent/ZA200810412B/xx unknown
- 2007-06-08 EP EP07809398A patent/EP2035552A2/en not_active Withdrawn
- 2007-06-08 MX MX2008015645A patent/MX2008015645A/es not_active Application Discontinuation
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2008
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2017
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