|
US653432A
(en)
*
|
1899-11-11 |
1900-07-10 |
George J Winter |
Door.
|
|
US3773919A
(en)
*
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
GB1573212A
(en)
*
|
1976-04-15 |
1980-08-20 |
Technicon Instr |
Immunoassay for gentamicin
|
|
US4275149A
(en)
*
|
1978-11-24 |
1981-06-23 |
Syva Company |
Macromolecular environment control in specific receptor assays
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
*
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
SE455445B
(sv)
|
1984-08-28 |
1988-07-11 |
Pharmacia Ab |
Antikroppar mot sialosyllaktotetraos (iv?723neuaclcose?714) och antikroppens resp antigenets anvendning vid tumordiagnostik
|
|
EP0173648A3
(en)
|
1984-08-30 |
1988-04-27 |
Ciba-Geigy Ag |
New monoclonal antibodies to glycoconjugates, processes for their production, and applications
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
US5061626A
(en)
*
|
1986-03-24 |
1991-10-29 |
University Of Sydney |
Antigenic anarogues of platelet activating factor
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
*
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4937232A
(en)
*
|
1986-09-15 |
1990-06-26 |
Duke University |
Inhibition of protein kinase C by long-chain bases
|
|
US4816450A
(en)
*
|
1986-09-15 |
1989-03-28 |
Duke University |
Inhibition of protein kinase C by long-chain bases
|
|
DE3741056A1
(de)
*
|
1987-12-04 |
1989-08-24 |
Behringwerke Ag |
Manumycin-derivate, verfahren zu ihrer herstellung und ihre verwendung
|
|
US5110987A
(en)
*
|
1988-06-17 |
1992-05-05 |
Emory University |
Method of preparing sphingosine derivatives
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5620689A
(en)
*
|
1989-10-20 |
1997-04-15 |
Sequus Pharmaceuuticals, Inc. |
Liposomes for treatment of B-cell and T-cell disorders
|
|
US5248824A
(en)
*
|
1990-12-31 |
1993-09-28 |
The Biomembrane Institute |
Method of preparing N,N,N-trimethylsphingosine
|
|
US5137919A
(en)
*
|
1990-12-31 |
1992-08-11 |
Biomembrane Institute |
Effect of N,N,N,-trimethylsphingosine on protein kinase C activity melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation
|
|
US5151360A
(en)
*
|
1990-12-31 |
1992-09-29 |
Biomembrane Institute |
Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
|
|
US5677288A
(en)
*
|
1991-05-15 |
1997-10-14 |
Cypros Pharmaceutical Corporation |
Use of aminoglycosides to protect against excitotoxic neuron damage
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
US5430160A
(en)
*
|
1991-09-23 |
1995-07-04 |
Florida State University |
Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
|
|
DE69232137T2
(de)
|
1991-11-25 |
2002-05-29 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
US5260288A
(en)
*
|
1992-04-03 |
1993-11-09 |
The Biomembrane Institute |
Method for inhibition of cell motility by sphingosine-1-phosphate and derivatives
|
|
ATE143730T1
(de)
|
1992-04-22 |
1996-10-15 |
Ecole Polytech |
Lipidmembranen fur biosensoranwendungen
|
|
US5369030A
(en)
*
|
1992-09-11 |
1994-11-29 |
Duke University |
Method of inducing cellular differentiations and altering cell phenotype using ceramide analogs
|
|
DE69331333T2
(de)
|
1992-10-01 |
2002-08-14 |
Australian Membrane And Biotechnology Research Institute Ltd., North Ryde |
Verbesserte sensormembranen
|
|
ATE372783T1
(de)
*
|
1993-01-22 |
2007-09-15 |
Sloan Kettering Inst Cancer |
Gangliosid-klh-konjugatimpfstoffe mit qs-21 zur verzögerung des wiederauftretens eines melanoms
|
|
US5444087A
(en)
*
|
1993-10-19 |
1995-08-22 |
Bristol-Myers Squibb Company |
Manumycin compounds
|
|
SG49032A1
(en)
*
|
1993-11-15 |
1998-05-18 |
Baker Med Res Inst |
A method for treating cardiac dysfunction and pharmaceutical compositions useful therefor
|
|
ES2149350T3
(es)
|
1994-02-02 |
2000-11-01 |
Liposome Co Inc |
Compuestos y liposomas farmaceuticamente activos y metodos para su utilizacion.
|
|
US5585476A
(en)
*
|
1994-02-15 |
1996-12-17 |
Maclennan; Alexander J. |
Molecular cloning and expression of G-protein coupled receptors
|
|
US5627171A
(en)
*
|
1994-04-11 |
1997-05-06 |
Oncomembrane, Inc. |
Sphingosine-1-phosphate/trimethylsphingosine composition
|
|
US6323201B1
(en)
*
|
1994-12-29 |
2001-11-27 |
The Regents Of The University Of California |
Compounds for inhibition of ceramide-mediated signal transduction
|
|
EP0736770A3
(fr)
|
1995-04-05 |
1997-05-02 |
Anda Biolog Sa |
Conjugué immunoréactif, procédé d'obtention de ce conjugué, anticorps dirigés contre ledit conjugué, composition pharmaceutique et dispositif de diagnostic les comprenant
|
|
US7060808B1
(en)
*
|
1995-06-07 |
2006-06-13 |
Imclone Systems Incorporated |
Humanized anti-EGF receptor monoclonal antibody
|
|
US5667337A
(en)
*
|
1995-09-15 |
1997-09-16 |
Lazes; Richard J. |
Rotating containment and repelling boom and method for confining a material floatable on a liquid surface
|
|
WO2001004108A1
(en)
|
1999-07-09 |
2001-01-18 |
Regents Of The University Of Michigan |
Amino ceramide-like compounds and therapeutic methods of use
|
|
WO1997010817A1
(en)
*
|
1995-09-20 |
1997-03-27 |
The Regents Of The University Of Michigan |
Amino ceramide-like compounds and therapeutic methods of use
|
|
JPH09110722A
(ja)
|
1995-10-20 |
1997-04-28 |
Toray Ind Inc |
抗腫瘍活性物質の腫瘍細胞内導入用イムノリポソーム及びその調製法
|
|
US5830916A
(en)
|
1996-05-23 |
1998-11-03 |
Duke University |
Inhibitor of ceramidase
|
|
DE19621038A1
(de)
*
|
1996-05-24 |
1997-11-27 |
Boehringer Ingelheim Kg |
Aminoguanidine, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten
|
|
EP0940409B1
(en)
|
1996-07-19 |
2004-05-12 |
Takara Shuzo Co. Ltd. |
Process for the preparation of sphingolipids and sphingolipid derivatives
|
|
US6140060A
(en)
*
|
1996-12-12 |
2000-10-31 |
Chun; Jerold J. M. |
Cloned lysophosphatidic acid receptors
|
|
US5919687A
(en)
*
|
1996-12-24 |
1999-07-06 |
John Hopkins University |
Recombinant N-SMases and nucleic acids encoding same
|
|
AU6310198A
(en)
|
1997-03-12 |
1998-09-29 |
Takara Shuzo Co., Ltd. |
Sphingosine analogues
|
|
KR20010005550A
(ko)
*
|
1997-03-21 |
2001-01-15 |
아타르진 테크놀로지스 인코퍼레이티드 |
리소포스포리피드 농도 변화와 연관된 암 감지 방법
|
|
CA2293718A1
(en)
*
|
1997-06-10 |
1998-12-17 |
Medlyte Diagnostics, Inc. |
Methods for early detection of heart disease
|
|
CA2300977A1
(en)
|
1997-08-11 |
1999-02-18 |
Wilhelm Stoffel |
Neutral sphingomyelinase
|
|
US5989803A
(en)
*
|
1997-09-05 |
1999-11-23 |
The Trustees Of Columbia University In The City Of New York |
Method for treating a subject suffering from a condition associated with an extracellular zinc sphingomyelinase
|
|
US6649362B2
(en)
*
|
1997-09-08 |
2003-11-18 |
Medvet Science Pty. Ltd. |
Screening method for an agent having an effect on a sphingosine kinase signaling pathway
|
|
WO1999012890A1
(fr)
|
1997-09-11 |
1999-03-18 |
Takara Shuzo Co., Ltd. |
Derives de sphingosine et composition medicamenteuse
|
|
US6423527B1
(en)
*
|
1997-09-29 |
2002-07-23 |
Children's Hospital Medical Center Of Northern California |
Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor
|
|
US6057126A
(en)
|
1997-12-24 |
2000-05-02 |
Allelix Biopharmaceuticals, Inc. |
Mammalian EDG-5 receptor homologs
|
|
US6300308B1
(en)
*
|
1997-12-31 |
2001-10-09 |
Board Of Regents, The University Of Texas System |
Methods and compositions for inducing autoimmunity in the treatment of cancers
|
|
EP1060256A1
(en)
*
|
1998-01-29 |
2000-12-20 |
Smithkline Beecham Plc |
Novel sphingosine-1 phosphate lyase
|
|
EP1053243B1
(en)
*
|
1998-02-12 |
2011-03-30 |
Emory University |
Sphingolipid derivatives and their methods of use
|
|
ES2226093T3
(es)
|
1998-02-16 |
2005-03-16 |
The Kitasato Institute |
Nuevas sustancias kf-1040 y procedimiento para su preparacion.
|
|
US5888793A
(en)
*
|
1998-02-25 |
1999-03-30 |
Incyte Pharmaceuticals, Inc. |
Human lysophosphatidic acid acyltransferase
|
|
WO1999046277A1
(en)
|
1998-03-09 |
1999-09-16 |
Smithkline Beecham Corporation |
HUMAN EDG-1c POLYNUCLEOTIDES AND POLYPEPTIDES AND METHODS OF USE
|
|
US6130067A
(en)
*
|
1998-05-20 |
2000-10-10 |
Smithkline Beecham Corporation |
Human EDG3sb gene
|
|
WO1999061581A2
(en)
|
1998-05-26 |
1999-12-02 |
Office Of The Dean Of Research And Graduate Education |
Sphingosine kinase, cloning, expression and methods of use
|
|
DE19828850A1
(de)
|
1998-06-27 |
1999-12-30 |
Gvs Ges Fuer Erwerb Und Verwer |
Sphingolipid-Desaturase
|
|
EP1091745B1
(en)
*
|
1998-06-29 |
2008-10-01 |
Children's Hospital Of Los Angeles |
Treatment of hyperproliferative disorders
|
|
US6818213B1
(en)
*
|
1998-07-13 |
2004-11-16 |
Board Of Regents, The University Of Texas System |
Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
|
|
US7067109B1
(en)
*
|
1998-07-13 |
2006-06-27 |
Board Of Regents, The University Of Texas System |
Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids
|
|
DE19847149A1
(de)
|
1998-10-13 |
2000-04-20 |
Max Planck Gesellschaft |
Pseudo-Ceramide
|
|
US6248553B1
(en)
*
|
1998-10-22 |
2001-06-19 |
Atairgin Technologies, Inc. |
Enzyme method for detecting lysophospholipids and phospholipids and for detecting and correlating conditions associated with altered levels of lysophospholipids
|
|
US6773916B1
(en)
|
1999-01-05 |
2004-08-10 |
The Flinders University Of South Australia |
Agents and methods for treatment and diagnosis of ocular disorders
|
|
AU2899900A
(en)
|
1999-03-02 |
2000-09-21 |
Nps Allelix Corp. |
Cloned human sphingosine kinase homologues
|
|
US6812335B1
(en)
|
1999-03-23 |
2004-11-02 |
The Regents Of The University Of California |
Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same
|
|
AU2856499A
(en)
|
1999-03-25 |
2000-10-16 |
Kitasato Institute, The |
Novel substances kf-1040t4a, kf-1040t4b, kf-1040t5a and kf-1040t5b and process for producing the same
|
|
US6830919B1
(en)
|
1999-03-26 |
2004-12-14 |
Takara Bio Inc. |
Ceramidase gene
|
|
US7820718B1
(en)
|
1999-04-07 |
2010-10-26 |
Roger Williams Hospital |
Combinations of ceramide and chemotherapeutic agents for inducing cell death and uses thereof in treating cancer
|
|
JP2000293181A
(ja)
|
1999-04-12 |
2000-10-20 |
Daiichikosho Co Ltd |
歌詞画像描出機能に特徴を有するカラオケ装置
|
|
EP1192247B9
(en)
|
1999-05-13 |
2007-10-31 |
Johnson & Johnson Pharmaceutical Research and Development LLC |
Sphingosine kinase enzyme
|
|
DE19924148A1
(de)
|
1999-05-26 |
2000-12-07 |
Univ Heidelberg |
Sphingomyelinasehemmer
|
|
WO2001004139A2
(en)
|
1999-07-13 |
2001-01-18 |
Smithkline Beecham Corporation |
Human axor29 receptor
|
|
IT1307786B1
(it)
|
1999-07-22 |
2001-11-19 |
Bracco Spa |
Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali.
|
|
JP2003512072A
(ja)
|
1999-10-28 |
2003-04-02 |
ワーナー−ランバート・カンパニー |
ヒトスフィンゴシンキナーゼ遺伝子
|
|
WO2001038295A1
(fr)
|
1999-11-24 |
2001-05-31 |
Taisho Pharmaceutical Co.,Ltd. |
Derives de sphingosine
|
|
US6312294B1
(en)
*
|
1999-12-27 |
2001-11-06 |
Hon Hai Precision Ind. Co., Ltd. |
Cable connector with improved terminals
|
|
AU2001233086A1
(en)
|
2000-01-28 |
2001-08-07 |
Musc Foundation For Research Development |
Ceramidase compositions and methods based thereon
|
|
US6306911B1
(en)
*
|
2000-02-07 |
2001-10-23 |
Ortho-Mcneil Pharmaceutical, Inc. |
Substituted amino acids as neutral sphingomyelinase inhibitors
|
|
EP1257559A1
(en)
|
2000-02-07 |
2002-11-20 |
Merck & Co., Inc. |
Mammalian sphingosine-1-phosphate phosphatase
|
|
EP1257637A2
(en)
|
2000-02-14 |
2002-11-20 |
Curagen Corporation |
Sphingosine kinases
|
|
JP2001261575A
(ja)
*
|
2000-03-13 |
2001-09-26 |
General Hospital Corp |
血管収縮を調節する方法とその組成物
|
|
US20020037495A1
(en)
|
2000-03-23 |
2002-03-28 |
Gutierrez Juan Antonio |
High throughput screening for inhibitors of fatty acid, ergosterol, sphingolipid, or phospholipid synthesis in fungi
|
|
WO2001072701A1
(en)
|
2000-03-28 |
2001-10-04 |
The Liposome Company, Inc. |
Ceramide derivatives and method of use
|
|
AU2001255477A1
(en)
|
2000-04-19 |
2001-11-07 |
The Trustees Of Columbia University In The City Of New York |
Detection and treatment of atherosclerosis based on plasma sphingomyelin concentration
|
|
US6500633B1
(en)
*
|
2000-04-26 |
2002-12-31 |
Atairgin Technologies, Inc. |
Method of detecting carcinomas
|
|
AU2001288563A1
(en)
|
2000-08-31 |
2002-03-13 |
University Of Connecticut |
Regulation of angiogenesis via modulation of edg receptor mediated signal transduction comprising sphingosine-1-phosphate administration
|
|
US20030125533A1
(en)
*
|
2000-10-06 |
2003-07-03 |
Sophia Kossida |
Regulation of human sphingosine kinase-like protein
|
|
CA2432978C
(en)
*
|
2000-12-22 |
2012-08-28 |
Medlyte, Inc. |
Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
|
|
US20020150582A1
(en)
*
|
2001-02-08 |
2002-10-17 |
Friedrichs Gregory S. |
Method of treating or inhibiting cellular injury or cell death
|
|
JP2002243737A
(ja)
|
2001-02-09 |
2002-08-28 |
Azwell Inc |
抗スフィンゴ脂質モノクローナル抗体
|
|
US6486334B1
(en)
|
2001-06-25 |
2002-11-26 |
Wisconsin Alumni Research Foundation |
Biomembrane mimetic surface coatings
|
|
US7674580B2
(en)
*
|
2002-01-17 |
2010-03-09 |
Children's Hospital & Research Center At Oakland |
Compositions and methods for the modulation of sphingolipid metabolism and/or signaling
|
|
EP2357009A1
(en)
|
2002-07-15 |
2011-08-17 |
Board of Regents, The University of Texas System |
Duramycin peptide binding to anionic phospholipids and aminophospholipids conjugates and their use in treating viral infections
|
|
DE10325829A1
(de)
*
|
2003-06-06 |
2004-12-30 |
Asc Biotech Gmbh |
Derivate natürlicher, halbsynthetischer und syntetischer Lipide aus der Gruppe der Ceramide und der Sphingosine und ihre Verwendung als Therapeutica in der Medizin, speziell in der Dermatologie
|
|
US7700792B2
(en)
*
|
2003-12-26 |
2010-04-20 |
Ono Pharmaceutical Co., Ltd. |
Highly active lysophosphatidic acid and method of screening therewith
|
|
US7794713B2
(en)
*
|
2004-04-07 |
2010-09-14 |
Lpath, Inc. |
Compositions and methods for the treatment and prevention of hyperproliferative diseases
|
|
WO2006105062A2
(en)
|
2005-03-29 |
2006-10-05 |
Verenium Corporation |
Altered antibody fc regions and uses thereof
|
|
US9163091B2
(en)
*
|
2007-05-30 |
2015-10-20 |
Lpath, Inc. |
Compositions and methods for binding lysophosphatidic acid
|
|
US8604172B2
(en)
*
|
2009-04-17 |
2013-12-10 |
Lpath, Inc. |
Humanized antibody compositions and methods for binding lysophosphatidic acid
|
|
US20110064744A1
(en)
*
|
2007-05-30 |
2011-03-17 |
Sabbadini Roger A |
Prevention and treatment of pain using antibodies to lysophosphatidic acid
|
|
EP2164992B1
(en)
*
|
2007-05-30 |
2016-05-04 |
Lpath, Inc. |
Compositions and methods for binding lysophosphatidic acid
|
