JP2009538932A5 - - Google Patents

Download PDF

Info

Publication number
JP2009538932A5
JP2009538932A5 JP2009513445A JP2009513445A JP2009538932A5 JP 2009538932 A5 JP2009538932 A5 JP 2009538932A5 JP 2009513445 A JP2009513445 A JP 2009513445A JP 2009513445 A JP2009513445 A JP 2009513445A JP 2009538932 A5 JP2009538932 A5 JP 2009538932A5
Authority
JP
Japan
Prior art keywords
cancer
antibody
cells
substance
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009513445A
Other languages
English (en)
Japanese (ja)
Other versions
JP6017108B2 (ja
JP2009538932A (ja
Filing date
Publication date
Priority claimed from US11/755,721 external-priority patent/US9217749B2/en
Application filed filed Critical
Publication of JP2009538932A publication Critical patent/JP2009538932A/ja
Publication of JP2009538932A5 publication Critical patent/JP2009538932A5/ja
Application granted granted Critical
Publication of JP6017108B2 publication Critical patent/JP6017108B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

JP2009513445A 2006-05-31 2007-05-31 リゾホスファチジン酸に反応する、免疫により誘導される物質(imune−derivedmoiety) Expired - Fee Related JP6017108B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US81018506P 2006-05-31 2006-05-31
US60/810,185 2006-05-31
US83556906P 2006-08-04 2006-08-04
US60/835,569 2006-08-04
US92364407P 2007-04-16 2007-04-16
US60/923,644 2007-04-16
US11/755,721 US9217749B2 (en) 2006-05-31 2007-05-30 Immune-derived moieties reactive against lysophosphatidic acid
US11/755,721 2007-05-30
PCT/US2007/070016 WO2007140434A2 (en) 2006-05-31 2007-05-31 Immune-derived moieties reactive against lysophosphatidic acid

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013173754A Division JP2014028817A (ja) 2006-05-31 2013-08-23 リゾホスファチジン酸に反応する、免疫により誘導される物質(imune−derivedmoiety)

Publications (3)

Publication Number Publication Date
JP2009538932A JP2009538932A (ja) 2009-11-12
JP2009538932A5 true JP2009538932A5 (https=) 2015-10-29
JP6017108B2 JP6017108B2 (ja) 2016-11-02

Family

ID=38779460

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009513445A Expired - Fee Related JP6017108B2 (ja) 2006-05-31 2007-05-31 リゾホスファチジン酸に反応する、免疫により誘導される物質(imune−derivedmoiety)
JP2013173754A Pending JP2014028817A (ja) 2006-05-31 2013-08-23 リゾホスファチジン酸に反応する、免疫により誘導される物質(imune−derivedmoiety)

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013173754A Pending JP2014028817A (ja) 2006-05-31 2013-08-23 リゾホスファチジン酸に反応する、免疫により誘導される物質(imune−derivedmoiety)

Country Status (6)

Country Link
US (2) US9217749B2 (https=)
EP (1) EP2029626B1 (https=)
JP (2) JP6017108B2 (https=)
AU (1) AU2007266493A1 (https=)
CA (1) CA2653931A1 (https=)
WO (1) WO2007140434A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US8796429B2 (en) * 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
US9163091B2 (en) 2007-05-30 2015-10-20 Lpath, Inc. Compositions and methods for binding lysophosphatidic acid
US8604172B2 (en) * 2009-04-17 2013-12-10 Lpath, Inc. Humanized antibody compositions and methods for binding lysophosphatidic acid
ES2585702T3 (es) * 2007-05-30 2016-10-07 Lpath, Inc Composiciones y métodos para la unión al ácido lisofosfatídico
JP2012511026A (ja) * 2008-12-05 2012-05-17 エルパス・インコーポレイテッド 抗脂抗体結晶構造を用いた抗体設計
US8401799B2 (en) * 2008-12-05 2013-03-19 Lpath, Inc. Antibody design using anti-lipid antibody crystal structures
US20100292443A1 (en) * 2009-02-26 2010-11-18 Sabbadini Roger A Humanized platelet activating factor antibody design using anti-lipid antibody templates
CA2766152A1 (en) 2009-06-24 2011-01-13 Lpath, Inc. Methods of increasing neuronal differentiation using antibodies to lysophosphatidic acid
WO2012109569A1 (en) * 2011-02-11 2012-08-16 The Trustees Of Columbia University In The City Of New York The receptor for advanced glycation endproducts (rage) is a receptor for lysophosphatidic acid (lpa)
WO2013130521A1 (en) * 2012-02-29 2013-09-06 Lpath, Inc. Methods and kits for detecting and diagnosing neurotrauma
US9352049B2 (en) 2013-03-14 2016-05-31 Albany Molecular Research, Inc. Ligand-therapeutic agent conjugates, silicon-based linkers, and methods for making and using them
KR102421466B1 (ko) * 2021-10-06 2022-07-18 (주)이노베이션바이오 암 진단용 바이오마커 및 이의 용도

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US653432A (en) * 1899-11-11 1900-07-10 George J Winter Door.
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
GB1573212A (en) * 1976-04-15 1980-08-20 Technicon Instr Immunoassay for gentamicin
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
SE455445B (sv) 1984-08-28 1988-07-11 Pharmacia Ab Antikroppar mot sialosyllaktotetraos (iv?723neuaclcose?714) och antikroppens resp antigenets anvendning vid tumordiagnostik
EP0173648A3 (en) 1984-08-30 1988-04-27 Ciba-Geigy Ag New monoclonal antibodies to glycoconjugates, processes for their production, and applications
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
WO1987005904A1 (en) * 1986-03-24 1987-10-08 The University Of Sydney Antigenic analogues of platelet activating factor (paf)
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
US4937232A (en) * 1986-09-15 1990-06-26 Duke University Inhibition of protein kinase C by long-chain bases
DE3741056A1 (de) * 1987-12-04 1989-08-24 Behringwerke Ag Manumycin-derivate, verfahren zu ihrer herstellung und ihre verwendung
US5110987A (en) * 1988-06-17 1992-05-05 Emory University Method of preparing sphingosine derivatives
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5620689A (en) * 1989-10-20 1997-04-15 Sequus Pharmaceuuticals, Inc. Liposomes for treatment of B-cell and T-cell disorders
US5137919A (en) * 1990-12-31 1992-08-11 Biomembrane Institute Effect of N,N,N,-trimethylsphingosine on protein kinase C activity melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation
US5248824A (en) * 1990-12-31 1993-09-28 The Biomembrane Institute Method of preparing N,N,N-trimethylsphingosine
US5151360A (en) * 1990-12-31 1992-09-29 Biomembrane Institute Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
US5677288A (en) * 1991-05-15 1997-10-14 Cypros Pharmaceutical Corporation Use of aminoglycosides to protect against excitotoxic neuron damage
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
ATE207080T1 (de) 1991-11-25 2001-11-15 Enzon Inc Multivalente antigen-bindende proteine
US5260288A (en) * 1992-04-03 1993-11-09 The Biomembrane Institute Method for inhibition of cell motility by sphingosine-1-phosphate and derivatives
WO1993021528A1 (en) 1992-04-22 1993-10-28 Ecole Polytechnique Federale De Lausanne (Epfl) Lipid membrane sensors
US5369030A (en) * 1992-09-11 1994-11-29 Duke University Method of inducing cellular differentiations and altering cell phenotype using ceramide analogs
JPH08505123A (ja) 1992-10-01 1996-06-04 オーストラリアン メンブレイン アンド バイオテクノロジィ リサーチ インスティチュート 改良されたセンサー膜
AU685776B2 (en) * 1993-01-22 1998-01-29 Sloan-Kettering Institute For Cancer Research Ganglioside-KLH conjugate vaccines with QS-21
US5444087A (en) * 1993-10-19 1995-08-22 Bristol-Myers Squibb Company Manumycin compounds
JPH09505058A (ja) * 1993-11-15 1997-05-20 ベイカー・メディカル・リサーチ・インスティテュート 心機能不全の治療方法およびそのために有用な医薬組成物
JPH09508900A (ja) 1994-02-02 1997-09-09 ザ リポソーム カンパニー、インコーポレーテッド 薬理学的に活性な化合物及びリポソーム並びにそれらの使用方法
US5585476A (en) * 1994-02-15 1996-12-17 Maclennan; Alexander J. Molecular cloning and expression of G-protein coupled receptors
US5627171A (en) * 1994-04-11 1997-05-06 Oncomembrane, Inc. Sphingosine-1-phosphate/trimethylsphingosine composition
US6323201B1 (en) * 1994-12-29 2001-11-27 The Regents Of The University Of California Compounds for inhibition of ceramide-mediated signal transduction
EP0736770A3 (fr) 1995-04-05 1997-05-02 Anda Biolog Sa Conjugué immunoréactif, procédé d'obtention de ce conjugué, anticorps dirigés contre ledit conjugué, composition pharmaceutique et dispositif de diagnostic les comprenant
US7060808B1 (en) * 1995-06-07 2006-06-13 Imclone Systems Incorporated Humanized anti-EGF receptor monoclonal antibody
US5667337A (en) * 1995-09-15 1997-09-16 Lazes; Richard J. Rotating containment and repelling boom and method for confining a material floatable on a liquid surface
WO2001004108A1 (en) 1999-07-09 2001-01-18 Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
US5916911A (en) * 1995-09-20 1999-06-29 The Regents Of The University Of Michigan Amino ceramide--like compounds and therapeutic methods of use
JPH09110722A (ja) 1995-10-20 1997-04-28 Toray Ind Inc 抗腫瘍活性物質の腫瘍細胞内導入用イムノリポソーム及びその調製法
US5830916A (en) 1996-05-23 1998-11-03 Duke University Inhibitor of ceramidase
DE19621038A1 (de) * 1996-05-24 1997-11-27 Boehringer Ingelheim Kg Aminoguanidine, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten
CA2260768C (en) 1996-07-19 2008-06-17 Takara Shuzo Co., Ltd. Methods for producing sphingolipids and sphingolipid derivatives
US6140060A (en) * 1996-12-12 2000-10-31 Chun; Jerold J. M. Cloned lysophosphatidic acid receptors
US5919687A (en) 1996-12-24 1999-07-06 John Hopkins University Recombinant N-SMases and nucleic acids encoding same
ATE314342T1 (de) 1997-03-12 2006-01-15 Takara Bio Inc Spingosinanaloga
KR20010005550A (ko) * 1997-03-21 2001-01-15 아타르진 테크놀로지스 인코퍼레이티드 리소포스포리피드 농도 변화와 연관된 암 감지 방법
JP5264026B2 (ja) 1997-06-10 2013-08-14 エルパス・インコーポレイテッド 心疾患の早期発見のための方法
US6740512B1 (en) 1997-08-11 2004-05-25 Memorec Biotec Gmbh Neutral sphingomyelinase
US5989803A (en) * 1997-09-05 1999-11-23 The Trustees Of Columbia University In The City Of New York Method for treating a subject suffering from a condition associated with an extracellular zinc sphingomyelinase
US6649362B2 (en) * 1997-09-08 2003-11-18 Medvet Science Pty. Ltd. Screening method for an agent having an effect on a sphingosine kinase signaling pathway
ATE332888T1 (de) 1997-09-11 2006-08-15 Takara Bio Inc Sphingosinderivate und medizinische zubereitung
US6423527B1 (en) 1997-09-29 2002-07-23 Children's Hospital Medical Center Of Northern California Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor
US6057126A (en) 1997-12-24 2000-05-02 Allelix Biopharmaceuticals, Inc. Mammalian EDG-5 receptor homologs
US6300308B1 (en) * 1997-12-31 2001-10-09 Board Of Regents, The University Of Texas System Methods and compositions for inducing autoimmunity in the treatment of cancers
EP1060256A1 (en) 1998-01-29 2000-12-20 Smithkline Beecham Plc Novel sphingosine-1 phosphate lyase
DE69943314D1 (de) 1998-02-12 2011-05-12 Kapil N Bhalla Sphingolipid-derivate und verfahren zu deren verwendung
NZ505420A (en) 1998-02-16 2002-08-28 Kitasato Inst A saccharide derivative KF-1040 produced by a Gliocladium fungi
US5888793A (en) * 1998-02-25 1999-03-30 Incyte Pharmaceuticals, Inc. Human lysophosphatidic acid acyltransferase
US6423508B1 (en) 1998-03-09 2002-07-23 Smithkline Beecham Corporation Polynucleotide sequences of human EDG-1c
US6130067A (en) * 1998-05-20 2000-10-10 Smithkline Beecham Corporation Human EDG3sb gene
CA2329124A1 (en) 1998-05-26 1999-12-02 Office Of The Dean Of Research And Graduate Education Sphingosine kinase, cloning, expression and methods of use
DE19828850A1 (de) 1998-06-27 1999-12-30 Gvs Ges Fuer Erwerb Und Verwer Sphingolipid-Desaturase
AU4724599A (en) * 1998-06-29 2000-01-17 Children's Hospital Of Los Angeles Treatment of hyperproliferative disorders
US7067109B1 (en) * 1998-07-13 2006-06-27 Board Of Regents, The University Of Texas System Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids
US6818213B1 (en) * 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
DE19847149A1 (de) 1998-10-13 2000-04-20 Max Planck Gesellschaft Pseudo-Ceramide
US6248553B1 (en) * 1998-10-22 2001-06-19 Atairgin Technologies, Inc. Enzyme method for detecting lysophospholipids and phospholipids and for detecting and correlating conditions associated with altered levels of lysophospholipids
WO2000040262A1 (en) 1999-01-05 2000-07-13 The Flinders University Of South Australia Novel agents and methods for treatment and diagnosis of ocular disorders
AU2899900A (en) 1999-03-02 2000-09-21 Nps Allelix Corp. Cloned human sphingosine kinase homologues
US6812335B1 (en) 1999-03-23 2004-11-02 The Regents Of The University Of California Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same
WO2000058491A1 (en) 1999-03-25 2000-10-05 The Kitasato Institute Novel substances kf-1040t4a, kf-1040t4b, kf-1040t5a and kf-1040t5b and process for producing the same
AU3326900A (en) 1999-03-26 2000-10-16 Takara Shuzo Co., Ltd. Ceramidase gene
US7820718B1 (en) 1999-04-07 2010-10-26 Roger Williams Hospital Combinations of ceramide and chemotherapeutic agents for inducing cell death and uses thereof in treating cancer
JP2000293181A (ja) 1999-04-12 2000-10-20 Daiichikosho Co Ltd 歌詞画像描出機能に特徴を有するカラオケ装置
KR100798375B1 (ko) 1999-05-13 2008-01-28 존슨 앤드 존슨 파머슈티컬 리서치 앤드 디벨로프먼트 엘엘씨 스핀고신 키나제 효소
DE19924148A1 (de) 1999-05-26 2000-12-07 Univ Heidelberg Sphingomyelinasehemmer
WO2001004139A2 (en) 1999-07-13 2001-01-18 Smithkline Beecham Corporation Human axor29 receptor
IT1307786B1 (it) 1999-07-22 2001-11-19 Bracco Spa Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali.
JP2003512072A (ja) 1999-10-28 2003-04-02 ワーナー−ランバート・カンパニー ヒトスフィンゴシンキナーゼ遺伝子
AU1548101A (en) 1999-11-24 2001-06-04 Sagami Chemical Research Center Sphingosine derivatives
US6312294B1 (en) * 1999-12-27 2001-11-06 Hon Hai Precision Ind. Co., Ltd. Cable connector with improved terminals
WO2001055410A2 (en) 2000-01-28 2001-08-02 Musc Foundation For Research Development Ceramidase compositions and methods based thereon
US6306911B1 (en) * 2000-02-07 2001-10-23 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as neutral sphingomyelinase inhibitors
EP1257559A1 (en) 2000-02-07 2002-11-20 Merck & Co., Inc. Mammalian sphingosine-1-phosphate phosphatase
AU3828301A (en) 2000-02-14 2001-08-27 Curagen Corp Novel sphingosine kinases
JP2001261575A (ja) * 2000-03-13 2001-09-26 General Hospital Corp 血管収縮を調節する方法とその組成物
WO2001071045A2 (en) 2000-03-23 2001-09-27 Millennium Pharmaceuticals, Inc. High throughput screening for inhibitors of fatty acid, ergosterol, sphingolipid, or phospholipid synthesis in fungi
AU2001255199A1 (en) 2000-03-28 2001-10-08 The Liposome Company, Inc. Ceramide derivatives and method of use
AU2001255477A1 (en) 2000-04-19 2001-11-07 The Trustees Of Columbia University In The City Of New York Detection and treatment of atherosclerosis based on plasma sphingomyelin concentration
US6500633B1 (en) * 2000-04-26 2002-12-31 Atairgin Technologies, Inc. Method of detecting carcinomas
WO2002017899A2 (en) 2000-08-31 2002-03-07 University Of Connecticut Regulation of angiogenesis via modulation of edg receptor mediated signal transduction comprising sphingosine-1-phosphate administration
US20030125533A1 (en) * 2000-10-06 2003-07-03 Sophia Kossida Regulation of human sphingosine kinase-like protein
CA2432978C (en) * 2000-12-22 2012-08-28 Medlyte, Inc. Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
US20020150582A1 (en) * 2001-02-08 2002-10-17 Friedrichs Gregory S. Method of treating or inhibiting cellular injury or cell death
JP2002243737A (ja) 2001-02-09 2002-08-28 Azwell Inc 抗スフィンゴ脂質モノクローナル抗体
US6486334B1 (en) 2001-06-25 2002-11-26 Wisconsin Alumni Research Foundation Biomembrane mimetic surface coatings
US7674580B2 (en) * 2002-01-17 2010-03-09 Children's Hospital & Research Center At Oakland Compositions and methods for the modulation of sphingolipid metabolism and/or signaling
KR20120068769A (ko) 2002-07-15 2012-06-27 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 음이온성 인지질 및 아미노인지질에 결합하는 선택된 항체 및 치료하는데 있어서 이의 용도
DE10325829A1 (de) * 2003-06-06 2004-12-30 Asc Biotech Gmbh Derivate natürlicher, halbsynthetischer und syntetischer Lipide aus der Gruppe der Ceramide und der Sphingosine und ihre Verwendung als Therapeutica in der Medizin, speziell in der Dermatologie
US7700792B2 (en) * 2003-12-26 2010-04-20 Ono Pharmaceutical Co., Ltd. Highly active lysophosphatidic acid and method of screening therewith
US7794713B2 (en) * 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20110123440A1 (en) 2005-03-29 2011-05-26 Genevieve Hansen Altered Antibody FC Regions and Uses Thereof
US8604172B2 (en) * 2009-04-17 2013-12-10 Lpath, Inc. Humanized antibody compositions and methods for binding lysophosphatidic acid
ES2585702T3 (es) 2007-05-30 2016-10-07 Lpath, Inc Composiciones y métodos para la unión al ácido lisofosfatídico
US9163091B2 (en) * 2007-05-30 2015-10-20 Lpath, Inc. Compositions and methods for binding lysophosphatidic acid
US20110064744A1 (en) * 2007-05-30 2011-03-17 Sabbadini Roger A Prevention and treatment of pain using antibodies to lysophosphatidic acid

Similar Documents

Publication Publication Date Title
JP2009538932A5 (https=)
TWI910725B (zh) 抗體-藥物結合物之用途
ES2910407T3 (es) Anticuerpos anti-CD71 activables y procedimientos de uso de los mismos
KR102070464B1 (ko) 면역접합체, 그를 함유하는 조성물, 및 제조 및 사용 방법
JP2010508847A5 (https=)
JP2017186337A5 (https=)
JP2009505676A5 (https=)
JP2010535713A5 (https=)
JP2014511348A5 (https=)
JP2009539380A5 (https=)
JP2005526044A5 (https=)
KR20180105271A (ko) 항체-약물 콘주게이트
JP2016503295A5 (https=)
JP2015534578A5 (https=)
JP2010516708A5 (https=)
JP2012507499A5 (https=)
JP2021513536A5 (https=)
JP2013513383A5 (https=)
JP2016504420A5 (https=)
JP2022527173A5 (https=)
Zhu et al. Advancements and challenges in CAR-T cell therapy for solid tumors: A comprehensive review of antigen targets, strategies, and future directions
Erkan The role of pancreatic stellate cells in pancreatic cancer
Kreitman Hairy cell leukemia—new genes, new targets
JP2013503842A5 (https=)
JP2017505755A5 (https=)