ATE332888T1 - Sphingosinderivate und medizinische zubereitung - Google Patents
Sphingosinderivate und medizinische zubereitungInfo
- Publication number
- ATE332888T1 ATE332888T1 AT98941825T AT98941825T ATE332888T1 AT E332888 T1 ATE332888 T1 AT E332888T1 AT 98941825 T AT98941825 T AT 98941825T AT 98941825 T AT98941825 T AT 98941825T AT E332888 T1 ATE332888 T1 AT E332888T1
- Authority
- AT
- Austria
- Prior art keywords
- sphingosine derivatives
- medical preparation
- different
- sphingosine
- same
- Prior art date
Links
- WWUZIQQURGPMPG-BXDGKWANSA-N (2R,3S,4Z)-2-aminooctadec-4-ene-1,3-diol Chemical class CCCCCCCCCCCCC\C=C/[C@H](O)[C@H](N)CO WWUZIQQURGPMPG-BXDGKWANSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003410 sphingosines Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 150000003408 sphingolipids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26796597 | 1997-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE332888T1 true ATE332888T1 (de) | 2006-08-15 |
Family
ID=17452059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98941825T ATE332888T1 (de) | 1997-09-11 | 1998-09-11 | Sphingosinderivate und medizinische zubereitung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6239297B1 (de) |
| EP (1) | EP1020429B1 (de) |
| JP (1) | JP4091250B2 (de) |
| KR (1) | KR100561890B1 (de) |
| AT (1) | ATE332888T1 (de) |
| AU (1) | AU9002298A (de) |
| DE (1) | DE69835223T2 (de) |
| WO (1) | WO1999012890A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1363643A2 (de) | 2000-12-22 | 2003-11-26 | Medlyte, Inc. | Zusammensetzungen und methoden zur behandlung und vorbeugung von kardiovaskulären erkrankungen und zur identifizierung therapeutischer mittel |
| AU2002237988B2 (en) * | 2001-01-30 | 2008-01-03 | University Of Virginia Patent Foundation | Agonists and antagonists of sphingosine-1-phosphate receptors |
| ITRM20010688A1 (it) * | 2001-11-21 | 2003-05-21 | Univ Roma | Composti immunoregolatori. |
| US6838114B2 (en) * | 2002-05-24 | 2005-01-04 | Micron Technology, Inc. | Methods for controlling gas pulsing in processes for depositing materials onto micro-device workpieces |
| NL1022443C2 (nl) * | 2003-01-20 | 2004-07-22 | Tno | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
| DE102004025000A1 (de) * | 2004-05-21 | 2005-12-08 | Bayer Technology Services Gmbh | Verfahren zur Herstellung von chemischen und pharmazeutischen Produkten mit integrierter Mehrsäulen-Chromatographie |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| GB0513431D0 (en) * | 2005-06-30 | 2005-08-10 | Kherion Technology Ltd | Prophylactic compositions and uses |
| CN101460458A (zh) | 2006-02-15 | 2009-06-17 | 阿勒根公司 | 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物 |
| US8097644B2 (en) * | 2006-03-28 | 2012-01-17 | Allergan, Inc. | Indole compounds having sphingosine-1-phosphate (S1P) receptor antagonist |
| US9217749B2 (en) | 2006-05-31 | 2015-12-22 | Lpath, Inc. | Immune-derived moieties reactive against lysophosphatidic acid |
| US9274130B2 (en) | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Prevention and treatment of pain using antibodies to lysophosphatidic acid |
| US9274129B2 (en) | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Methods and reagents for detecting bioactive lipids |
| US8796429B2 (en) | 2006-05-31 | 2014-08-05 | Lpath, Inc. | Bioactive lipid derivatives, and methods of making and using same |
| RU2460541C2 (ru) | 2006-10-27 | 2012-09-10 | Лпат, Инк. | Композиции и способы связывания сфингозин-1-фосфата |
| US8524917B2 (en) * | 2007-01-11 | 2013-09-03 | Allergan, Inc. | 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
| KR20090101307A (ko) | 2007-01-11 | 2009-09-24 | 알러간, 인코포레이티드 | 스핑고신-1-포스페이트(ｓ1ｐ) 수용체 길항제 생물학적 활성을 갖는 6-치환된 인돌-3-카르복실산 아미드 화합물 |
| US7888336B2 (en) * | 2007-09-24 | 2011-02-15 | Allergan, Inc. | Indole compounds bearing aryl or heteroaryl groups having sphingosine 1-phosphate (S1P) receptor biological activity |
| US8143291B2 (en) | 2008-05-09 | 2012-03-27 | Allergan, Inc. | Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological activity |
| RU2505527C2 (ru) * | 2008-08-12 | 2014-01-27 | Аллерган, Инк. | Антагонисты рецептора сфингозин-1-фосфата (s1p) и способы их применения |
| US8871202B2 (en) | 2008-10-24 | 2014-10-28 | Lpath, Inc. | Prevention and treatment of pain using antibodies to sphingosine-1-phosphate |
| KR20120028867A (ko) * | 2009-04-02 | 2012-03-23 | 알러간, 인코포레이티드 | 프로스타글란딘 ｅ 수용체 길항제 |
| US20120088800A1 (en) | 2009-06-30 | 2012-04-12 | Allergan, Inc. | 2-(SUBSTITUTED) (ARYLMETHYL, ARYLOXY and ARYLTHIO))-N-(SUBSTITUTED PYRIDIN-2-YL)-2-(SUBSTITUTED ARYL) COMPOUNDS AS SUBTYPE-SELECTIVE MODULATORS OF SPHINGOSINE-1-PHOSPHATE-3 (S1P3) RECEPTORS |
| US8168795B2 (en) | 2009-08-11 | 2012-05-01 | Allergan, Inc. | Selective sphingosine-1-phosphate receptor antagonists |
| WO2011028927A1 (en) | 2009-09-04 | 2011-03-10 | Allergan, Inc. | Selective sphingosine-1-phosphate receptor antagonists |
| AU2010300791A1 (en) | 2009-09-29 | 2012-04-19 | Allergan, Inc. | Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (S1P2) receptors |
| US8741875B2 (en) | 2009-11-24 | 2014-06-03 | Allergan, Inc. | Compounds as receptor modulators with therapeutic utility |
| MX2012006022A (es) | 2009-11-24 | 2012-08-15 | Allergan Inc | Compuestos novedosos como moduladores de receptor con utilidad terapeutica. |
| BR112013012719A2 (pt) | 2010-11-22 | 2019-09-24 | Allergan Inc | "compostos como moduladores de receptor com utilidade terapêutica". |
| AU2012316085A1 (en) * | 2011-09-29 | 2014-05-22 | Emory University | Sphingosine analogs, compositions, and methods related thereto |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02215711A (ja) * | 1989-02-03 | 1990-08-28 | Biomembrane Inst | プロテインキナーゼ阻害剤としての、ｎ‐メチル‐スフィンゴシン誘導体及びその立体異性体 |
| JP2560250B2 (ja) * | 1994-03-18 | 1996-12-04 | 工業技術院長 | 天然型スフィンゴシン類の製造方法とその合成中間体 |
| KR100487703B1 (ko) * | 1996-03-12 | 2005-06-16 | 다카라 바이오 가부시키가이샤 | 생리활성물질tkr1785류,제조방법및미생물 |
-
1998
- 1998-09-11 AU AU90022/98A patent/AU9002298A/en not_active Abandoned
- 1998-09-11 US US09/508,462 patent/US6239297B1/en not_active Expired - Fee Related
- 1998-09-11 EP EP98941825A patent/EP1020429B1/de not_active Expired - Lifetime
- 1998-09-11 JP JP2000510703A patent/JP4091250B2/ja not_active Expired - Fee Related
- 1998-09-11 DE DE69835223T patent/DE69835223T2/de not_active Expired - Fee Related
- 1998-09-11 KR KR1020007002122A patent/KR100561890B1/ko not_active IP Right Cessation
- 1998-09-11 WO PCT/JP1998/004093 patent/WO1999012890A1/ja active IP Right Grant
- 1998-09-11 AT AT98941825T patent/ATE332888T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU9002298A (en) | 1999-03-29 |
| KR100561890B1 (ko) | 2006-03-16 |
| EP1020429A1 (de) | 2000-07-19 |
| WO1999012890A1 (fr) | 1999-03-18 |
| EP1020429B1 (de) | 2006-07-12 |
| JP4091250B2 (ja) | 2008-05-28 |
| DE69835223D1 (de) | 2006-08-24 |
| EP1020429A4 (de) | 2004-09-08 |
| DE69835223T2 (de) | 2007-05-31 |
| KR20010023477A (ko) | 2001-03-26 |
| US6239297B1 (en) | 2001-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |