JP2009536155A5 - - Google Patents
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- Publication number
- JP2009536155A5 JP2009536155A5 JP2009505472A JP2009505472A JP2009536155A5 JP 2009536155 A5 JP2009536155 A5 JP 2009536155A5 JP 2009505472 A JP2009505472 A JP 2009505472A JP 2009505472 A JP2009505472 A JP 2009505472A JP 2009536155 A5 JP2009536155 A5 JP 2009536155A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- optionally substituted
- compound according
- independently
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 CC[C@@](C)C(*N)N(C1C(NC2*CCC2)=NC(NC(C#CC2)=C(C)*=C2C(N(C)C)=O)=N[C@]1C)C#C Chemical compound CC[C@@](C)C(*N)N(C1C(NC2*CCC2)=NC(NC(C#CC2)=C(C)*=C2C(N(C)C)=O)=N[C@]1C)C#C 0.000 description 4
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79132706P | 2006-04-12 | 2006-04-12 | |
| US60/791,327 | 2006-04-12 | ||
| US83872006P | 2006-08-18 | 2006-08-18 | |
| US60/838,720 | 2006-08-18 | ||
| PCT/US2007/009006 WO2007120752A2 (en) | 2006-04-12 | 2007-04-12 | 4, 5-dihydro- [1, 2, 4] triazolo [4, 3-f] pteridines as protein kinase plk1 inhibitors for the treatment of proliferative disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009536155A JP2009536155A (ja) | 2009-10-08 |
| JP2009536155A5 true JP2009536155A5 (https=) | 2010-05-27 |
| JP5313875B2 JP5313875B2 (ja) | 2013-10-09 |
Family
ID=38544378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505472A Expired - Fee Related JP5313875B2 (ja) | 2006-04-12 | 2007-04-12 | 増殖性疾患の処置のためのタンパク質キナーゼｐｌｋ１の阻害剤として有用な４，５−ジヒドロ−［１，２，４］トリアゾロ［４，３−ｆ］プテリジン |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7763629B2 (https=) |
| EP (1) | EP2010542B1 (https=) |
| JP (1) | JP5313875B2 (https=) |
| KR (1) | KR101432316B1 (https=) |
| AR (1) | AR060432A1 (https=) |
| AT (1) | ATE542823T1 (https=) |
| AU (1) | AU2007238690B2 (https=) |
| CA (1) | CA2649324A1 (https=) |
| ES (1) | ES2381212T3 (https=) |
| IL (1) | IL194699A (https=) |
| MX (1) | MX2008013110A (https=) |
| NO (1) | NO20084747L (https=) |
| NZ (1) | NZ571969A (https=) |
| RU (1) | RU2441006C2 (https=) |
| TW (1) | TW200808805A (https=) |
| WO (1) | WO2007120752A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2695753A1 (en) * | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | Compounds useful as protein kinases inhibitors |
| BRPI0821209A2 (pt) | 2007-12-19 | 2019-09-24 | Amgen Inc | composto, composição farmacêutica, métodos de tratar câncer, para reduzir o tamanho de tumor, para tratar distúrbios, e para reduzir metástase em um tumor. |
| US8389533B2 (en) | 2008-04-07 | 2013-03-05 | Amgen Inc. | Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors |
| WO2010008459A1 (en) * | 2008-06-23 | 2010-01-21 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| MX2011000026A (es) * | 2008-06-23 | 2011-02-24 | Vertex Pharma | Inhibidores de proteina cinasas. |
| CA2773827A1 (en) * | 2009-09-25 | 2011-03-31 | Vertex Pharmaceuticals Incorporated | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| SG179206A1 (en) | 2009-09-25 | 2012-04-27 | Vertex Pharma | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| US8541418B2 (en) | 2009-12-23 | 2013-09-24 | Elan Pharmaceutical, Inc. | Inhibitors of polo-like kinase |
| JP5850321B2 (ja) * | 2010-02-10 | 2016-02-03 | 公立大学法人横浜市立大学 | 神経選択的転写抑制因子ＮＲＳＦに特異的に結合するｍＳｉｎ３Ｂに結合する化合物の利用 |
| US8933070B2 (en) | 2010-07-02 | 2015-01-13 | University Health Network | Methods of targeting PTEN mutant diseases and compositions therefor |
| US20120115848A1 (en) | 2010-10-08 | 2012-05-10 | Elan Pharmaceuticals, Inc. | Inhibitors of Polo-Like Kinase |
| TW201307347A (zh) | 2010-11-01 | 2013-02-16 | Arqule Inc | 經取代苯並－咪唑並－吡啶並－二氮呯化合物 |
| CN103703000B (zh) | 2011-03-23 | 2015-11-25 | 安姆根有限公司 | Cdk4/6和flt3的稠合三环双重抑制剂 |
| MD4300C1 (ro) * | 2012-12-28 | 2015-03-31 | Государственный Университет Молд0 | Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel |
| US9840503B2 (en) | 2015-05-11 | 2017-12-12 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| WO2017027717A1 (en) | 2015-08-12 | 2017-02-16 | Incyte Corporation | Bicyclic fused pyrimidine compounds as tam inhibitors |
| US10053465B2 (en) | 2015-08-26 | 2018-08-21 | Incyte Corporation | Pyrrolopyrimidine derivatives as TAM inhibitors |
| MD3436461T2 (ro) | 2016-03-28 | 2024-05-31 | Incyte Corp | Compuși pirolotriazină ca inhibitori TAM |
| SI3687996T1 (sl) | 2017-09-27 | 2022-04-29 | Incyte Corporation | Soli pirolotriazinskih derivatov, ki so uporabne kot zaviralci TAM |
| MD3813800T2 (ro) | 2018-06-29 | 2025-10-31 | Incyte Corp | Formulări de inhibitor al AXL/MER |
| CN109734809A (zh) * | 2019-02-27 | 2019-05-10 | 南方科技大学 | 治疗性的人Plk1蛋白单克隆抗体及其制备方法 |
| EP4114401A1 (en) | 2020-03-06 | 2023-01-11 | Incyte Corporation | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| JP7545622B2 (ja) | 2021-02-08 | 2024-09-05 | 江蘇星盛新輝医薬有限公司 | ５，６－ジドヒロチエノ［３，４－ｈ］キナゾリン系化合物 |
| EP4157849A4 (en) * | 2021-08-10 | 2024-12-11 | Uppthera, Inc. | NOVEL PLK1 DEGRADATION-INDUCING COMPOUND |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA973884B (en) | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| EP1409487A1 (en) * | 1999-09-15 | 2004-04-21 | Warner-Lambert Company Llc | Pteridinones as kinase inhibitors |
| WO2002076985A1 (en) | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
| KR20120032574A (ko) | 2002-10-03 | 2012-04-05 | 탈자진 인코포레이티드 | 혈관항상성 유지제 및 그의 사용 방법 |
| RU2351586C2 (ru) * | 2002-10-03 | 2009-04-10 | Таргеджен, Инк. | Васкулостатические агенты и способы их применения |
| CA2528975A1 (en) | 2003-06-10 | 2004-12-16 | Pfizer Inc. | Therapeutic combinations comprising pde inhibitors and vasopressin receptor antagonists for the treatment of dysmenorrhoea |
| GB0315966D0 (en) * | 2003-07-08 | 2003-08-13 | Cyclacel Ltd | Compounds |
| GB0400700D0 (en) | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
| GB0412874D0 (en) | 2004-06-09 | 2004-07-14 | Pfizer Ltd | Novel pharmaceuticals |
| DE102004029784A1 (de) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
-
2007
- 2007-04-12 CA CA002649324A patent/CA2649324A1/en not_active Abandoned
- 2007-04-12 JP JP2009505472A patent/JP5313875B2/ja not_active Expired - Fee Related
- 2007-04-12 AT AT07755318T patent/ATE542823T1/de active
- 2007-04-12 US US11/786,578 patent/US7763629B2/en not_active Expired - Fee Related
- 2007-04-12 MX MX2008013110A patent/MX2008013110A/es active IP Right Grant
- 2007-04-12 TW TW096112918A patent/TW200808805A/zh unknown
- 2007-04-12 RU RU2008144584/04A patent/RU2441006C2/ru not_active IP Right Cessation
- 2007-04-12 NZ NZ571969A patent/NZ571969A/en not_active IP Right Cessation
- 2007-04-12 AR ARP070101560A patent/AR060432A1/es unknown
- 2007-04-12 AU AU2007238690A patent/AU2007238690B2/en not_active Ceased
- 2007-04-12 KR KR1020087027593A patent/KR101432316B1/ko not_active Expired - Fee Related
- 2007-04-12 EP EP07755318A patent/EP2010542B1/en not_active Not-in-force
- 2007-04-12 ES ES07755318T patent/ES2381212T3/es active Active
- 2007-04-12 WO PCT/US2007/009006 patent/WO2007120752A2/en not_active Ceased
-
2008
- 2008-10-12 IL IL194699A patent/IL194699A/en not_active IP Right Cessation
- 2008-11-10 NO NO20084747A patent/NO20084747L/no not_active Application Discontinuation
-
2010
- 2010-06-08 US US12/796,174 patent/US8067417B2/en not_active Expired - Fee Related
-
2011
- 2011-10-05 US US13/253,196 patent/US8524902B2/en not_active Expired - Fee Related
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