MD4300C1 - Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel - Google Patents

Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel

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Publication number
MD4300C1
MD4300C1 MDA20120128A MD20120128A MD4300C1 MD 4300 C1 MD4300 C1 MD 4300C1 MD A20120128 A MDA20120128 A MD A20120128A MD 20120128 A MD20120128 A MD 20120128A MD 4300 C1 MD4300 C1 MD 4300C1
Authority
MD
Moldova
Prior art keywords
liver cancer
cell proliferation
inhibitor
hepg2 cell
thiosemicarbazono
Prior art date
Application number
MDA20120128A
Other languages
English (en)
Russian (ru)
Other versions
MD4300B1 (ro
Inventor
Аурелиан ГУЛЯ
Анжела ЖАЛБЭ
Виктор ЦАПКОВ
Серджиу ШОВА
Дональд ПОЙРИЕР
Алена КОТОВАЯ
Original Assignee
Государственный Университет Молд0
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Государственный Университет Молд0 filed Critical Государственный Университет Молд0
Priority to MDA20120128A priority Critical patent/MD4300C1/ro
Publication of MD4300B1 publication Critical patent/MD4300B1/ro
Publication of MD4300C1 publication Critical patent/MD4300C1/ro

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Abstract

Invenţia se referă la chimie, şi anume la sinteza compuşilor coordinativi din clasa tiosemicarbazonaţilor metalelor de tranziţie, şi poate fi aplicată în medicină ca remediu citostatic la profilaxia şi tratarea cancerului hepatic.Esenţa invenţiei constă în aceea că în calitate de inhibitor al proliferării celulelor HepG2 în cancerul hepatic se propune utilizarea unui nou compus, cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel cu formula :.Compusul revendicat se manifestă ca un inhibitor efectiv al proliferării celulelor HepG2 în cancerul hepatic în concentraţii 10-5…10-6 mol/L.
MDA20120128A 2012-12-28 2012-12-28 Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel MD4300C1 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20120128A MD4300C1 (ro) 2012-12-28 2012-12-28 Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20120128A MD4300C1 (ro) 2012-12-28 2012-12-28 Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel

Publications (2)

Publication Number Publication Date
MD4300B1 MD4300B1 (ro) 2014-08-31
MD4300C1 true MD4300C1 (ro) 2015-03-31

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Application Number Title Priority Date Filing Date
MDA20120128A MD4300C1 (ro) 2012-12-28 2012-12-28 Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4407C1 (ro) * 2015-04-29 2016-10-31 Государственный Университет Молд0 Inhibitor al celulelor HL-60 ale leucemiei umane mieloide în baza hidratului clorurii de bis[N-(prop-2-en-1-il)-2-(piridin-2-ilmetiliden)-hidrazincarbotioamid]-nichel(II)

Citations (7)

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RU2008144584A (ru) * 2006-04-12 2010-05-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) 4,5-дигидро-[1,2,4]триазоло[4,3-f]птеридины в качестве ингибиторов протеинкиназы plk1 для лечения пролиферативных заболеваний
CN102038934A (zh) * 2005-11-03 2011-05-04 福建医科大学 南瓜蛋白在制备治疗乳腺癌药物中的应用
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Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD891G2 (ro) * 1996-06-24 1998-07-31 Николае ЕРЕМИЯ Metodă de stimulare a sistemului imun al animalelor
CN102038934A (zh) * 2005-11-03 2011-05-04 福建医科大学 南瓜蛋白在制备治疗乳腺癌药物中的应用
RU2008144584A (ru) * 2006-04-12 2010-05-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) 4,5-дигидро-[1,2,4]триазоло[4,3-f]птеридины в качестве ингибиторов протеинкиназы plk1 для лечения пролиферативных заболеваний
CN101204401A (zh) * 2007-12-14 2008-06-25 中国科学院南海海洋研究所 一种海胆提取物及其制备方法和抗癌应用
CN101205233A (zh) * 2007-12-14 2008-06-25 中国科学院南海海洋研究所 一种二聚黄酮化合物及其制备方法和抗癌应用
CN101333236A (zh) * 2008-08-05 2008-12-31 浙江大学 克力托辛的制备方法及在抗肿瘤药物中的应用
CN102219822A (zh) * 2011-03-24 2011-10-19 上海交通大学 灵芝酸t酰胺衍生物tlto-a及其合成及应用

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* Cited by examiner, † Cited by third party
Title
Mohammad M. Hassanien, Wael I. Mortada, Ali M. Hassan, Ahmed A. El-Asmy Synthesis, characterization and biological activities of 4-(p-chlorophenyl)-1-(pyridine-2-yl)thiosemicarbazibe and its metal complexes. Journal of the Korean Chemical Society, 2012, vol. 56. Nr. 6. p. 679 - 691 *
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Qi Qin, Yi-Wei Lin, Xiang-Yi Zheng, Hong Chen, Qi-Qi Mao, Kai Yang, Shou-Jiang Huang, Zheng-Yan Zhao. RNAa-mediated overexpression of WT1 induces apoptosis in HepG2 cells. World Journal of Surgical Oncology 2012,10:11, p. 1-8 *
Горбунова В. А. Новые цитостатики в лечении злокачественных опухолей. Медицина, 1998, 128с *

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KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
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