RU2441006C2 - 4, 5-ДИГИДРО-[1, 2, 4]ТРИАЗОЛО[4, 3-F]ПТЕРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗЫ Plk1 ДЛЯ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ - Google Patents
4, 5-ДИГИДРО-[1, 2, 4]ТРИАЗОЛО[4, 3-F]ПТЕРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗЫ Plk1 ДЛЯ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ Download PDFInfo
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- RU2441006C2 RU2441006C2 RU2008144584/04A RU2008144584A RU2441006C2 RU 2441006 C2 RU2441006 C2 RU 2441006C2 RU 2008144584/04 A RU2008144584/04 A RU 2008144584/04A RU 2008144584 A RU2008144584 A RU 2008144584A RU 2441006 C2 RU2441006 C2 RU 2441006C2
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US79132706P | 2006-04-12 | 2006-04-12 | |
| US60/791,327 | 2006-04-12 | ||
| US83872006P | 2006-08-18 | 2006-08-18 | |
| US60/838,720 | 2006-08-18 |
Publications (2)
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| RU2008144584A RU2008144584A (ru) | 2010-05-20 |
| RU2441006C2 true RU2441006C2 (ru) | 2012-01-27 |
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| AU2008287339A1 (en) * | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5H-pyrimido [4, 5-b][1, 4] diazepin-2-ylamino)-3-methoxybenzamide Derivatives as Inhibitors of the Human Protein Kinases PLK1 to PLK4 for the Treatment of Proliferative Diseases |
| EA201001030A1 (ru) | 2007-12-19 | 2011-02-28 | Амген Инк. | Конденсированные соединения пиридина, пиримидина и триазина в качестве ингибиторов клеточного цикла |
| US8389533B2 (en) | 2008-04-07 | 2013-03-05 | Amgen Inc. | Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors |
| MX2011000021A (es) * | 2008-06-23 | 2011-02-24 | Vertex Pharma | Inhibidores de proteina cinasas. |
| AU2009271658B2 (en) * | 2008-06-23 | 2014-04-10 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| CN102548994A (zh) | 2009-09-25 | 2012-07-04 | 沃泰克斯药物股份有限公司 | 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法 |
| CN103492391A (zh) * | 2009-09-25 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法 |
| RU2012131124A (ru) | 2009-12-23 | 2014-01-27 | Элан Фармасьютикалз, Инк. | Птеридиноны как ингибиторы polo-подобных киназ |
| WO2011099502A1 (ja) * | 2010-02-10 | 2011-08-18 | 公立大学法人横浜市立大学 | 神経選択的転写抑制因子NRSFに特異的に結合するmSin3B に結合する化合物の利用 |
| ES2706066T3 (es) | 2010-07-02 | 2019-03-27 | Univ Health Network | Procedimiento dirigido a enfermedades mutantes con PTEN y composiciones para las mismas |
| CN103403010A (zh) * | 2010-10-08 | 2013-11-20 | 依兰制药公司 | Polo样激酶的抑制剂 |
| WO2012061342A2 (en) | 2010-11-01 | 2012-05-10 | Arqule, Inc. | Substituted benzo-imidazo-pyrido-diazepine compounds |
| EP2937349B1 (en) | 2011-03-23 | 2016-12-28 | Amgen Inc. | Fused tricyclic dual inhibitors of cdk 4/6 and flt3 |
| MD4300C1 (ro) * | 2012-12-28 | 2015-03-31 | Государственный Университет Молд0 | Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel |
| US9840503B2 (en) | 2015-05-11 | 2017-12-12 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| US9708333B2 (en) | 2015-08-12 | 2017-07-18 | Incyte Corporation | Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors |
| WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
| KR102483020B1 (ko) | 2016-03-28 | 2023-01-04 | 인사이트 코포레이션 | Tam 저해제로서의 피롤로트리아진 화합물 |
| MA50655B1 (fr) | 2017-09-27 | 2021-11-30 | Incyte Corp | Sels de dérivés de pyrrolotriazine utiles en tant qu'inhibiteurs de tam |
| AR117600A1 (es) | 2018-06-29 | 2021-08-18 | Incyte Corp | Formulaciones de un inhibidor de axl / mer |
| CN109734809A (zh) * | 2019-02-27 | 2019-05-10 | 南方科技大学 | 治疗性的人Plk1蛋白单克隆抗体及其制备方法 |
| WO2021178779A1 (en) | 2020-03-06 | 2021-09-10 | Incyte Corporation | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| CN121537408A (zh) | 2021-02-08 | 2026-02-17 | 上海复星医药产业发展有限公司 | 5，6-二氢噻吩并[3，4-h]喹唑啉类化合物 |
| PE20240894A1 (es) * | 2021-08-10 | 2024-04-24 | Uppthera Inc | Compuesto inductor de la degradacion de plk1 novedoso |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA005287B1 (ru) * | 1999-09-15 | 2004-12-30 | Уорнер-Ламберт Компани | Птеридиноны в качестве ингибиторов киназ |
| RU2005113978A (ru) * | 2002-10-03 | 2005-11-20 | Таргеджен, Инк. (US) | Васкулостатические агенты и способы их применения |
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| ZA973884B (en) | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| WO2002076985A1 (en) * | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
| AU2003282726B2 (en) | 2002-10-03 | 2010-10-07 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
| WO2004108138A1 (en) | 2003-06-10 | 2004-12-16 | Pfizer Limited | Therapeutic combinations comprising pde inhibitors and vasopressin receptor antagonists for the treatment of dysmenorrhoea |
| GB0315966D0 (en) * | 2003-07-08 | 2003-08-13 | Cyclacel Ltd | Compounds |
| GB0400700D0 (en) | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
| GB0412874D0 (en) | 2004-06-09 | 2004-07-14 | Pfizer Ltd | Novel pharmaceuticals |
| DE102004029784A1 (de) * | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EA005287B1 (ru) * | 1999-09-15 | 2004-12-30 | Уорнер-Ламберт Компани | Птеридиноны в качестве ингибиторов киназ |
| RU2005113978A (ru) * | 2002-10-03 | 2005-11-20 | Таргеджен, Инк. (US) | Васкулостатические агенты и способы их применения |
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| AU2007238690B2 (en) | 2013-05-02 |
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| IL194699A (en) | 2014-07-31 |
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| IL194699A0 (en) | 2009-08-03 |
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| US7763629B2 (en) | 2010-07-27 |
| US8524902B2 (en) | 2013-09-03 |
| TW200808805A (en) | 2008-02-16 |
| RU2008144584A (ru) | 2010-05-20 |
| AU2007238690A1 (en) | 2007-10-25 |
| JP2009536155A (ja) | 2009-10-08 |
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