TW200808805A - Tetrahydropteridines useful as inhibitors of protein kinases - Google Patents

Tetrahydropteridines useful as inhibitors of protein kinases Download PDF

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Publication number
TW200808805A
TW200808805A TW096112918A TW96112918A TW200808805A TW 200808805 A TW200808805 A TW 200808805A TW 096112918 A TW096112918 A TW 096112918A TW 96112918 A TW96112918 A TW 96112918A TW 200808805 A TW200808805 A TW 200808805A
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Taiwan
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group
compound
aliphatic
doc
optionally substituted
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TW096112918A
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English (en)
Chinese (zh)
Inventor
Jean-Damien Charrier
David Kay
Ronald Knegtel
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Vertex Pharma
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Publication of TW200808805A publication Critical patent/TW200808805A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
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    • A61P35/00Antineoplastic agents
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    • A61P37/00Drugs for immunological or allergic disorders
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    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/08Antiallergic agents
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Hematology (AREA)
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  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW096112918A 2006-04-12 2007-04-12 Tetrahydropteridines useful as inhibitors of protein kinases TW200808805A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79132706P 2006-04-12 2006-04-12
US83872006P 2006-08-18 2006-08-18

Publications (1)

Publication Number Publication Date
TW200808805A true TW200808805A (en) 2008-02-16

Family

ID=38544378

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096112918A TW200808805A (en) 2006-04-12 2007-04-12 Tetrahydropteridines useful as inhibitors of protein kinases

Country Status (16)

Country Link
US (3) US7763629B2 (https=)
EP (1) EP2010542B1 (https=)
JP (1) JP5313875B2 (https=)
KR (1) KR101432316B1 (https=)
AR (1) AR060432A1 (https=)
AT (1) ATE542823T1 (https=)
AU (1) AU2007238690B2 (https=)
CA (1) CA2649324A1 (https=)
ES (1) ES2381212T3 (https=)
IL (1) IL194699A (https=)
MX (1) MX2008013110A (https=)
NO (1) NO20084747L (https=)
NZ (1) NZ571969A (https=)
RU (1) RU2441006C2 (https=)
TW (1) TW200808805A (https=)
WO (1) WO2007120752A2 (https=)

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AU2008287339A1 (en) * 2007-08-15 2009-02-19 Vertex Pharmaceuticals Incorporated 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5H-pyrimido [4, 5-b][1, 4] diazepin-2-ylamino)-3-methoxybenzamide Derivatives as Inhibitors of the Human Protein Kinases PLK1 to PLK4 for the Treatment of Proliferative Diseases
EA201001030A1 (ru) 2007-12-19 2011-02-28 Амген Инк. Конденсированные соединения пиридина, пиримидина и триазина в качестве ингибиторов клеточного цикла
US8389533B2 (en) 2008-04-07 2013-03-05 Amgen Inc. Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
MX2011000021A (es) * 2008-06-23 2011-02-24 Vertex Pharma Inhibidores de proteina cinasas.
AU2009271658B2 (en) * 2008-06-23 2014-04-10 Vertex Pharmaceuticals Incorporated Protein kinase inhibitors
CN102548994A (zh) 2009-09-25 2012-07-04 沃泰克斯药物股份有限公司 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法
CN103492391A (zh) * 2009-09-25 2014-01-01 沃泰克斯药物股份有限公司 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法
RU2012131124A (ru) 2009-12-23 2014-01-27 Элан Фармасьютикалз, Инк. Птеридиноны как ингибиторы polo-подобных киназ
WO2011099502A1 (ja) * 2010-02-10 2011-08-18 公立大学法人横浜市立大学 神経選択的転写抑制因子NRSFに特異的に結合するmSin3B に結合する化合物の利用
ES2706066T3 (es) 2010-07-02 2019-03-27 Univ Health Network Procedimiento dirigido a enfermedades mutantes con PTEN y composiciones para las mismas
CN103403010A (zh) * 2010-10-08 2013-11-20 依兰制药公司 Polo样激酶的抑制剂
WO2012061342A2 (en) 2010-11-01 2012-05-10 Arqule, Inc. Substituted benzo-imidazo-pyrido-diazepine compounds
EP2937349B1 (en) 2011-03-23 2016-12-28 Amgen Inc. Fused tricyclic dual inhibitors of cdk 4/6 and flt3
MD4300C1 (ro) * 2012-12-28 2015-03-31 Государственный Университет Молд0 Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel
US9840503B2 (en) 2015-05-11 2017-12-12 Incyte Corporation Heterocyclic compounds and uses thereof
US9708333B2 (en) 2015-08-12 2017-07-18 Incyte Corporation Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors
WO2017035366A1 (en) 2015-08-26 2017-03-02 Incyte Corporation Pyrrolopyrimidine derivatives as tam inhibitors
KR102483020B1 (ko) 2016-03-28 2023-01-04 인사이트 코포레이션 Tam 저해제로서의 피롤로트리아진 화합물
MA50655B1 (fr) 2017-09-27 2021-11-30 Incyte Corp Sels de dérivés de pyrrolotriazine utiles en tant qu'inhibiteurs de tam
AR117600A1 (es) 2018-06-29 2021-08-18 Incyte Corp Formulaciones de un inhibidor de axl / mer
CN109734809A (zh) * 2019-02-27 2019-05-10 南方科技大学 治疗性的人Plk1蛋白单克隆抗体及其制备方法
WO2021178779A1 (en) 2020-03-06 2021-09-10 Incyte Corporation Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors
CN121537408A (zh) 2021-02-08 2026-02-17 上海复星医药产业发展有限公司 5,6-二氢噻吩并[3,4-h]喹唑啉类化合物
PE20240894A1 (es) * 2021-08-10 2024-04-24 Uppthera Inc Compuesto inductor de la degradacion de plk1 novedoso

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ZA973884B (en) 1996-05-23 1998-11-06 Du Pont Merck Pharma Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
US7169778B2 (en) * 1999-09-15 2007-01-30 Warner-Lambert Company Pteridinones as kinase inhibitors
WO2002076985A1 (en) * 2001-03-23 2002-10-03 Smithkline Beecham Corporation Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
AU2003282726B2 (en) 2002-10-03 2010-10-07 Targegen, Inc. Vasculostatic agents and methods of use thereof
CN1720224A (zh) * 2002-10-03 2006-01-11 塔尔基公司 血管平衡剂及其使用方法
WO2004108138A1 (en) 2003-06-10 2004-12-16 Pfizer Limited Therapeutic combinations comprising pde inhibitors and vasopressin receptor antagonists for the treatment of dysmenorrhoea
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GB0400700D0 (en) 2004-01-13 2004-02-18 Pfizer Ltd Compounds useful in therapy
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DE102004029784A1 (de) * 2004-06-21 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel

Also Published As

Publication number Publication date
US8067417B2 (en) 2011-11-29
WO2007120752A3 (en) 2008-05-08
NZ571969A (en) 2011-10-28
AU2007238690B2 (en) 2013-05-02
CA2649324A1 (en) 2007-10-25
EP2010542B1 (en) 2012-01-25
ATE542823T1 (de) 2012-02-15
AR060432A1 (es) 2008-06-18
ES2381212T3 (es) 2012-05-24
MX2008013110A (es) 2009-03-06
WO2007120752A2 (en) 2007-10-25
JP5313875B2 (ja) 2013-10-09
RU2441006C2 (ru) 2012-01-27
US20110021519A1 (en) 2011-01-27
NO20084747L (no) 2008-11-25
US20120277425A1 (en) 2012-11-01
US20090062292A1 (en) 2009-03-05
KR101432316B1 (ko) 2014-08-29
IL194699A (en) 2014-07-31
KR20080109919A (ko) 2008-12-17
HK1134486A1 (en) 2010-04-30
IL194699A0 (en) 2009-08-03
EP2010542A2 (en) 2009-01-07
US7763629B2 (en) 2010-07-27
US8524902B2 (en) 2013-09-03
RU2008144584A (ru) 2010-05-20
AU2007238690A1 (en) 2007-10-25
JP2009536155A (ja) 2009-10-08

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