|
EP1679668B1
(en)
*
|
1996-09-04 |
2010-01-27 |
Intertrust Technologies Corp. |
Trusted infrastructure support systems, methods and techniques for secure electronic commerce, electronic transactions, commerce process control and automation, distributed computing, and rights management
|
|
PL2041139T3
(pl)
*
|
2006-04-26 |
2012-05-31 |
Hoffmann La Roche |
Związki farmaceutyczne
|
|
MX2008013583A
(es)
|
2006-04-26 |
2008-10-31 |
Genentech Inc |
Compuestos del inhibidor de fosfoinositido 3-cinasa y composiciones farmaceuticas que los contienen.
|
|
PE20081679A1
(es)
|
2006-12-07 |
2008-12-18 |
Hoffmann La Roche |
Compuestos del inhibidor de fosfoinositida 3-cinasa y metodos de uso
|
|
AR064154A1
(es)
*
|
2006-12-07 |
2009-03-18 |
Piramed Ltd |
Compuestos inhibidores de fodfoinostida 3- quinasas y composiciones farmaceuticas
|
|
US9370508B2
(en)
*
|
2007-02-20 |
2016-06-21 |
Novartis Ag |
Imidazoquinolines as dual lipid kinase and mTOR inhibitors
|
|
EP2158207B1
(en)
*
|
2007-06-12 |
2011-05-25 |
F. Hoffmann-La Roche AG |
Thiazoliopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase
|
|
CA2699202C
(en)
*
|
2007-09-12 |
2016-09-27 |
F. Hoffmann-La Roche Ag |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
JP5736171B2
(ja)
|
2007-09-24 |
2015-06-17 |
ジェネンテック， インコーポレイテッド |
チアゾロピリミジンｐｉ３ｋ阻害剤化合物および使用方法
|
|
EP2214675B1
(en)
|
2007-10-25 |
2013-11-20 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
|
GB0721095D0
(en)
*
|
2007-10-26 |
2007-12-05 |
Piramed Ltd |
Pharmaceutical compounds
|
|
ES2537624T3
(es)
*
|
2007-10-26 |
2015-06-10 |
F. Hoffmann-La Roche Ag |
Derivados purina útiles como inhibidores de la quinasa PI3
|
|
CA2723987C
(en)
|
2008-05-14 |
2019-06-11 |
Agriculture Victoria Services Pty Ltd |
Use of angiogenin or angiogenin agonists for treating diseases and disorders
|
|
CA2721851A1
(en)
*
|
2008-05-30 |
2009-12-03 |
Genentech, Inc. |
Purine pi3k inhibitor compounds and methods of use
|
|
UA101676C2
(uk)
*
|
2008-07-31 |
2013-04-25 |
Дженентек, Инк. |
Піримідинові сполуки, композиції і способи застосування
|
|
TWI378933B
(en)
|
2008-10-14 |
2012-12-11 |
Daiichi Sankyo Co Ltd |
Morpholinopurine derivatives
|
|
EP2344484B1
(en)
*
|
2008-10-17 |
2016-06-08 |
Akaal Pharma Pty Ltd |
S1p receptors modulators and use thereof
|
|
US9181182B2
(en)
|
2008-10-17 |
2015-11-10 |
Akaal Pharma Pty Ltd |
S1P receptors modulators
|
|
US8586582B2
(en)
|
2008-11-11 |
2013-11-19 |
Xcovery Holding Company, Llc |
PI3K/mTOR kinase inhibitors
|
|
SG171765A1
(en)
*
|
2008-11-20 |
2011-07-28 |
Genentech Inc |
Pyrazolopyridine pi3k inhibitor compounds and methods of use
|
|
SI2373640T1
(sl)
|
2009-01-08 |
2014-11-28 |
Merck Patent Gmbh |
Nove polimorfne oblike hidrokloridne soli 3-(1-(3-(5-(1-metil-piperidin-4ilmetoksi)-pirimidin-2-il)-benzil)-6- okso-1,6-dihidro-piridazin-3-il)-benzonitrila in postopki proizvodnje le-teh
|
|
DK2385832T3
(en)
|
2009-01-08 |
2015-09-21 |
Curis Inc |
Phosphoinositid-3-kinase-inhibitorer med en zink-bindingsdel
|
|
BRPI1006189A2
(pt)
|
2009-03-12 |
2020-08-18 |
Genentech Inc |
uso de uma combinação terapêutica, formulação farmacêutica, artigo de manufatura, produto, método para determinar compostos a serem utilizados em combinação para o tratamento de uma malignidade hematopoiética e método para selecionar compostos a serem utilizados em combinação para o tratamento de câncer
|
|
US8901132B2
(en)
*
|
2009-03-13 |
2014-12-02 |
Katholieke Universiteit Leuven, K.U. Leuven R&D |
Thiazolopyrimidine modulators as immunosuppressive agents
|
|
US8785651B2
(en)
|
2009-03-24 |
2014-07-22 |
Sumitomo Chemical Company, Limited |
Method for manufacturing a boronic acid ester compound
|
|
US8461158B2
(en)
|
2009-03-27 |
2013-06-11 |
Pathway Therapeutics Inc. |
Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
|
|
WO2010136491A1
(en)
*
|
2009-05-27 |
2010-12-02 |
F. Hoffmann-La Roche Ag |
Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
|
|
US8173650B2
(en)
*
|
2009-05-27 |
2012-05-08 |
Genentech, Inc. |
Bicyclic pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use
|
|
CA2766151A1
(en)
*
|
2009-06-24 |
2010-12-29 |
Genentech, Inc. |
Oxo-heterocycle fused pyrimidine compounds, compositions and methods of use
|
|
US8486939B2
(en)
|
2009-07-07 |
2013-07-16 |
Pathway Therapeutics Inc. |
Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
|
|
WO2011017520A1
(en)
*
|
2009-08-05 |
2011-02-10 |
Wake Forest University Health Sciences |
Compositions and methods for inducing apoptosis in prostate cancer cells
|
|
GEP201706639B
(en)
|
2009-08-17 |
2017-03-27 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
|
JP5746172B2
(ja)
|
2009-08-20 |
2015-07-08 |
カルス セラピューティクス リミテッド |
ホスホイノシチド３−キナーゼ阻害剤としての三環式複素環化合物
|
|
WO2011031896A2
(en)
*
|
2009-09-09 |
2011-03-17 |
Avila Therapeutics, Inc. |
Pi3 kinase inhibitors and uses thereof
|
|
US20130012709A1
(en)
*
|
2009-09-10 |
2013-01-10 |
Centre National De La Recherche Scientifique |
NOVEL INHIBITORS OF STEAROYL-CoA-DESATURASE-1 AND THEIR USES
|
|
JP5546636B2
(ja)
|
2009-09-28 |
2014-07-09 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
ベンゾキセピンｐｉ３ｋ阻害剤化合物及び使用方法
|
|
WO2011049625A1
(en)
|
2009-10-20 |
2011-04-28 |
Mansour Samadpour |
Method for aflatoxin screening of products
|
|
PT2496567T
(pt)
|
2009-11-05 |
2017-11-15 |
Rhizen Pharmaceuticals S A |
Novos moduladores de quinase benzopiran
|
|
KR101447789B1
(ko)
*
|
2009-11-12 |
2014-10-06 |
에프. 호프만-라 로슈 아게 |
Ｎ-7 치환된 퓨린 및 피라졸로피리미딘 화합물, 조성물 및 사용 방법
|
|
MX2012005463A
(es)
*
|
2009-11-12 |
2012-09-12 |
Hoffmann La Roche |
Compuestos de purina n/9 sustituida, composiciones y metodos de uso.
|
|
US8633183B2
(en)
*
|
2010-01-26 |
2014-01-21 |
Boehringer Ingelheim International Gmbh |
5-alkynyl-pyrimidines
|
|
EP2539337A1
(en)
|
2010-02-22 |
2013-01-02 |
F. Hoffmann-La Roche AG |
Pyrido[3,2-d]pyrimidine pi3k delta inhibitor compounds and methods of use
|
|
UY33304A
(es)
*
|
2010-04-02 |
2011-10-31 |
Amgen Inc |
Compuestos heterocíclicos y sus usos
|
|
CA2802808A1
(en)
|
2010-07-14 |
2012-01-19 |
F. Hoffmann-La Roche Ag |
Purine compounds selective for pi3k p110 delta, and methods of use
|
|
CA2820078C
(en)
*
|
2010-12-16 |
2019-02-12 |
F. Hoffmann-La Roche Ag |
Tricyclic pi3k inhibitor compounds and methods of use
|
|
EP2667874A4
(en)
*
|
2011-01-27 |
2014-07-30 |
Univ Princeton |
MTOR KINASE HEMMER AS ANTIVIRUS AGENT
|
|
JP5766820B2
(ja)
*
|
2011-02-09 |
2015-08-19 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
Ｐｉ３キナーゼ阻害剤としての複素環化合物
|
|
MX340013B
(es)
|
2011-03-21 |
2016-06-22 |
Hoffmann La Roche |
Compuestos de benzoxazepina selectivos para fosfatidilinositol 3-cinasa (pi3k) p110 delta y metodos de uso.
|
|
CA2831582C
(en)
|
2011-03-28 |
2019-01-08 |
Mei Pharma, Inc. |
(alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
|
|
PL3111938T3
(pl)
*
|
2011-04-01 |
2019-09-30 |
Curis, Inc. |
Inhibitor 3-kinazy fosfoinozytydowej z grupą wiążącą cynk
|
|
RS58326B1
(sr)
|
2011-05-04 |
2019-03-29 |
Rhizen Pharmaceuticals S A |
Nova jedinjenja kao modulatori proteinskih kinaza
|
|
EP2524918A1
(en)
|
2011-05-19 |
2012-11-21 |
Centro Nacional de Investigaciones Oncológicas (CNIO) |
Imidazopyrazines derivates as kinase inhibitors
|
|
KR101255939B1
(ko)
*
|
2011-05-31 |
2013-04-23 |
동화약품주식회사 |
4-(1ｈ-인다졸-6-일아미노)-ｎ-아이소프로필-2-(메틸티오)피리미딘-5-카르복스아미드 화합물 또는 이의 약학적으로 허용가능한 염을 포함하는 당뇨병 예방 또는 치료용 조성물
|
|
JP6062442B2
(ja)
*
|
2011-10-13 |
2017-01-18 |
ジェネンテック， インコーポレイテッド |
薬剤誘発性低酸症の治療
|
|
EP2776837A4
(en)
*
|
2011-11-11 |
2015-05-20 |
Intellikine Llc |
COMBINATION OF KINASEINHIBITORS AND THEIR USE
|
|
CN102643272B
(zh)
*
|
2011-12-30 |
2015-03-11 |
沈阳药科大学 |
新的噻吩并[3,2-d]嘧啶类化合物
|
|
GB201204125D0
(en)
|
2012-03-08 |
2012-04-25 |
Karus Therapeutics Ltd |
Compounds
|
|
FR2988722B1
(fr)
|
2012-04-03 |
2014-05-09 |
Sanofi Sa |
Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
|
|
US9499561B2
(en)
|
2012-04-10 |
2016-11-22 |
Shanghai Yingli Pharmaceutical Co., Ltd. |
Fused pyrimidine compound, and preparation method, intermediate, composition, and uses thereof
|
|
WO2013158649A1
(en)
|
2012-04-16 |
2013-10-24 |
Case Western Reserve University |
Compositions and methods of modulating 15-pgdh activity
|
|
WO2016144958A1
(en)
|
2015-03-08 |
2016-09-15 |
Case Western Reserve University |
Inhibitors of short-chain dehydrogenase activity for treating fibrosis
|
|
US9801863B2
(en)
|
2012-04-16 |
2017-10-31 |
Case Western Reserve University |
Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis
|
|
PL2848254T3
(pl)
*
|
2012-05-07 |
2017-03-31 |
Kissei Pharmaceutical Co., Ltd. |
Pochodne pirazolu i ich zastosowanie w celach medycznych
|
|
AU2013204740C1
(en)
|
2012-05-10 |
2015-10-01 |
Agriculture Victoria Services Pty Ltd |
Methods of treating cancer using angiogenin or an angiogenin agonist
|
|
KR20160027219A
(ko)
|
2012-05-23 |
2016-03-09 |
에프. 호프만-라 로슈 아게 |
내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법
|
|
KR101915942B1
(ko)
|
2012-06-08 |
2018-11-06 |
에프. 호프만-라 로슈 아게 |
암의 치료를 위한 포스포이노시타이드 3 키나제 억제제 화합물 및 화학치료제의 돌연변이체 선택성 및 조합물
|
|
KR101988079B1
(ko)
|
2012-07-04 |
2019-06-11 |
리젠 파마슈티컬스 소시에떼 아노님 |
선택적 pi3k 델타 억제제
|
|
CN104583215B
(zh)
*
|
2012-08-30 |
2016-12-07 |
霍夫曼-拉罗奇有限公司 |
二噁烯并-和噁嗪-[2,3-d]嘧啶pi3k抑制剂化合物及使用方法
|
|
US20150258127A1
(en)
|
2012-10-31 |
2015-09-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for preventing antiphospholipid syndrome (aps)
|
|
AU2013343291B2
(en)
|
2012-11-07 |
2018-05-10 |
Karus Therapeutics Ltd |
Novel histone deacetylase inhibitors and their use in therapy
|
|
MX2015014387A
(es)
|
2013-04-12 |
2017-04-10 |
Asana Biosciences Llc |
Quinazolinas y azaquinazolinas como inhibidores duales de vias ras/raf/mek/erk y pi3k/akt/pten/mtor.
|
|
EP2994465B1
(en)
|
2013-05-10 |
2018-08-15 |
Karus Therapeutics Limited |
Novel histone deacetylase inhibitors
|
|
DE102013008118A1
(de)
*
|
2013-05-11 |
2014-11-13 |
Merck Patent Gmbh |
Arylchinazoline
|
|
WO2014203129A1
(en)
|
2013-06-19 |
2014-12-24 |
Olema Pharmaceuticals, Inc. |
Combinations of benzopyran compounds, compositions and uses thereof
|
|
WO2015043398A1
(zh)
|
2013-09-30 |
2015-04-02 |
上海璎黎药业有限公司 |
稠合嘧啶类化合物、中间体、其制备方法、组合物和应用
|
|
US9789116B2
(en)
|
2013-10-15 |
2017-10-17 |
Case Western Reserve University |
Compositions and methods of modulating short-chain dehydrogenase activity
|
|
CA2926596C
(en)
|
2013-10-16 |
2020-07-14 |
Shanghai Yingli Pharmaceutical Co., Ltd |
Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof
|
|
CA2938719A1
(en)
|
2014-02-06 |
2015-08-13 |
Abbvie, Inc. |
6-heteroaryloxy- and 6-aryloxy-quinoline-2-carboxamides and uses thereof
|
|
GB201402431D0
(en)
|
2014-02-12 |
2014-03-26 |
Karus Therapeutics Ltd |
Compounds
|
|
GB201419264D0
(en)
|
2014-10-29 |
2014-12-10 |
Karus Therapeutics Ltd |
Compounds
|
|
GB201419228D0
(en)
|
2014-10-29 |
2014-12-10 |
Karus Therapeutics Ltd |
Compounds
|
|
WO2016154075A1
(en)
*
|
2015-03-20 |
2016-09-29 |
Vertex Pharmaceuticals Incorporated |
Bicyclic heteroaryl compounds useful as inhibitors of the par-2 signaling pathway
|
|
AR104068A1
(es)
|
2015-03-26 |
2017-06-21 |
Hoffmann La Roche |
Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
|
|
KR20170131444A
(ko)
*
|
2015-03-30 |
2017-11-29 |
다이이찌 산쿄 가부시키가이샤 |
6-모르폴리닐-2-피라졸릴-9h-푸린 유도체 및 pi3k 저해제로서의 이들의 용도
|
|
JP2018511616A
(ja)
*
|
2015-04-14 |
2018-04-26 |
ケース ウエスタン リザーブ ユニバーシティ |
短鎖デヒドロゲナーゼ活性を調節する組成物および方法
|
|
AU2016287189A1
(en)
|
2015-06-29 |
2017-10-12 |
F. Hoffmann-La Roche Ag |
Methods of treatment with taselisib
|
|
GB201514758D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Formulation
|
|
GB201514751D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Compounds
|
|
GB201514760D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Compounds and method of use
|
|
GB201514754D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Compounds
|
|
EP3394056B1
(en)
|
2015-12-22 |
2021-04-14 |
Shy Therapeutics LLC |
Compounds for the treatment of cancer and inflammatory disease
|
|
CN107098846B
(zh)
*
|
2016-02-26 |
2020-10-09 |
中国医学科学院药物研究所 |
N-酰基磺酰胺类FBPase抑制剂、其制备方法、药物组合物及用途
|
|
EP3454852A4
(en)
|
2016-05-11 |
2020-02-26 |
Emory University |
PHOSPHOTIDYLINOSITOL 3-KINASES INHIBITORS
|
|
RU2743170C2
(ru)
|
2016-06-01 |
2021-02-15 |
Байер Энимал Хелс Гмбх |
Замещенные индазолы, пригодные для лечения и предупреждения аллергических и/или воспалительных заболеваний у животных
|
|
WO2018057588A1
(en)
*
|
2016-09-21 |
2018-03-29 |
Vertex Pharmaceuticals Incorporated |
Furo[3,2-b]pyridine compounds useful as inhibitors of the par-2 signaling pathway
|
|
TW201813963A
(zh)
|
2016-09-23 |
2018-04-16 |
美商基利科學股份有限公司 |
磷脂醯肌醇3-激酶抑制劑
|
|
TW201825465A
(zh)
|
2016-09-23 |
2018-07-16 |
美商基利科學股份有限公司 |
磷脂醯肌醇3-激酶抑制劑
|
|
TW201815787A
(zh)
|
2016-09-23 |
2018-05-01 |
美商基利科學股份有限公司 |
磷脂醯肌醇3-激酶抑制劑
|
|
CA3063976A1
(en)
|
2017-05-23 |
2018-11-29 |
Mei Pharma, Inc. |
Combination therapy
|
|
CA3066939A1
(en)
*
|
2017-06-21 |
2018-12-27 |
SHY Therapeutics LLC |
Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
|
|
MX2020001727A
(es)
|
2017-08-14 |
2020-03-20 |
Mei Pharma Inc |
Terapia de combinacion.
|
|
CN109796465B
(zh)
*
|
2017-11-16 |
2020-07-14 |
华中科技大学同济医学院附属协和医院 |
靶向pet显像化合物、包含该化合物的显象剂及其制备方法和用途
|
|
US12324807B2
(en)
|
2018-06-01 |
2025-06-10 |
Cornell University |
Combination therapy for PI3K-associated disease or disorder
|
|
CN113164466B
(zh)
|
2018-09-11 |
2025-07-08 |
柯瑞斯公司 |
使用具有锌结合部分的磷酸肌醇3-激酶抑制剂的联合治疗
|
|
WO2020077174A1
(en)
*
|
2018-10-12 |
2020-04-16 |
Board Of Regents Of The University Of Nebraska |
Phosphodiesterase inhibitors
|
|
US12391705B2
(en)
|
2018-12-19 |
2025-08-19 |
Shy Therapeutics, Llc |
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
|
|
GB201909468D0
(en)
|
2019-07-01 |
2019-08-14 |
Karus Therapeutics Ltd |
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|
|
KR20220140515A
(ko)
|
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2022-10-18 |
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치환된 피라졸로-피리미딘 및 그의 용도
|
|
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(en)
*
|
2020-06-03 |
2024-07-17 |
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|
|
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(en)
*
|
2020-11-10 |
2024-11-20 |
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COMPOUNDS AND USES THEREOF
|
|
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(zh)
*
|
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2022-09-09 |
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|
|
US20240226126A1
(en)
*
|
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2024-07-11 |
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|
|
WO2022268025A1
(zh)
*
|
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2022-12-29 |
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|
|
JP2024533630A
(ja)
*
|
2021-09-30 |
2024-09-12 |
ハンミ ファーマシューティカルズ カンパニー リミテッド |
ＰＩＫｆｙｖｅキナーゼ阻害剤
|
|
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(zh)
*
|
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2025-10-17 |
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嘧啶并环类化合物及其衍生物、制备方法、药物组合物和应用
|
|
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(zh)
*
|
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|
|
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(zh)
*
|
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|
|
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(en)
|
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|
|
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(zh)
*
|
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|