KR101402474B1 - 포스포이노시티드 3-키나제 억제제 화합물 및 이를 포함하는 약학적 조성물 - Google Patents

포스포이노시티드 3-키나제 억제제 화합물 및 이를 포함하는 약학적 조성물 Download PDF

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KR101402474B1
KR101402474B1 KR1020087028893A KR20087028893A KR101402474B1 KR 101402474 B1 KR101402474 B1 KR 101402474B1 KR 1020087028893 A KR1020087028893 A KR 1020087028893A KR 20087028893 A KR20087028893 A KR 20087028893A KR 101402474 B1 KR101402474 B1 KR 101402474B1
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indazol
morpholinothieno
pyrimidin
pyrimidine
methyl
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KR20090024682A (ko
Inventor
조젯 카스타네도
리차드 골드스미드
자넷 건즈너
팀 헤프론
킴벌리 말레스키
시먼 마티유
앨런 올리베로
다니엘 피. 서덜린
비키 추이
슈메이 왕
크리스티안 바이스만
빙-얀 주
제나퍼 닷슨
아드리안 폴크스
스티븐 셔틀워스
샐리 옥센포드
팀 핸콕스
트레이시 베이리스
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제넨테크, 인크.
에프. 호프만-라 로슈 아게
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Application filed by 제넨테크, 인크., 에프. 호프만-라 로슈 아게 filed Critical 제넨테크, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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    • C07D495/04—Ortho-condensed systems

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KR1020087028893A 2006-04-26 2007-04-24 포스포이노시티드 3-키나제 억제제 화합물 및 이를 포함하는 약학적 조성물 Expired - Fee Related KR101402474B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79504706P 2006-04-26 2006-04-26
US60/795,047 2006-04-26
PCT/US2007/009880 WO2007127183A1 (en) 2006-04-26 2007-04-24 Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
KR20090024682A KR20090024682A (ko) 2009-03-09
KR101402474B1 true KR101402474B1 (ko) 2014-06-19

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KR1020087028893A Expired - Fee Related KR101402474B1 (ko) 2006-04-26 2007-04-24 포스포이노시티드 3-키나제 억제제 화합물 및 이를 포함하는 약학적 조성물

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US (2) US7846929B2 (enExample)
EP (1) EP2046799B1 (enExample)
JP (1) JP5291616B2 (enExample)
KR (1) KR101402474B1 (enExample)
CN (1) CN101511840A (enExample)
AR (1) AR060632A1 (enExample)
AU (1) AU2007243466B2 (enExample)
BR (1) BRPI0710908A2 (enExample)
CA (1) CA2650295C (enExample)
CL (1) CL2007001166A1 (enExample)
IL (1) IL194761A0 (enExample)
MX (1) MX2008013583A (enExample)
NO (1) NO20084927L (enExample)
RU (1) RU2437888C2 (enExample)
TW (1) TW200801012A (enExample)
WO (1) WO2007127183A1 (enExample)
ZA (1) ZA200810023B (enExample)

Cited By (2)

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KR20200041294A (ko) * 2017-06-21 2020-04-21 샤이 테라퓨틱스 엘엘씨 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물
WO2023055181A1 (ko) * 2021-09-30 2023-04-06 한미약품 주식회사 PIKfyve 키나아제 억제제

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