NO20084927L - Fosfoinositid-3-kinaseinhibitorforbindelser og farmasoytiske sammensetninger inneholdende dem - Google Patents

Fosfoinositid-3-kinaseinhibitorforbindelser og farmasoytiske sammensetninger inneholdende dem

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Publication number
NO20084927L
NO20084927L NO20084927A NO20084927A NO20084927L NO 20084927 L NO20084927 L NO 20084927L NO 20084927 A NO20084927 A NO 20084927A NO 20084927 A NO20084927 A NO 20084927A NO 20084927 L NO20084927 L NO 20084927L
Authority
NO
Norway
Prior art keywords
phosphoinositide
pharmaceutical compositions
compositions containing
kinase inhibitor
inhibitor compounds
Prior art date
Application number
NO20084927A
Other languages
English (en)
Inventor
Vickie Hsiao-Wei Tsui
Janet Gunzner
Georgette Castanedo
Shumei Wang
Kimberly Malesky
Alan Olivero
Jennafer Dotson
Richard Goldsmith
Tim Heffron
Simon Mathieu
Daniel P Sutherlin
Christian Weismann
Zhu Bing-Yan
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38561741&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20084927(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of NO20084927L publication Critical patent/NO20084927L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Surgery (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

Forbindelser med formlene (Ia) og (Ib), innbefattende stereoisomerer, geometriske isomerer, tautomerer, solvater, metabolitter og farmasøytisk akseptable salter derav, er nyttige for å hemme lipidkinaser iberegnet PI3K, og for å behandle forstyrrelser så som kreft mediert av lipidkinaser. Metoder for å anvende forbindelser med formel (Ia) og (Ib) for diagnose in vitro, in situ og in vivo, for forhindring eller behandling av slike forstyrrelser i pattedyrceller eller forbundne patologiske tilstander, er beskrevet.
NO20084927A 2006-04-26 2008-11-25 Fosfoinositid-3-kinaseinhibitorforbindelser og farmasoytiske sammensetninger inneholdende dem NO20084927L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79504706P 2006-04-26 2006-04-26
PCT/US2007/009880 WO2007127183A1 (en) 2006-04-26 2007-04-24 Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
NO20084927L true NO20084927L (no) 2009-01-23

Family

ID=38561741

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084927A NO20084927L (no) 2006-04-26 2008-11-25 Fosfoinositid-3-kinaseinhibitorforbindelser og farmasoytiske sammensetninger inneholdende dem

Country Status (17)

Country Link
US (2) US7846929B2 (no)
EP (1) EP2046799B1 (no)
JP (1) JP5291616B2 (no)
KR (1) KR101402474B1 (no)
CN (1) CN101511840A (no)
AR (1) AR060632A1 (no)
AU (1) AU2007243466B2 (no)
BR (1) BRPI0710908A2 (no)
CA (1) CA2650295C (no)
CL (1) CL2007001166A1 (no)
IL (1) IL194761A0 (no)
MX (1) MX2008013583A (no)
NO (1) NO20084927L (no)
RU (1) RU2437888C2 (no)
TW (1) TW200801012A (no)
WO (1) WO2007127183A1 (no)
ZA (1) ZA200810023B (no)

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