JP2009530416A5 - - Google Patents
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- JP2009530416A5 JP2009530416A5 JP2009501679A JP2009501679A JP2009530416A5 JP 2009530416 A5 JP2009530416 A5 JP 2009530416A5 JP 2009501679 A JP2009501679 A JP 2009501679A JP 2009501679 A JP2009501679 A JP 2009501679A JP 2009530416 A5 JP2009530416 A5 JP 2009530416A5
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- Prior art keywords
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- 238000000034 method Methods 0.000 claims description 114
- 239000003814 drug Substances 0.000 claims description 36
- 229940079593 drug Drugs 0.000 claims description 35
- 229920000642 polymer Polymers 0.000 claims description 29
- 239000007962 solid dispersion Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000004094 surface-active agent Substances 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims 94
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 57
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 41
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 32
- 239000000203 mixture Substances 0.000 claims 30
- 229960000583 acetic acid Drugs 0.000 claims 16
- 239000012362 glacial acetic acid Substances 0.000 claims 16
- 208000005176 Hepatitis C Diseases 0.000 claims 12
- 239000003443 antiviral agent Substances 0.000 claims 12
- -1 anti-thyroid Substances 0.000 claims 11
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 10
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 9
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 9
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 8
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 8
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 8
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 8
- 229920003169 water-soluble polymer Polymers 0.000 claims 8
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 6
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 6
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 6
- 235000004626 essential fatty acids Nutrition 0.000 claims 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 4
- GAMPNQJDUFQVQO-UHFFFAOYSA-N acetic acid;phthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC=C1C(O)=O GAMPNQJDUFQVQO-UHFFFAOYSA-N 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000001419 dependent effect Effects 0.000 claims 4
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 4
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 4
- GSNUFIFRDBKVIE-UHFFFAOYSA-N DMF Natural products CC1=CC=C(C)O1 GSNUFIFRDBKVIE-UHFFFAOYSA-N 0.000 claims 3
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 3
- 229940122236 Histamine receptor antagonist Drugs 0.000 claims 3
- 229930003427 Vitamin E Natural products 0.000 claims 3
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 claims 3
- 229940035676 analgesics Drugs 0.000 claims 3
- 239000000730 antalgic agent Substances 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 3
- 230000003276 anti-hypertensive effect Effects 0.000 claims 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 3
- 230000000078 anti-malarial effect Effects 0.000 claims 3
- 230000002460 anti-migrenic effect Effects 0.000 claims 3
- 230000001022 anti-muscarinic effect Effects 0.000 claims 3
- 230000000118 anti-neoplastic effect Effects 0.000 claims 3
- 239000000883 anti-obesity agent Substances 0.000 claims 3
- 229940124605 anti-osteoporosis drug Drugs 0.000 claims 3
- 230000000648 anti-parkinson Effects 0.000 claims 3
- 230000000842 anti-protozoal effect Effects 0.000 claims 3
- 230000003208 anti-thyroid effect Effects 0.000 claims 3
- 239000003416 antiarrhythmic agent Substances 0.000 claims 3
- 239000003146 anticoagulant agent Substances 0.000 claims 3
- 229940127219 anticoagulant drug Drugs 0.000 claims 3
- 239000001961 anticonvulsive agent Substances 0.000 claims 3
- 239000000935 antidepressant agent Substances 0.000 claims 3
- 229940005513 antidepressants Drugs 0.000 claims 3
- 239000003472 antidiabetic agent Substances 0.000 claims 3
- 229940125708 antidiabetic agent Drugs 0.000 claims 3
- 239000003429 antifungal agent Substances 0.000 claims 3
- 229940121375 antifungal agent Drugs 0.000 claims 3
- 229960002708 antigout preparations Drugs 0.000 claims 3
- 239000000739 antihistaminic agent Substances 0.000 claims 3
- 239000003430 antimalarial agent Substances 0.000 claims 3
- 229940034982 antineoplastic agent Drugs 0.000 claims 3
- 239000003096 antiparasitic agent Substances 0.000 claims 3
- 229940125687 antiparasitic agent Drugs 0.000 claims 3
- 239000000939 antiparkinson agent Substances 0.000 claims 3
- 239000003904 antiprotozoal agent Substances 0.000 claims 3
- 229940043671 antithyroid preparations Drugs 0.000 claims 3
- 239000002249 anxiolytic agent Substances 0.000 claims 3
- 230000000949 anxiolytic effect Effects 0.000 claims 3
- 239000002876 beta blocker Substances 0.000 claims 3
- 229940097320 beta blocking agent Drugs 0.000 claims 3
- 239000002475 cognitive enhancer Substances 0.000 claims 3
- 239000003246 corticosteroid Substances 0.000 claims 3
- 229940111134 coxibs Drugs 0.000 claims 3
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 3
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 3
- 239000002934 diuretic Substances 0.000 claims 3
- 230000001882 diuretic effect Effects 0.000 claims 3
- 239000008157 edible vegetable oil Substances 0.000 claims 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 3
- 230000002496 gastric effect Effects 0.000 claims 3
- 239000003163 gonadal steroid hormone Substances 0.000 claims 3
- 230000000147 hypnotic effect Effects 0.000 claims 3
- 229960003444 immunosuppressant agent Drugs 0.000 claims 3
- 230000001861 immunosuppressant effect Effects 0.000 claims 3
- 239000003018 immunosuppressive agent Substances 0.000 claims 3
- 201000001881 impotence Diseases 0.000 claims 3
- 239000003199 leukotriene receptor blocking agent Substances 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 3
- 229940041033 macrolides Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229940035363 muscle relaxants Drugs 0.000 claims 3
- 239000003158 myorelaxant agent Substances 0.000 claims 3
- 239000003176 neuroleptic agent Substances 0.000 claims 3
- 230000000701 neuroleptic effect Effects 0.000 claims 3
- 235000015097 nutrients Nutrition 0.000 claims 3
- 239000000014 opioid analgesic Substances 0.000 claims 3
- 229940005483 opioid analgesics Drugs 0.000 claims 3
- 239000000932 sedative agent Substances 0.000 claims 3
- 230000001624 sedative effect Effects 0.000 claims 3
- 229940126586 small molecule drug Drugs 0.000 claims 3
- 239000000021 stimulant Substances 0.000 claims 3
- 235000019165 vitamin E Nutrition 0.000 claims 3
- 229940046009 vitamin E Drugs 0.000 claims 3
- 239000011709 vitamin E Substances 0.000 claims 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 2
- 229920000858 Cyclodextrin Polymers 0.000 claims 2
- 239000001856 Ethyl cellulose Substances 0.000 claims 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 2
- 206010020880 Hypertrophy Diseases 0.000 claims 2
- 229940124091 Keratolytic Drugs 0.000 claims 2
- 206010046543 Urinary incontinence Diseases 0.000 claims 2
- 230000003257 anti-anginal effect Effects 0.000 claims 2
- 230000003177 cardiotonic effect Effects 0.000 claims 2
- 229920002301 cellulose acetate Polymers 0.000 claims 2
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 2
- WZNRVWBKYDHTKI-UHFFFAOYSA-N cellulose, acetate 1,2,4-benzenetricarboxylate Chemical compound OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O.OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O.CC(=O)OCC1OC(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(COC(C)=O)O1.CC(=O)OCC1OC(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(COC(C)=O)O1.OC(=O)C1=CC(C(=O)O)=CC=C1C(=O)OCC1C(OC2C(C(OC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)C(OC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)C(COC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)O2)OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)O1 WZNRVWBKYDHTKI-UHFFFAOYSA-N 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 229920006037 cross link polymer Polymers 0.000 claims 2
- 229920001249 ethyl cellulose Polymers 0.000 claims 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims 2
- 230000000762 glandular Effects 0.000 claims 2
- 230000001530 keratinolytic effect Effects 0.000 claims 2
- 229920000609 methyl cellulose Polymers 0.000 claims 2
- 239000001923 methylcellulose Substances 0.000 claims 2
- 235000010981 methylcellulose Nutrition 0.000 claims 2
- 229960002900 methylcellulose Drugs 0.000 claims 2
- 229920000193 polymethacrylate Polymers 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 2
- 238000001694 spray drying Methods 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 125000005591 trimellitate group Chemical group 0.000 claims 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010021639 Incontinence Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 239000004004 anti-anginal agent Substances 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 239000004041 inotropic agent Substances 0.000 claims 1
- PURKAOJPTOLRMP-UHFFFAOYSA-N ivacaftor Chemical compound C1=C(O)C(C(C)(C)C)=CC(C(C)(C)C)=C1NC(=O)C1=CNC2=CC=CC=C2C1=O PURKAOJPTOLRMP-UHFFFAOYSA-N 0.000 claims 1
- 239000003410 keratolytic agent Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 241000124008 Mammalia Species 0.000 description 1
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78427506P | 2006-03-20 | 2006-03-20 | |
| US87169206P | 2006-12-22 | 2006-12-22 | |
| PCT/US2007/064294 WO2007109605A2 (en) | 2006-03-20 | 2007-03-19 | Pharmaceutical compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013240174A Division JP2014037435A (ja) | 2006-03-20 | 2013-11-20 | 医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009530416A JP2009530416A (ja) | 2009-08-27 |
| JP2009530416A5 true JP2009530416A5 (https=) | 2010-05-06 |
Family
ID=38523222
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501679A Withdrawn JP2009530416A (ja) | 2006-03-20 | 2007-03-19 | 医薬組成物 |
| JP2013240174A Pending JP2014037435A (ja) | 2006-03-20 | 2013-11-20 | 医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013240174A Pending JP2014037435A (ja) | 2006-03-20 | 2013-11-20 | 医薬組成物 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US20070218012A1 (https=) |
| EP (1) | EP2001497A4 (https=) |
| JP (2) | JP2009530416A (https=) |
| KR (2) | KR20140107691A (https=) |
| CN (1) | CN103272234A (https=) |
| AR (1) | AR063468A1 (https=) |
| AU (2) | AU2007226984B2 (https=) |
| BR (1) | BRPI0708957A2 (https=) |
| CA (1) | CA2646335A1 (https=) |
| EA (1) | EA018811B1 (https=) |
| EC (1) | ECSP088759A (https=) |
| GE (1) | GEP20125378B (https=) |
| IL (1) | IL194176A (https=) |
| MX (1) | MX2008011976A (https=) |
| NO (1) | NO20084334L (https=) |
| NZ (1) | NZ571934A (https=) |
| PE (1) | PE20080170A1 (https=) |
| RS (1) | RS20090406A (https=) |
| SG (1) | SG170087A1 (https=) |
| TW (2) | TWI428125B (https=) |
| UY (1) | UY30225A1 (https=) |
| WO (1) | WO2007109605A2 (https=) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1019A (en) | 1996-10-18 | 2001-10-16 | Vertex Pharma | Inhibitors of serinre proteases, particularly hepatitis C virus NS3 protease. |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| UY28500A1 (es) | 2003-09-05 | 2005-04-29 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc. |
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| AU2007217355B2 (en) | 2006-02-27 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Co-crystals comprising VX-950 and pharmaceutical compositions comprising the same |
| WO2007109080A2 (en) | 2006-03-16 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
| EP2674428B1 (en) | 2006-04-07 | 2016-04-06 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| MX2009006806A (es) * | 2006-12-22 | 2009-08-27 | Vertex Pharma | Secado por rocio fluidizado. |
| HRP20120330T1 (hr) | 2007-02-27 | 2012-05-31 | Vertex Pharmaceuticals Incorporated | Sukristali i farmaceutski pripravci koji ih sadrže |
| WO2008106058A2 (en) | 2007-02-27 | 2008-09-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| NZ583699A (en) | 2007-08-30 | 2012-04-27 | Vertex Pharma | Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same |
| WO2009117151A2 (en) | 2008-03-20 | 2009-09-24 | Virun, Inc. | Compositions containing non-polar compounds |
| MX2010010050A (es) * | 2008-03-20 | 2011-03-15 | Virun Inc Star | Emulsiones que incluyen un derivado de polietilen glicol de tocoferol. |
| WO2010093843A2 (en) | 2009-02-12 | 2010-08-19 | Vertex Pharmaceuticals Incorporated | Hcv combination therapies |
| TW201043269A (en) * | 2009-04-14 | 2010-12-16 | Bristol Myers Squibb Co | Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
| NZ596610A (en) | 2009-05-27 | 2014-04-30 | Samyang Biopharmaceuticals | A poorly soluble drug containing microsphere with improved bioavailability and method of preparing the same |
| WO2011025771A1 (en) * | 2009-08-25 | 2011-03-03 | Biogen Idec Ma Inc. | Compositions for delivery of insoluble agents |
| AU2011210795A1 (en) | 2010-01-29 | 2012-08-02 | Vertex Pharmaceuticals Incorporated | Therapies for treating Hepatitis C virus infection |
| CN103037708B (zh) * | 2010-03-23 | 2015-05-20 | 维尔恩公司 | 含有蔗糖脂肪酸酯的纳米乳液 |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| SI2826776T1 (sl) * | 2010-03-25 | 2021-02-26 | Vertex Pharmaceuticals Incorporated | Trdna disperzija amorfne oblike (R)-1(2,2-difluorobenzo(D)(1,3)dioksol-5-il)-N-(1-(2,3-dihidroksipropil) -6-fluoro-2-(1-hidroksi-2-metilpropan-2-il)-1H-indol-5-il)- ciklopropankarboksamida |
| MX353408B (es) | 2010-04-22 | 2018-01-11 | Vertex Pharma | Proceso para producir compuestos de cicloalquilcarboxamido-indol. |
| WO2011162802A1 (en) | 2010-06-21 | 2011-12-29 | Virun, Inc. | Compositions containing non-polar compounds |
| CN102293734A (zh) * | 2010-06-25 | 2011-12-28 | 江苏恒瑞医药股份有限公司 | 托伐普坦固体分散体及其制备方法 |
| EP2593105A1 (en) | 2010-07-14 | 2013-05-22 | Vertex Pharmaceuticals Incorporated | Palatable pharmaceutical composition comprising vx-950 |
| WO2012054870A2 (en) | 2010-10-21 | 2012-04-26 | Vertex Pharmaceuticals Incorporated | Biomarkers for hcv infected patients |
| WO2012063246A1 (en) * | 2010-11-11 | 2012-05-18 | Mapi Pharma Ltd. | Amorphous form of lurasidone hydrochloride |
| WO2012109646A1 (en) | 2011-02-11 | 2012-08-16 | Vertex Pharmaceuticals Incorporated | Treatment of hcv in hiv infection patients |
| WO2013014665A1 (en) | 2011-07-28 | 2013-01-31 | Mapi Pharma Ltd. | Intermediate compounds and process for the preparation of lurasidone and salts thereof |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| SE1450131A1 (sv) | 2011-10-21 | 2014-05-07 | Abbvie Inc | DAA-kombinationsbehandling (t.ex. med ABT-072 eller ABT-333)för användning vid behandling av HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| DE112012002748T5 (de) | 2011-10-21 | 2014-07-31 | Abbvie Inc. | Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon |
| WO2013089479A1 (ko) * | 2011-12-15 | 2013-06-20 | 주식회사 삼양바이오팜 | 세레콕시브 함유 고체분산체 및 그 제조방법 |
| US20130195797A1 (en) | 2012-01-31 | 2013-08-01 | Vertex Pharmaceuticals Incorporated | High potency formulations of vx-950 |
| EP2811847B1 (en) | 2012-02-10 | 2017-12-13 | Virun, Inc. | Beverage compositions containing non-polar compounds |
| AR092857A1 (es) | 2012-07-16 | 2015-05-06 | Vertex Pharma | Composiciones farmaceuticas de (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1h-indol-5-il)ciclopropancarboxamida y administracion de las mismas |
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- 2007-03-19 US US11/687,779 patent/US20070218012A1/en not_active Abandoned
- 2007-03-19 KR KR1020147022986A patent/KR20140107691A/ko not_active Ceased
- 2007-03-19 CN CN2013101589038A patent/CN103272234A/zh active Pending
- 2007-03-19 CA CA002646335A patent/CA2646335A1/en not_active Abandoned
- 2007-03-19 GE GEAP200710941A patent/GEP20125378B/en unknown
- 2007-03-19 KR KR1020087025510A patent/KR20090025187A/ko not_active Abandoned
- 2007-03-19 AU AU2007226984A patent/AU2007226984B2/en not_active Ceased
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- 2007-03-19 TW TW102143937A patent/TW201414469A/zh unknown
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- 2007-03-19 JP JP2009501679A patent/JP2009530416A/ja not_active Withdrawn
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