JP2009528271A5 - - Google Patents
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- Publication number
- JP2009528271A5 JP2009528271A5 JP2008552268A JP2008552268A JP2009528271A5 JP 2009528271 A5 JP2009528271 A5 JP 2009528271A5 JP 2008552268 A JP2008552268 A JP 2008552268A JP 2008552268 A JP2008552268 A JP 2008552268A JP 2009528271 A5 JP2009528271 A5 JP 2009528271A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- disease
- compound
- alzheimer
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 208000037259 Amyloid Plaque Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 108700028369 Alleles Proteins 0.000 claims 2
- 108010060159 Apolipoprotein E4 Proteins 0.000 claims 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 206010044688 Trisomy 21 Diseases 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000025688 early-onset autosomal dominant Alzheimer disease Diseases 0.000 claims 2
- 208000015756 familial Alzheimer disease Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- FYTAUNFPOYWHBC-UHFFFAOYSA-N 2-[6-(methylamino)pyridin-3-yl]-1,3-benzothiazol-6-ol Chemical compound C1=NC(NC)=CC=C1C1=NC2=CC=C(O)C=C2S1 FYTAUNFPOYWHBC-UHFFFAOYSA-N 0.000 claims 1
- ANXFFSCEPWNLTC-UHFFFAOYSA-N 5-[6-[tert-butyl(dimethyl)silyl]oxy-1,3-benzothiazol-2-yl]pyridin-2-amine Chemical compound S1C2=CC(O[Si](C)(C)C(C)(C)C)=CC=C2N=C1C1=CC=C(N)N=C1 ANXFFSCEPWNLTC-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000011503 in vivo imaging Methods 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 238000004611 spectroscopical analysis Methods 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76265406P | 2006-01-27 | 2006-01-27 | |
| US60/762,654 | 2006-01-27 | ||
| PCT/SE2007/000068 WO2007086800A1 (en) | 2006-01-27 | 2007-01-25 | Novel heteroaryl substituted benzothiazoles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528271A JP2009528271A (ja) | 2009-08-06 |
| JP2009528271A5 true JP2009528271A5 (cg-RX-API-DMAC7.html) | 2010-03-04 |
| JP5289061B2 JP5289061B2 (ja) | 2013-09-11 |
Family
ID=38309497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552268A Expired - Fee Related JP5289061B2 (ja) | 2006-01-27 | 2007-01-25 | 新規なへテロアリール置換ベンゾチアゾール |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8163928B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1981883A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5289061B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101406248B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101410393B (cg-RX-API-DMAC7.html) |
| AR (1) | AR059178A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007207904C1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0707283A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2640213A1 (cg-RX-API-DMAC7.html) |
| EC (1) | ECSP088645A (cg-RX-API-DMAC7.html) |
| IL (1) | IL192876A0 (cg-RX-API-DMAC7.html) |
| NO (1) | NO20083394L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ569667A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2448106C2 (cg-RX-API-DMAC7.html) |
| SA (1) | SA07280009B1 (cg-RX-API-DMAC7.html) |
| TW (2) | TW201018678A (cg-RX-API-DMAC7.html) |
| UA (1) | UA95267C2 (cg-RX-API-DMAC7.html) |
| UY (1) | UY30112A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007086800A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200806075B (cg-RX-API-DMAC7.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201018678A (en) | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
| TW200813035A (en) | 2006-06-19 | 2008-03-16 | Astrazeneca Ab | Novel heteroaryl substituted benzoxazoles |
| TW200901998A (en) | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
| US8557222B2 (en) | 2008-04-04 | 2013-10-15 | Avid Radiopharmaceuticals, Inc. | Radiopharmaceutical imaging of neurodegenerative diseases |
| ES2554772T3 (es) | 2008-05-30 | 2015-12-23 | Merck Sharp & Dohme Corp. | Azabenzoxazoles sustituidos novedosos |
| US8193363B2 (en) * | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
| CA2741668A1 (en) * | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel substituted azabenzoxazoles |
| EP2501696B1 (en) * | 2009-10-15 | 2016-12-28 | Guerbet | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
| WO2011163636A2 (en) * | 2010-06-24 | 2011-12-29 | The Regents Of The University Of California | Compounds and uses thereof in modulating levels of various amyloid beta peptide alloforms |
| WO2012145169A2 (en) * | 2011-04-21 | 2012-10-26 | The Regents Of The University Of California | Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles |
| WO2013040183A1 (en) * | 2011-09-16 | 2013-03-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Beta-amyloid imaging agents, methods of manufacture, and methods of use thereof |
| CN102558091B (zh) * | 2011-12-22 | 2014-10-08 | 合肥工业大学 | 一种苯并噻唑类衍生物及其用途 |
| CN102659772B (zh) * | 2012-05-03 | 2015-02-11 | 北京师范大学 | 一种与Aβ斑块有亲和力的2-芳基苯并杂环化合物及其制备方法和应用 |
| KR102053484B1 (ko) * | 2012-12-21 | 2019-12-06 | 국립연구개발법인 양자과학기술연구개발기구 | 뇌 안에 축적된 타우 단백질을 이미징하기 위한 신규한 화합물 |
| EP2968296B1 (en) | 2013-03-12 | 2020-09-02 | The Regents of the University of California | Gamma-secretase modulators |
| TWI652014B (zh) * | 2013-09-13 | 2019-03-01 | 美商艾佛艾姆希公司 | 雜環取代之雙環唑殺蟲劑 |
| WO2015051188A1 (en) | 2013-10-02 | 2015-04-09 | Washington University | Heterocyclic molecules for biomedical imaging and therapeutic applications |
| WO2016004513A1 (en) * | 2014-07-11 | 2016-01-14 | Simon Fraser University | Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods |
| JP6562361B2 (ja) * | 2014-07-16 | 2019-08-21 | 国立研究開発法人科学技術振興機構 | ベンゾチアゾール化合物及びこれを含有する医薬 |
| WO2016070107A1 (en) | 2014-10-31 | 2016-05-06 | The General Hospital Corporation | Potent gamma-secretase modulators |
| EP3227287B1 (de) | 2014-12-02 | 2019-08-07 | Bayer Pharma Aktiengesellschaft | Heteroaryl-substituierte imidazo[1,2-a]pyridine und ihre verwendung |
| JP2017537916A (ja) * | 2014-12-02 | 2017-12-21 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 有害生物防除剤としての二環式化合物 |
| EP3268359B1 (en) * | 2015-03-12 | 2019-12-18 | FMC Corporation | Heterocycle-substituted bicyclic azole pesticides |
| MX382156B (es) | 2015-08-28 | 2025-03-13 | Chdi Foundation Inc | Sondas para formar imagenes de proteina de huntingtina. |
| GB201617339D0 (en) * | 2016-10-12 | 2016-11-23 | Lytix Biopharma As | Therapeutic compounds |
| AU2018312558B2 (en) | 2017-08-02 | 2022-09-29 | Spinogenix, Inc. | Benzothiazole and related compounds |
| CA3099318C (en) | 2018-05-09 | 2024-02-13 | Aprinoia Therapeutics Inc. | Heteroaryl compounds and uses thereof |
| CA3100235A1 (en) | 2018-05-16 | 2019-11-21 | Emory University | Styrylbenzothiazole derivatives and uses in imaging |
| HUE072464T2 (hu) | 2019-01-31 | 2025-11-28 | Spinogenix Inc | Spinogenézis egy promoterének szilárd formái |
| GB201914989D0 (en) * | 2019-10-16 | 2019-11-27 | Karin & Sten Mortstedt Cbd Solutions Ab | Selective ligands for TAU Aggregates |
| CA3161455A1 (en) | 2019-11-13 | 2021-05-20 | Aprinoia Therapeutics Limited | Compounds for degrading tau protein aggregates and uses thereof |
| KR102682408B1 (ko) * | 2021-05-12 | 2024-07-05 | 에이치케이이노엔 주식회사 | 신규한 벤조티아졸 유도체, 이의 제조방법 및 이의 간질환 예방 또는 치료 용도 |
| CN114478431B (zh) * | 2022-03-09 | 2024-07-02 | 台州学院 | 一种双取代苯并噻吩类钾离子通道激动剂的制备方法 |
| CN114380731B (zh) * | 2022-03-09 | 2024-07-02 | 台州学院 | 一种kcnq钾离子通道激动剂、药物组合物及其应用 |
| JP2025540931A (ja) | 2022-11-03 | 2025-12-17 | セントニックス インコーポレイテッド | タウ凝集体に対する選択的リガンド |
| WO2025202955A1 (en) | 2024-03-28 | 2025-10-02 | Pi Industries Ltd. | Fused bicyclic compounds and their use as pest control agents |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU523040B2 (en) * | 1978-05-15 | 1982-07-08 | Kanebo Limited | Calcium -antagonistic composition |
| GB8305245D0 (en) | 1983-02-25 | 1983-03-30 | Fujisawa Pharmaceutical Co | Imidazo-heterocyclic compounds |
| US4556411A (en) * | 1984-12-07 | 1985-12-03 | Fmc Corporation | Benzothiazole derivatives for plant growth and development modification |
| JPS6394248A (ja) | 1986-10-08 | 1988-04-25 | Canon Inc | 電子写真感光体 |
| CA2034309C (en) * | 1990-01-22 | 1997-04-01 | Takashi Iwaki | Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus |
| WO1995017095A1 (en) | 1993-12-21 | 1995-06-29 | Eli Lilly And Company | Methods for the treatment or prevention of conditions associated with amyloidogenic reptides |
| US5518713A (en) * | 1995-02-13 | 1996-05-21 | 3V Inc. | Benzoxazole derivatives, the use thereof as sunscreens and cosmetic compositions containing them |
| JPH11116476A (ja) | 1997-10-16 | 1999-04-27 | Sankyo Co Ltd | 縮合複素環化合物 |
| EP1334091B1 (en) * | 2000-08-24 | 2012-09-19 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Thioflavin derivatives and their use in diagnosis and therapy of alzheimer's disease |
| US7045539B2 (en) * | 2000-12-22 | 2006-05-16 | Astrazeneca Ab | Therapeutic benzoxazole compounds |
| US6596731B2 (en) | 2001-03-27 | 2003-07-22 | Hoffmann-La Roche Inc. | Substituted imidazo[1,2-A] pyridine derivatives |
| KR20040058111A (ko) | 2001-04-23 | 2004-07-03 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 아밀로이드 플라크 응집 억제제 및 진단 영상화제 |
| AU2002349477A1 (en) * | 2001-11-26 | 2003-06-10 | Takeda Chemical Industries, Ltd. | Bicyclic derivative, process for producing the same, and use |
| GB0130305D0 (en) | 2001-12-19 | 2002-02-06 | Amersham Plc | Compounds for imaging alzheimers disease |
| WO2003106439A1 (ja) | 2002-06-12 | 2003-12-24 | 株式会社ビーエフ研究所 | アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬 |
| TW200401194A (en) | 2002-07-11 | 2004-01-16 | Advanced Micro Devices Inc | Method and apparatus for determining a processor state without interrupting processor operation |
| ATE425753T1 (de) | 2002-08-02 | 2009-04-15 | Genesoft Pharmaceuticals Inc | Biaryl-verbindungen mit antiinfektiver wirkung |
| JP2004250411A (ja) | 2003-02-21 | 2004-09-09 | Bf Kenkyusho:Kk | アミロイドβ蓄積性疾患の診断プローブおよび治療用化合物 |
| CA2438032C (en) * | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
| US20060276433A1 (en) | 2003-03-31 | 2006-12-07 | Keiichi Kawagoe | Hydrazone derivative |
| US7329682B2 (en) * | 2003-04-03 | 2008-02-12 | Ewha University-Industry Collaboration Foundation | Method for inhibiting 5-lipoxygenase using a benzoxazole derivative |
| CN100372844C (zh) | 2003-05-13 | 2008-03-05 | 弗·哈夫曼-拉罗切有限公司 | 作为腺苷受体配体的2-咪唑-苯并噻唑 |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| CA2609980C (en) | 2005-05-27 | 2015-10-13 | Queen's University At Kingston | Treatment of protein folding disorders |
| WO2007033080A2 (en) | 2005-09-12 | 2007-03-22 | Emory University | Alzheimer's disease imaging agents |
| WO2007035405A2 (en) | 2005-09-16 | 2007-03-29 | University Of Pittsburgh | In-vivo and in-vitro method for detecting amyloid deposits having at least one amyloidogenic protein |
| EP1945622B1 (en) | 2005-10-11 | 2011-12-28 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Isotopically-labeled benzofuran compounds as imagingagents for amyloidogenic proteins |
| ATE533485T1 (de) | 2005-10-31 | 2011-12-15 | Merck Sharp & Dohme | Cetp-inhibitoren |
| WO2007063946A1 (ja) | 2005-11-30 | 2007-06-07 | Fujifilm Ri Pharma Co., Ltd. | アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬 |
| TW201018678A (en) | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
| WO2008118122A2 (en) * | 2006-05-08 | 2008-10-02 | Molecular Neuroimaging, Llc | Compounds and amyloid probes thereof for therapeutic and imaging uses |
| TW200813035A (en) | 2006-06-19 | 2008-03-16 | Astrazeneca Ab | Novel heteroaryl substituted benzoxazoles |
| BRPI0806621A2 (pt) | 2007-01-22 | 2011-09-13 | Astrazeneca Ab | composto, uso de um composto, composição farmacêutica, e, método in vivo para medir depósitos amilóides em um indivìduo |
-
2007
- 2007-01-19 TW TW098145976A patent/TW201018678A/zh unknown
- 2007-01-19 TW TW096102118A patent/TW200736252A/zh unknown
- 2007-01-24 SA SA7280009A patent/SA07280009B1/ar unknown
- 2007-01-24 AR ARP070100305A patent/AR059178A1/es unknown
- 2007-01-25 EP EP20070709290 patent/EP1981883A4/en not_active Withdrawn
- 2007-01-25 CA CA002640213A patent/CA2640213A1/en not_active Abandoned
- 2007-01-25 NZ NZ569667A patent/NZ569667A/en not_active IP Right Cessation
- 2007-01-25 WO PCT/SE2007/000068 patent/WO2007086800A1/en not_active Ceased
- 2007-01-25 US US12/162,255 patent/US8163928B2/en not_active Expired - Fee Related
- 2007-01-25 JP JP2008552268A patent/JP5289061B2/ja not_active Expired - Fee Related
- 2007-01-25 UA UAA200809015A patent/UA95267C2/ru unknown
- 2007-01-25 CN CN2007800112344A patent/CN101410393B/zh not_active Expired - Fee Related
- 2007-01-25 AU AU2007207904A patent/AU2007207904C1/en not_active Ceased
- 2007-01-25 RU RU2008130965/04A patent/RU2448106C2/ru not_active IP Right Cessation
- 2007-01-25 BR BRPI0707283-0A patent/BRPI0707283A2/pt not_active IP Right Cessation
- 2007-01-25 KR KR1020087020871A patent/KR101406248B1/ko not_active Expired - Fee Related
- 2007-01-26 UY UY30112A patent/UY30112A1/es not_active Application Discontinuation
-
2008
- 2008-07-11 ZA ZA2008/06075A patent/ZA200806075B/en unknown
- 2008-07-17 IL IL192876A patent/IL192876A0/en unknown
- 2008-07-22 EC EC2008008645A patent/ECSP088645A/es unknown
- 2008-08-01 NO NO20083394A patent/NO20083394L/no not_active Application Discontinuation
-
2012
- 2012-04-23 US US13/453,579 patent/US8957215B2/en not_active Expired - Fee Related