JP2009526751A5 - - Google Patents

Download PDF

Info

Publication number
JP2009526751A5
JP2009526751A5 JP2008548499A JP2008548499A JP2009526751A5 JP 2009526751 A5 JP2009526751 A5 JP 2009526751A5 JP 2008548499 A JP2008548499 A JP 2008548499A JP 2008548499 A JP2008548499 A JP 2008548499A JP 2009526751 A5 JP2009526751 A5 JP 2009526751A5
Authority
JP
Japan
Prior art keywords
infection
salt
animal
benzoxabolol
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008548499A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009526751A (ja
Filing date
Publication date
Priority claimed from US11/357,687 external-priority patent/US7582621B2/en
Application filed filed Critical
Priority claimed from PCT/US2006/032238 external-priority patent/WO2007078340A2/en
Publication of JP2009526751A publication Critical patent/JP2009526751A/ja
Publication of JP2009526751A5 publication Critical patent/JP2009526751A5/ja
Pending legal-status Critical Current

Links

JP2008548499A 2005-12-30 2006-08-16 ホウ素含有小分子 Pending JP2009526751A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75522705P 2005-12-30 2005-12-30
US11/357,687 US7582621B2 (en) 2005-02-16 2006-02-16 Boron-containing small molecules
PCT/US2006/005542 WO2006089067A2 (en) 2005-02-16 2006-02-16 Boron-containing small molecules
US74636106P 2006-05-03 2006-05-03
PCT/US2006/032238 WO2007078340A2 (en) 2005-12-30 2006-08-16 Boron-containing small molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014264693A Division JP6109140B2 (ja) 2005-12-30 2014-12-26 ホウ素含有小分子

Publications (2)

Publication Number Publication Date
JP2009526751A JP2009526751A (ja) 2009-07-23
JP2009526751A5 true JP2009526751A5 (enExample) 2009-10-01

Family

ID=38225302

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008548499A Pending JP2009526751A (ja) 2005-12-30 2006-08-16 ホウ素含有小分子

Country Status (11)

Country Link
US (14) US7767657B2 (enExample)
EP (1) EP1976536A4 (enExample)
JP (1) JP2009526751A (enExample)
KR (1) KR20080110984A (enExample)
CN (3) CN106008571A (enExample)
AU (1) AU2006333527B2 (enExample)
BR (1) BRPI0621279B1 (enExample)
CA (1) CA2635680A1 (enExample)
IL (1) IL192402A (enExample)
RU (1) RU2008131324A (enExample)
WO (1) WO2007078340A2 (enExample)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2872962T3 (es) 2005-02-16 2021-11-03 Anacor Pharmaceuticals Inc Boronoftalidas para uso terapéutico
US7793666B2 (en) * 2005-07-28 2010-09-14 Innovation Biomedical Devices, Inc. Apparatus and method for treatment of infected nail
CN106008571A (zh) 2005-12-30 2016-10-12 安纳考尔医药公司 含硼的小分子
CN101420854B (zh) 2006-02-16 2013-08-07 安纳考尔医药公司 作为抗炎药的含硼的小分子
JP2009536660A (ja) * 2006-05-02 2009-10-15 アナコール ファーマシューティカルズ,インコーポレイテッド 加水分解耐性ホウ素含有治療剤及びその使用方法
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
RU2015109165A (ru) 2008-03-06 2015-11-10 Анакор Фармасьютикалз, Инк. Борсодержащие малые молекулы в качестве противовоспалительных агентов
CA2721060A1 (en) 2008-04-09 2009-10-15 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
US20100256092A1 (en) * 2008-05-12 2010-10-07 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2010011354A2 (en) * 2008-07-25 2010-01-28 Innovation Biomedical Devices, Inc. Enchanced trans-keratin drug delivery
WO2010027975A1 (en) * 2008-09-04 2010-03-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US8461336B2 (en) * 2008-09-04 2013-06-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2010045503A1 (en) 2008-10-15 2010-04-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agents
JP2012512262A (ja) * 2008-12-17 2012-05-31 アナコール ファーマシューティカルズ,インコーポレーテッド (s)−3−アミノメチル−7−(3−ヒドロキシ−プロポキシ)−3h−ベンゾ[c][1,2]オキサボロール−1−オールの多形体
CA2757679A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
AU2010234449A1 (en) 2009-04-07 2011-11-03 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
EP2458995A1 (en) 2009-07-28 2012-06-06 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
WO2011019612A1 (en) 2009-08-14 2011-02-17 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
US9440994B2 (en) 2009-08-14 2016-09-13 Anacor Pharmaceuticals, Inc. Boron containing small molecules as antiprotozoal agents
WO2011019616A1 (en) 2009-08-14 2011-02-17 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
MX2012002031A (es) 2009-08-19 2012-07-04 Anacor Pharmaceuticals Inc Moleculas pequeñas que contienen boro como agentes antiprotozoarios.
WO2011037731A1 (en) 2009-09-25 2011-03-31 Anacor Pharmaceuticals, Inc. Boron containing small molecules
US8979820B2 (en) 2009-10-09 2015-03-17 Cynthia S. Bailey Method and apparatus for improving the appearance of nails affected by onychomycosis through the topical application of an aqueous solution containing boric acid and camphor or other terpenes
WO2011049971A1 (en) 2009-10-20 2011-04-28 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011060196A1 (en) 2009-11-11 2011-05-19 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2011063293A1 (en) 2009-11-20 2011-05-26 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antihelminth agents
WO2011094450A1 (en) 2010-01-27 2011-08-04 Anacor Pharmaceuticals, Inc Boron-containing small molecules
MX361011B (es) 2010-02-03 2018-11-26 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de ácido graso.
WO2011116348A1 (en) 2010-03-19 2011-09-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agent
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
RS62548B1 (sr) 2010-09-07 2021-12-31 Anacor Pharmaceuticals Inc Derivati benzoksaborola za lečenje bakterijskih infekcija
US9162999B2 (en) 2011-09-28 2015-10-20 Wisconsin Alumni Research Foundation Catalytic conversion of cellulose to fuels and chemicals using boronic acids
AU2012320382B2 (en) * 2011-10-07 2015-11-26 Syngenta Participations Ag Method for protecting useful plants or plant propagation material
AR088668A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Moleculas pequeñas que contienen boro
AR088669A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos
US9732101B2 (en) 2012-01-18 2017-08-15 Wisconsin Alumni Research Foundation Bioreversible boronates for delivery of molecules into cells
US9234048B2 (en) 2012-01-18 2016-01-12 Wisconsin Alumni Research Foundation Boronate-mediated delivery of molecules into cells
US20150080342A1 (en) 2012-04-14 2015-03-19 Anacor Pharmaceuticals, Inc. Benzoxaborole compounds and uses thereof
WO2014007831A1 (en) 2012-07-06 2014-01-09 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US8980544B2 (en) 2012-11-27 2015-03-17 The Penn State Research Foundation Boronic and borinic acid compounds as inhibitors of sulfenic acid-containing proteins
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
PE20151299A1 (es) * 2013-01-30 2015-09-18 Dow Agrosciences Llc Uso de benzoxaboroles como agentes antimicrobianos volatiles en carnes, plantas o partes de plantas
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
US9598443B2 (en) 2013-02-01 2017-03-21 Anacor Pharmaceuticals, Inc. Boron containing small molecules as antiprotozoal agents
AR094961A1 (es) 2013-03-15 2015-09-09 Lilly Co Eli 1-hidroxi-benzooxaboroles como agentes antiparasitarios
WO2014173880A1 (en) 2013-04-22 2014-10-30 Syngenta Participations Ag Novel microbiocides
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
WO2015021396A2 (en) * 2013-08-09 2015-02-12 Glaxosmithkline Intellectual Property (No.2) Limited Tricyclic benzoxaborole compounds and uses thereof
EP3052487B1 (en) 2013-10-03 2018-09-05 Dow Pharmaceutical Sciences, Inc. Stabilized efinaconazole compositions
EP3071295A4 (en) 2013-11-22 2017-05-31 Dow Pharmaceutical Sciences, Inc. Anti-infective methods, compositions, and devices
BR112016014601B1 (pt) 2013-12-23 2021-01-19 Medical Brands Research B.V. composição dermatológica, dispositivo aplicador e método para preparar uma composição dermatológica
UY36000A (es) * 2014-02-17 2015-09-30 Syngenta Participations Ag ?compuestos microbicidas, método para controlar o prevenir la infestación de microorganismos fitopa togenos, y composición de los mismos?.
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
JP2015212249A (ja) * 2014-05-05 2015-11-26 アナコール ファーマシューティカルズ,インコーポレイテッド 化合物および爪光沢剤
JP6682454B2 (ja) * 2014-05-12 2020-04-15 アグロフレッシュ インコーポレイテッド 病原体に対する揮発適用
KR20170024068A (ko) 2014-07-01 2017-03-06 다이이찌 산쿄 가부시키가이샤 항박테리아제로서의 삼환식 벤즈옥사보롤
US20160051565A1 (en) * 2014-08-20 2016-02-25 Professional Compounding Centers Of America (Pcca) Transdermal Pharmaceutical Compositions Including Testosterone and an Aromatase Inhibitor
WO2016061619A1 (en) 2014-10-21 2016-04-28 Hexima Limited A method of treatment
MA41494B1 (fr) 2015-02-12 2020-10-28 Glaxosmithkline Ip No 2 Ltd Composés benzoxaborole substitués en position 4 et utilisations associées
US10011616B2 (en) 2015-04-09 2018-07-03 Mmv Medicines For Malaria Venture Boron-containing small molecules as antiprotozoal1 agents
CA2981773C (en) 2015-04-09 2022-03-15 The Penn State Research Foundation Synergistic benzoxaborole-containing anti-fungicidal composition
US10160867B2 (en) * 2015-08-06 2018-12-25 The Penn State Research Foundation Benzoxaborole-containing coating resistant to cellulose-supportable fungus
WO2017031041A1 (en) * 2015-08-17 2017-02-23 Channel Therapeutics, Inc. Functionalized aminobenzoboroxoles
EP3971191A1 (en) 2016-03-02 2022-03-23 Bill And Melinda Gates Foundation Boron-containing small molecules
US10874679B2 (en) 2016-03-02 2020-12-29 Bill & Melinda Gates Foundation Boron-containing small molecules
CN113845536A (zh) 2016-03-02 2021-12-28 比尔及梅琳达盖茨基金会 含硼小分子
NZ745681A (en) 2016-03-07 2022-05-27 Agrofresh Inc Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
US10435419B2 (en) 2016-04-18 2019-10-08 Biophore India Pharmaceuticals Pvt. Ltd. Process for the preparation of tavaborole, its novel polymorphic forms and the polymorphs thereof
KR102221472B1 (ko) 2016-05-09 2021-03-02 아나코르 파마슈티칼스 인코포레이티드 유리 형태의 크리사보롤의 결정 형태 및 그의 제조 방법 및 용도
US11447506B2 (en) 2016-05-09 2022-09-20 Anacor Pharmaceuticals, Inc. Crystal forms of crisaborole in free form and preparation method and use thereof
CN109219351A (zh) 2016-06-03 2019-01-15 巴斯夫欧洲公司 苯并氧杂硼戊环化合物
WO2019190503A1 (en) * 2018-03-28 2019-10-03 Cove Bio Llc Methods and compositions for treating parkinson's disease
WO2018150327A1 (en) * 2017-02-14 2018-08-23 Wavelength Enterprises Ltd Crisaborole production process
WO2019096113A1 (zh) * 2017-11-14 2019-05-23 深圳市塔吉瑞生物医药有限公司 一种氘代的含硼的化合物及药物组合物和用途
EP3716766A4 (en) * 2017-11-30 2021-12-22 Boragen, Inc. BENZOXABOROLE COMPOUNDS AND THEIR FORMULATIONS
AU2019325436B2 (en) 2018-08-18 2023-10-26 5Metis, Inc. Solid forms of substituted benzoxaborole and compositions thereof
WO2020123881A1 (en) * 2018-12-12 2020-06-18 Boragen, Inc. Boron containing compounds and their uses
US20220187712A1 (en) * 2019-04-16 2022-06-16 Basf Se Composition for avoiding pattern collapse when treating patterned materials with line-space dimensions of 50 nm or below comprising a boron-type additive
US20220275007A1 (en) * 2019-07-30 2022-09-01 Boragen, Inc. Flow reaction process for manufacture of boron-containing agrochemicals
EP4204012A1 (en) 2020-08-31 2023-07-05 Pfizer Inc. Methods of protecting rna
CN114249756A (zh) * 2020-09-21 2022-03-29 广东和博制药有限公司 一种他伐硼罗的合成方法
CN115894575B (zh) * 2022-08-10 2024-11-19 河南大学 一种由非经典三层笼状簇构筑的多金属氧酸盐材料及其制备方法与应用

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2260336A (en) * 1939-10-16 1941-10-28 Dow Chemical Co Method of preparation of organic borates
US2741548A (en) 1954-10-15 1956-04-10 Standard Oil Co Leaded motor fuel containing boron compounds
GB791688A (en) 1955-05-12 1958-03-12 May & Baker Ltd Improvements in or relating to pyrazole derivatives
US3093659A (en) 1956-06-20 1963-06-11 Pfizer & Co C Antifungal and insecticidal halokojic acid metal complexes
US3104255A (en) 1960-06-16 1963-09-17 Standard Oil Co Telomerization of unsaturated hydrocarbons with alkylene glycol borates and telomeric products obtained thereby
US3297525A (en) 1962-10-19 1967-01-10 Merck & Co Inc Fungicidal compositions comprising salicylates of 8 hydroxy quinoline carboxylic esters
NL134354C (enExample) 1963-05-23
US3686398A (en) * 1970-07-20 1972-08-22 Chevron Res 10,9-boroxarophenanthrene as fungicides
US3816472A (en) 1972-07-06 1974-06-11 Schering Corp Azido analogs of griseofulvin
GB1396904A (en) * 1972-08-11 1975-06-11 Ici Ltd Method for the control of micro-organisms
US4766113A (en) 1975-10-24 1988-08-23 Chapman Chemical Company Antimicrobial compositions and methods of using same
US4602011A (en) 1975-10-24 1986-07-22 Chapman Chemical Company Antimicrobial compositions and methods of using same
AT354187B (de) 1976-11-22 1979-12-27 Hoffmann La Roche Fungizides mittel
US4716035A (en) 1985-05-24 1987-12-29 The Procter & Gamble Company Oral compositions and methods for treating gingivitis
JPH0676285B2 (ja) 1985-11-01 1994-09-28 三井東圧化学株式会社 ベンジルアミン誘導体、その製造法およびその用途
US5962498A (en) 1986-06-11 1999-10-05 Procyon Pharmaceuticals, Inc. Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity
US4894220A (en) 1987-01-30 1990-01-16 Colgate-Palmolive Company Antibacterial antiplaque oral composition
DE3720147A1 (de) 1987-06-16 1988-12-29 Hoechst Ag Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung
US4977268A (en) 1988-04-08 1990-12-11 Duke University Boron dipeptide compounds
US4919934A (en) 1989-03-02 1990-04-24 Richardson-Vicks Inc. Cosmetic sticks
SG47101A1 (en) 1992-07-31 1998-03-20 Us Bioscience Crystalline amifostine compositions and methods for the preparation and use of same
US5348947A (en) 1993-05-07 1994-09-20 American Cyanamid Company Diarylboron ester and thioester fungicidal agents
US5348948A (en) 1993-05-07 1994-09-20 American Cyanamid Company 2,2-diaryl-1-(oxa and thia)-2a-azonia-2-borataacenaphthene fungicidal
US5821233A (en) * 1993-09-29 1998-10-13 Gist-Brocades, N.V. Antifungal composition
US5594151A (en) 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexing reagents derived from aminosalicylic acid
GB9411587D0 (en) * 1994-06-09 1994-08-03 Zeneca Ltd Compound, composition and use
US5498407A (en) 1994-10-24 1996-03-12 Atlas; Sheldon M. Poly(2-hydroxyethyl methacrylate) and all copolymers of poly-HEMA fibers and cosmetic compositions containing same
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5696164A (en) 1994-12-22 1997-12-09 Johnson & Johnson Consumer Products, Inc. Antifungal treatment of nails
GB9500856D0 (en) 1995-01-17 1995-03-08 Zeneca Ltd Composition and use
JPH09124620A (ja) 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
US6632955B1 (en) 1996-12-02 2003-10-14 Chisso Corporation Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for preparing the same
GB9604926D0 (en) 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
JP4373497B2 (ja) 1996-06-19 2009-11-25 ローン−プーラン・ロレ・リミテツド 置換されたアザビシクロ化合物、ならびにtnfおよびサイクリックampホスホジエステラーゼ産生の阻害剤としてのそれらの使用
US5831046A (en) * 1996-08-05 1998-11-03 Prolinx, Incorporated Boronic acid-contaning nucleic acid monomers
WO1998012206A1 (en) 1996-09-19 1998-03-26 The Board Of Trustees Of Leland Stanford Jr. University Dna adenine methyltransferases and uses thereof
US6221640B1 (en) 1997-05-14 2001-04-24 Cubist Pharmaceuticals, Inc. Enterococcal aminoacyl-trna synthetase proteins, nucleic acids and strains comprising same
US6140328A (en) * 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
DK0983037T3 (da) 1998-02-09 2003-09-01 Macrochem Corp Fungicid neglelak
IL138889A0 (en) 1998-04-17 2001-11-25 Bertek Pharm Inc Topical formulations for the treatment of nail fungal diseases
DE19829947A1 (de) 1998-07-04 2000-01-05 Bayer Ag Elektrolumineszierende Anordnungen mit Bor-Chelaten
US6462036B1 (en) 1998-11-06 2002-10-08 Basf Aktiengesellschaft Tricyclic pyrazole derivatives
BR9915132A (pt) 1998-11-06 2001-08-07 Basf Ag Método para inibir a atividade de quinase de proteìna, compostos da fórmula i e sais farmaceuticamente aceitáveis dos mesmos, uso do mesmo, e, composição farmacêutica.
EP1155698A4 (en) 1999-01-29 2003-01-15 Nitto Kasei Co Ltd ORGANOBORAL COMPOUNDS HAVING COCCIDIOSTAT ACTIVITY
EP1181291A2 (en) 1999-05-25 2002-02-27 The Penn State Research Foundation Dna methyltransferase inhibitors
US6306628B1 (en) * 1999-08-25 2001-10-23 Ambergen, Incorporated Methods for the detection, analysis and isolation of Nascent proteins
WO2001014578A1 (en) 1999-08-25 2001-03-01 Ambergen, Inc. Methods for the detection, analysis and isolation of nascent proteins
AU7995300A (en) 1999-10-05 2001-05-10 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
CO5271678A1 (es) 2000-01-06 2003-04-30 Marantech Holding Llc Composiciones para facilitar el crecimiento de la piel y metodos y articulos que las emplean
US7074392B1 (en) 2000-03-27 2006-07-11 Taro Pharmaceutical Industries Limited Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections
US6521619B2 (en) 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
DE10032017A1 (de) 2000-07-01 2002-01-10 Clariant Gmbh Verfahren zur Herstellung hochreiner Formylphenylboronsäuren
EP1303625A2 (en) 2000-07-14 2003-04-23 Zycos Inc. Alpha-msh related compounds and methods of use
HUP0400651A2 (hu) * 2000-11-07 2004-06-28 Bristol-Myers Squibb Company Szerin proteáz inhibitorokként alkalmazható savszármazékok és ezeket tartalmazó gyógyszerkészítmények
JP2004524281A (ja) 2000-11-30 2004-08-12 ザ ペン ステート リサーチ ファウンデイション Dnaメチルトランスフェラーゼ阻害剤
DE10110051C2 (de) 2001-03-02 2003-07-03 Clariant Gmbh Verfahren zur Herstellung von Boron- und Borinsäuren
US6878365B2 (en) * 2001-03-10 2005-04-12 James Edward Brehove Topical application for treating toenail fungus
ES2332090T3 (es) 2001-04-06 2010-01-26 Biocryst Pharmaceuticals, Inc. Compuestos biarilicos como inhibidores de serina proteasa.
GB0117645D0 (en) 2001-07-19 2001-09-12 Isis Innovation Therapeutic stratergies for prevention and treatment of alzheimers disease
US7825104B2 (en) * 2001-07-23 2010-11-02 Ramot At Tel Aviv University Ltd. Methods and compositions for treating fungal infections
DE10143979A1 (de) * 2001-09-07 2003-03-27 Clariant Gmbh Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren
JPWO2003033002A1 (ja) 2001-10-11 2005-02-03 御子柴 克彦 細胞内カルシウム濃度上昇抑制剤
JP4209659B2 (ja) 2001-11-15 2009-01-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 アミジノ誘導体並びにそれを用いた抗血液凝固剤および血栓症治療剤
JP4138662B2 (ja) 2002-01-10 2008-08-27 ザ・ペンシルバニア・ステイト・リサーチ・フアウンデイシヨン アルキルジアリールボリネートおよび錯化ジアリールボロン酸を調製するための方法。
EP1578362A4 (en) 2002-07-09 2008-11-05 Point Therapeutics Inc COMBINATION THERAPY WITH A BOROPROLINE COMPOUND
CA2504941C (en) * 2002-11-08 2012-06-26 Neurogen Corporation 3-substituted-6-aryl pyridines
EP1567464B1 (en) 2002-12-02 2007-04-18 Solvias AG Catalytic hydrogeneration of carbon-heteroatom double bonds
US7390806B2 (en) 2002-12-18 2008-06-24 Anacor Pharmaceuticals, Inc. Antibiotics containing borinic acid complexes and methods of use
BR0317564A (pt) 2002-12-18 2005-11-22 Anacor Pharmaceuticals Inc Compostos, composições e métodos para tratar doenças causadas por bactérias ou fungos
AU2004220176A1 (en) 2003-03-14 2004-09-23 Astrazeneca Ab Novel fused triazolones and the uses thereof
WO2005000200A2 (en) 2003-05-09 2005-01-06 Sugen, Inc. Novel kinases
RU2006101228A (ru) * 2003-06-16 2006-07-27 Анакор Фармасьютикалз, Инк. (Us) Гидролитически устойчивые борсодержащие терапевтические агенты и способы их применения
JP2005022986A (ja) 2003-06-30 2005-01-27 Sankyo Co Ltd Edg受容体拮抗作用を有するアルキン誘導体
PL1643998T3 (pl) * 2003-07-03 2008-01-31 Hoffmann La Roche Podwójni antagoniści NK1/NK3 do leczenia schizofrenii
WO2005066172A1 (en) 2003-12-29 2005-07-21 3M Innovative Properties Company Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds
WO2005112970A2 (en) 2004-05-12 2005-12-01 The Brigham And Women's Hospital, Inc. Use of gelsolin to treat infections
EP1753428A4 (en) 2004-05-14 2010-09-15 Abbott Lab INHIBITORS OF KINASES AS THERAPEUTIC AGENTS
AR049915A1 (es) 2004-06-14 2006-09-13 Anacor Pharmaceuticals Inc Compuestos con contenido de boro y metodos de uso de los mismos
KR100624238B1 (ko) * 2004-06-22 2006-09-19 한국화학연구원 알파-아릴메톡시아크릴레이트 유도체를 함유하는 대사성골 질환의 예방 및 치료용 약학 조성물
WO2006062731A1 (en) 2004-11-19 2006-06-15 University Of North Texas Health Science Center At Fort Worth Phenanthroline and derivatives thereof used to lower intraocular pressure in an affected eye
GB0501944D0 (en) 2005-01-31 2005-03-09 Univ Cambridge Tech Compounds for use in chemical detection and/or quantitation
ES2872962T3 (es) 2005-02-16 2021-11-03 Anacor Pharmaceuticals Inc Boronoftalidas para uso terapéutico
WO2006096131A1 (en) 2005-03-08 2006-09-14 Agency For Science, Technology And Research Chiral bisoxazoline catalysts
US20060229347A1 (en) 2005-03-30 2006-10-12 Astion Development A/S Treatment of eczemas
US20070028682A1 (en) 2005-08-04 2007-02-08 Geon Sagong System for measuring fluid level using acoustic impedance matching
US20080234229A1 (en) 2005-08-18 2008-09-25 Auspex Pharmaceuticals, Inc. Novel Therapeutic Agents for the Treatment of Cancer, Metabolic Diseases and Skin Disorders
CN106008571A (zh) 2005-12-30 2016-10-12 安纳考尔医药公司 含硼的小分子
CN101420854B (zh) 2006-02-16 2013-08-07 安纳考尔医药公司 作为抗炎药的含硼的小分子
CA2654449A1 (en) 2006-06-12 2007-12-21 Anacor Pharmaceuticals, Inc. Compounds for the treatment of periodontal disease
US20070286822A1 (en) * 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
KR100848491B1 (ko) 2007-01-16 2008-07-28 영진약품공업주식회사 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법
JO3396B1 (ar) 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
KR100895300B1 (ko) 2007-07-20 2009-05-07 한국전자통신연구원 생체신호 측정의복과 생체신호 처리시스템
WO2009111676A2 (en) 2008-03-06 2009-09-11 Anacor Pharmaceuticals, Inc Boron-containing small molecules as anti-inflammatory agents
RU2015109165A (ru) 2008-03-06 2015-11-10 Анакор Фармасьютикалз, Инк. Борсодержащие малые молекулы в качестве противовоспалительных агентов
US20100256092A1 (en) 2008-05-12 2010-10-07 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US8461336B2 (en) 2008-09-04 2013-06-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2010027975A1 (en) 2008-09-04 2010-03-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2010045503A1 (en) 2008-10-15 2010-04-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agents
WO2010045505A1 (en) 2008-10-15 2010-04-22 Anacor Pharmaceuticals, Inc Boron-containing small molecules as anti-protozoal agents
JP2012512262A (ja) 2008-12-17 2012-05-31 アナコール ファーマシューティカルズ,インコーポレーテッド (s)−3−アミノメチル−7−(3−ヒドロキシ−プロポキシ)−3h−ベンゾ[c][1,2]オキサボロール−1−オールの多形体
EP2458995A1 (en) 2009-07-28 2012-06-06 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
WO2011060196A1 (en) 2009-11-11 2011-05-19 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2011094450A1 (en) 2010-01-27 2011-08-04 Anacor Pharmaceuticals, Inc Boron-containing small molecules
AR080834A1 (es) 2010-04-07 2012-05-09 Glaxosmithkline Llc Proceso para la preparacion de benzoxaboroles
RS62548B1 (sr) 2010-09-07 2021-12-31 Anacor Pharmaceuticals Inc Derivati benzoksaborola za lečenje bakterijskih infekcija
AR088668A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Moleculas pequeñas que contienen boro
AR088669A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos
JP2015212249A (ja) 2014-05-05 2015-11-26 アナコール ファーマシューティカルズ,インコーポレイテッド 化合物および爪光沢剤

Similar Documents

Publication Publication Date Title
JP2009526751A5 (enExample)
RU2470016C2 (ru) Производное бипиразола
JP6382798B2 (ja) 局所非水性医薬製剤
JP2013541514A5 (enExample)
JP2005537234A5 (enExample)
JP2007504269A5 (enExample)
EA200802412A1 (ru) Терапевтические комбинации для сопровождающихся болью медицинских состояний
WO2009088549A3 (en) Methods of inhibiting bacterial virulence and compounds relating thereto
EP4233899A3 (en) Methods of vaccine administration
EP1791561A4 (en) HEMRAGHIC FELINES CALICIVIRUS, CALICIVIRUS VACCINE, AND METHOD FOR PREVENTING CALICIVIRUS INFECTION OR DISEASE
EP4464375A3 (en) Methods of treatment using single doses of oritavancin
US20180221405A1 (en) Silicate containing compositions and methods of treatment
BRPI0920605A2 (pt) composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para o tratamento ou profilaxia de infecção pelo hiv ou para o tratamento, profilaxia, ou retardo no início ou progressão da aids em um paciente em necessidade deste.
JP2010500284A5 (enExample)
JP2006507295A5 (enExample)
JP2012520665A5 (enExample)
JP2002537256A5 (enExample)
WO2009070564A3 (en) Compositions and methods for prevention of infection in transcutaneous osseointegrated implants
JP2010526884A5 (enExample)
JP2005506959A5 (enExample)
MX2009006670A (es) Composicion farmaceutica que usa el aliskiren y el avosentan.
NO20074949L (no) Farmasoytisk preparat som kan administreres oralt for behandling av fisk, fremstillingsmetode for angitte preparat og anvendelse derav
RU2006146326A (ru) Способ лечения хронического вирусного гепатита с
WO2007144889A3 (en) Treatment of neurofibromatosis
JP6434650B2 (ja) 糖尿病創傷治療用イソキノリン誘導体の新規使用