RU2008131324A - Борсодержащие малые молекулы - Google Patents
Борсодержащие малые молекулы Download PDFInfo
- Publication number
- RU2008131324A RU2008131324A RU2008131324/04A RU2008131324A RU2008131324A RU 2008131324 A RU2008131324 A RU 2008131324A RU 2008131324/04 A RU2008131324/04 A RU 2008131324/04A RU 2008131324 A RU2008131324 A RU 2008131324A RU 2008131324 A RU2008131324 A RU 2008131324A
- Authority
- RU
- Russia
- Prior art keywords
- substituted
- unsubstituted
- compound
- alkyl
- trna synthetase
- Prior art date
Links
- 150000003384 small molecules Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 151
- 125000000217 alkyl group Chemical group 0.000 claims abstract 99
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 59
- 125000003118 aryl group Chemical group 0.000 claims abstract 58
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 58
- 125000004404 heteroalkyl group Chemical group 0.000 claims abstract 58
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract 58
- 125000004429 atom Chemical group 0.000 claims abstract 45
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 35
- 229910052736 halogen Inorganic materials 0.000 claims abstract 28
- 150000002367 halogens Chemical class 0.000 claims abstract 27
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 16
- -1 methoxymethoxy Chemical group 0.000 claims 368
- 238000000034 method Methods 0.000 claims 112
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 56
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 56
- 244000005700 microbiome Species 0.000 claims 46
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 43
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 29
- 210000000282 nail Anatomy 0.000 claims 29
- 125000003710 aryl alkyl group Chemical group 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 17
- 229940079593 drug Drugs 0.000 claims 17
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 16
- 230000002401 inhibitory effect Effects 0.000 claims 15
- 239000000825 pharmaceutical preparation Substances 0.000 claims 15
- 238000002360 preparation method Methods 0.000 claims 14
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 12
- 241000233866 Fungi Species 0.000 claims 12
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 12
- 229910052796 boron Inorganic materials 0.000 claims 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 11
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 11
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 241001465754 Metazoa Species 0.000 claims 9
- 241000223238 Trichophyton Species 0.000 claims 9
- 208000015181 infectious disease Diseases 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- LFQDNHWZDQTITF-UHFFFAOYSA-N tavaborole Chemical compound FC1=CC=C2B(O)OCC2=C1 LFQDNHWZDQTITF-UHFFFAOYSA-N 0.000 claims 9
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- 125000004288 oxazolidin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])OC1([H])* 0.000 claims 8
- MLRBNIXMTWSDJU-UHFFFAOYSA-N 2-benzylfuran Chemical class C=1C=CC=CC=1CC1=CC=CO1 MLRBNIXMTWSDJU-UHFFFAOYSA-N 0.000 claims 7
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 7
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 7
- 108010071170 Leucine-tRNA ligase Proteins 0.000 claims 7
- 102100023342 Leucine-tRNA ligase, mitochondrial Human genes 0.000 claims 7
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 7
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 7
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 7
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
- 238000006243 chemical reaction Methods 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 125000001153 fluoro group Chemical group F* 0.000 claims 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 7
- 125000000593 indol-1-yl group Chemical group [H]C1=C([H])C([H])=C2N([*])C([H])=C([H])C2=C1[H] 0.000 claims 7
- 125000005358 mercaptoalkyl group Chemical group 0.000 claims 7
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 7
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 7
- 125000006518 morpholino carbonyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])N(C(*)=O)C1([H])[H] 0.000 claims 7
- 125000002757 morpholinyl group Chemical group 0.000 claims 7
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 7
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 6
- 125000004663 dialkyl amino group Chemical group 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 6
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 5
- 108010058060 Alanine-tRNA ligase Proteins 0.000 claims 5
- 102000006268 Alanine-tRNA ligase Human genes 0.000 claims 5
- 241001480035 Epidermophyton Species 0.000 claims 5
- 108010092041 Lysine-tRNA Ligase Proteins 0.000 claims 5
- 102000017737 Lysine-tRNA Ligase Human genes 0.000 claims 5
- 108010003060 Methionine-tRNA ligase Proteins 0.000 claims 5
- 102000004587 Methionine-tRNA ligase Human genes 0.000 claims 5
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 5
- 102000001618 Threonine-tRNA Ligase Human genes 0.000 claims 5
- 108010029287 Threonine-tRNA ligase Proteins 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 5
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 5
- 230000035772 mutation Effects 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 5
- 150000003212 purines Chemical class 0.000 claims 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 5
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 5
- 150000003222 pyridines Chemical class 0.000 claims 5
- 150000003230 pyrimidines Chemical class 0.000 claims 5
- 239000010802 sludge Substances 0.000 claims 5
- 241001480043 Arthrodermataceae Species 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 4
- 208000007163 Dermatomycoses Diseases 0.000 claims 4
- 238000003747 Grignard reaction Methods 0.000 claims 4
- 102000011782 Keratins Human genes 0.000 claims 4
- 108010076876 Keratins Proteins 0.000 claims 4
- 241001480037 Microsporum Species 0.000 claims 4
- 208000010195 Onychomycosis Diseases 0.000 claims 4
- 108010004478 Phenylalanine-tRNA Ligase Proteins 0.000 claims 4
- 102000002798 Phenylalanine-tRNA Ligase Human genes 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 241000223229 Trichophyton rubrum Species 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 230000004071 biological effect Effects 0.000 claims 4
- 125000001589 carboacyl group Chemical group 0.000 claims 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 4
- 201000003929 dermatomycosis Diseases 0.000 claims 4
- 230000037304 dermatophytes Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 150000002460 imidazoles Chemical class 0.000 claims 4
- 244000045947 parasite Species 0.000 claims 4
- 230000000149 penetrating effect Effects 0.000 claims 4
- 238000001953 recrystallisation Methods 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011593 sulfur Chemical group 0.000 claims 4
- 125000001544 thienyl group Chemical group 0.000 claims 4
- 201000005882 tinea unguium Diseases 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 241001149956 Cladosporium herbarum Species 0.000 claims 3
- 206010016654 Fibrosis Diseases 0.000 claims 3
- 102000029793 Isoleucine-tRNA ligase Human genes 0.000 claims 3
- 101710176147 Isoleucine-tRNA ligase, cytoplasmic Proteins 0.000 claims 3
- 101710149031 Probable isoleucine-tRNA ligase, cytoplasmic Proteins 0.000 claims 3
- 102100026126 Proline-tRNA ligase Human genes 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 239000004327 boric acid Substances 0.000 claims 3
- UYANAUSDHIFLFQ-UHFFFAOYSA-N borinic acid Chemical compound OB UYANAUSDHIFLFQ-UHFFFAOYSA-N 0.000 claims 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000001086 cytosolic effect Effects 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 230000004761 fibrosis Effects 0.000 claims 3
- 125000001041 indolyl group Chemical group 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 229950003188 isovaleryl diethylamide Drugs 0.000 claims 3
- 230000002438 mitochondrial effect Effects 0.000 claims 3
- 125000001979 organolithium group Chemical group 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 108010042589 prolyl T RNA synthetase Proteins 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- BUDOHXRLVIXTME-UHFFFAOYSA-N 3,4-dimethyldioxaborinane Chemical compound CB1OOCCC1C BUDOHXRLVIXTME-UHFFFAOYSA-N 0.000 claims 2
- DHANQIJKGVELAS-UHFFFAOYSA-N 3-phenyldioxaborolane Chemical class O1OCCB1C1=CC=CC=C1 DHANQIJKGVELAS-UHFFFAOYSA-N 0.000 claims 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 2
- 229930024421 Adenine Natural products 0.000 claims 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical class NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 2
- 241000223602 Alternaria alternata Species 0.000 claims 2
- 101000787278 Arabidopsis thaliana Valine-tRNA ligase, chloroplastic/mitochondrial 2 Proteins 0.000 claims 2
- 101000787296 Arabidopsis thaliana Valine-tRNA ligase, mitochondrial 1 Proteins 0.000 claims 2
- 241000228245 Aspergillus niger Species 0.000 claims 2
- 241000223678 Aureobasidium pullulans Species 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- FRDOMQZQFJXSJN-UHFFFAOYSA-N CC1(C)BOOC1(C)C Chemical class CC1(C)BOOC1(C)C FRDOMQZQFJXSJN-UHFFFAOYSA-N 0.000 claims 2
- 241000222122 Candida albicans Species 0.000 claims 2
- 241001149472 Clonostachys rosea Species 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 101000787280 Dictyostelium discoideum Probable valine-tRNA ligase, mitochondrial Proteins 0.000 claims 2
- 206010015150 Erythema Diseases 0.000 claims 2
- 208000002584 Fungal Eye Infections Diseases 0.000 claims 2
- 241000427940 Fusarium solani Species 0.000 claims 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 206010041736 Sporotrichosis Diseases 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical class O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- 102000013625 Valine-tRNA Ligase Human genes 0.000 claims 2
- 229960000643 adenine Drugs 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 229940095731 candida albicans Drugs 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 231100000321 erythema Toxicity 0.000 claims 2
- 210000004904 fingernail bed Anatomy 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- 230000007062 hydrolysis Effects 0.000 claims 2
- 238000006460 hydrolysis reaction Methods 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 239000011630 iodine Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical class CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims 1
- 206010063409 Acarodermatitis Diseases 0.000 claims 1
- 241000228212 Aspergillus Species 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 206010004950 Birth mark Diseases 0.000 claims 1
- 241000335423 Blastomyces Species 0.000 claims 1
- 206010005098 Blastomycosis Diseases 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 206010008803 Chromoblastomycosis Diseases 0.000 claims 1
- 208000015116 Chromomycosis Diseases 0.000 claims 1
- 241001337994 Cryptococcus <scale insect> Species 0.000 claims 1
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims 1
- 208000002506 Darier Disease Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010048768 Dermatosis Diseases 0.000 claims 1
- 206010053177 Epidermolysis Diseases 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 208000014260 Fungal keratitis Diseases 0.000 claims 1
- 241000223218 Fusarium Species 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 206010018612 Gonorrhoea Diseases 0.000 claims 1
- 206010018691 Granuloma Diseases 0.000 claims 1
- 208000007514 Herpes zoster Diseases 0.000 claims 1
- 241000228402 Histoplasma Species 0.000 claims 1
- 206010020649 Hyperkeratosis Diseases 0.000 claims 1
- 208000001126 Keratosis Diseases 0.000 claims 1
- 206010023369 Keratosis follicular Diseases 0.000 claims 1
- 206010024229 Leprosy Diseases 0.000 claims 1
- 241000555676 Malassezia Species 0.000 claims 1
- 241000041810 Mycetoma Species 0.000 claims 1
- 206010028698 Nail dystrophy Diseases 0.000 claims 1
- 206010061304 Nail infection Diseases 0.000 claims 1
- 208000005775 Parakeratosis Diseases 0.000 claims 1
- 241001464933 Penium Species 0.000 claims 1
- 241001193612 Phoma violacea Species 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 208000033464 Reiter syndrome Diseases 0.000 claims 1
- 241000235527 Rhizopus Species 0.000 claims 1
- 241000447727 Scabies Species 0.000 claims 1
- 241000132889 Scedosporium Species 0.000 claims 1
- 241000825258 Scopulariopsis brevicaulis Species 0.000 claims 1
- 241000371621 Stemphylium Species 0.000 claims 1
- 241000187747 Streptomyces Species 0.000 claims 1
- 208000033809 Suppuration Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 208000034784 Tularaemia Diseases 0.000 claims 1
- 208000000260 Warts Diseases 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- 208000004631 alopecia areata Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- SIPUZPBQZHNSDW-UHFFFAOYSA-N bis(2-methylpropyl)aluminum Chemical compound CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 claims 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 238000005660 chlorination reaction Methods 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical class O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 claims 1
- 239000001177 diphosphate Substances 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 208000001786 gonorrhea Diseases 0.000 claims 1
- 210000000003 hoof Anatomy 0.000 claims 1
- 210000003284 horn Anatomy 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 201000004607 keratosis follicularis Diseases 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 201000011486 lichen planus Diseases 0.000 claims 1
- 201000006506 lobomycosis Diseases 0.000 claims 1
- 238000004020 luminiscence type Methods 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 150000004712 monophosphates Chemical class 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 201000009838 otomycosis Diseases 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 238000010791 quenching Methods 0.000 claims 1
- 230000000171 quenching effect Effects 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 208000005687 scabies Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 206010040872 skin infection Diseases 0.000 claims 1
- 201000010153 skin papilloma Diseases 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000004611 spectroscopical analysis Methods 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 208000006379 syphilis Diseases 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 229940113082 thymine Drugs 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
- 239000001226 triphosphate Substances 0.000 claims 1
- 235000011178 triphosphate Nutrition 0.000 claims 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical class OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 0 Cc1c(C)c(*)c(*)c(B(*)*)c1[*+] Chemical compound Cc1c(C)c(*)c(*)c(B(*)*)c1[*+] 0.000 description 3
- XUHPQFXGJYTXNA-UHFFFAOYSA-N CC1(C)COB(OCc(cc(cc2)F)c2Br)OC1 Chemical compound CC1(C)COB(OCc(cc(cc2)F)c2Br)OC1 XUHPQFXGJYTXNA-UHFFFAOYSA-N 0.000 description 1
- GOURXZMIYWNJNU-QDJBOYPESA-N CCC(C(NC1[C@H]([n]2c(ncnc3N)c3nc2)O[C@H](CO)C1O)=O)N Chemical compound CCC(C(NC1[C@H]([n]2c(ncnc3N)c3nc2)O[C@H](CO)C1O)=O)N GOURXZMIYWNJNU-QDJBOYPESA-N 0.000 description 1
- XPTOZRHSBJSDJR-UHFFFAOYSA-N CCOC(C)OCc1c(B2OCCCO2)ccc(F)c1 Chemical compound CCOC(C)OCc1c(B2OCCCO2)ccc(F)c1 XPTOZRHSBJSDJR-UHFFFAOYSA-N 0.000 description 1
- GWYGVTXANGKQGE-UHFFFAOYSA-N CSc(cc1)ccc1Sc1cc(B(O)OC2)c2cc1 Chemical compound CSc(cc1)ccc1Sc1cc(B(O)OC2)c2cc1 GWYGVTXANGKQGE-UHFFFAOYSA-N 0.000 description 1
- YWBMZHAXENUPNP-UHFFFAOYSA-N C[n](cc(c1c2)SCCC#N)c1ccc2OC Chemical compound C[n](cc(c1c2)SCCC#N)c1ccc2OC YWBMZHAXENUPNP-UHFFFAOYSA-N 0.000 description 1
- RDVBFLOYBBNXOQ-UHFFFAOYSA-N C[n]1c(ccc(Cl)c2)c2c(Sc2ccccc2)c1 Chemical compound C[n]1c(ccc(Cl)c2)c2c(Sc2ccccc2)c1 RDVBFLOYBBNXOQ-UHFFFAOYSA-N 0.000 description 1
- VUMAOSLVZGFDAT-UHFFFAOYSA-N C[n]1c(cccc2)c2c(Sc2ccccc2)c1 Chemical compound C[n]1c(cccc2)c2c(Sc2ccccc2)c1 VUMAOSLVZGFDAT-UHFFFAOYSA-N 0.000 description 1
- DSILZTFDSQUNAV-UHFFFAOYSA-N Fc(cc1)cc(COB(OC2)OC2c2ccccc2)c1Br Chemical compound Fc(cc1)cc(COB(OC2)OC2c2ccccc2)c1Br DSILZTFDSQUNAV-UHFFFAOYSA-N 0.000 description 1
- SCWBLFWWWFBQAJ-UHFFFAOYSA-N Fc(cc1)cc(COB2OCCCCO2)c1I Chemical compound Fc(cc1)cc(COB2OCCCCO2)c1I SCWBLFWWWFBQAJ-UHFFFAOYSA-N 0.000 description 1
- BDLAKAMWILIVFM-UHFFFAOYSA-N N#Cc1cccc(COc2ccc(B(O)OC3)c3c2)c1 Chemical compound N#Cc1cccc(COc2ccc(B(O)OC3)c3c2)c1 BDLAKAMWILIVFM-UHFFFAOYSA-N 0.000 description 1
- QWUBOCQWTPCPNE-UHFFFAOYSA-N OB(c(c(C=O)c1)ccc1F)O Chemical compound OB(c(c(C=O)c1)ccc1F)O QWUBOCQWTPCPNE-UHFFFAOYSA-N 0.000 description 1
- QURDBPNEPVWVOA-UHFFFAOYSA-N OB(c1c2)OCc1ccc2-[n](cc(c1c2)Sc3ccccc3)c1ccc2Cl Chemical compound OB(c1c2)OCc1ccc2-[n](cc(c1c2)Sc3ccccc3)c1ccc2Cl QURDBPNEPVWVOA-UHFFFAOYSA-N 0.000 description 1
- WVKHHUQRVWIKLZ-UHFFFAOYSA-N OB(c1c2)OCc1ccc2N(CC1)CCN1c1ccccn1 Chemical compound OB(c1c2)OCc1ccc2N(CC1)CCN1c1ccccn1 WVKHHUQRVWIKLZ-UHFFFAOYSA-N 0.000 description 1
- LYIQOEKWJGDOCM-UHFFFAOYSA-N OB(c1c2)OCc1ccc2NS(c1ccccc1)(=O)=O Chemical compound OB(c1c2)OCc1ccc2NS(c1ccccc1)(=O)=O LYIQOEKWJGDOCM-UHFFFAOYSA-N 0.000 description 1
- MPDQGMVOZYTKKO-UHFFFAOYSA-N OB1OCc2c1c(CO)ccc2 Chemical compound OB1OCc2c1c(CO)ccc2 MPDQGMVOZYTKKO-UHFFFAOYSA-N 0.000 description 1
- JEQBSYARWIGITH-UHFFFAOYSA-N OB1OCc2cc(OCC(N(CC3)CCN3c3ncccn3)=O)ccc12 Chemical compound OB1OCc2cc(OCC(N(CC3)CCN3c3ncccn3)=O)ccc12 JEQBSYARWIGITH-UHFFFAOYSA-N 0.000 description 1
- YELXOARSABPVMP-UHFFFAOYSA-O [NH3+]c(cc1)c(COB(OC2)OC2c2ccccc2)cc1F Chemical compound [NH3+]c(cc1)c(COB(OC2)OC2c2ccccc2)cc1F YELXOARSABPVMP-UHFFFAOYSA-O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75522705P | 2005-12-30 | 2005-12-30 | |
| US60/755,227 | 2005-12-30 | ||
| USPCT/US2006/005542 | 2006-02-16 | ||
| US11/357,687 | 2006-02-16 | ||
| US11/357,687 US7582621B2 (en) | 2005-02-16 | 2006-02-16 | Boron-containing small molecules |
| US74636106P | 2006-05-03 | 2006-05-03 | |
| US60/746,361 | 2006-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008131324A true RU2008131324A (ru) | 2010-02-10 |
Family
ID=38225302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008131324/04A RU2008131324A (ru) | 2005-12-30 | 2006-08-16 | Борсодержащие малые молекулы |
Country Status (11)
| Country | Link |
|---|---|
| US (14) | US7767657B2 (enExample) |
| EP (1) | EP1976536A4 (enExample) |
| JP (1) | JP2009526751A (enExample) |
| KR (1) | KR20080110984A (enExample) |
| CN (3) | CN106008571A (enExample) |
| AU (1) | AU2006333527B2 (enExample) |
| BR (1) | BRPI0621279B1 (enExample) |
| CA (1) | CA2635680A1 (enExample) |
| IL (1) | IL192402A (enExample) |
| RU (1) | RU2008131324A (enExample) |
| WO (1) | WO2007078340A2 (enExample) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006214247C1 (en) | 2005-02-16 | 2012-11-08 | Anacor Pharmaceuticals, Llc | Boron-containing small molecules |
| US7793666B2 (en) * | 2005-07-28 | 2010-09-14 | Innovation Biomedical Devices, Inc. | Apparatus and method for treatment of infected nail |
| BRPI0621279B1 (pt) * | 2005-12-30 | 2021-07-20 | Anacor Pharmaceuticals, Inc | Moléculas pequenas contendo boro |
| CA2642583C (en) * | 2006-02-16 | 2016-08-23 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
| WO2007131072A2 (en) * | 2006-05-02 | 2007-11-15 | Anacor Pharmaceuticals, Inc. | Hydrolytically-resistant boron-containing therapeutics and methods of use |
| JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| JO3396B1 (ar) | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| US20090175810A1 (en) | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
| CN102014927A (zh) | 2008-03-06 | 2011-04-13 | 安纳考尔医药公司 | 作为抗炎药的含硼的小分子 |
| CA2721060A1 (en) | 2008-04-09 | 2009-10-15 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| EP2285384A4 (en) * | 2008-05-12 | 2012-04-25 | Anacor Pharmaceuticals Inc | BORN SMALL MOLECULES |
| US20100021530A1 (en) * | 2008-07-25 | 2010-01-28 | Innovation Biomedical Devices, Inc. | Enhanced trans-keratin drug delivery |
| WO2010028005A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2010027975A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US9493489B2 (en) * | 2008-10-15 | 2016-11-15 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
| AU2009335744A1 (en) | 2008-12-17 | 2010-07-15 | Anacor Pharmaceuticals, Inc. | Polymorphs of (S)-3-aminomethyl-7-(3-hydroxy-propoxy) -3H-benzo[c][1,2] oxaborol-1-ol |
| US8546564B2 (en) | 2009-04-07 | 2013-10-01 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| US8541581B2 (en) | 2009-04-07 | 2013-09-24 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| JP2013500974A (ja) * | 2009-07-28 | 2013-01-10 | アナコール ファーマシューティカルズ，インコーポレイテッド | 三置換ホウ素含有分子 |
| AP4039A (en) | 2009-08-14 | 2017-02-28 | Daitao Chen | Boron-containing small molecules as antiprotozoal agents |
| WO2011019616A1 (en) | 2009-08-14 | 2011-02-17 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
| WO2011019612A1 (en) | 2009-08-14 | 2011-02-17 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
| MX2012002031A (es) * | 2009-08-19 | 2012-07-04 | Anacor Pharmaceuticals Inc | Moleculas pequeñas que contienen boro como agentes antiprotozoarios. |
| US20110124597A1 (en) * | 2009-09-25 | 2011-05-26 | Anacor Pharmaceuticals, Inc. | Boron containing small molecules |
| US8979820B2 (en) | 2009-10-09 | 2015-03-17 | Cynthia S. Bailey | Method and apparatus for improving the appearance of nails affected by onychomycosis through the topical application of an aqueous solution containing boric acid and camphor or other terpenes |
| US9346834B2 (en) | 2009-10-20 | 2016-05-24 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
| WO2011060199A1 (en) | 2009-11-11 | 2011-05-19 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2011063293A1 (en) * | 2009-11-20 | 2011-05-26 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antihelminth agents |
| WO2011094450A1 (en) | 2010-01-27 | 2011-08-04 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules |
| JP2013518886A (ja) | 2010-02-03 | 2013-05-23 | インフイニトイ プハルマセウトイカルス インコーポレイテッド | 脂肪酸アミドヒドロラーゼ阻害剤 |
| WO2011116348A1 (en) | 2010-03-19 | 2011-09-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agent |
| US8039494B1 (en) | 2010-07-08 | 2011-10-18 | Dow Pharmaceutical Sciences, Inc. | Compositions and methods for treating diseases of the nail |
| SMT202100643T1 (it) | 2010-09-07 | 2022-01-10 | Anacor Pharmaceuticals Inc | Derivati del benzossaborolo per il trattamento delle infezioni batteriche |
| US9162999B2 (en) | 2011-09-28 | 2015-10-20 | Wisconsin Alumni Research Foundation | Catalytic conversion of cellulose to fuels and chemicals using boronic acids |
| US10130096B2 (en) | 2011-10-07 | 2018-11-20 | Syngenta Participations Ag | Method for protecting useful plants or plant propagation material |
| AR088669A1 (es) * | 2011-11-21 | 2014-06-25 | Lilly Co Eli | Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos |
| AR088668A1 (es) | 2011-11-21 | 2014-06-25 | Lilly Co Eli | Moleculas pequeñas que contienen boro |
| US9732101B2 (en) | 2012-01-18 | 2017-08-15 | Wisconsin Alumni Research Foundation | Bioreversible boronates for delivery of molecules into cells |
| US9234048B2 (en) | 2012-01-18 | 2016-01-12 | Wisconsin Alumni Research Foundation | Boronate-mediated delivery of molecules into cells |
| US20150080342A1 (en) * | 2012-04-14 | 2015-03-19 | Anacor Pharmaceuticals, Inc. | Benzoxaborole compounds and uses thereof |
| WO2014007831A1 (en) | 2012-07-06 | 2014-01-09 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US8980544B2 (en) | 2012-11-27 | 2015-03-17 | The Penn State Research Foundation | Boronic and borinic acid compounds as inhibitors of sulfenic acid-containing proteins |
| US8669207B1 (en) | 2013-01-30 | 2014-03-11 | Dow Agrosciences, Llc. | Compounds and compositions |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| US9585396B2 (en) | 2013-01-30 | 2017-03-07 | Agrofresh Inc. | Volatile applications against pathogens |
| EP2950644B1 (en) * | 2013-01-30 | 2017-07-19 | AgroFresh Inc. | Use of benzoxaboroles as volatile antimicrobial agents on meats, plants, or plant parts |
| US9598443B2 (en) | 2013-02-01 | 2017-03-21 | Anacor Pharmaceuticals, Inc. | Boron containing small molecules as antiprotozoal agents |
| AR094961A1 (es) | 2013-03-15 | 2015-09-09 | Lilly Co Eli | 1-hidroxi-benzooxaboroles como agentes antiparasitarios |
| WO2014173880A1 (en) * | 2013-04-22 | 2014-10-30 | Syngenta Participations Ag | Novel microbiocides |
| KR101636431B1 (ko) | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도 |
| WO2015021396A2 (en) | 2013-08-09 | 2015-02-12 | Glaxosmithkline Intellectual Property (No.2) Limited | Tricyclic benzoxaborole compounds and uses thereof |
| KR102320051B1 (ko) | 2013-10-03 | 2021-10-29 | 다우 파마슈티컬 사이언시즈, 인코포레이티드 | 안정화된 에피나코나졸 조성물 |
| KR102612453B1 (ko) | 2013-11-22 | 2023-12-08 | 다우 파마슈티컬 사이언시즈, 인코포레이티드 | 항감염 방법，조성물，및 장치 |
| EP3086797B1 (en) | 2013-12-23 | 2018-05-23 | Medical Brands Research B.V. | Dermatological composition based on algae and olive leaf extracts |
| US10040806B2 (en) * | 2014-02-17 | 2018-08-07 | Syngenta Participations Ag | Microbiocidally active benzoxaboroles |
| US11039621B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| JP2015212249A (ja) * | 2014-05-05 | 2015-11-26 | アナコール ファーマシューティカルズ，インコーポレイテッド | 化合物および爪光沢剤 |
| JP6682454B2 (ja) * | 2014-05-12 | 2020-04-15 | アグロフレッシュ インコーポレイテッド | 病原体に対する揮発適用 |
| ES2732465T3 (es) | 2014-07-01 | 2019-11-22 | Daiichi Sankyo Co Ltd | Benzoxaboroles tricíclicos como agentes antibacterianos |
| US20160051565A1 (en) * | 2014-08-20 | 2016-02-25 | Professional Compounding Centers Of America (Pcca) | Transdermal Pharmaceutical Compositions Including Testosterone and an Aromatase Inhibitor |
| HRP20211477T8 (hr) | 2014-10-21 | 2022-03-04 | Hexima Limited | Postupak liječenja gljivičnih infekcija |
| MA41495A (fr) | 2015-02-12 | 2017-12-19 | Anacor Pharmaceuticals Inc | Composés benzoxaborole et leurs utilisations |
| SG11201707713UA (en) | 2015-04-09 | 2017-10-30 | Anacor Pharmaceuticals Inc | Boron-containing small molecules as antiprotozoal agents |
| BR112017021478B1 (pt) | 2015-04-09 | 2022-04-19 | The Penn State Research Foundation | Composição antifúngica sinérgica que contém benzoxaborol |
| WO2017024022A1 (en) * | 2015-08-06 | 2017-02-09 | The Penn State Research Foundation | Benzoxaborole-containing coating resistant to cellulose-supportable fungus |
| US10633399B2 (en) | 2015-08-17 | 2020-04-28 | Channel Therapeutics, Inc. | Functionalized aminobenzoboroxoles |
| US10874679B2 (en) | 2016-03-02 | 2020-12-29 | Bill & Melinda Gates Foundation | Boron-containing small molecules |
| WO2017151492A1 (en) | 2016-03-02 | 2017-09-08 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2017151489A1 (en) | 2016-03-02 | 2017-09-08 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| EP3426029B1 (en) | 2016-03-07 | 2023-08-30 | AgroFresh Inc. | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
| US10435419B2 (en) | 2016-04-18 | 2019-10-08 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the preparation of tavaborole, its novel polymorphic forms and the polymorphs thereof |
| SG11201809984PA (en) | 2016-05-09 | 2018-12-28 | Anacor Pharmaceuticals Inc | Crystal forms of crisaborole in free form and preparation method and use thereof |
| US11447506B2 (en) | 2016-05-09 | 2022-09-20 | Anacor Pharmaceuticals, Inc. | Crystal forms of crisaborole in free form and preparation method and use thereof |
| BR112018074276B1 (pt) | 2016-06-03 | 2022-11-08 | Basf Se | Uso de compostos de fórmula (i), compostos de fórmula (i), composição agroquímica e método para controlar vegetação indesejada |
| WO2019190503A1 (en) * | 2018-03-28 | 2019-10-03 | Cove Bio Llc | Methods and compositions for treating parkinson's disease |
| WO2018150327A1 (en) * | 2017-02-14 | 2018-08-23 | Wavelength Enterprises Ltd | Crisaborole production process |
| CN109206446B (zh) * | 2017-11-14 | 2021-08-03 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的含硼的化合物及包含该化合物的药物组合物 |
| CA3120976A1 (en) | 2017-11-30 | 2019-06-06 | Boragen, Inc. | Benzoxaborole compounds and formulations thereof |
| MX2021001904A (es) | 2018-08-18 | 2021-05-27 | Boragen Inc | Formas solidas de benzoxaborol sustituido y composiciones de las mismas. |
| WO2020123881A1 (en) * | 2018-12-12 | 2020-06-18 | Boragen, Inc. | Boron containing compounds and their uses |
| EP3956729A1 (en) * | 2019-04-16 | 2022-02-23 | Basf Se | Composition for avoiding pattern collapse when treating patterned materials with line-space dimensions of 50 nm or below comprising a boron-type additive |
| AR119515A1 (es) * | 2019-07-30 | 2021-12-22 | Boragen Inc | Proceso de reacción de flujo para la fabricación de agroquímicos que contienen boro |
| US20230340530A1 (en) | 2020-08-31 | 2023-10-26 | Pfizer Inc. | Methods of Protecting RNA |
| CN114249756A (zh) * | 2020-09-21 | 2022-03-29 | 广东和博制药有限公司 | 一种他伐硼罗的合成方法 |
| CN115894575B (zh) * | 2022-08-10 | 2024-11-19 | 河南大学 | 一种由非经典三层笼状簇构筑的多金属氧酸盐材料及其制备方法与应用 |
Family Cites Families (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2260336A (en) * | 1939-10-16 | 1941-10-28 | Dow Chemical Co | Method of preparation of organic borates |
| US2741548A (en) | 1954-10-15 | 1956-04-10 | Standard Oil Co | Leaded motor fuel containing boron compounds |
| GB791688A (en) | 1955-05-12 | 1958-03-12 | May & Baker Ltd | Improvements in or relating to pyrazole derivatives |
| US3093659A (en) | 1956-06-20 | 1963-06-11 | Pfizer & Co C | Antifungal and insecticidal halokojic acid metal complexes |
| US3104255A (en) | 1960-06-16 | 1963-09-17 | Standard Oil Co | Telomerization of unsaturated hydrocarbons with alkylene glycol borates and telomeric products obtained thereby |
| US3297525A (en) | 1962-10-19 | 1967-01-10 | Merck & Co Inc | Fungicidal compositions comprising salicylates of 8 hydroxy quinoline carboxylic esters |
| NL134354C (enExample) | 1963-05-23 | |||
| US3686398A (en) * | 1970-07-20 | 1972-08-22 | Chevron Res | 10,9-boroxarophenanthrene as fungicides |
| US3816472A (en) | 1972-07-06 | 1974-06-11 | Schering Corp | Azido analogs of griseofulvin |
| GB1396904A (en) * | 1972-08-11 | 1975-06-11 | Ici Ltd | Method for the control of micro-organisms |
| US4766113A (en) * | 1975-10-24 | 1988-08-23 | Chapman Chemical Company | Antimicrobial compositions and methods of using same |
| US4602011A (en) * | 1975-10-24 | 1986-07-22 | Chapman Chemical Company | Antimicrobial compositions and methods of using same |
| AT354187B (de) | 1976-11-22 | 1979-12-27 | Hoffmann La Roche | Fungizides mittel |
| US4716035A (en) * | 1985-05-24 | 1987-12-29 | The Procter & Gamble Company | Oral compositions and methods for treating gingivitis |
| JPH0676285B2 (ja) | 1985-11-01 | 1994-09-28 | 三井東圧化学株式会社 | ベンジルアミン誘導体、その製造法およびその用途 |
| US5962498A (en) * | 1986-06-11 | 1999-10-05 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity |
| US4894220A (en) * | 1987-01-30 | 1990-01-16 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition |
| DE3720147A1 (de) | 1987-06-16 | 1988-12-29 | Hoechst Ag | Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung |
| US4977268A (en) | 1988-04-08 | 1990-12-11 | Duke University | Boron dipeptide compounds |
| US4919934A (en) | 1989-03-02 | 1990-04-24 | Richardson-Vicks Inc. | Cosmetic sticks |
| SG47101A1 (en) * | 1992-07-31 | 1998-03-20 | Us Bioscience | Crystalline amifostine compositions and methods for the preparation and use of same |
| US5348948A (en) * | 1993-05-07 | 1994-09-20 | American Cyanamid Company | 2,2-diaryl-1-(oxa and thia)-2a-azonia-2-borataacenaphthene fungicidal |
| US5348947A (en) * | 1993-05-07 | 1994-09-20 | American Cyanamid Company | Diarylboron ester and thioester fungicidal agents |
| JPH08503966A (ja) * | 1993-09-29 | 1996-04-30 | ギスト ブロカデス ナムローゼ フェンノートシャップ | 新規な抗真菌性組成物 |
| US5594151A (en) * | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexing reagents derived from aminosalicylic acid |
| GB9411587D0 (en) | 1994-06-09 | 1994-08-03 | Zeneca Ltd | Compound, composition and use |
| US5498407A (en) | 1994-10-24 | 1996-03-12 | Atlas; Sheldon M. | Poly(2-hydroxyethyl methacrylate) and all copolymers of poly-HEMA fibers and cosmetic compositions containing same |
| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| US5696164A (en) | 1994-12-22 | 1997-12-09 | Johnson & Johnson Consumer Products, Inc. | Antifungal treatment of nails |
| GB9500856D0 (en) | 1995-01-17 | 1995-03-08 | Zeneca Ltd | Composition and use |
| JPH09124620A (ja) | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
| US6766183B2 (en) | 1995-11-22 | 2004-07-20 | Medtronic Minimed, Inc. | Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers |
| GB9604926D0 (en) * | 1996-03-08 | 1996-05-08 | Sandoz Ltd | Organic compounds |
| WO1997048697A1 (en) * | 1996-06-19 | 1997-12-24 | Rhone-Poulenc Rorer Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
| US5831046A (en) * | 1996-08-05 | 1998-11-03 | Prolinx, Incorporated | Boronic acid-contaning nucleic acid monomers |
| WO1998012206A1 (en) | 1996-09-19 | 1998-03-26 | The Board Of Trustees Of Leland Stanford Jr. University | Dna adenine methyltransferases and uses thereof |
| EP0947498B1 (en) | 1996-12-02 | 2004-09-15 | Chisso Corporation | Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for preparing the same |
| US6221640B1 (en) | 1997-05-14 | 2001-04-24 | Cubist Pharmaceuticals, Inc. | Enterococcal aminoacyl-trna synthetase proteins, nucleic acids and strains comprising same |
| US6140328A (en) * | 1997-12-12 | 2000-10-31 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| CA2278328C (en) | 1998-02-09 | 2008-07-22 | Macrochem Corporation | Antifungal nail lacquer and method using same |
| CA2325553A1 (en) | 1998-04-17 | 1999-10-28 | Penederm Inc. | Topical formulations for the treatment of nail fungal diseases |
| DE19829947A1 (de) | 1998-07-04 | 2000-01-05 | Bayer Ag | Elektrolumineszierende Anordnungen mit Bor-Chelaten |
| US6462036B1 (en) | 1998-11-06 | 2002-10-08 | Basf Aktiengesellschaft | Tricyclic pyrazole derivatives |
| TR200102277T2 (tr) | 1998-11-06 | 2002-01-21 | Basf Aktiengesellschaft Ag. | Üç halkalı (Trisiklik) pirazol türevleri |
| WO2000044387A1 (fr) | 1999-01-29 | 2000-08-03 | Nitto Kasei Co., Ltd. | Composes organobores presentant une activite de coccidiostats |
| CN1370170A (zh) | 1999-05-25 | 2002-09-18 | 宾夕法尼亚州研究基金会 | Dna甲基转移酶抑制剂 |
| US6306628B1 (en) * | 1999-08-25 | 2001-10-23 | Ambergen, Incorporated | Methods for the detection, analysis and isolation of Nascent proteins |
| CA2383554C (en) | 1999-08-25 | 2008-03-18 | Ambergen, Inc. | Methods for the detection, analysis and isolation of nascent proteins |
| AU7995300A (en) * | 1999-10-05 | 2001-05-10 | Bethesda Pharmaceuticals, Inc. | Dithiolane derivatives |
| CO5271678A1 (es) | 2000-01-06 | 2003-04-30 | Marantech Holding Llc | Composiciones para facilitar el crecimiento de la piel y metodos y articulos que las emplean |
| US7074392B1 (en) | 2000-03-27 | 2006-07-11 | Taro Pharmaceutical Industries Limited | Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections |
| US6521619B2 (en) | 2000-06-29 | 2003-02-18 | Icos Corporation | Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents |
| DE10032017A1 (de) | 2000-07-01 | 2002-01-10 | Clariant Gmbh | Verfahren zur Herstellung hochreiner Formylphenylboronsäuren |
| CA2415938A1 (en) * | 2000-07-14 | 2002-01-24 | Zycos Inc. | Alpha-msh related compounds and methods of use |
| US6642252B2 (en) * | 2000-11-07 | 2003-11-04 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
| JP2004524281A (ja) | 2000-11-30 | 2004-08-12 | ザ ペン ステート リサーチ ファウンデイション | Ｄｎａメチルトランスフェラーゼ阻害剤 |
| DE10110051C2 (de) * | 2001-03-02 | 2003-07-03 | Clariant Gmbh | Verfahren zur Herstellung von Boron- und Borinsäuren |
| US6878365B2 (en) * | 2001-03-10 | 2005-04-12 | James Edward Brehove | Topical application for treating toenail fungus |
| ES2332090T3 (es) | 2001-04-06 | 2010-01-26 | Biocryst Pharmaceuticals, Inc. | Compuestos biarilicos como inhibidores de serina proteasa. |
| GB0117645D0 (en) * | 2001-07-19 | 2001-09-12 | Isis Innovation | Therapeutic stratergies for prevention and treatment of alzheimers disease |
| IL160010A0 (en) * | 2001-07-23 | 2004-06-20 | Univ Ramot | Methods and compositions for treating fungal infections |
| DE10143979A1 (de) * | 2001-09-07 | 2003-03-27 | Clariant Gmbh | Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren |
| WO2003033002A1 (en) | 2001-10-11 | 2003-04-24 | Ono Pharmaceutical Co | Intracellular calcium concentration increase inhibitors |
| JP4209659B2 (ja) | 2001-11-15 | 2009-01-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | アミジノ誘導体並びにそれを用いた抗血液凝固剤および血栓症治療剤 |
| CA2473238A1 (en) | 2002-01-10 | 2003-07-24 | The Penn State Research Foundation | Methods for the preparation of alkyl diaryl borinates and complexed diarylboronic acids |
| JP2006507352A (ja) | 2002-07-09 | 2006-03-02 | ポイント セラピューティクス， インコーポレイテッド | イソロイシンのボロプロリン化合物に関する方法および組成物 |
| AU2003291403A1 (en) * | 2002-11-08 | 2004-06-03 | Neurogen Corporation | 3-substituted-6-aryl pyridined as ligands of c5a receptors |
| ES2283867T3 (es) | 2002-12-02 | 2007-11-01 | Solvias Ag | Hidrogenacion catalitica de dobles enlaces de carbonoheteroatomo. |
| US7390806B2 (en) | 2002-12-18 | 2008-06-24 | Anacor Pharmaceuticals, Inc. | Antibiotics containing borinic acid complexes and methods of use |
| CA2509645A1 (en) * | 2002-12-18 | 2004-07-08 | Anacor Pharmaceuticals, Inc. | Antibiotics containing borinic acid complexes and methods of use |
| AU2004220176A1 (en) | 2003-03-14 | 2004-09-23 | Astrazeneca Ab | Novel fused triazolones and the uses thereof |
| US20050125852A1 (en) * | 2003-05-09 | 2005-06-09 | Sugen, Inc. | Novel kinases |
| WO2005013892A2 (en) * | 2003-06-16 | 2005-02-17 | Anacor Pharmaceuticals, Inc. | Hydrolytically-resistant boron-containing therapeutics and methods of use |
| JP2005022986A (ja) | 2003-06-30 | 2005-01-27 | Sankyo Co Ltd | Ｅｄｇ受容体拮抗作用を有するアルキン誘導体 |
| BRPI0412291A (pt) * | 2003-07-03 | 2006-09-19 | Hoffmann La Roche | antagonistas duplos de nka/nk3 para o tratamento de esquizofrenia |
| CA2552101A1 (en) | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds |
| DK1755661T3 (da) * | 2004-05-12 | 2014-06-16 | Brigham & Womens Hospital | Gelsolin til anvendelse til behandling af infektioner |
| CA2566158A1 (en) | 2004-05-14 | 2005-11-24 | Abbott Laboratories | Kinase inhibitors as therapeutic agents |
| AR049915A1 (es) | 2004-06-14 | 2006-09-13 | Anacor Pharmaceuticals Inc | Compuestos con contenido de boro y metodos de uso de los mismos |
| KR100624238B1 (ko) * | 2004-06-22 | 2006-09-19 | 한국화학연구원 | 알파-아릴메톡시아크릴레이트 유도체를 함유하는 대사성골 질환의 예방 및 치료용 약학 조성물 |
| WO2006062731A1 (en) | 2004-11-19 | 2006-06-15 | University Of North Texas Health Science Center At Fort Worth | Phenanthroline and derivatives thereof used to lower intraocular pressure in an affected eye |
| GB0501944D0 (en) | 2005-01-31 | 2005-03-09 | Univ Cambridge Tech | Compounds for use in chemical detection and/or quantitation |
| AU2006214247C1 (en) | 2005-02-16 | 2012-11-08 | Anacor Pharmaceuticals, Llc | Boron-containing small molecules |
| WO2006096131A1 (en) | 2005-03-08 | 2006-09-14 | Agency For Science, Technology And Research | Chiral bisoxazoline catalysts |
| US20060222671A1 (en) * | 2005-03-30 | 2006-10-05 | Astion Development A/S | Dermatological compositions and salts for the treatment of dermatological diseases |
| US20070028682A1 (en) | 2005-08-04 | 2007-02-08 | Geon Sagong | System for measuring fluid level using acoustic impedance matching |
| WO2007022437A2 (en) | 2005-08-18 | 2007-02-22 | Auspex Pharmaceuticals, Inc. | Therapeutic agents for the treatment of cancer and metabolic disorders |
| BRPI0621279B1 (pt) | 2005-12-30 | 2021-07-20 | Anacor Pharmaceuticals, Inc | Moléculas pequenas contendo boro |
| CA2642583C (en) | 2006-02-16 | 2016-08-23 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
| WO2007146965A2 (en) | 2006-06-12 | 2007-12-21 | Anacor Pharmaceuticals, Inc. | Compounds for the treatment of periodontal disease |
| US20070286822A1 (en) * | 2006-06-12 | 2007-12-13 | Anacor Pharmaceuticals Inc. | Compounds for the Treatment of Periodontal Disease |
| KR100848491B1 (ko) | 2007-01-16 | 2008-07-28 | 영진약품공업주식회사 | 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법 |
| JO3396B1 (ar) | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| KR100895300B1 (ko) | 2007-07-20 | 2009-05-07 | 한국전자통신연구원 | 생체신호 측정의복과 생체신호 처리시스템 |
| EP2187893A4 (en) | 2008-03-06 | 2012-02-22 | Anacor Pharmaceuticals Inc | SMALL BORON-CONTAINING MOLECULES AS ANTI-INFLAMMATORY AGENTS |
| CN102014927A (zh) | 2008-03-06 | 2011-04-13 | 安纳考尔医药公司 | 作为抗炎药的含硼的小分子 |
| EP2285384A4 (en) * | 2008-05-12 | 2012-04-25 | Anacor Pharmaceuticals Inc | BORN SMALL MOLECULES |
| WO2010027975A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2010028005A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2010045505A1 (en) | 2008-10-15 | 2010-04-22 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules as anti-protozoal agents |
| US9493489B2 (en) | 2008-10-15 | 2016-11-15 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
| AU2009335744A1 (en) | 2008-12-17 | 2010-07-15 | Anacor Pharmaceuticals, Inc. | Polymorphs of (S)-3-aminomethyl-7-(3-hydroxy-propoxy) -3H-benzo[c][1,2] oxaborol-1-ol |
| JP2013500974A (ja) | 2009-07-28 | 2013-01-10 | アナコール ファーマシューティカルズ，インコーポレイテッド | 三置換ホウ素含有分子 |
| WO2011060199A1 (en) | 2009-11-11 | 2011-05-19 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2011094450A1 (en) | 2010-01-27 | 2011-08-04 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules |
| AU2011237681B2 (en) | 2010-04-07 | 2015-01-22 | Glaxosmithkline Llc | Process for preparing benzoxaboroles |
| SMT202100643T1 (it) | 2010-09-07 | 2022-01-10 | Anacor Pharmaceuticals Inc | Derivati del benzossaborolo per il trattamento delle infezioni batteriche |
| AR088668A1 (es) | 2011-11-21 | 2014-06-25 | Lilly Co Eli | Moleculas pequeñas que contienen boro |
| AR088669A1 (es) | 2011-11-21 | 2014-06-25 | Lilly Co Eli | Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos |
| JP2015212249A (ja) | 2014-05-05 | 2015-11-26 | アナコール ファーマシューティカルズ，インコーポレイテッド | 化合物および爪光沢剤 |
-
2006
- 2006-08-16 BR BRPI0621279-4A patent/BRPI0621279B1/pt active IP Right Grant
- 2006-08-16 WO PCT/US2006/032238 patent/WO2007078340A2/en not_active Ceased
- 2006-08-16 CN CN201610328016.4A patent/CN106008571A/zh active Pending
- 2006-08-16 JP JP2008548499A patent/JP2009526751A/ja active Pending
- 2006-08-16 EP EP06801794A patent/EP1976536A4/en not_active Withdrawn
- 2006-08-16 CN CN201610327999.XA patent/CN105949230A/zh active Pending
- 2006-08-16 AU AU2006333527A patent/AU2006333527B2/en active Active
- 2006-08-16 RU RU2008131324/04A patent/RU2008131324A/ru not_active Application Discontinuation
- 2006-08-16 CN CN201610328000.3A patent/CN106008583A/zh active Pending
- 2006-08-16 KR KR1020087018808A patent/KR20080110984A/ko not_active Withdrawn
- 2006-08-16 CA CA002635680A patent/CA2635680A1/en not_active Abandoned
- 2006-08-16 US US11/505,591 patent/US7767657B2/en active Active
-
2008
- 2008-06-23 IL IL192402A patent/IL192402A/en active IP Right Grant
-
2009
- 2009-12-02 US US12/629,753 patent/US8115026B2/en active Active
-
2012
- 2012-01-23 US US13/356,488 patent/US8722917B2/en active Active
- 2012-09-07 US US13/607,405 patent/US20130064783A1/en not_active Abandoned
- 2012-09-07 US US13/607,321 patent/US20130059803A1/en not_active Abandoned
- 2012-09-07 US US13/607,250 patent/US20130059802A1/en not_active Abandoned
-
2013
- 2013-04-12 US US13/861,846 patent/US20130210770A1/en not_active Abandoned
-
2014
- 2014-03-07 US US14/201,459 patent/US9353133B2/en active Active
- 2014-11-10 US US14/537,771 patent/US20150119364A1/en not_active Abandoned
-
2016
- 2016-02-17 US US15/046,322 patent/US9566289B2/en not_active Expired - Fee Related
- 2016-03-11 US US15/068,352 patent/US9549938B2/en not_active Expired - Fee Related
- 2016-04-05 US US15/091,394 patent/US9572823B2/en not_active Expired - Fee Related
- 2016-04-20 US US15/134,286 patent/US9566290B2/en not_active Expired - Fee Related
- 2016-11-18 US US15/355,393 patent/US20170066787A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2008131324A (ru) | Борсодержащие малые молекулы | |
| US20220048908A1 (en) | Compositions and methods for modulating hair growth | |
| Karpenko et al. | Synthesis and antiherpetic activity of acyclovir phosphonates | |
| CN101505603A (zh) | 含硼的小分子 | |
| JP6109140B2 (ja) | ホウ素含有小分子 | |
| Au et al. | The pharmacology of ftorafur (R, S-1-(tetrahydro-2-furanyl)-5-fluorouracil) | |
| ATE252595T1 (de) | A2a rezeptor agonisten | |
| Monaselidze et al. | Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability | |
| BRPI0413290A (pt) | composto para a vacinação de um animal, molécula de ácido nucleico, vetor de expressão, célula hospedeira, vacina, composição farmacêutica, métodos para imunizar um animal contra uma doença, e para combater uma doença em um animal, doença em animal, uso de um composto e um ácido nucleico, e para determinar se a um animal foi administrado com um composto, kit de partes, e, método para vacinar um animal | |
| HK1228916A (en) | Boron-containing small molecules | |
| HK1228916A1 (en) | Boron-containing small molecules | |
| HK1228915A (en) | Boron-containing small molecules | |
| HK1228915A1 (zh) | 含硼的小分子 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20110704 |