JP2009526018A5 - - Google Patents

Download PDF

Info

Publication number
JP2009526018A5
JP2009526018A5 JP2008553758A JP2008553758A JP2009526018A5 JP 2009526018 A5 JP2009526018 A5 JP 2009526018A5 JP 2008553758 A JP2008553758 A JP 2008553758A JP 2008553758 A JP2008553758 A JP 2008553758A JP 2009526018 A5 JP2009526018 A5 JP 2009526018A5
Authority
JP
Japan
Prior art keywords
hydroxy
steroidal anti
inflammatory agent
pharmaceutical composition
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008553758A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009526018A (ja
JP5616021B2 (ja
Filing date
Publication date
Priority claimed from GBGB0602778.3A external-priority patent/GB0602778D0/en
Application filed filed Critical
Publication of JP2009526018A publication Critical patent/JP2009526018A/ja
Publication of JP2009526018A5 publication Critical patent/JP2009526018A5/ja
Application granted granted Critical
Publication of JP5616021B2 publication Critical patent/JP5616021B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2008553758A 2006-02-10 2007-02-08 ビフェニル−２−イルカルバミン酸１−［２−（２−クロロ−４−｛［（ｒ）−２−ヒドロキシ−２−（８−ヒドロキシ−２−オキソ−１，２−ジヒドロキノリン−５−イル）エチルアミノメチル］｝−５−メトキシフェニルカルバモイル）エチル］ピペリジン−４−イルエステルのコハク酸塩および肺疾患治療におけるその使用 Expired - Fee Related JP5616021B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0602778.3 2006-02-10
GBGB0602778.3A GB0602778D0 (en) 2006-02-10 2006-02-10 Novel compound
PCT/EP2007/051196 WO2007090859A1 (en) 2006-02-10 2007-02-08 Succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{ [ (r)-2-hydroxy-2- (8-hydroxy-2-oxo-1, 2-dihydroquinolin-5-yl) eth ylaminoimethyl] } -5-methoxyphenylcarbamoyl) ethyl] piperidin-4-yl ester and its use for the treatment of pulmonary disorders

Publications (3)

Publication Number Publication Date
JP2009526018A JP2009526018A (ja) 2009-07-16
JP2009526018A5 true JP2009526018A5 (https=) 2010-03-18
JP5616021B2 JP5616021B2 (ja) 2014-10-29

Family

ID=36119909

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008553758A Expired - Fee Related JP5616021B2 (ja) 2006-02-10 2007-02-08 ビフェニル−２−イルカルバミン酸１−［２−（２−クロロ−４−｛［（ｒ）−２−ヒドロキシ−２−（８−ヒドロキシ−２−オキソ−１，２−ジヒドロキノリン−５−イル）エチルアミノメチル］｝−５−メトキシフェニルカルバモイル）エチル］ピペリジン−４−イルエステルのコハク酸塩および肺疾患治療におけるその使用

Country Status (33)

Country Link
US (1) US7960551B2 (https=)
EP (1) EP1981872B1 (https=)
JP (1) JP5616021B2 (https=)
KR (1) KR101488691B1 (https=)
CN (1) CN101379057B (https=)
AR (2) AR059409A1 (https=)
AU (1) AU2007213767B2 (https=)
BR (1) BRPI0707559B8 (https=)
CA (1) CA2641769C (https=)
CR (1) CR10227A (https=)
CY (1) CY1119238T1 (https=)
DK (1) DK1981872T3 (https=)
EA (1) EA016580B1 (https=)
ES (1) ES2640226T3 (https=)
GB (1) GB0602778D0 (https=)
HR (1) HRP20171304T1 (https=)
HU (1) HUE034315T2 (https=)
IL (1) IL193103A (https=)
JO (1) JO3389B1 (https=)
LT (1) LT1981872T (https=)
MA (1) MA30273B1 (https=)
MY (1) MY153656A (https=)
NO (1) NO341343B1 (https=)
NZ (1) NZ570242A (https=)
PE (2) PE20110120A1 (https=)
PL (1) PL1981872T3 (https=)
PT (1) PT1981872T (https=)
SG (1) SG169404A1 (https=)
SI (1) SI1981872T1 (https=)
TW (1) TWI401251B (https=)
UA (1) UA100364C2 (https=)
WO (1) WO2007090859A1 (https=)
ZA (1) ZA200806782B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG175023A1 (en) 2009-04-14 2011-11-28 Glaxo Group Ltd Process for the preparation of a biphenyl-2-ylcarbamic acid ester
SG175330A1 (en) 2009-04-23 2011-11-28 Theravance Inc DIAMIDE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND ß2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
AU2015234331B2 (en) * 2009-04-23 2017-08-03 Theravance Biopharma R&D Ip, Llc Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
WO2011081937A1 (en) 2009-12-15 2011-07-07 Gilead Sciences, Inc. Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
ITRM20110083U1 (it) 2010-05-13 2011-11-14 De La Cruz Jose Antonio Freire Piastra per la costruzione di carrelli per aeroplani
AR083115A1 (es) * 2010-09-30 2013-01-30 Theravance Inc Sales oxalato cristalinas de un compuesto diamida
WO2013017494A1 (en) * 2011-08-02 2013-02-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Pharmaceutical composition of oxidised avidin suitable for inhalation
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
ES2750523T3 (es) * 2012-12-18 2020-03-26 Almirall Sa Derivados de ciclohexil y quinuclidinil carbamato que tienen actividades de agonista beta2 adrenérgicos y antagonistas muscarínicos M3
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
GB201500447D0 (en) * 2015-01-12 2015-02-25 Glaxosmithkline Ip Dev Ltd Novel Combination Product
CN106632257B (zh) * 2016-12-15 2019-02-12 上海市奉贤区中心医院 Gsk961081及其中间体的合成方法
WO2020047225A1 (en) 2018-08-30 2020-03-05 Theravance Biopharma R&D Ip, Llc Methods for treating chronic obstructive pulmonary disease

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026897A (en) * 1974-01-31 1977-05-31 Otsuka Pharmaceutical Company 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives
DE3134590A1 (de) 1981-09-01 1983-03-10 Boehringer Ingelheim KG, 6507 Ingelheim Neue benzo-heterocyclen
US4460581A (en) * 1982-10-12 1984-07-17 Boehringer Ingelheim Kg (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
US4894219A (en) * 1988-03-29 1990-01-16 University Of Florida Beta-agonist carbostyril derivatives, assay method and pharmacological composition
DK443489D0 (da) 1989-09-08 1989-09-08 Ferrosan As Substituerede urinstofforbindelser, deres fremstilling og anvendelse
CZ236894A3 (en) 1992-03-31 1995-09-13 Glaxo Group Ltd Substituted phenylcarbonates and phenylureas, their use for the preparation of pharmaceutical preparations, pharmaceuticals containing thereof and process for preparing such compounds
CA2123728A1 (en) * 1993-05-21 1994-11-22 Noriyoshi Sueda Urea derivatives and their use as acat inhibitors
WO1995006635A1 (en) 1993-09-02 1995-03-09 Yamanouchi Pharmaceutical Co., Ltd. Carbamate derivative and medicine containing the same
WO1995021820A1 (en) 1994-02-10 1995-08-17 Yamanouchi Pharmaceutical Co., Ltd. Novel carbamate derivative and medicinal composition containing the same
ATE205490T1 (de) 1995-10-13 2001-09-15 Banyu Pharma Co Ltd Substituierte heteroaromatische derivate
PE92198A1 (es) 1996-08-01 1999-01-09 Banyu Pharma Co Ltd Derivados de 1,4-piperidina disustituida que contienen fluor
US6040344A (en) * 1996-11-11 2000-03-21 Sepracor Inc. Formoterol process
EP1047691A1 (en) 1997-12-12 2000-11-02 Smithkline Beecham Plc Quinolinepiperazine and quinolinepiperidine derivatives, their preparation and their use as combined 5-ht1a, 5-ht1b and 5-ht1d receptor antagonists
US6713651B1 (en) * 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
SG80041A1 (en) 1998-06-08 2001-04-17 Advanced Medicine Inc Muscarinic receptor antagonists
US6541669B1 (en) * 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
US6693202B1 (en) * 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
US6593497B1 (en) * 1999-06-02 2003-07-15 Theravance, Inc. β2-adrenergic receptor agonists
AU783095B2 (en) 1999-12-07 2005-09-22 Theravance Biopharma R&D Ip, Llc Carbamate derivatives having muscarinic receptor antagonist activity
UA73543C2 (uk) * 1999-12-07 2005-08-15 Тераванс, Інк. Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором
UA73965C2 (en) * 1999-12-08 2005-10-17 Theravance Inc b2 ADRENERGIC RECEPTOR ANTAGONISTS
WO2001051919A2 (en) * 2000-01-07 2001-07-19 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
NZ522882A (en) 2000-06-05 2004-07-30 Altana Pharma Bv Pyridazinone compounds effective as beta-2-adrenoreceptor agonists as well as PDE4-inhibitors
JP4445704B2 (ja) 2000-12-22 2010-04-07 アルミラル・ソシエダッド・アノニマ キヌクリジンカルバメート誘導体およびｍ３アンダゴニストとしてのそれらの使用
GB0103630D0 (en) 2001-02-14 2001-03-28 Glaxo Group Ltd Chemical compounds
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
US6653323B2 (en) * 2001-11-13 2003-11-25 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
TWI249515B (en) * 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
EP1497289B1 (de) 2002-04-12 2005-08-24 Boehringer Ingelheim Pharma GmbH & Co.KG Arzneimittel enthaltend betamimetika und ein neues anticholinergikum
EP1507754A1 (en) * 2002-05-28 2005-02-23 Theravance, Inc. Alkoxy aryl beta-2 adrenergic receptor agonists
GB0217225D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicinal compounds
AR040779A1 (es) 2002-08-06 2005-04-20 Glaxo Group Ltd Compuesto de tiazol anilina su uso para preparar una formulacion farmaceutica dicha formulacion recipiente que la contiene y dispositivo adaptado para la administracion intranasal de la formulacion
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
JP4767842B2 (ja) 2003-04-01 2011-09-07 セラヴァンス， インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物
DE602004021921D1 (de) * 2003-05-28 2009-08-20 Theravance Inc Azabicycloalkanverbindungen als muscarinrezeptor antagonisten
US7345060B2 (en) * 2003-11-21 2008-03-18 Theravance, Inc. Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity
US7320990B2 (en) * 2004-02-13 2008-01-22 Theravance, Inc. Crystalline form of a biphenyl compound
US7569586B2 (en) * 2004-08-16 2009-08-04 Theravance, Inc. Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity
JP2008510014A (ja) * 2004-08-16 2008-04-03 セラヴァンス， インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物
TWI374883B (en) 2004-08-16 2012-10-21 Theravance Inc Crystalline form of a biphenyl compound

Similar Documents

Publication Publication Date Title
JP2009526018A5 (https=)
HRP20171304T1 (hr) Sol s jantarnom kiselinom 1-[2-(2-klor-4-{[(r)-2-hidroksi-2-(8-hidroksi-2-okso-1,2-dihidrokinolin-5-il)etilaminometil]}-5-metoksifenilkarbamoil)etil]piperidin-4-ilnog estera bifenil-2-ilkarbaminske kiseline i njezina upotreba u liječenju plućnih poremećaja
AU2004226824B2 (en) Quinoline-2-one-derivatives for the treatment of airways diseases
RU2007109598A (ru) Кристаллическая форма бифенильного соединения
JP2022068321A5 (https=)
CN105175473A (zh) 一种奥贝胆酸晶型i及其制备方法、药物组合物和用途
US20120108555A1 (en) Mixtures or Organic Compounds for the Treatment of Airway Diseases
CN101412700B (zh) 非布司他的晶型及其制备方法
CN101903389A (zh) (3-{[[3-(6-氨基-2-丁氧基-8-氧代-7,8-二氢-9h-嘌呤-9-基)丙基](3-(吗啉-4-基)丙基)氨基]甲基}苯基)乙酸甲酯的可药用盐和它们在治疗中的用途
JP2013538857A5 (https=)
JP2009535340A5 (https=)
JP2012533550A5 (https=)
JP2010514807A5 (https=)
JP4508651B2 (ja) ２−フロ酸フルチカゾンの結晶性複合体
CN102336801A (zh) 醋酸阿比特龙多晶型物和药用组合物
CA2552938A1 (en) Combination of benzothiazol-2-one beta2 adrenoceptor agonists and corticosteroids for the treatment of respiratory diseases
JP2007518767A5 (https=)
HRP20121074T1 (hr) Derivati kinolina i njihovi farmaceutski sastavi
CN104203918A (zh) 作为β2肾上腺素受体激动剂的5-(2-{[6-(2,2-二氟-2-苯乙氧基)己基]氨基}-1-(R)-羟乙基)-8-羟基喹啉-2(1H)-酮,半萘二磺酸盐的新的多晶型
JP2006501207A5 (https=)
WO2015062498A1 (zh) 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物
CN102066330A (zh) 8-羟基-5-[(1r)-1-羟基-2-[[(1r)-2-(4-甲氧基苯基)-1-甲基乙基]氨基]乙基]-2(1h)-喹啉酮一盐酸盐的多晶型
CN102066329A (zh) 8-羟基-5-[(1r)-1-羟基-2-[[(1r)-2-(4-甲氧基苯基)-1-甲基乙基]氨基]乙基]-2(1h)-喹啉酮一盐酸盐的晶型
JP2009530279A5 (https=)