JP2022068321A5 - - Google Patents
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- Publication number
- JP2022068321A5 JP2022068321A5 JP2022025300A JP2022025300A JP2022068321A5 JP 2022068321 A5 JP2022068321 A5 JP 2022068321A5 JP 2022025300 A JP2022025300 A JP 2022025300A JP 2022025300 A JP2022025300 A JP 2022025300A JP 2022068321 A5 JP2022068321 A5 JP 2022068321A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- impurities
- suspension
- total amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000013078 crystal Substances 0.000 claims 9
- 239000000725 suspension Substances 0.000 claims 9
- 239000012535 impurity Substances 0.000 claims 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 6
- 238000010438 heat treatment Methods 0.000 claims 5
- 238000001816 cooling Methods 0.000 claims 4
- 230000002757 inflammatory effect Effects 0.000 claims 4
- 230000000414 obstructive effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000023504 respiratory system disease Diseases 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims 2
- 229940011051 isopropyl acetate Drugs 0.000 claims 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000007922 nasal spray Substances 0.000 claims 1
- 239000006199 nebulizer Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- -1 transdermal patches Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13189784 | 2013-10-22 | ||
| EP13189784.5 | 2013-10-22 | ||
| JP2020173216A JP7051970B2 (ja) | 2013-10-22 | 2020-10-14 | Ｐｄｅ４抑制活性を有する化合物の製造方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173216A Division JP7051970B2 (ja) | 2013-10-22 | 2020-10-14 | Ｐｄｅ４抑制活性を有する化合物の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022068321A JP2022068321A (ja) | 2022-05-09 |
| JP2022068321A5 true JP2022068321A5 (https=) | 2022-06-01 |
| JP7534346B2 JP7534346B2 (ja) | 2024-08-14 |
Family
ID=49385193
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519348A Active JP6458957B2 (ja) | 2013-10-22 | 2014-10-17 | Ｐｄｅ４阻害剤の製造方法 |
| JP2018189627A Pending JP2019038813A (ja) | 2013-10-22 | 2018-10-05 | Ｐｄｅ４抑制活性を有する化合物の結晶形態 |
| JP2020173216A Active JP7051970B2 (ja) | 2013-10-22 | 2020-10-14 | Ｐｄｅ４抑制活性を有する化合物の製造方法 |
| JP2022025240A Active JP7345581B2 (ja) | 2013-10-22 | 2022-02-22 | Ｐｄｅ４抑制活性を有する化合物の製造方法 |
| JP2022025300A Active JP7534346B2 (ja) | 2013-10-22 | 2022-02-22 | Ｐｄｅ４抑制活性を有する化合物の製造方法 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519348A Active JP6458957B2 (ja) | 2013-10-22 | 2014-10-17 | Ｐｄｅ４阻害剤の製造方法 |
| JP2018189627A Pending JP2019038813A (ja) | 2013-10-22 | 2018-10-05 | Ｐｄｅ４抑制活性を有する化合物の結晶形態 |
| JP2020173216A Active JP7051970B2 (ja) | 2013-10-22 | 2020-10-14 | Ｐｄｅ４抑制活性を有する化合物の製造方法 |
| JP2022025240A Active JP7345581B2 (ja) | 2013-10-22 | 2022-02-22 | Ｐｄｅ４抑制活性を有する化合物の製造方法 |
Country Status (29)
| Country | Link |
|---|---|
| US (7) | US9434691B2 (https=) |
| EP (5) | EP3060551B1 (https=) |
| JP (5) | JP6458957B2 (https=) |
| KR (3) | KR102240865B1 (https=) |
| CN (5) | CN110256338A (https=) |
| AR (4) | AR098128A1 (https=) |
| AU (1) | AU2014339136C1 (https=) |
| BR (1) | BR112016008161B1 (https=) |
| CA (3) | CA3115587C (https=) |
| CY (1) | CY1123811T1 (https=) |
| DK (3) | DK3293176T3 (https=) |
| ES (3) | ES2980505T3 (https=) |
| FI (1) | FI3587400T3 (https=) |
| HR (3) | HRP20240783T1 (https=) |
| HU (3) | HUE067681T2 (https=) |
| IL (4) | IL285532B2 (https=) |
| LT (2) | LT3587400T (https=) |
| MX (4) | MX370104B (https=) |
| MY (1) | MY182559A (https=) |
| PH (3) | PH12020500162B1 (https=) |
| PL (3) | PL3587400T3 (https=) |
| PT (3) | PT3587400T (https=) |
| RS (2) | RS61558B1 (https=) |
| RU (1) | RU2682660C9 (https=) |
| SG (4) | SG10201903575UA (https=) |
| SI (3) | SI3060551T1 (https=) |
| TW (3) | TWI685486B (https=) |
| UA (2) | UA121853C2 (https=) |
| WO (1) | WO2015059050A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3246016T3 (da) | 2010-08-03 | 2025-05-19 | Chiesi Farm Spa | Tørpulverformulering indeholdende en fosfodiesterasehæmmer |
| SI3060551T1 (sl) * | 2013-10-22 | 2019-11-29 | Chiesi Farm Spa | Postopek za pripravo inhibitorja PDE4 |
| WO2018017713A1 (en) * | 2016-07-20 | 2018-01-25 | Allergan, Inc. | Methods, compositions, and compounds for treatment of dermatological and ocular conditions |
| JP7361584B2 (ja) * | 2018-12-19 | 2023-10-16 | 高砂香料工業株式会社 | アミドの還元によるアミンの製造方法 |
| JP6780763B2 (ja) | 2018-12-25 | 2020-11-04 | トヨタ自動車株式会社 | 内燃機関の制御装置 |
| US11149615B2 (en) | 2018-12-25 | 2021-10-19 | Toyota Jidosha Kabushiki Kaisha | Control device for internal combustion engine |
| CN111808029A (zh) * | 2020-08-31 | 2020-10-23 | 兰晟生物医药(苏州)有限公司 | 一种pde4抑制剂氯比普兰的制备方法 |
| EP4452223A1 (en) | 2021-12-21 | 2024-10-30 | Chiesi Farmaceutici S.p.A. | Dry powder formulations filled in an inhaler with improved resistance to humidity |
| AU2023262106A1 (en) | 2022-04-27 | 2024-12-05 | Chiesi Farmaceutici S.P.A. | Crystal form of a pde4 inhibitor |
| CN115304542B (zh) * | 2022-07-18 | 2024-02-02 | 湖南华纳大药厂手性药物有限公司 | 一种3-羟基吡啶的合成工艺 |
| WO2024027901A1 (en) | 2022-08-02 | 2024-02-08 | Chiesi Farmaceutici S.P.A. | Predictive biomarker of clinical response to a pde4 inhibitor |
| KR20250069950A (ko) | 2022-09-22 | 2025-05-20 | 키에시 파르마슈티시 엣스. 피. 에이. | 포스포다이에스테라제-4 억제제의 투여를 위한 캡슐 흡입기 |
| PE20251716A1 (es) | 2022-09-22 | 2025-07-07 | Chiesi Farm Spa | Inhalador de capsula para la administracion de un inhibidor de fosfodiesterasa-4 |
| EP4590272A1 (en) | 2022-09-22 | 2025-07-30 | Chiesi Farmaceutici S.p.A. | Capsule inhaler for the administration of a phosphodiesterase-4 inhibitor |
| KR102925863B1 (ko) | 2023-11-27 | 2026-02-09 | 국립한국해양대학교산학협력단 | 복수의 학습모델을 이용한 이미지 기반의 강도 추정 장치 및 방법 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5935978A (en) * | 1991-01-28 | 1999-08-10 | Rhone-Poulenc Rorer Limited | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group |
| AU2001239442A1 (en) * | 2000-03-30 | 2001-10-15 | Chirotech Technology Limited | Ruthenium-diphosphine complexes and their use as catalysts |
| WO2005026095A1 (en) | 2003-09-12 | 2005-03-24 | Ranbaxy Laboratories Limited | Process for the preparation of roflumilast |
| PL1740593T3 (pl) | 2004-04-19 | 2016-09-30 | Sposoby wytwarzania wodorosiarczanu klopidogrelu w formie polimorficznej I | |
| ATE459618T1 (de) * | 2004-04-29 | 2010-03-15 | Aventis Pharma Inc | 3-piperidinylisochroman-5-ole als dopaminagonisten |
| KR20070079278A (ko) | 2006-02-01 | 2007-08-06 | 삼성전자주식회사 | 수신자 제한 시스템을 이용하는 디지털 멀티미디어시스템에서 수신기의 채널 전환 시간 단축 장치 및 방법 |
| DE602007012105D1 (de) * | 2006-07-14 | 2011-03-03 | Chiesi Farma Spa | Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren |
| EP2125736B1 (en) * | 2006-12-22 | 2011-03-30 | Leo Pharma A/S | Substituted acetophenones useful as pde4 inhibitors |
| EP2022783A1 (en) * | 2007-08-08 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors" |
| US20100015430A1 (en) | 2008-07-16 | 2010-01-21 | Outlast Technologies, Inc. | Heat Regulating Article With Moisture Enhanced Temperature Control |
| EP2216327A1 (en) * | 2009-02-06 | 2010-08-11 | CHIESI FARMACEUTICI S.p.A. | Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors |
| ES2528957T3 (es) | 2010-06-14 | 2015-02-13 | Chiesi Farmaceutici S.P.A. | Forma cristalina del cloruro de glicopirronio |
| DK3246016T3 (da) * | 2010-08-03 | 2025-05-19 | Chiesi Farm Spa | Tørpulverformulering indeholdende en fosfodiesterasehæmmer |
| CA2807406C (en) * | 2010-08-03 | 2018-12-11 | Chiesi Farmaceutici S.P.A. | Pharmaceutical formulation comprising a phosphodiesterase inhibitor |
| PT2643322T (pt) | 2010-11-23 | 2017-11-13 | Abbvie Inc | Sais e formas cristalinas de um agente indutor de apoptose |
| WO2012097479A1 (en) * | 2011-01-21 | 2012-07-26 | Abbott Laboratories | Bicyclic inhibitors of anaphastic lymphoma kinase |
| CN103827088B (zh) * | 2011-09-26 | 2017-10-13 | 奇斯药制品公司 | 作为磷酸二酯酶抑制剂的1‑苯基‑2‑吡啶基烷基醇的衍生物 |
| WO2013087749A1 (en) * | 2011-12-16 | 2013-06-20 | Chiesi Farmaceutici S.P.A. | Potentiation induced by pde4 inhibitors in the treatment of leukemia |
| KR102192739B1 (ko) * | 2012-12-05 | 2020-12-18 | 키에시 파르마슈티시 엣스. 피. 에이. | 포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체 |
| CN103304408B (zh) * | 2013-06-05 | 2016-10-05 | 威海迪素制药有限公司 | 罗氟司特中间体3-环丙甲氧基-4-二氟甲氧基苯甲酸的制备 |
| US9427376B2 (en) * | 2013-10-10 | 2016-08-30 | Chiesi Farmaceutici S.P.A. | Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient |
| SI3060551T1 (sl) * | 2013-10-22 | 2019-11-29 | Chiesi Farm Spa | Postopek za pripravo inhibitorja PDE4 |
| KR101591785B1 (ko) | 2013-12-24 | 2016-02-04 | 주식회사 투게더 | 데이터 입력 장치, 이를 이용한 데이터 전송 시스템 및 방법 |
| BR112020012972A2 (pt) * | 2017-12-28 | 2020-11-24 | Chiesi Farmaceutici S.P.A. | uso de derivados de álcool 1-fenil-2-piridinil alquílico para tratar fibrose cística |
| EP4452223A1 (en) * | 2021-12-21 | 2024-10-30 | Chiesi Farmaceutici S.p.A. | Dry powder formulations filled in an inhaler with improved resistance to humidity |
-
2014
- 2014-10-17 SI SI201431364T patent/SI3060551T1/sl unknown
- 2014-10-17 PL PL19183016.5T patent/PL3587400T3/pl unknown
- 2014-10-17 UA UAA201604362A patent/UA121853C2/uk unknown
- 2014-10-17 EP EP14795565.2A patent/EP3060551B1/en active Active
- 2014-10-17 HU HUE19183016A patent/HUE067681T2/hu unknown
- 2014-10-17 AU AU2014339136A patent/AU2014339136C1/en active Active
- 2014-10-17 SG SG10201903575UA patent/SG10201903575UA/en unknown
- 2014-10-17 RS RS20210247A patent/RS61558B1/sr unknown
- 2014-10-17 CN CN201910622800.XA patent/CN110256338A/zh active Pending
- 2014-10-17 IL IL285532A patent/IL285532B2/en unknown
- 2014-10-17 RS RS20240463A patent/RS65452B1/sr unknown
- 2014-10-17 CA CA3115587A patent/CA3115587C/en active Active
- 2014-10-17 DK DK17192278.4T patent/DK3293176T3/da active
- 2014-10-17 PL PL17192278T patent/PL3293176T3/pl unknown
- 2014-10-17 EP EP17192278.4A patent/EP3293176B1/en active Active
- 2014-10-17 DK DK19183016.5T patent/DK3587400T3/da active
- 2014-10-17 HU HUE14795565A patent/HUE046637T2/hu unknown
- 2014-10-17 PT PT191830165T patent/PT3587400T/pt unknown
- 2014-10-17 PH PH1/2020/500162A patent/PH12020500162B1/en unknown
- 2014-10-17 CN CN201480058065.XA patent/CN105658629B/zh active Active
- 2014-10-17 HR HRP20240783TT patent/HRP20240783T1/hr unknown
- 2014-10-17 ES ES19183016T patent/ES2980505T3/es active Active
- 2014-10-17 EP EP20207308.6A patent/EP3798209A1/en active Pending
- 2014-10-17 CN CN202510734070.8A patent/CN120607463A/zh active Pending
- 2014-10-17 FI FIEP19183016.5T patent/FI3587400T3/fi active
- 2014-10-17 HR HRP20192152TT patent/HRP20192152T1/hr unknown
- 2014-10-17 LT LTEP19183016.5T patent/LT3587400T/lt unknown
- 2014-10-17 PL PL14795565T patent/PL3060551T3/pl unknown
- 2014-10-17 JP JP2016519348A patent/JP6458957B2/ja active Active
- 2014-10-17 SG SG11201603130TA patent/SG11201603130TA/en unknown
- 2014-10-17 PT PT171922784T patent/PT3293176T/pt unknown
- 2014-10-17 WO PCT/EP2014/072334 patent/WO2015059050A1/en not_active Ceased
- 2014-10-17 SI SI201431775T patent/SI3293176T1/sl unknown
- 2014-10-17 EP EP19183016.5A patent/EP3587400B1/en active Active
- 2014-10-17 US US14/516,976 patent/US9434691B2/en active Active
- 2014-10-17 KR KR1020167010773A patent/KR102240865B1/ko active Active
- 2014-10-17 KR KR1020217004798A patent/KR102287596B1/ko active Active
- 2014-10-17 BR BR112016008161-7A patent/BR112016008161B1/pt active IP Right Grant
- 2014-10-17 DK DK14795565T patent/DK3060551T3/da active
- 2014-10-17 CN CN202510293709.3A patent/CN120136784A/zh active Pending
- 2014-10-17 HU HUE17192278A patent/HUE053112T2/hu unknown
- 2014-10-17 SG SG10201912852YA patent/SG10201912852YA/en unknown
- 2014-10-17 LT LTEP17192278.4T patent/LT3293176T/lt unknown
- 2014-10-17 EP EP22169035.7A patent/EP4059921A1/en active Pending
- 2014-10-17 RU RU2016115246A patent/RU2682660C9/ru active
- 2014-10-17 CA CA3115570A patent/CA3115570C/en active Active
- 2014-10-17 PT PT147955652T patent/PT3060551T/pt unknown
- 2014-10-17 MY MYPI2016000681A patent/MY182559A/en unknown
- 2014-10-17 SG SG10202112587RA patent/SG10202112587RA/en unknown
- 2014-10-17 CA CA2928242A patent/CA2928242C/en active Active
- 2014-10-17 CN CN202210366235.7A patent/CN114621139B/zh active Active
- 2014-10-17 MX MX2016004834A patent/MX370104B/es active IP Right Grant
- 2014-10-17 ES ES14795565T patent/ES2759514T3/es active Active
- 2014-10-17 PH PH1/2021/550257A patent/PH12021550257A1/en unknown
- 2014-10-17 ES ES17192278T patent/ES2857629T3/es active Active
- 2014-10-17 MX MX2019014408A patent/MX389002B/es unknown
- 2014-10-17 KR KR1020217004799A patent/KR102287598B1/ko active Active
- 2014-10-17 UA UAA201909177A patent/UA127453C2/uk unknown
- 2014-10-17 IL IL285528A patent/IL285528B2/en unknown
- 2014-10-17 SI SI201432068T patent/SI3587400T1/sl unknown
- 2014-10-20 TW TW107133858A patent/TWI685486B/zh active
- 2014-10-20 TW TW109102549A patent/TWI720803B/zh active
- 2014-10-20 AR ARP140103938A patent/AR098128A1/es active IP Right Grant
- 2014-10-20 TW TW103136112A patent/TWI651305B/zh active
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2016
- 2016-04-14 MX MX2022000030A patent/MX2022000030A/es unknown
- 2016-04-14 MX MX2022000036A patent/MX2022000036A/es unknown
- 2016-04-20 IL IL245220A patent/IL245220A/en active IP Right Grant
- 2016-04-20 PH PH12016500737A patent/PH12016500737B1/en unknown
- 2016-07-22 US US15/217,468 patent/US9890122B2/en active Active
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2017
- 2017-06-11 IL IL252834A patent/IL252834B/en unknown
- 2017-11-03 US US15/802,737 patent/US10323003B2/en active Active
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2018
- 2018-10-05 JP JP2018189627A patent/JP2019038813A/ja active Pending
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2019
- 2019-04-23 US US16/391,952 patent/US10759761B2/en active Active
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2020
- 2020-02-17 AR ARP200100438A patent/AR118124A2/es active IP Right Grant
- 2020-07-21 US US16/934,527 patent/US11352327B2/en active Active
- 2020-10-14 JP JP2020173216A patent/JP7051970B2/ja active Active
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2021
- 2021-02-15 CY CY20211100122T patent/CY1123811T1/el unknown
- 2021-03-01 HR HRP20210336TT patent/HRP20210336T1/hr unknown
- 2021-05-27 AR ARP210101431A patent/AR122183A2/es unknown
- 2021-05-27 AR ARP210101430A patent/AR122182A2/es unknown
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2022
- 2022-02-22 JP JP2022025240A patent/JP7345581B2/ja active Active
- 2022-02-22 JP JP2022025300A patent/JP7534346B2/ja active Active
- 2022-05-06 US US17/738,630 patent/US11981639B2/en active Active
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2024
- 2024-01-02 US US18/401,832 patent/US20240166605A1/en not_active Abandoned
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