DK3587400T3 - Fremgangsmåde til fremstilling af en PDE4-inhibitor - Google Patents

Fremgangsmåde til fremstilling af en PDE4-inhibitor Download PDF

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Publication number
DK3587400T3
DK3587400T3 DK19183016.5T DK19183016T DK3587400T3 DK 3587400 T3 DK3587400 T3 DK 3587400T3 DK 19183016 T DK19183016 T DK 19183016T DK 3587400 T3 DK3587400 T3 DK 3587400T3
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Denmark
Prior art keywords
production
pde4 inhibitor
pde4
inhibitor
Prior art date
Application number
DK19183016.5T
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English (en)
Inventor
Alessandro Falchi
Emilio Lutero
Emanuele Ferrari
Fausto Pivetti
Rocco Bussolati
Edoardo Mariani
Orsola Vecchi
Erhard Bappert
Caterina Ventrici
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Chiesi Farm Spa
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49385193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3587400(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
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Publication of DK3587400T3 publication Critical patent/DK3587400T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
DK19183016.5T 2013-10-22 2014-10-17 Fremgangsmåde til fremstilling af en PDE4-inhibitor DK3587400T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13189784 2013-10-22
EP14795565.2A EP3060551B1 (en) 2013-10-22 2014-10-17 Process for the preparation of a pde4 inhibitor

Publications (1)

Publication Number Publication Date
DK3587400T3 true DK3587400T3 (da) 2024-04-02

Family

ID=49385193

Family Applications (3)

Application Number Title Priority Date Filing Date
DK19183016.5T DK3587400T3 (da) 2013-10-22 2014-10-17 Fremgangsmåde til fremstilling af en PDE4-inhibitor
DK17192278.4T DK3293176T3 (da) 2013-10-22 2014-10-17 Krystalform af en pde4-inhibitor
DK14795565T DK3060551T3 (da) 2013-10-22 2014-10-17 Fremgangsmåde til fremstilling af en PDE4-hæmmer

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK17192278.4T DK3293176T3 (da) 2013-10-22 2014-10-17 Krystalform af en pde4-inhibitor
DK14795565T DK3060551T3 (da) 2013-10-22 2014-10-17 Fremgangsmåde til fremstilling af en PDE4-hæmmer

Country Status (29)

Country Link
US (6) US9434691B2 (da)
EP (5) EP3587400B1 (da)
JP (5) JP6458957B2 (da)
KR (3) KR102240865B1 (da)
CN (3) CN114621139A (da)
AR (4) AR098128A1 (da)
AU (1) AU2014339136C1 (da)
BR (1) BR112016008161B1 (da)
CA (3) CA3115570C (da)
CY (1) CY1123811T1 (da)
DK (3) DK3587400T3 (da)
ES (2) ES2759514T3 (da)
HK (1) HK1223926A1 (da)
HR (2) HRP20192152T1 (da)
HU (2) HUE046637T2 (da)
IL (4) IL285532B2 (da)
LT (2) LT3293176T (da)
MX (4) MX370104B (da)
MY (1) MY182559A (da)
PH (2) PH12016500737A1 (da)
PL (2) PL3293176T3 (da)
PT (2) PT3060551T (da)
RS (1) RS61558B1 (da)
RU (1) RU2682660C9 (da)
SG (4) SG10201903575UA (da)
SI (2) SI3060551T1 (da)
TW (3) TWI651305B (da)
UA (2) UA121853C2 (da)
WO (1) WO2015059050A1 (da)

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EP3587400B1 (en) * 2013-10-22 2024-03-20 Chiesi Farmaceutici S.p.A. Process for the preparation of a pde4 inhibitor
WO2018017713A1 (en) * 2016-07-20 2018-01-25 Allergan, Inc. Methods, compositions, and compounds for treatment of dermatological and ocular conditions
JP7361584B2 (ja) * 2018-12-19 2023-10-16 高砂香料工業株式会社 アミドの還元によるアミンの製造方法
JP6780763B2 (ja) 2018-12-25 2020-11-04 トヨタ自動車株式会社 内燃機関の制御装置
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WO2023117985A1 (en) 2021-12-21 2023-06-29 Chiesi Farmaceutici S.P.A. Dry powder formulations filled in an inhaler with improved resistance to humidity
WO2023208982A1 (en) 2022-04-27 2023-11-02 Chiesi Farmaceutici S.P.A. Crystal form of a pde4 inhibitor
CN115304542B (zh) * 2022-07-18 2024-02-02 湖南华纳大药厂手性药物有限公司 一种3-羟基吡啶的合成工艺
WO2024027901A1 (en) 2022-08-02 2024-02-08 Chiesi Farmaceutici S.P.A. Predictive biomarker of clinical response to a pde4 inhibitor
WO2024062005A1 (en) 2022-09-22 2024-03-28 Chiesi Farmaceutici S.P.A. Capsule inhaler for the administration of a phosphodiesterase-4 inhibitor
WO2024062006A1 (en) 2022-09-22 2024-03-28 Chiesi Farmaceutici S.P.A. Capsule inhaler for the administration of a phosphodiesterase-4 inhibitor
WO2024062007A1 (en) 2022-09-22 2024-03-28 Chiesi Farmaceutici S.P.A. Capsule inhaler for the administration of a phosphodiesterase-4 inhibitor

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UA112296C2 (uk) * 2010-08-03 2016-08-25 К'Єзі Фармачеутічі С.П.А. Сухий порошковий препарат, який містить інгібітор фосфодіестерази
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WO2023117985A1 (en) * 2021-12-21 2023-06-29 Chiesi Farmaceutici S.P.A. Dry powder formulations filled in an inhaler with improved resistance to humidity

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JP2022068321A (ja) 2022-05-09
SG10202112587RA (en) 2021-12-30
SG10201903575UA (en) 2019-05-30
AR122182A2 (es) 2022-08-24
US20190345108A1 (en) 2019-11-14
MY182559A (en) 2021-01-25
KR102240865B1 (ko) 2021-04-16
AR122183A2 (es) 2022-08-24
PH12016500737B1 (en) 2016-05-30
JP7051970B2 (ja) 2022-04-11
AU2014339136B2 (en) 2018-05-31
US10759761B2 (en) 2020-09-01
ES2759514T3 (es) 2020-05-11
US20150111931A1 (en) 2015-04-23
IL285532B1 (en) 2023-11-01
TWI651305B (zh) 2019-02-21
US10323003B2 (en) 2019-06-18
TWI685486B (zh) 2020-02-21
CA2928242A1 (en) 2015-04-30
US20160326117A1 (en) 2016-11-10
EP3798209A1 (en) 2021-03-31
LT3587400T (lt) 2024-04-25
MX2022000036A (es) 2022-07-19
IL252834A0 (en) 2017-08-31
KR20160072127A (ko) 2016-06-22
RS61558B1 (sr) 2021-04-29
PL3293176T3 (pl) 2021-06-28
MX2016004834A (es) 2016-07-19
EP4059921A1 (en) 2022-09-21
IL245220A (en) 2017-06-29
PH12020500162A1 (en) 2021-08-02
HRP20192152T1 (hr) 2020-02-21
DK3060551T3 (da) 2019-10-28
HRP20210336T1 (hr) 2021-04-16
AU2014339136C1 (en) 2019-10-31
RU2016115246A3 (da) 2018-06-27
LT3293176T (lt) 2021-03-25
US20180118686A1 (en) 2018-05-03
PT3060551T (pt) 2019-12-09
TW201904945A (zh) 2019-02-01
EP3587400A3 (en) 2020-03-25
HK1223926A1 (zh) 2017-08-11
AR098128A1 (es) 2016-05-04
JP2021011494A (ja) 2021-02-04
JP2022071008A (ja) 2022-05-13
TW201605804A (zh) 2016-02-16
CN114621139A (zh) 2022-06-14
CN105658629B (zh) 2019-07-16
EP3587400A2 (en) 2020-01-01
CN105658629A (zh) 2016-06-08
EP3060551A1 (en) 2016-08-31
UA127453C2 (uk) 2023-08-30
JP2019038813A (ja) 2019-03-14
IL245220A0 (en) 2016-06-30
SG10201912852YA (en) 2020-02-27
KR20210021415A (ko) 2021-02-25
JP2017505752A (ja) 2017-02-23
DK3293176T3 (da) 2021-02-15
EP3587400B1 (en) 2024-03-20
US20220348545A1 (en) 2022-11-03
HUE053112T2 (hu) 2021-06-28
US11352327B2 (en) 2022-06-07
PL3060551T3 (pl) 2020-03-31
EP3293176B1 (en) 2020-12-02
US9890122B2 (en) 2018-02-13
MX2019014408A (es) 2020-01-27
AR118124A2 (es) 2021-09-22
JP6458957B2 (ja) 2019-01-30
RU2016115246A (ru) 2017-11-27
RU2682660C2 (ru) 2019-03-20
KR20210021416A (ko) 2021-02-25
US9434691B2 (en) 2016-09-06
SG11201603130TA (en) 2016-05-30
SI3060551T1 (sl) 2019-11-29
IL252834B (en) 2021-09-30
EP3293176A1 (en) 2018-03-14
IL285532B2 (en) 2024-03-01
EP3060551B1 (en) 2019-09-18
KR102287598B1 (ko) 2021-08-11
CY1123811T1 (el) 2022-05-27
WO2015059050A1 (en) 2015-04-30
US20210040040A1 (en) 2021-02-11
BR112016008161B1 (pt) 2022-11-29
UA121853C2 (uk) 2020-08-10
MX2022000030A (es) 2022-07-19
MX370104B (es) 2019-12-02
ES2857629T3 (es) 2021-09-29
HUE046637T2 (hu) 2020-03-30
TW202021952A (zh) 2020-06-16
KR102240865B9 (ko) 2021-12-13
KR102287596B1 (ko) 2021-08-11
RU2682660C9 (ru) 2019-06-21
CA3115570A1 (en) 2015-04-30
BR112016008161A2 (da) 2017-08-01
IL285532A (en) 2021-09-30
JP7345581B2 (ja) 2023-09-15
SI3293176T1 (sl) 2021-04-30
PH12016500737A1 (en) 2016-05-30
IL285528A (en) 2021-09-30
CA2928242C (en) 2022-03-15
CA3115570C (en) 2024-01-30
CA3115587A1 (en) 2015-04-30
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PT3293176T (pt) 2021-03-03
CN110256338A (zh) 2019-09-20

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