JP2009535340A5 - - Google Patents
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- JP2009535340A5 JP2009535340A5 JP2009507797A JP2009507797A JP2009535340A5 JP 2009535340 A5 JP2009535340 A5 JP 2009535340A5 JP 2009507797 A JP2009507797 A JP 2009507797A JP 2009507797 A JP2009507797 A JP 2009507797A JP 2009535340 A5 JP2009535340 A5 JP 2009535340A5
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- JP
- Japan
- Prior art keywords
- free base
- crystalline free
- base form
- item
- form according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012458 free base Substances 0.000 claims description 62
- 238000000113 differential scanning calorimetry Methods 0.000 claims description 12
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 9
- 241000124008 Mammalia Species 0.000 claims description 6
- 230000001747 exhibiting effect Effects 0.000 claims description 6
- QMOVGVNKXUTCQU-UHFFFAOYSA-N (2-phenylphenyl)carbamic acid Chemical compound OC(=O)NC1=CC=CC=C1C1=CC=CC=C1 QMOVGVNKXUTCQU-UHFFFAOYSA-N 0.000 claims description 5
- -1 4-{[(R) -2- (3-formylamino-4-hydroxyphenyl) -2-hydroxyethylamino] methyl} -2,5-dimethylphenyl Carbamoyl Chemical group 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 208000019693 Lung disease Diseases 0.000 claims description 4
- YZHRQETVEBXYFP-BBQAJUCSSA-N O[C@@H](CNCC(C=CC1)=CC1(C1=CC=CC=C1)NC(O)=O)C(C=C1)=CC(NC=O)=C1O Chemical compound O[C@@H](CNCC(C=CC1)=CC1(C1=CC=CC=C1)NC(O)=O)C(C=C1)=CC(NC=O)=C1O YZHRQETVEBXYFP-BBQAJUCSSA-N 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 230000007883 bronchodilation Effects 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000002294 steroidal antiinflammatory agent Substances 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 108060003345 Adrenergic Receptor Proteins 0.000 claims description 2
- 102000017910 Adrenergic receptor Human genes 0.000 claims description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 2
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 claims description 2
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 4
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 230000003042 antagnostic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79470906P | 2006-04-25 | 2006-04-25 | |
| PCT/US2007/010120 WO2007127297A2 (en) | 2006-04-25 | 2007-04-24 | Crystalline forms of a dimethylphenyl compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009535340A JP2009535340A (ja) | 2009-10-01 |
| JP2009535340A5 true JP2009535340A5 (https=) | 2011-05-19 |
Family
ID=38556280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507797A Pending JP2009535340A (ja) | 2006-04-25 | 2007-04-24 | ジメチルフェニル化合物の結晶性形態 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7880010B2 (https=) |
| EP (1) | EP2010490B1 (https=) |
| JP (1) | JP2009535340A (https=) |
| CN (1) | CN101426765A (https=) |
| AR (1) | AR060648A1 (https=) |
| AT (1) | ATE520660T1 (https=) |
| CA (1) | CA2650631A1 (https=) |
| PE (1) | PE20080195A1 (https=) |
| TW (1) | TW200811104A (https=) |
| WO (1) | WO2007127297A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6693202B1 (en) * | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| US7638138B2 (en) * | 2003-02-21 | 2009-12-29 | Translational Research, Ltd. | Compositions for nasal administration of pharmaceuticals |
| AU2003220808B2 (en) | 2003-03-27 | 2008-08-21 | Bioactis Limited | Powder medicine applicator for nasal cavity |
| WO2006016530A1 (ja) * | 2004-08-10 | 2006-02-16 | Translational Research, Ltd. | 速効性でかつ高い吸収性を可能とする経鼻投与用組成物 |
| WO2006023457A1 (en) * | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| TW200811105A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| US20080071141A1 (en) * | 2006-09-18 | 2008-03-20 | Abhisuek Gattani | Method and apparatus for measuring attributes of an anatomical feature during a medical procedure |
| US8337817B2 (en) | 2006-12-26 | 2012-12-25 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
| US20090216010A1 (en) * | 2008-02-22 | 2009-08-27 | Wei-Hong Tseng | Crystalline carbapenem compound and produced method thereof |
| JP5540075B2 (ja) * | 2009-04-14 | 2014-07-02 | グラクソ グループ リミテッド | ビフェニル−２−イルカルバミン酸エステルの調製方法 |
| MX2011011156A (es) | 2009-04-23 | 2011-11-04 | Theravance Inc | COMPUESTOS DIAMIDA QUE TIENE ACTIVIDAD COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS Y COMO AGONISTAS DE LOS RECEPTORES ANDRENERGICOS ß2. |
| WO2010131486A1 (en) * | 2009-05-15 | 2010-11-18 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
| WO2011013003A2 (en) | 2009-07-31 | 2011-02-03 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
| WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| AR083115A1 (es) | 2010-09-30 | 2013-01-30 | Theravance Inc | Sales oxalato cristalinas de un compuesto diamida |
| EP2592077A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| JP5877277B2 (ja) * | 2013-04-26 | 2016-03-02 | 富士フイルム株式会社 | 撮像装置及び画像表示方法 |
| CN107108502A (zh) * | 2015-05-14 | 2017-08-29 | 四川海思科制药有限公司 | 具有β2受体激动及M受体拮抗活性的联苯衍生物及其在医药上的用途 |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995006635A1 (en) | 1993-09-02 | 1995-03-09 | Yamanouchi Pharmaceutical Co., Ltd. | Carbamate derivative and medicine containing the same |
| AU685225B2 (en) | 1994-02-10 | 1998-01-15 | Yamanouchi Pharmaceutical Co., Ltd. | Novel carbamate derivative and medicinal composition containing the same |
| US6040344A (en) | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| UA73965C2 (en) | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
| US20030018019A1 (en) | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| US6653323B2 (en) | 2001-11-13 | 2003-11-25 | Theravance, Inc. | Aryl aniline β2 adrenergic receptor agonists |
| TWI249515B (en) | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| EP1622875B1 (en) * | 2003-05-08 | 2009-12-02 | Theravance, Inc. | Crystalline forms of an arylaniline beta-2 adrenergic receptor agonist |
| ES2329586T3 (es) * | 2003-11-21 | 2009-11-27 | Theravance, Inc. | Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino. |
| TWI374883B (en) * | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
| WO2006023457A1 (en) | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| WO2006023460A2 (en) | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| US7558576B2 (en) * | 2005-03-29 | 2009-07-07 | Qualcomm Incorporated | Employing frequency offset to compensate for Doppler shift |
| TW200811105A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
-
2007
- 2007-04-23 TW TW096114174A patent/TW200811104A/zh unknown
- 2007-04-24 WO PCT/US2007/010120 patent/WO2007127297A2/en not_active Ceased
- 2007-04-24 CA CA002650631A patent/CA2650631A1/en not_active Abandoned
- 2007-04-24 US US11/789,154 patent/US7880010B2/en not_active Expired - Fee Related
- 2007-04-24 JP JP2009507797A patent/JP2009535340A/ja active Pending
- 2007-04-24 AT AT07794375T patent/ATE520660T1/de not_active IP Right Cessation
- 2007-04-24 AR ARP070101778A patent/AR060648A1/es unknown
- 2007-04-24 EP EP07794375A patent/EP2010490B1/en active Active
- 2007-04-24 PE PE2007000508A patent/PE20080195A1/es not_active Application Discontinuation
- 2007-04-24 CN CNA2007800142180A patent/CN101426765A/zh active Pending
-
2010
- 2010-12-16 US US12/970,013 patent/US20110086881A1/en not_active Abandoned
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