JP5616021B2 - ビフェニル−２−イルカルバミン酸１−［２−（２−クロロ−４−｛［（ｒ）−２−ヒドロキシ−２−（８−ヒドロキシ−２−オキソ−１，２−ジヒドロキノリン−５−イル）エチルアミノメチル］｝−５−メトキシフェニルカルバモイル）エチル］ピペリジン−４−イルエステルのコハク酸塩および肺疾患治療におけるその使用 - Google Patents

ビフェニル−２−イルカルバミン酸１−［２−（２−クロロ−４−｛［（ｒ）−２−ヒドロキシ−２−（８−ヒドロキシ−２−オキソ−１，２−ジヒドロキノリン−５−イル）エチルアミノメチル］｝−５−メトキシフェニルカルバモイル）エチル］ピペリジン−４−イルエステルのコハク酸塩および肺疾患治療におけるその使用 Download PDF

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Publication number
JP5616021B2
JP5616021B2 JP2008553758A JP2008553758A JP5616021B2 JP 5616021 B2 JP5616021 B2 JP 5616021B2 JP 2008553758 A JP2008553758 A JP 2008553758A JP 2008553758 A JP2008553758 A JP 2008553758A JP 5616021 B2 JP5616021 B2 JP 5616021B2
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hydroxy
ester
methyl
piperidin
chloro
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Expired - Fee Related
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JP2008553758A
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Japanese (ja)
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JP2009526018A5 (https=
JP2009526018A (ja
Inventor
チューダサマ，レーシュマ
ケネディ，アンドリュー
キンドン，リーンダ，ジェーン
マレット，フランク，パトリック
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Glaxo Group Ltd
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Glaxo Group Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
JP2008553758A 2006-02-10 2007-02-08 ビフェニル−２−イルカルバミン酸１−［２−（２−クロロ−４−｛［（ｒ）−２−ヒドロキシ−２−（８−ヒドロキシ−２−オキソ−１，２−ジヒドロキノリン−５−イル）エチルアミノメチル］｝−５−メトキシフェニルカルバモイル）エチル］ピペリジン−４−イルエステルのコハク酸塩および肺疾患治療におけるその使用 Expired - Fee Related JP5616021B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0602778.3 2006-02-10
GBGB0602778.3A GB0602778D0 (en) 2006-02-10 2006-02-10 Novel compound
PCT/EP2007/051196 WO2007090859A1 (en) 2006-02-10 2007-02-08 Succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{ [ (r)-2-hydroxy-2- (8-hydroxy-2-oxo-1, 2-dihydroquinolin-5-yl) eth ylaminoimethyl] } -5-methoxyphenylcarbamoyl) ethyl] piperidin-4-yl ester and its use for the treatment of pulmonary disorders

Publications (3)

Publication Number Publication Date
JP2009526018A JP2009526018A (ja) 2009-07-16
JP2009526018A5 JP2009526018A5 (https=) 2010-03-18
JP5616021B2 true JP5616021B2 (ja) 2014-10-29

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ID=36119909

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JP2008553758A Expired - Fee Related JP5616021B2 (ja) 2006-02-10 2007-02-08 ビフェニル−２−イルカルバミン酸１−［２−（２−クロロ−４−｛［（ｒ）−２−ヒドロキシ−２−（８−ヒドロキシ−２−オキソ−１，２−ジヒドロキノリン−５−イル）エチルアミノメチル］｝−５−メトキシフェニルカルバモイル）エチル］ピペリジン−４−イルエステルのコハク酸塩および肺疾患治療におけるその使用

Country Status (33)

Country Link
US (1) US7960551B2 (https=)
EP (1) EP1981872B1 (https=)
JP (1) JP5616021B2 (https=)
KR (1) KR101488691B1 (https=)
CN (1) CN101379057B (https=)
AR (2) AR059409A1 (https=)
AU (1) AU2007213767B2 (https=)
BR (1) BRPI0707559B8 (https=)
CA (1) CA2641769C (https=)
CR (1) CR10227A (https=)
CY (1) CY1119238T1 (https=)
DK (1) DK1981872T3 (https=)
EA (1) EA016580B1 (https=)
ES (1) ES2640226T3 (https=)
GB (1) GB0602778D0 (https=)
HR (1) HRP20171304T1 (https=)
HU (1) HUE034315T2 (https=)
IL (1) IL193103A (https=)
JO (1) JO3389B1 (https=)
LT (1) LT1981872T (https=)
MA (1) MA30273B1 (https=)
MY (1) MY153656A (https=)
NO (1) NO341343B1 (https=)
NZ (1) NZ570242A (https=)
PE (2) PE20110120A1 (https=)
PL (1) PL1981872T3 (https=)
PT (1) PT1981872T (https=)
SG (1) SG169404A1 (https=)
SI (1) SI1981872T1 (https=)
TW (1) TWI401251B (https=)
UA (1) UA100364C2 (https=)
WO (1) WO2007090859A1 (https=)
ZA (1) ZA200806782B (https=)

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MA38260B1 (fr) 2012-12-18 2018-04-30 Almirall Sa Nouveaux dérivés de cyclohexyl et quinuclidinyl carbamate ayant une activité d'agoniste adrénergique beta2 et une activité d'antagoniste muscarinique m3
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
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Also Published As

Publication number Publication date
TW200800948A (en) 2008-01-01
AR104288A2 (es) 2017-07-12
US7960551B2 (en) 2011-06-14
UA100364C2 (xx) 2012-12-25
PE20071249A1 (es) 2008-01-16
BRPI0707559B8 (pt) 2021-05-25
KR20080114723A (ko) 2008-12-31
IL193103A (en) 2013-06-27
LT1981872T (lt) 2017-09-11
SG169404A1 (en) 2011-03-30
BRPI0707559B1 (pt) 2021-01-12
ZA200806782B (en) 2009-10-28
MA30273B1 (fr) 2009-03-02
EP1981872A1 (en) 2008-10-22
AR059409A1 (es) 2008-04-09
HRP20171304T1 (hr) 2017-10-20
CN101379057B (zh) 2013-02-13
ES2640226T3 (es) 2017-11-02
EA016580B1 (ru) 2012-06-29
SI1981872T1 (sl) 2017-10-30
NO341343B1 (no) 2017-10-16
US20070281971A1 (en) 2007-12-06
CR10227A (es) 2008-10-29
MY153656A (en) 2015-03-13
WO2007090859A1 (en) 2007-08-16
DK1981872T3 (en) 2017-09-11
PE20110120A1 (es) 2011-03-08
CY1119238T1 (el) 2018-02-14
JO3389B1 (ar) 2019-03-13
JP2009526018A (ja) 2009-07-16
NZ570242A (en) 2011-09-30
EP1981872B1 (en) 2017-06-21
TWI401251B (zh) 2013-07-11
CA2641769C (en) 2014-02-04
BRPI0707559A2 (pt) 2011-05-10
CN101379057A (zh) 2009-03-04
NO20083425L (no) 2008-09-09
KR101488691B1 (ko) 2015-02-02
GB0602778D0 (en) 2006-03-22
EA200801691A1 (ru) 2009-02-27
PT1981872T (pt) 2017-09-13
CA2641769A1 (en) 2007-08-16
PL1981872T3 (pl) 2017-11-30
AU2007213767A1 (en) 2007-08-16
AU2007213767B2 (en) 2012-04-26
BRPI0707559A8 (pt) 2019-01-29
HUE034315T2 (en) 2018-02-28
IL193103A0 (en) 2009-02-11

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