JP2009523226A5 - - Google Patents
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- JP2009523226A5 JP2009523226A5 JP2008538977A JP2008538977A JP2009523226A5 JP 2009523226 A5 JP2009523226 A5 JP 2009523226A5 JP 2008538977 A JP2008538977 A JP 2008538977A JP 2008538977 A JP2008538977 A JP 2008538977A JP 2009523226 A5 JP2009523226 A5 JP 2009523226A5
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- 239000000090 biomarker Substances 0.000 claims 46
- 238000000034 method Methods 0.000 claims 33
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 25
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 25
- 102000057041 human TNF Human genes 0.000 claims 23
- 201000004595 synovitis Diseases 0.000 claims 22
- 239000000427 antigen Substances 0.000 claims 20
- 102000036639 antigens Human genes 0.000 claims 20
- 108091007433 antigens Proteins 0.000 claims 20
- 230000011382 collagen catabolic process Effects 0.000 claims 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims 11
- 239000002452 tumor necrosis factor alpha inhibitor Substances 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 10
- 108010074051 C-Reactive Protein Proteins 0.000 claims 6
- 102100032752 C-reactive protein Human genes 0.000 claims 6
- 235000004279 alanine Nutrition 0.000 claims 6
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 6
- 238000002203 pretreatment Methods 0.000 claims 5
- 102000000422 Matrix Metalloproteinase 3 Human genes 0.000 claims 4
- 108010016160 Matrix Metalloproteinase 3 Proteins 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 4
- 238000002965 ELISA Methods 0.000 claims 3
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 3
- 230000007170 pathology Effects 0.000 claims 3
- 230000002485 urinary effect Effects 0.000 claims 3
- VKUYLANQOAKALN-UHFFFAOYSA-N 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-n-hydroxy-4-methylpentanamide Chemical group C1=CC(OC)=CC=C1S(=O)(=O)N(C(CC(C)C)C(=O)NO)CC1=CC=CC=C1 VKUYLANQOAKALN-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102000000503 Collagen Type II Human genes 0.000 claims 2
- 108010041390 Collagen Type II Proteins 0.000 claims 2
- LOJFGJZQOKTUBR-XAQOOIOESA-N NC(N)=NCCC[C@@H](C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(O)=O)C)CC1=CN=CN1 Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(O)=O)C)CC1=CN=CN1 LOJFGJZQOKTUBR-XAQOOIOESA-N 0.000 claims 2
- 102100030416 Stromelysin-1 Human genes 0.000 claims 2
- 101710108790 Stromelysin-1 Proteins 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 229960002964 adalimumab Drugs 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 108010049937 collagen type I trimeric cross-linked peptide Proteins 0.000 claims 2
- 230000003013 cytotoxicity Effects 0.000 claims 2
- 231100000135 cytotoxicity Toxicity 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 108010008165 Etanercept Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229960000403 etanercept Drugs 0.000 claims 1
- 229960001743 golimumab Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 210000001258 synovial membrane Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73244405P | 2005-11-01 | 2005-11-01 | |
| US60/732,444 | 2005-11-01 | ||
| PCT/US2006/042564 WO2007089303A2 (en) | 2005-11-01 | 2006-10-31 | Methods and compositions for diagnosing ankylosing spondylitis using biomarkers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011251783A Division JP2012093361A (ja) | 2005-11-01 | 2011-11-17 | バイオマーカーを用いて強直性脊椎炎を診断するための方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009523226A JP2009523226A (ja) | 2009-06-18 |
| JP2009523226A5 true JP2009523226A5 (https=) | 2009-12-17 |
| JP5198277B2 JP5198277B2 (ja) | 2013-05-15 |
Family
ID=38327823
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538977A Expired - Fee Related JP5198277B2 (ja) | 2005-11-01 | 2006-10-31 | バイオマーカーを用いて強直性脊椎炎を診断するための方法及び組成物 |
| JP2011251783A Ceased JP2012093361A (ja) | 2005-11-01 | 2011-11-17 | バイオマーカーを用いて強直性脊椎炎を診断するための方法及び組成物 |
| JP2013156781A Ceased JP2014013241A (ja) | 2005-11-01 | 2013-07-29 | バイオマーカーを用いて強直性脊椎炎を診断するための方法及び組成物 |
| JP2014241725A Pending JP2015096856A (ja) | 2005-11-01 | 2014-11-28 | バイオマーカーを用いて強直性脊椎炎を診断するための方法及び組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011251783A Ceased JP2012093361A (ja) | 2005-11-01 | 2011-11-17 | バイオマーカーを用いて強直性脊椎炎を診断するための方法及び組成物 |
| JP2013156781A Ceased JP2014013241A (ja) | 2005-11-01 | 2013-07-29 | バイオマーカーを用いて強直性脊椎炎を診断するための方法及び組成物 |
| JP2014241725A Pending JP2015096856A (ja) | 2005-11-01 | 2014-11-28 | バイオマーカーを用いて強直性脊椎炎を診断するための方法及び組成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7919264B2 (https=) |
| EP (2) | EP2357479A1 (https=) |
| JP (4) | JP5198277B2 (https=) |
| KR (2) | KR20140012160A (https=) |
| CN (2) | CN101663048A (https=) |
| AU (1) | AU2006337105B2 (https=) |
| BR (1) | BRPI0618085A2 (https=) |
| CA (1) | CA2626804A1 (https=) |
| DK (1) | DK1948235T3 (https=) |
| ES (1) | ES2431643T3 (https=) |
| HR (1) | HRP20131112T1 (https=) |
| IL (2) | IL190964A0 (https=) |
| NZ (3) | NZ567286A (https=) |
| PL (1) | PL1948235T3 (https=) |
| PT (1) | PT1948235E (https=) |
| RS (1) | RS53055B (https=) |
| RU (2) | RU2438704C2 (https=) |
| SG (1) | SG169361A1 (https=) |
| SI (1) | SI1948235T1 (https=) |
| TW (2) | TW201337266A (https=) |
| WO (1) | WO2007089303A2 (https=) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
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| US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
| US20040219142A1 (en) * | 2002-07-19 | 2004-11-04 | Abbott Laboratories S.A. | Treatment of skin and nail disorders using TNFalpha inhibitors |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| MY150740A (en) * | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| TWI439284B (zh) | 2004-04-09 | 2014-06-01 | 艾伯維生物技術有限責任公司 | 用於治療ＴＮＦα相關失調症之多重可變劑量療法 |
| GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
| US20060083741A1 (en) * | 2004-10-08 | 2006-04-20 | Hoffman Rebecca S | Treatment of respiratory syncytial virus (RSV) infection |
| CN102961746B (zh) | 2005-05-16 | 2016-06-15 | 艾伯维生物技术有限公司 | TNFα抑制剂治疗腐蚀性多关节炎的用途 |
| US8874477B2 (en) | 2005-10-04 | 2014-10-28 | Steven Mark Hoffberg | Multifactorial optimization system and method |
| NZ567286A (en) | 2005-11-01 | 2012-03-30 | Abbott Biotechnolgy Ltd | Methods and compositions for diagnosing ankylosing spondylitis using biomarkers |
| KR20140071452A (ko) * | 2006-04-05 | 2014-06-11 | 애브비 바이오테크놀로지 리미티드 | 항체 정제 |
| US20080118496A1 (en) * | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
| US9399061B2 (en) * | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
| EP2007426A4 (en) | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | COMPOSITIONS FOR THE TREATMENT OF PSORIASTIC POLYARTHRITIS AND THEIR APPLICATIONS |
| EP2012586A4 (en) * | 2006-04-10 | 2010-08-18 | Abbott Biotech Ltd | USES AND COMPOSITIONS FOR THE TREATMENT OF ANKYLOSANTE SPONDYLARTHRITIS |
| US9605064B2 (en) * | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| US20090317399A1 (en) * | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
| US20080131374A1 (en) * | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
| US20080311043A1 (en) * | 2006-06-08 | 2008-12-18 | Hoffman Rebecca S | Uses and compositions for treatment of psoriatic arthritis |
| US20100021451A1 (en) | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
| KR101396797B1 (ko) | 2006-06-30 | 2014-05-26 | 애브비 바이오테크놀로지 리미티드 | 자동 주사 장치 |
| WO2008057240A2 (en) * | 2006-10-27 | 2008-05-15 | Abbott Biotechnology Ltd. | Crystalline anti-htnfalpha antibodies |
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| EP2171451A4 (en) | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS |
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| EP2185201A4 (en) * | 2007-08-08 | 2011-11-30 | Abbott Lab | COMPOSITIONS AND METHODS FOR CRYSTALLIZING ANTIBODIES |
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| US9404932B2 (en) * | 2007-11-05 | 2016-08-02 | Nordic Bioscience A/S | Pathology biomarker assay |
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| TWI848959B (zh) * | 2018-07-10 | 2024-07-21 | 中央研究院 | 用於診斷、評估預後及治療僵直性脊椎炎的生物標記及標的 |
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