JP2018512417A5 - - Google Patents
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- JP2018512417A5 JP2018512417A5 JP2017550154A JP2017550154A JP2018512417A5 JP 2018512417 A5 JP2018512417 A5 JP 2018512417A5 JP 2017550154 A JP2017550154 A JP 2017550154A JP 2017550154 A JP2017550154 A JP 2017550154A JP 2018512417 A5 JP2018512417 A5 JP 2018512417A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- binding protein
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562142257P | 2015-04-02 | 2015-04-02 | |
| US62/142,257 | 2015-04-02 | ||
| PCT/US2016/025336 WO2016161154A1 (en) | 2015-04-02 | 2016-03-31 | Methods for treating obesity and nonalcoholic fatty liver disease or nonalcoholic steatohepatitis using glucagon receptor antagonistic antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512417A JP2018512417A (ja) | 2018-05-17 |
| JP2018512417A5 true JP2018512417A5 (https=) | 2019-05-09 |
| JP6861641B2 JP6861641B2 (ja) | 2021-04-21 |
Family
ID=57006366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017550154A Expired - Fee Related JP6861641B2 (ja) | 2015-04-02 | 2016-03-31 | グルカゴン受容体アンタゴニスト抗体を用いた肥満症および非アルコール性脂肪性肝疾患または非アルコール性脂肪性肝炎を治療するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10752693B2 (https=) |
| EP (1) | EP3277830A4 (https=) |
| JP (1) | JP6861641B2 (https=) |
| KR (1) | KR20170138456A (https=) |
| CN (1) | CN107614695B (https=) |
| AU (1) | AU2016242935B2 (https=) |
| CA (1) | CA2980765A1 (https=) |
| MX (1) | MX392496B (https=) |
| WO (1) | WO2016161154A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10226474B2 (en) | 2017-01-09 | 2019-03-12 | Temple University—Of The Commonwealth Sytem Of Higher Education | Methods and compositions for treatment of non-alcoholic steatohepatitis |
| SG11201906682YA (en) * | 2017-01-27 | 2019-08-27 | Ngm Biopharmaceuticals Inc | Glucagon receptor binding proteins and methods of use thereof |
| AU2018314773A1 (en) * | 2017-08-09 | 2020-03-26 | Sanofi | GLP-1/glucagon receptor agonists in the treatment of fatty liver disease and steatohepatitis |
| CA3089649A1 (en) * | 2018-03-08 | 2019-09-12 | Phanes Therapeutics, Inc. | Anti-tip-1 antibodies and uses thereof |
| CN110357959B (zh) | 2018-04-10 | 2023-02-28 | 鸿运华宁（杭州）生物医药有限公司 | Gcgr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用 |
| US10961315B2 (en) | 2018-07-27 | 2021-03-30 | Ngm Biopharmaceuticals, Inc. | Method of treating type I diabetes by administering a combination of a glucagon receptor antagonist and an anti-CD3 antibody |
| CN111068042B (zh) * | 2018-10-18 | 2023-10-13 | 中山大学 | 一种多肽化合物在制备治疗非酒精性肝病、特发性肺间质纤维化和动脉硬化药物中的应用 |
| EP3876924A4 (en) * | 2018-11-06 | 2022-08-10 | Georgetown University | TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS WITH CCK INHIBITORS |
| KR20210109552A (ko) | 2018-12-21 | 2021-09-06 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 이중특이적 단백질 |
| WO2025178928A1 (en) * | 2024-02-23 | 2025-08-28 | Remd Biotherapeutics, Inc. | Combination therapy for the treatment of obesity |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2007002668A1 (es) * | 2006-09-20 | 2008-05-09 | Amgen Inc | Proteina de union a antigeno que se une al receptor de glucagon humano; acido nucleico que la codifica; metodo de produccion; composicion farmaceutica que la comprende; y su uso para tratar o prevenir la diabetes tipo 2. |
| WO2009149379A2 (en) | 2008-06-05 | 2009-12-10 | Regents Of The University Of Michigan | Use of leptin for the treatment of fatty liver diseases and conditions |
| EP2300037B1 (en) * | 2008-06-17 | 2016-03-30 | Indiana University Research and Technology Corporation | Glucagon/glp-1 receptor co-agonists |
| ES2796556T3 (es) * | 2011-09-20 | 2020-11-27 | Ionis Pharmaceuticals Inc | Modulación antisentido de la expresión de GCGR |
| MX2015015339A (es) * | 2013-05-07 | 2016-07-15 | Rinat Neuroscience Corp | Anticuerpos de receptor anti-glucagon y metodos de uso de los mismos. |
| WO2015189698A2 (en) * | 2014-06-08 | 2015-12-17 | Beijing Cosci-Remd Bio Med Tech Company Ltd | Methods for treating type 1 diabetes using glucagon receptor antagonistic antibodies |
-
2016
- 2016-03-31 WO PCT/US2016/025336 patent/WO2016161154A1/en not_active Ceased
- 2016-03-31 EP EP16774227.9A patent/EP3277830A4/en not_active Ceased
- 2016-03-31 KR KR1020177031693A patent/KR20170138456A/ko not_active Ceased
- 2016-03-31 CA CA2980765A patent/CA2980765A1/en active Pending
- 2016-03-31 JP JP2017550154A patent/JP6861641B2/ja not_active Expired - Fee Related
- 2016-03-31 AU AU2016242935A patent/AU2016242935B2/en not_active Ceased
- 2016-03-31 US US15/563,162 patent/US10752693B2/en active Active
- 2016-03-31 CN CN201680030380.0A patent/CN107614695B/zh not_active Expired - Fee Related
- 2016-03-31 MX MX2017012694A patent/MX392496B/es unknown
-
2020
- 2020-07-14 US US16/928,441 patent/US20200339697A1/en not_active Abandoned
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