JP2009521911A5 - - Google Patents

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JP2009521911A5
JP2009521911A5 JP2008547880A JP2008547880A JP2009521911A5 JP 2009521911 A5 JP2009521911 A5 JP 2009521911A5 JP 2008547880 A JP2008547880 A JP 2008547880A JP 2008547880 A JP2008547880 A JP 2008547880A JP 2009521911 A5 JP2009521911 A5 JP 2009521911A5
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variant
asp
protein
ser259asp
substitution
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JP2008547880A
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JP5175214B2 (ja
JP2009521911A (ja
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Priority claimed from PCT/EP2006/012301 external-priority patent/WO2007076933A1/en
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Publication of JP2009521911A5 publication Critical patent/JP2009521911A5/ja
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JP2008547880A 2005-12-30 2006-12-20 改良された安定性を有するインターロイキン−１２ｐ４０変種 Active JP5175214B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75538205P 2005-12-30 2005-12-30
US60/755,382 2005-12-30
PCT/EP2006/012301 WO2007076933A1 (en) 2005-12-30 2006-12-20 Interleukin-12p40 variants with improved stability

Publications (3)

Publication Number Publication Date
JP2009521911A JP2009521911A (ja) 2009-06-11
JP2009521911A5 true JP2009521911A5 (enExample) 2010-02-18
JP5175214B2 JP5175214B2 (ja) 2013-04-03

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JP2008547880A Active JP5175214B2 (ja) 2005-12-30 2006-12-20 改良された安定性を有するインターロイキン−１２ｐ４０変種

Country Status (18)

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US (3) US7872107B2 (enExample)
EP (1) EP1966238B1 (enExample)
JP (1) JP5175214B2 (enExample)
KR (1) KR101343682B1 (enExample)
CN (1) CN101351475B (enExample)
AT (1) ATE555125T1 (enExample)
AU (1) AU2006332138B2 (enExample)
BR (1) BRPI0620648B1 (enExample)
CA (1) CA2635618C (enExample)
CY (1) CY1112884T1 (enExample)
DK (1) DK1966238T3 (enExample)
EA (1) EA015338B1 (enExample)
ES (1) ES2384055T3 (enExample)
PL (1) PL1966238T3 (enExample)
PT (1) PT1966238E (enExample)
SI (1) SI1966238T1 (enExample)
WO (1) WO2007076933A1 (enExample)
ZA (1) ZA200806611B (enExample)

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US12195528B2 (en) 2017-11-28 2025-01-14 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule having adjustable ligand-binding activity
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CN110264184B (zh) * 2019-06-28 2021-07-23 Oppo（重庆）智能科技有限公司 支付控制方法及相关产品
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EP4037700A2 (en) * 2019-10-03 2022-08-10 Xencor, Inc. Targeted il-12 heterodimeric fc-fusion proteins
CA3172641A1 (en) * 2020-04-01 2021-10-07 Xilio Development, Inc. Masked il-12 cytokines and their cleavage products
WO2021212083A2 (en) * 2020-04-17 2021-10-21 The Board Of Trustees Of The Leland Stanford Junior University Engineered il-12 and il-23 polypeptides and uses thereof
US20230295327A1 (en) * 2020-08-11 2023-09-21 Kanaph Therapeutics Inc. Fusion protein comprising il-12 and anti-cd20 antibody and use thereof
EP4277922A4 (en) * 2021-01-12 2025-01-22 Askgene Pharma, Inc. CHIMERIC MOLECULES WITH IL-12 AGONIST POLYPEPTIDE
TW202321281A (zh) * 2021-07-19 2023-06-01 日商中外製藥股份有限公司 使用融合多肽之蛋白酶媒介之靶特異性細胞激素傳遞
AU2022345103A1 (en) * 2021-09-17 2024-03-28 Bicara Therapeutics Inc. Caix targeting il-12 fusion proteins and methods of use thereof
CA3234437A1 (en) * 2021-10-20 2023-04-27 Scott Mccauley Human il-12p40 variants and uses thereof
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AU2023217551A1 (en) * 2022-02-11 2024-08-22 Kanaph Therapeutics Inc. Pharmaceutical composition for cancer treatment comprising fusion protein including il-12 and anti-fap antibody and anticancer agent
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CN119768414A (zh) * 2022-11-10 2025-04-04 康立泰生物医药(青岛)有限公司 聚乙二醇定点修饰异源聚体蛋白或多肽及其制备方法与应用
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