JP2009520691A5 - - Google Patents

Info

Publication number

JP2009520691A5

JP2009520691A5 JP2008543748A JP2008543748A JP2009520691A5 JP 2009520691 A5 JP2009520691 A5 JP 2009520691A5 JP 2008543748 A JP2008543748 A JP 2008543748A JP 2008543748 A JP2008543748 A JP 2008543748A JP 2009520691 A5 JP2009520691 A5 JP 2009520691A5

Authority

JP

Japan

Prior art keywords

antibody molecule

purified antibody

nucleic acid

asn

heavy chain

Prior art date

2006-12-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims 17
• 150000007523 nucleic acids Chemical class 0.000 claims 15
• 150000001413 amino acids Chemical class 0.000 claims 14
• 108020004707 nucleic acids Proteins 0.000 claims 13
• 102000039446 nucleic acids Human genes 0.000 claims 13
• 239000000203 mixture Substances 0.000 claims 12
• 229920001184 polypeptide Polymers 0.000 claims 9
• 102000004196 processed proteins & peptides Human genes 0.000 claims 9
• 150000001508 asparagines Chemical class 0.000 claims 8
• 235000001014 amino acid Nutrition 0.000 claims 7
• 229940024606 amino acid Drugs 0.000 claims 7
• 238000000034 method Methods 0.000 claims 7
• 208000037259 Amyloid Plaque Diseases 0.000 claims 6
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 239000012634 fragment Substances 0.000 claims 6
• 230000003941 amyloidogenesis Effects 0.000 claims 5
• 239000000427 antigen Substances 0.000 claims 5
• 102000036639 antigens Human genes 0.000 claims 5
• 108091007433 antigens Proteins 0.000 claims 5
• 230000007505 plaque formation Effects 0.000 claims 5
• 238000002360 preparation method Methods 0.000 claims 5
• 238000000746 purification Methods 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 2
• 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 2
• 206010012289 Dementia Diseases 0.000 claims 2
• 238000009007 Diagnostic Kit Methods 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 238000005342 ion exchange Methods 0.000 claims 2
• 206010065040 AIDS dementia complex Diseases 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 230000007351 Aβ plaque formation Effects 0.000 claims 1
• 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
• 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
• 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
• 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
• 201000010374 Down Syndrome Diseases 0.000 claims 1
• 208000012902 Nervous system disease Diseases 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 206010044688 Trisomy 21 Diseases 0.000 claims 1
• 230000032683 aging Effects 0.000 claims 1
• 206010002022 amyloidosis Diseases 0.000 claims 1
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
• 238000012435 analytical chromatography Methods 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 238000005277 cation exchange chromatography Methods 0.000 claims 1
• 210000004748 cultured cell Anatomy 0.000 claims 1
• 230000000593 degrading effect Effects 0.000 claims 1
• 230000018109 developmental process Effects 0.000 claims 1
• 230000007717 exclusion Effects 0.000 claims 1
• 230000033581 fucosylation Effects 0.000 claims 1
• 230000013595 glycosylation Effects 0.000 claims 1
• 238000006206 glycosylation reaction Methods 0.000 claims 1
• 238000002649 immunization Methods 0.000 claims 1
• 230000003053 immunization Effects 0.000 claims 1
• 239000000543 intermediate Substances 0.000 claims 1
• 210000004558 lewy body Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 201000001119 neuropathy Diseases 0.000 claims 1
• 230000007823 neuropathy Effects 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 208000033808 peripheral neuropathy Diseases 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 238000003259 recombinant expression Methods 0.000 claims 1