SI1960428T1 - Protitelesa proti amiloidu beta z glikoziliranjem v variabilni regiji - Google Patents
Protitelesa proti amiloidu beta z glikoziliranjem v variabilni regijiInfo
- Publication number
- SI1960428T1 SI1960428T1 SI200631096T SI200631096T SI1960428T1 SI 1960428 T1 SI1960428 T1 SI 1960428T1 SI 200631096 T SI200631096 T SI 200631096T SI 200631096 T SI200631096 T SI 200631096T SI 1960428 T1 SI1960428 T1 SI 1960428T1
- Authority
- SI
- Slovenia
- Prior art keywords
- glycosylation
- variable region
- antibodies against
- amyloid beta
- against amyloid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05027090 | 2005-12-12 | ||
EP06829502A EP1960428B1 (en) | 2005-12-12 | 2006-12-11 | Antibodies against amyloid beta with glycosylation in the variable region |
PCT/EP2006/011914 WO2007068429A1 (en) | 2005-12-12 | 2006-12-11 | Antibodies against amyloid beta 4 with glycosylated in the variable region |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1960428T1 true SI1960428T1 (sl) | 2011-10-28 |
Family
ID=37745986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200631096T SI1960428T1 (sl) | 2005-12-12 | 2006-12-11 | Protitelesa proti amiloidu beta z glikoziliranjem v variabilni regiji |
Country Status (34)
Country | Link |
---|---|
US (2) | US8906370B2 (sl) |
EP (2) | EP2377886A1 (sl) |
JP (1) | JP5145241B2 (sl) |
KR (2) | KR20080077132A (sl) |
CN (2) | CN102659943B (sl) |
AR (1) | AR057233A1 (sl) |
AT (1) | ATE517923T1 (sl) |
AU (1) | AU2006326301B2 (sl) |
BR (1) | BRPI0619605B8 (sl) |
CA (1) | CA2632828C (sl) |
CR (1) | CR10000A (sl) |
CY (1) | CY1114783T1 (sl) |
DK (1) | DK1960428T3 (sl) |
DO (1) | DOP2006000278A (sl) |
EC (1) | ECSP088524A (sl) |
ES (1) | ES2368591T3 (sl) |
HK (2) | HK1176075A1 (sl) |
IL (1) | IL191004A (sl) |
JO (1) | JO2824B1 (sl) |
MA (1) | MA30038B1 (sl) |
MY (1) | MY155286A (sl) |
NO (1) | NO346105B1 (sl) |
NZ (1) | NZ568241A (sl) |
PE (3) | PE20100748A1 (sl) |
PL (1) | PL1960428T3 (sl) |
PT (1) | PT1960428E (sl) |
RS (1) | RS52004B (sl) |
RU (1) | RU2438706C2 (sl) |
SI (1) | SI1960428T1 (sl) |
TW (1) | TWI382990B (sl) |
UA (1) | UA99097C2 (sl) |
UY (1) | UY30003A1 (sl) |
WO (1) | WO2007068429A1 (sl) |
ZA (1) | ZA200805038B (sl) |
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AR038568A1 (es) | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
EP1976877B2 (en) | 2005-11-30 | 2016-10-05 | AbbVie Inc. | Monoclonal antibodies against amyloid beta protein and uses thereof |
DK1954718T3 (en) | 2005-11-30 | 2014-12-15 | Abbvie Inc | Anti-A-globulomer antibodies antigenbindingsgrupper thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods for producing said antibodies, |
TWI382990B (zh) * | 2005-12-12 | 2013-01-21 | Hoffmann La Roche | 可變區域抗體之糖化 |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
MX2009006199A (es) * | 2006-12-11 | 2009-06-22 | Hoffmann La Roche | Formulacion parenteral de anticuerpos abeta. |
EP2486928A1 (en) | 2007-02-27 | 2012-08-15 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
BRPI0813963A2 (pt) | 2007-06-29 | 2015-01-06 | Hoffmann La Roche | Mutante de cadeia pesada que leva a uma melhor produção de imunoglobulina |
KR101637533B1 (ko) * | 2007-08-20 | 2016-07-11 | 글락소 그룹 리미티드 | 제조 방법 |
CA2701793C (en) | 2007-10-05 | 2017-04-25 | Genentech, Inc. | Use of anti-amyloid beta antibody in ocular diseases |
UA101487C2 (en) * | 2007-12-21 | 2013-04-10 | Ф. Хоффманн-Ля Рош Аг | Humanized b-ly1 antibody formulation |
ES2458541T3 (es) * | 2008-05-02 | 2014-05-06 | Seattle Genetics, Inc. | Métodos y composiciones para elaborar anticuerpos y derivados de anticuerpos con fucosilación del núcleo reducida |
WO2010127069A1 (en) * | 2009-04-29 | 2010-11-04 | Schering Corporation | Antibody purification |
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CA2796339C (en) | 2010-04-15 | 2020-03-31 | Abbott Laboratories | Amyloid-beta binding proteins |
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US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
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CN104159613B (zh) * | 2012-03-08 | 2016-11-23 | 霍夫曼-拉罗奇有限公司 | Abeta抗体制剂 |
NZ703585A (en) * | 2012-08-29 | 2018-03-23 | Hoffmann La Roche | Blood brain barrier shuttle |
CN102998454A (zh) * | 2012-12-11 | 2013-03-27 | 华中师范大学 | 一种检测生物体内邻苯二甲酸二丁酯相对含量的方法 |
US9790276B2 (en) | 2012-12-18 | 2017-10-17 | The Rockefeller University | Glycan-modified anti-CD4 antibodies for HIV prevention and therapy |
US9587022B2 (en) | 2012-12-18 | 2017-03-07 | The Rockefeller University | Glycan-modified anti-CD4 antibody with improved HIV-1 neutralizing activity |
ES2755181T3 (es) | 2013-02-13 | 2020-04-21 | Lab Francais Du Fractionnement | Anticuerpos anti-TNF-alfa altamente galactosilados y usos de los mismos |
JP6169885B2 (ja) | 2013-05-07 | 2017-07-26 | 株式会社日立製作所 | 精製装置及び精製方法 |
KR102571391B1 (ko) | 2013-09-13 | 2023-08-29 | 제넨테크, 인크. | 정제된 재조합 폴리펩티드를 포함하는 방법 및 조성물 |
PL3044323T3 (pl) | 2013-09-13 | 2022-06-27 | F.Hoffmann-La Roche Ag | Sposoby wykrywania i ilościowego oznaczania białka komórki gospodarza w liniach komórkowych |
WO2015075942A1 (ja) | 2013-11-22 | 2015-05-28 | 国立大学法人 東京大学 | 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法 |
WO2015155694A1 (en) | 2014-04-08 | 2015-10-15 | Prothena Biosciences Limited | Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein |
WO2015165961A1 (en) | 2014-04-29 | 2015-11-05 | Affiris Ag | Treatment and prevention of alzheimer's disease (ad) |
EP4074730A1 (en) | 2015-06-24 | 2022-10-19 | F. Hoffmann-La Roche AG | Anti-transferrin receptor antibodies with tailored affinity |
WO2017032686A1 (en) * | 2015-08-21 | 2017-03-02 | F. Hoffmann-La Roche Ag | Method for the reduction of host cell proteins in affinity chromatography |
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NZ741067A (en) | 2015-10-02 | 2023-07-28 | Hoffmann La Roche | Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use |
HUE057085T2 (hu) * | 2015-10-16 | 2022-04-28 | Hoffmann La Roche | Egy rendszer mûködtetésére szolgáló eljárás és egy rendszer |
EP3374379A4 (en) | 2015-11-09 | 2019-05-15 | The University Of British Columbia | N-TERMINAL EPITOPES IN BETA-AMYLOID AND CONFORMATIONALLY SELECTIVE ANTIBODIES THEREOF |
EP3374381A4 (en) | 2015-11-09 | 2019-05-15 | The University Of British Columbia | EPITAOPES IN THE CENTRAL REGION OF BETA-AMYLOID AND RELATED CONFORMATIONAL ANTIBODIES |
JP7452829B2 (ja) | 2015-11-09 | 2024-03-19 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | アミロイドベータのエピトープおよびそれに対する抗体 |
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TWI735600B (zh) | 2016-07-01 | 2021-08-11 | 美商美國禮來大藥廠 | 抗-N3pGlu類澱粉β肽抗體及其用途 |
US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
JPWO2018221244A1 (ja) * | 2017-05-30 | 2019-11-21 | 森永乳業株式会社 | 脳機能改善用組成物 |
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CN108048477A (zh) * | 2017-12-15 | 2018-05-18 | 南京理工大学 | 基于大肠杆菌表达系统的制备多肽的方法 |
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TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
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2006
- 2006-12-11 TW TW095146304A patent/TWI382990B/zh active
- 2006-12-11 PE PE2010000560A patent/PE20100748A1/es active IP Right Grant
- 2006-12-11 NZ NZ568241A patent/NZ568241A/en unknown
- 2006-12-11 RS RS20110401A patent/RS52004B/en unknown
- 2006-12-11 NO NO20082874A patent/NO346105B1/no unknown
- 2006-12-11 DK DK06829502.1T patent/DK1960428T3/da active
- 2006-12-11 CN CN201210137369.8A patent/CN102659943B/zh active Active
- 2006-12-11 KR KR1020087012289A patent/KR20080077132A/ko active Search and Examination
- 2006-12-11 CA CA2632828A patent/CA2632828C/en active Active
- 2006-12-11 MY MYPI20081349A patent/MY155286A/en unknown
- 2006-12-11 AU AU2006326301A patent/AU2006326301B2/en active Active
- 2006-12-11 AR ARP060105433A patent/AR057233A1/es unknown
- 2006-12-11 BR BRPI0619605A patent/BRPI0619605B8/pt active IP Right Grant
- 2006-12-11 DO DO2006000278A patent/DOP2006000278A/es unknown
- 2006-12-11 ES ES06829502T patent/ES2368591T3/es active Active
- 2006-12-11 RU RU2008128138/10A patent/RU2438706C2/ru active
- 2006-12-11 PL PL06829502T patent/PL1960428T3/pl unknown
- 2006-12-11 AT AT06829502T patent/ATE517923T1/de active
- 2006-12-11 EP EP11169488A patent/EP2377886A1/en not_active Withdrawn
- 2006-12-11 EP EP06829502A patent/EP1960428B1/en active Active
- 2006-12-11 SI SI200631096T patent/SI1960428T1/sl unknown
- 2006-12-11 PE PE2006001587A patent/PE20071002A1/es not_active Application Discontinuation
- 2006-12-11 UY UY30003A patent/UY30003A1/es unknown
- 2006-12-11 CN CN2006800463079A patent/CN101351476B/zh active Active
- 2006-12-11 WO PCT/EP2006/011914 patent/WO2007068429A1/en active Application Filing
- 2006-12-11 PE PE2010000354A patent/PE20100684A1/es not_active Application Discontinuation
- 2006-12-11 PT PT06829502T patent/PT1960428E/pt unknown
- 2006-12-11 JO JO2006444A patent/JO2824B1/en active
- 2006-12-11 KR KR1020127010552A patent/KR101401159B1/ko active IP Right Grant
- 2006-12-11 UA UAA200808791A patent/UA99097C2/ru unknown
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2008
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- 2008-06-09 MA MA31014A patent/MA30038B1/fr unknown
- 2008-06-10 EC EC2008008524A patent/ECSP088524A/es unknown
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2009
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2014
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