UY30003A1 - Anticuerpos glicosilados en la region variable - Google Patents

Anticuerpos glicosilados en la region variable

Info

Publication number
UY30003A1
UY30003A1 UY30003A UY30003A UY30003A1 UY 30003 A1 UY30003 A1 UY 30003A1 UY 30003 A UY30003 A UY 30003A UY 30003 A UY30003 A UY 30003A UY 30003 A1 UY30003 A1 UY 30003A1
Authority
UY
Uruguay
Prior art keywords
variable region
glycosilated
antibodies
amyloidosis
asn
Prior art date
Application number
UY30003A
Other languages
English (en)
Inventor
Bohrmann Bernd Brockhaus M And
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY30003A1 publication Critical patent/UY30003A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La presente invención se refiere a una preparación de molécula de anticuerpo purificado con al menos un sitio de unión al antígeno que comprende una asparagina (Asn) glicosilada en la región variable de la cadena pesada (VH). La composición está dirigida contra el A-beta y/o un fragmento del mismo, y es útil en el tratamiento o diagnóstico de una enfermedad asociada con la amiloidosis y/o formación de placas de amiloide, como por ejemplo el Alzheimer.
UY30003A 2005-12-12 2006-12-11 Anticuerpos glicosilados en la region variable UY30003A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05027090 2005-12-12

Publications (1)

Publication Number Publication Date
UY30003A1 true UY30003A1 (es) 2007-08-31

Family

ID=37745986

Family Applications (1)

Application Number Title Priority Date Filing Date
UY30003A UY30003A1 (es) 2005-12-12 2006-12-11 Anticuerpos glicosilados en la region variable

Country Status (34)

Country Link
US (2) US8906370B2 (es)
EP (2) EP1960428B1 (es)
JP (1) JP5145241B2 (es)
KR (2) KR20080077132A (es)
CN (2) CN101351476B (es)
AR (1) AR057233A1 (es)
AT (1) ATE517923T1 (es)
AU (1) AU2006326301B2 (es)
BR (1) BRPI0619605B8 (es)
CA (1) CA2632828C (es)
CR (1) CR10000A (es)
CY (1) CY1114783T1 (es)
DK (1) DK1960428T3 (es)
DO (1) DOP2006000278A (es)
EC (1) ECSP088524A (es)
ES (1) ES2368591T3 (es)
HK (2) HK1130066A1 (es)
IL (1) IL191004A (es)
JO (1) JO2824B1 (es)
MA (1) MA30038B1 (es)
MY (1) MY155286A (es)
NO (1) NO346105B1 (es)
NZ (1) NZ568241A (es)
PE (3) PE20100748A1 (es)
PL (1) PL1960428T3 (es)
PT (1) PT1960428E (es)
RS (1) RS52004B (es)
RU (1) RU2438706C2 (es)
SI (1) SI1960428T1 (es)
TW (1) TWI382990B (es)
UA (1) UA99097C2 (es)
UY (1) UY30003A1 (es)
WO (1) WO2007068429A1 (es)
ZA (1) ZA200805038B (es)

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Also Published As

Publication number Publication date
DK1960428T3 (da) 2011-08-22
BRPI0619605B8 (pt) 2021-05-25
JP5145241B2 (ja) 2013-02-13
BRPI0619605B1 (pt) 2019-08-13
DOP2006000278A (es) 2007-07-15
PT1960428E (pt) 2011-10-07
KR20080077132A (ko) 2008-08-21
RU2008128138A (ru) 2010-01-20
JO2824B1 (en) 2014-09-15
CN102659943A (zh) 2012-09-12
CA2632828C (en) 2012-07-10
NO346105B1 (no) 2022-02-21
CN101351476B (zh) 2013-04-03
JP2009520691A (ja) 2009-05-28
PE20100748A1 (es) 2010-11-12
NO20082874L (no) 2008-08-28
BRPI0619605A2 (pt) 2011-10-11
EP1960428A1 (en) 2008-08-27
CR10000A (es) 2008-07-29
WO2007068429A1 (en) 2007-06-21
ATE517923T1 (de) 2011-08-15
KR101401159B1 (ko) 2014-05-29
IL191004A (en) 2013-08-29
RS52004B (en) 2012-04-30
AU2006326301B2 (en) 2011-04-21
EP1960428B1 (en) 2011-07-27
TWI382990B (zh) 2013-01-21
MA30038B1 (fr) 2008-12-01
UA99097C2 (ru) 2012-07-25
EP2377886A1 (en) 2011-10-19
US20150165022A1 (en) 2015-06-18
PE20100684A1 (es) 2010-10-04
NZ568241A (en) 2011-08-26
KR20120089483A (ko) 2012-08-10
BRPI0619605A8 (pt) 2019-01-15
CA2632828A1 (en) 2007-06-21
TW200736273A (en) 2007-10-01
AR057233A1 (es) 2007-11-21
CN102659943B (zh) 2015-07-01
US20090252724A1 (en) 2009-10-08
US9272031B2 (en) 2016-03-01
RU2438706C2 (ru) 2012-01-10
ECSP088524A (es) 2008-07-30
MY155286A (en) 2015-09-30
CN101351476A (zh) 2009-01-21
SI1960428T1 (sl) 2011-10-28
US8906370B2 (en) 2014-12-09
PL1960428T3 (pl) 2012-02-29
ES2368591T3 (es) 2011-11-18
ZA200805038B (en) 2009-06-24
HK1130066A1 (en) 2009-12-18
PE20071002A1 (es) 2007-11-19
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HK1176075A1 (en) 2013-07-19
CY1114783T1 (el) 2016-12-14

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