JP2005508165A5 - - Google Patents

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Publication number

JP2005508165A5

JP2005508165A5 JP2003534444A JP2003534444A JP2005508165A5 JP 2005508165 A5 JP2005508165 A5 JP 2005508165A5 JP 2003534444 A JP2003534444 A JP 2003534444A JP 2003534444 A JP2003534444 A JP 2003534444A JP 2005508165 A5 JP2005508165 A5 JP 2005508165A5

Authority

JP

Japan

Prior art keywords

polypeptide

seq

amino acids

polynucleotide

acid sequence

Prior art date

2002-10-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• 229920001184 polypeptide Polymers 0.000 claims 96
• 108090000765 processed proteins & peptides Proteins 0.000 claims 96
• 102000004196 processed proteins & peptides Human genes 0.000 claims 96
• 150000001413 amino acids Chemical class 0.000 claims 95
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 58
• 102000040430 polynucleotide Human genes 0.000 claims 41
• 108091033319 polynucleotide Proteins 0.000 claims 41
• 239000002157 polynucleotide Substances 0.000 claims 41
• 230000014511 neuron projection development Effects 0.000 claims 24
• 102000005781 Nogo Receptor Human genes 0.000 claims 22
• 108020003872 Nogo receptor Proteins 0.000 claims 22
• 230000001404 mediated effect Effects 0.000 claims 22
• 230000005764 inhibitory process Effects 0.000 claims 19
• 239000012634 fragment Substances 0.000 claims 11
• 239000000203 mixture Substances 0.000 claims 10
• 150000007523 nucleic acids Chemical class 0.000 claims 10
• 210000004027 cell Anatomy 0.000 claims 7
• 102000039446 nucleic acids Human genes 0.000 claims 7
• 108020004707 nucleic acids Proteins 0.000 claims 7
• 102000002260 Alkaline Phosphatase Human genes 0.000 claims 4
• 108020004774 Alkaline Phosphatase Proteins 0.000 claims 4
• 102000005720 Glutathione transferase Human genes 0.000 claims 4
• 108010070675 Glutathione transferase Proteins 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 208000016192 Demyelinating disease Diseases 0.000 claims 3
• 241000124008 Mammalia Species 0.000 claims 3
• 206010052428 Wound Diseases 0.000 claims 3
• 208000027418 Wounds and injury Diseases 0.000 claims 3
• 230000003376 axonal effect Effects 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 230000002401 inhibitory effect Effects 0.000 claims 3
• 210000002569 neuron Anatomy 0.000 claims 3
• 230000008929 regeneration Effects 0.000 claims 3
• 238000011069 regeneration method Methods 0.000 claims 3
• -1 antibody Substances 0.000 claims 2
• 210000003169 central nervous system Anatomy 0.000 claims 2
• 230000002490 cerebral effect Effects 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 238000002360 preparation method Methods 0.000 claims 2
• 230000001737 promoting effect Effects 0.000 claims 2
• 238000006467 substitution reaction Methods 0.000 claims 2
• 208000011403 Alexander disease Diseases 0.000 claims 1
• 206010003694 Atrophy Diseases 0.000 claims 1
• 208000022526 Canavan disease Diseases 0.000 claims 1
• 206010012305 Demyelination Diseases 0.000 claims 1
• 208000010055 Globoid Cell Leukodystrophy Diseases 0.000 claims 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• 208000028226 Krabbe disease Diseases 0.000 claims 1
• 208000034800 Leukoencephalopathies Diseases 0.000 claims 1
• 102100026784 Myelin proteolipid protein Human genes 0.000 claims 1
• 206010056332 Panencephalitis Diseases 0.000 claims 1
• 208000017493 Pelizaeus-Merzbacher disease Diseases 0.000 claims 1
• 102100029826 Reticulon-4 receptor Human genes 0.000 claims 1
• 230000001919 adrenal effect Effects 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 230000037444 atrophy Effects 0.000 claims 1
• 208000015114 central nervous system disease Diseases 0.000 claims 1
• 230000007850 degeneration Effects 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 201000002491 encephalomyelitis Diseases 0.000 claims 1
• 210000003527 eukaryotic cell Anatomy 0.000 claims 1
• 208000014674 injury Diseases 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000007912 intraperitoneal administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 208000036546 leukodystrophy Diseases 0.000 claims 1
• 230000003458 metachromatic effect Effects 0.000 claims 1
• 238000000520 microinjection Methods 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 230000023105 myelination Effects 0.000 claims 1
• 238000007911 parenteral administration Methods 0.000 claims 1
• 210000000278 spinal cord Anatomy 0.000 claims 1
• 208000023516 stroke disease Diseases 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 230000008733 trauma Effects 0.000 claims 1
• 210000004885 white matter Anatomy 0.000 claims 1