JP2012508027A5 - - Google Patents
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- Publication number
- JP2012508027A5 JP2012508027A5 JP2011535765A JP2011535765A JP2012508027A5 JP 2012508027 A5 JP2012508027 A5 JP 2012508027A5 JP 2011535765 A JP2011535765 A JP 2011535765A JP 2011535765 A JP2011535765 A JP 2011535765A JP 2012508027 A5 JP2012508027 A5 JP 2012508027A5
- Authority
- JP
- Japan
- Prior art keywords
- cadherin
- seq
- diabody
- cells
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000000905 Cadherin Human genes 0.000 description 26
- 108050007957 Cadherin Proteins 0.000 description 26
- 108050000637 N-cadherin Proteins 0.000 description 24
- 210000004027 cell Anatomy 0.000 description 13
- 206010028980 Neoplasm Diseases 0.000 description 10
- 150000007523 nucleic acids Chemical class 0.000 description 8
- 108020004707 nucleic acids Proteins 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 230000027455 binding Effects 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 201000011510 cancer Diseases 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 3
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 3
- 238000000684 flow cytometry Methods 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 108020004999 messenger RNA Proteins 0.000 description 3
- 238000004091 panning Methods 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 2
- 230000004807 localization Effects 0.000 description 2
- -1 nucleotides Nucleic acids Chemical class 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 101000714537 Homo sapiens Cadherin-2 Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 102000048721 human CDH2 Human genes 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 210000005267 prostate cell Anatomy 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11304208P | 2008-11-10 | 2008-11-10 | |
| US61/113,042 | 2008-11-10 | ||
| PCT/US2009/063881 WO2010054377A2 (en) | 2008-11-10 | 2009-11-10 | Fully human antibodies against n-cadherin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012508027A JP2012508027A (ja) | 2012-04-05 |
| JP2012508027A5 true JP2012508027A5 (enExample) | 2012-12-20 |
Family
ID=42153647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535765A Pending JP2012508027A (ja) | 2008-11-10 | 2009-11-10 | N−カドヘリンに対する完全ヒト抗体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8703920B2 (enExample) |
| EP (1) | EP2356145A4 (enExample) |
| JP (1) | JP2012508027A (enExample) |
| KR (1) | KR20110084309A (enExample) |
| CN (1) | CN102300873A (enExample) |
| AU (1) | AU2009313239A1 (enExample) |
| BR (1) | BRPI0921457A2 (enExample) |
| CA (1) | CA2743122A1 (enExample) |
| CO (1) | CO6362022A2 (enExample) |
| IL (1) | IL212795A0 (enExample) |
| MX (1) | MX2011004945A (enExample) |
| RU (1) | RU2011123655A (enExample) |
| WO (1) | WO2010054377A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8663635B2 (en) * | 2006-03-21 | 2014-03-04 | The Regents Of The University Of California | N-cadherin: target for cancer diagnosis and therapy |
| WO2007109347A2 (en) * | 2006-03-21 | 2007-09-27 | The Regents Of The University Of California | N-cadherin and ly6 e: targets for cancer diagnosis and therapy |
| EA201001603A1 (ru) * | 2008-04-04 | 2011-06-30 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Антитела против кадгерина, блокирующие рост опухоли, ангиогенез и метастазирование |
| US8703920B2 (en) | 2008-11-10 | 2014-04-22 | The Regents Of The University Of California | Fully human antibodies against N-cadherin |
| GB201119089D0 (en) | 2011-11-04 | 2011-12-21 | Isis Innovation | Treatment of musculoskeletal fibroproliferative disorders |
| EP2830659A1 (en) | 2012-03-27 | 2015-02-04 | Novartis AG | Treatment of fibrosis |
| WO2016028663A1 (en) * | 2014-08-21 | 2016-02-25 | Johnson Controls Technology Company | Battery monitoring system |
| WO2018226795A1 (en) * | 2017-06-06 | 2018-12-13 | The Regents Of The University Of California | Humanized anti-n-cadherin antibodies and uses thereof |
| US20240239885A1 (en) * | 2021-05-13 | 2024-07-18 | WuXi Biologics Ireland Limited | Antibody conjugate comprising anti-p-cadherin antibody and uses thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5889157A (en) | 1990-10-12 | 1999-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Humanized B3 antibody fragments, fusion proteins, and uses thereof |
| AU669124B2 (en) | 1991-09-18 | 1996-05-30 | Kyowa Hakko Kirin Co., Ltd. | Process for producing humanized chimera antibody |
| US6680175B2 (en) | 1998-05-05 | 2004-01-20 | Adherex Technologies, Inc. | Methods for diagnosing and evaluating cancer |
| US6277824B1 (en) | 1998-07-10 | 2001-08-21 | Adherex Technologies | Compounds and methods for modulating adhesion molecule function |
| AU2001249064A1 (en) | 2000-02-22 | 2001-09-03 | Mount Sinai School Of Medicine Of New York University | N-cadherin modulated migration, invasion, and metastasis |
| US20030190602A1 (en) | 2001-03-12 | 2003-10-09 | Monogen, Inc. | Cell-based detection and differentiation of disease states |
| CA2523716C (en) * | 2003-05-31 | 2014-11-25 | Micromet Ag | Human anti-human cd3 binding molecules |
| WO2005097184A2 (en) * | 2004-03-26 | 2005-10-20 | Human Genome Sciences, Inc. | Antibodies against nogo receptor |
| WO2006138275A2 (en) | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| WO2007109347A2 (en) | 2006-03-21 | 2007-09-27 | The Regents Of The University Of California | N-cadherin and ly6 e: targets for cancer diagnosis and therapy |
| US20100278821A1 (en) | 2006-03-21 | 2010-11-04 | The Regents Of The University Of California | N-cadherin: target for cancer diagnosis and therapy |
| US8663635B2 (en) | 2006-03-21 | 2014-03-04 | The Regents Of The University Of California | N-cadherin: target for cancer diagnosis and therapy |
| EA201001603A1 (ru) | 2008-04-04 | 2011-06-30 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Антитела против кадгерина, блокирующие рост опухоли, ангиогенез и метастазирование |
| US8703920B2 (en) | 2008-11-10 | 2014-04-22 | The Regents Of The University Of California | Fully human antibodies against N-cadherin |
-
2009
- 2009-11-09 US US12/590,601 patent/US8703920B2/en not_active Expired - Fee Related
- 2009-11-10 WO PCT/US2009/063881 patent/WO2010054377A2/en not_active Ceased
- 2009-11-10 EP EP09825592A patent/EP2356145A4/en not_active Withdrawn
- 2009-11-10 JP JP2011535765A patent/JP2012508027A/ja active Pending
- 2009-11-10 CN CN2009801544698A patent/CN102300873A/zh active Pending
- 2009-11-10 RU RU2011123655/10A patent/RU2011123655A/ru unknown
- 2009-11-10 CA CA2743122A patent/CA2743122A1/en not_active Abandoned
- 2009-11-10 BR BRPI0921457A patent/BRPI0921457A2/pt not_active Application Discontinuation
- 2009-11-10 AU AU2009313239A patent/AU2009313239A1/en not_active Abandoned
- 2009-11-10 MX MX2011004945A patent/MX2011004945A/es unknown
- 2009-11-10 KR KR1020117013339A patent/KR20110084309A/ko not_active Withdrawn
-
2011
- 2011-05-09 IL IL212795A patent/IL212795A0/en unknown
- 2011-06-08 CO CO11070983A patent/CO6362022A2/es not_active Application Discontinuation
-
2013
- 2013-06-17 US US13/919,652 patent/US20140017240A1/en not_active Abandoned
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