JP2008509658A5 - - Google Patents
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- Publication number
- JP2008509658A5 JP2008509658A5 JP2007521793A JP2007521793A JP2008509658A5 JP 2008509658 A5 JP2008509658 A5 JP 2008509658A5 JP 2007521793 A JP2007521793 A JP 2007521793A JP 2007521793 A JP2007521793 A JP 2007521793A JP 2008509658 A5 JP2008509658 A5 JP 2008509658A5
- Authority
- JP
- Japan
- Prior art keywords
- rhd
- cells
- cell
- antibody
- recombinant polyclonal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 58
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- 238000004519 manufacturing process Methods 0.000 claims 10
- 239000013598 vector Substances 0.000 claims 9
- 239000013604 expression vector Substances 0.000 claims 7
- 102000018120 Recombinases Human genes 0.000 claims 5
- 108010091086 Recombinases Proteins 0.000 claims 5
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 241000699802 Cricetulus griseus Species 0.000 claims 2
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000002949 hemolytic effect Effects 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200401133 | 2004-07-20 | ||
| DKPA200401133 | 2004-07-20 | ||
| DKPA200401992 | 2004-12-22 | ||
| DKPA200401992 | 2004-12-22 | ||
| PCT/DK2005/000501 WO2006007850A1 (en) | 2004-07-20 | 2005-07-18 | Anti-rhesus d recombinant polyclonal antibody and methods of manufacture |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008509658A JP2008509658A (ja) | 2008-04-03 |
| JP2008509658A5 true JP2008509658A5 (enExample) | 2008-07-03 |
| JP4926054B2 JP4926054B2 (ja) | 2012-05-09 |
Family
ID=35159789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007521793A Expired - Fee Related JP4926054B2 (ja) | 2004-07-20 | 2005-07-18 | 抗−RhD組換えポリクローナル抗体及び製造方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8198415B2 (enExample) |
| EP (2) | EP1967529A1 (enExample) |
| JP (1) | JP4926054B2 (enExample) |
| KR (1) | KR20070038556A (enExample) |
| AU (1) | AU2005263331B8 (enExample) |
| BR (1) | BRPI0513706A (enExample) |
| CA (1) | CA2574062A1 (enExample) |
| EA (1) | EA014182B1 (enExample) |
| IL (1) | IL179658A (enExample) |
| MX (1) | MX2007000644A (enExample) |
| NO (1) | NO20070927L (enExample) |
| NZ (1) | NZ552265A (enExample) |
| WO (1) | WO2006007850A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| EA013225B1 (ru) * | 2003-01-07 | 2010-04-30 | Симфоген А/С | Способ получения линии клеток, продуцирующей рекомбинантный поликлональный белок, способ получения поликлонального белка, линия клеток, продуцирующая рекомбинантный поликлональный белок, библиотека векторов, популяция клеток |
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| TWI333977B (en) * | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| ES2332524T3 (es) | 2004-07-20 | 2010-02-08 | Symphogen A/S | Un procedimiento para la caracterizacion de una linea celular policlonal. |
| WO2007065433A2 (en) | 2005-12-05 | 2007-06-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| TW200846362A (en) * | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
| BRPI0808551B1 (pt) * | 2007-03-01 | 2022-04-05 | Symphogen A/S | Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende |
| NZ578851A (en) | 2007-03-01 | 2011-09-30 | Symphogen As | Method for cloning cognate antibodies |
| CA2678628A1 (en) | 2007-03-06 | 2008-09-12 | Symphogen A/S | Recombinant antibodies for treatment of respiratory syncytial virus infections |
| JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
| BRPI0812091A2 (pt) * | 2007-05-25 | 2014-10-14 | Symphogen As | Método para fabricar uma proteína policlonal recombinante |
| AU2008295248A1 (en) * | 2007-09-07 | 2009-03-12 | Symphogen A/S | Methods for recombinant manufacturing of anti-RSV antibodies |
| US20090093004A1 (en) * | 2007-10-04 | 2009-04-09 | Symphogen A/S | Potency assay |
| WO2009065414A1 (en) * | 2007-11-22 | 2009-05-28 | Symphogen A/S | A method for characterization of a recombinant polyclonal protein |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| TW201920257A (zh) * | 2008-04-11 | 2019-06-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗原結合分子 |
| RU2010147652A (ru) * | 2008-04-23 | 2012-05-27 | Симфоген А/С (Dk) | Способы производства поликлонального белка |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| KR20110047258A (ko) * | 2008-08-26 | 2011-05-06 | 심포젠 에이/에스 | 저혈소판증의 치료 방법 |
| CA2735020A1 (en) * | 2008-08-29 | 2010-03-04 | Symphogen A/S | Method for cloning avian-derived antibodies |
| MX2011001927A (es) | 2008-08-29 | 2011-04-21 | Symphogen As | Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. |
| CN102265152A (zh) * | 2008-10-06 | 2011-11-30 | 西福根有限公司 | 鉴定和选择用于组合药品的药物候选物 |
| FR2942799B1 (fr) * | 2009-03-06 | 2011-02-25 | Lfb Biotechnologies | Anticorps monoclonal anti-rhesus d |
| BR112012007815A2 (pt) | 2009-10-09 | 2018-03-20 | Symphogen As | quantificação multiplex de proteínas recombinantes em uma mistura por peptídeos de assinatura e espectrometria de massa. |
| SG10201609665PA (en) | 2011-02-25 | 2017-01-27 | Chugai Pharmaceutical Co Ltd | FcɣRIIb-SPECIFIC Fc ANTIBODY |
| DK2864346T3 (en) * | 2012-06-21 | 2019-02-04 | Synthon Biopharmaceuticals Bv | Method of purifying an antibody. |
| EP2711428A1 (en) * | 2012-09-21 | 2014-03-26 | Lonza Biologics plc. | Site-specific integration |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| RS64268B1 (sr) | 2013-09-20 | 2023-07-31 | Bristol Myers Squibb Co | Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora |
| UA122479C2 (uk) | 2014-01-24 | 2020-11-25 | Дана-Фарбер Кенсер Інстітьют, Інк. | Виділена молекула антитіла, яка зв’язується з людським білком програмованої смерті-1 (pd-1) |
| EA201691765A1 (ru) | 2014-03-14 | 2016-12-30 | Новартис Аг | Молекулы антител против lag-3 и их применения |
| US9683017B2 (en) | 2014-07-17 | 2017-06-20 | University Tennessee Research Foundation | Inhibitory peptides of viral infection |
| US10213506B2 (en) | 2014-08-26 | 2019-02-26 | University Of Tennessee Research Foundation | Targeting immunotherapy for amyloidosis |
| US20180340025A1 (en) | 2015-07-29 | 2018-11-29 | Novartis Ag | Combination therapies comprising antibody molecules to lag-3 |
| CN108495651A (zh) | 2015-12-17 | 2018-09-04 | 诺华股份有限公司 | 抗pd-1的抗体分子及其用途 |
| WO2017184973A1 (en) | 2016-04-22 | 2017-10-26 | University Of Tennessee Research Foundation | Identifying amyloidogenic proteins & amyloidogenic risk |
| WO2018222718A1 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Treatment of lag-3 positive tumors |
| JP7301002B2 (ja) | 2017-05-30 | 2023-06-30 | ブリストル-マイヤーズ スクイブ カンパニー | 抗lag-3抗体または抗lag-3抗体および抗pd-1もしくは抗pd-l1抗体を含む組成物 |
| US12247065B2 (en) * | 2018-06-22 | 2025-03-11 | Genmab A/S | Method for producing a controlled mixture of two or more different antibodies |
| KR102559149B1 (ko) | 2018-10-26 | 2023-07-24 | 에프. 호프만-라 로슈 아게 | 재조합효소 매개 카세트 교환을 이용한 다중특이적 항체 스크리닝 방법 |
| CN113661173B (zh) | 2019-03-29 | 2024-10-01 | 豪夫迈·罗氏有限公司 | 通过以限定的组织形式靶向整合多个表达盒来产生表达FcRn的细胞的方法 |
| US12479908B2 (en) | 2019-03-29 | 2025-11-25 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Antibodies against programmed cell death protein 1 (PD1) and uses thereof |
| AU2020297940A1 (en) | 2019-06-19 | 2021-12-16 | F. Hoffmann-La Roche Ag | Method for the generation of a multivalent, bispecific antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization |
| CA3140297A1 (en) | 2019-06-19 | 2020-12-24 | Simon Auslaender | Method for the generation of a protein expressing cell by targeted integration using cre mrna |
| AU2020294879A1 (en) | 2019-06-19 | 2021-12-16 | F. Hoffmann-La Roche Ag | Method for the generation of a bivalent, bispecific antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization |
| WO2020254351A1 (en) | 2019-06-19 | 2020-12-24 | F. Hoffmann-La Roche Ag | Method for the generation of a multivalent, multispecific antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization |
| KR20220024637A (ko) | 2019-06-19 | 2022-03-03 | 에프. 호프만-라 로슈 아게 | 정의된 조직의 다수 발현 카세트들의 표적화 통합에 의한 3가 항체 발현 세포의 생성 방법 |
| CA3196496A1 (en) | 2020-10-23 | 2022-04-28 | Laurence David TOMS | Lag-3 antagonist therapy for lung cancer |
| WO2022150654A2 (en) * | 2021-01-08 | 2022-07-14 | 10X Genomics, Inc. | Antigen-binding polypeptides specific for coronaviruses and uses thereof |
| RU2770654C1 (ru) * | 2021-06-17 | 2022-04-20 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный педиатрический медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПбГПМУ Минздрава России) | Способ профилактики тяжелой формы гемолитической болезни новорожденных при резус-иммунизации у беременных с соматической патологией и потерями плода в анамнезе |
| AU2024328783A1 (en) * | 2023-08-23 | 2026-03-12 | Australian Red Cross Society | Anti-rhesus d human monoclonal antibodies |
| CN119176879B (zh) * | 2024-09-05 | 2025-08-05 | 西安市中心血站(陕西省血液中心) | 一种中和抗d抗体的抗独特型抗体及其应用 |
| WO2026132369A1 (en) | 2024-12-22 | 2026-06-25 | F. Hoffmann-La Roche Ag | Method for the generation of a bivalent, bispecific fragment antigen binding expressing mammalian cells |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985002413A1 (en) | 1983-11-28 | 1985-06-06 | The Board Of Trustees Of The Leland Stanford Jr. U | HUMAN MONOCLONAL ANTIBODY AGAINST Rh(D) ANTIGEN AND ITS USES |
| US5126130A (en) * | 1986-11-24 | 1992-06-30 | The Childrens Hospital Incorporated | Monoclonal antibodies reactive with specific antigenic sites on human cytomegalovirus glycoprotein a |
| GB8722019D0 (en) | 1987-09-18 | 1987-10-28 | Central Blood Lab Authority | Human anti-rh(d)monoclonal antibodies |
| GB8722020D0 (en) | 1987-09-18 | 1987-10-28 | Central Blood Lab Authority | Human anti-rh(d)monoclonal antibodies |
| GB8722018D0 (en) | 1987-09-18 | 1987-10-28 | Central Blood Lab Authority | Human anti-rh(d)monoclonal antibodies |
| FI903489A7 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö |
| GB8906129D0 (en) | 1989-03-17 | 1989-05-04 | Central Blood Lab Authority | Pharmaceutical preparations |
| GB8919761D0 (en) | 1989-09-01 | 1989-10-18 | Central Blood Lab Authority | Chemical compounds |
| WO1992015694A1 (en) | 1991-03-08 | 1992-09-17 | The Salk Institute For Biological Studies | Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor |
| US5837268A (en) | 1991-10-16 | 1998-11-17 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
| FI940811L (fi) | 1992-06-26 | 1994-02-21 | Aetsrn | Ihmisen monoklonaalisia anti-Rhesus(D) -vasta-aineita ja niitä tuottavat solulinjat |
| AU679949B2 (en) | 1992-10-21 | 1997-07-17 | Stefan Miltenyi | Direct selection of cells by secretion product |
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| ES2201097T3 (es) * | 1994-01-31 | 2004-03-16 | Trustees Of Boston University | Bibliotecas de anticuerpos policlonales. |
| FR2724182B1 (fr) * | 1994-09-02 | 1996-12-13 | Pasteur Institut | Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations |
| US6025155A (en) | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| DK0920509T3 (da) | 1996-06-24 | 2004-12-06 | Zlb Behring Ag | Polypeptider, der er i stand til at danne antigenbindende strukturer med specificitet for Rhesus D-antigener, DNA, der koder herfor, samt fremgangsmåde til fremstilling heraf og anvendelse heraf |
| US5876925A (en) * | 1996-10-11 | 1999-03-02 | The Trustees Of The University Of Pennsylvania | Magnetically activated cell sorting for production of proteins |
| US6255455B1 (en) * | 1996-10-11 | 2001-07-03 | The Trustees Of The University Of Pennsylvania | Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| PT1034262E (pt) | 1997-11-18 | 2005-10-31 | Pioneer Hi Bred Int | Composicoes e metodos para a modificacao genetica de plantas |
| WO2000005393A2 (en) | 1998-07-21 | 2000-02-03 | Cobra Therapeutics Limited | A polynucleotide comprising a ubiquitous chromatin opening element (ucoe) |
| US20020155114A1 (en) * | 1998-08-31 | 2002-10-24 | James D. Marks | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| DE60044142D1 (de) | 1999-07-23 | 2010-05-20 | Univ California | Dna-rekombination in eukaryotischen zellen mittels des rekombinationszentrums vom bakteriophag phic31 |
| EP1106625A1 (en) | 1999-11-17 | 2001-06-13 | ZLB Bioplasma AG | Rhesus D specific peptide sequences |
| MXPA02007664A (es) | 2000-02-08 | 2004-08-23 | Univ Michigan | Separacion y representacion de proteinas. |
| EP1385869A2 (en) | 2000-02-08 | 2004-02-04 | The Regents Of The University Of Michigan | Protein mapping |
| MXPA02007665A (es) | 2000-02-08 | 2004-08-23 | Univ Michigan | Trazado de despliegue diferencial de proteinas. |
| CN1437482A (zh) | 2000-05-26 | 2003-08-20 | 西福根有限公司 | 用于治疗变态反应的重组的或纯化的多克隆抗体 |
| BR0112633A (pt) | 2000-07-21 | 2003-09-16 | Us Agriculture | Método para substituir, translocar e empilhar dna em genomas eucarióticos |
| US6610472B1 (en) | 2000-10-31 | 2003-08-26 | Genetastix Corporation | Assembly and screening of highly complex and fully human antibody repertoire in yeast |
| WO2002044361A2 (en) | 2000-11-28 | 2002-06-06 | Applied Molecular Evolution, Inc. | Eukaryotic expression libraries based on double lox recombination and methods of use |
| WO2002052259A1 (en) | 2000-12-26 | 2002-07-04 | The Institute For Systems Biology | Rapid and quantitative proteome analysis and related methods |
| WO2003102539A2 (en) | 2002-05-31 | 2003-12-11 | The Regents Of The University Of Michigan | Automated protein analysis system comprising capillary electrophoresis-tandem mass spectrometry |
| NZ537277A (en) | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| WO2004035169A2 (en) | 2002-10-15 | 2004-04-29 | The Regents Of The University Of Michigan | Multidimensional protein separation system |
| US20060275766A1 (en) * | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
| EA013225B1 (ru) * | 2003-01-07 | 2010-04-30 | Симфоген А/С | Способ получения линии клеток, продуцирующей рекомбинантный поликлональный белок, способ получения поликлонального белка, линия клеток, продуцирующая рекомбинантный поликлональный белок, библиотека векторов, популяция клеток |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| ES2332524T3 (es) | 2004-07-20 | 2010-02-08 | Symphogen A/S | Un procedimiento para la caracterizacion de una linea celular policlonal. |
-
2005
- 2005-07-18 JP JP2007521793A patent/JP4926054B2/ja not_active Expired - Fee Related
- 2005-07-18 AU AU2005263331A patent/AU2005263331B8/en not_active Ceased
- 2005-07-18 KR KR1020077003955A patent/KR20070038556A/ko not_active Ceased
- 2005-07-18 NZ NZ552265A patent/NZ552265A/en not_active IP Right Cessation
- 2005-07-18 MX MX2007000644A patent/MX2007000644A/es active IP Right Grant
- 2005-07-18 EP EP08157871A patent/EP1967529A1/en not_active Withdrawn
- 2005-07-18 WO PCT/DK2005/000501 patent/WO2006007850A1/en not_active Ceased
- 2005-07-18 EA EA200700249A patent/EA014182B1/ru not_active IP Right Cessation
- 2005-07-18 CA CA002574062A patent/CA2574062A1/en not_active Abandoned
- 2005-07-18 US US11/632,937 patent/US8198415B2/en not_active Expired - Fee Related
- 2005-07-18 EP EP05760588A patent/EP1771483A1/en not_active Withdrawn
- 2005-07-18 BR BRPI0513706-3A patent/BRPI0513706A/pt not_active IP Right Cessation
-
2006
- 2006-11-28 IL IL179658A patent/IL179658A/en not_active IP Right Cessation
-
2007
- 2007-02-19 NO NO20070927A patent/NO20070927L/no not_active Application Discontinuation
-
2012
- 2012-06-11 US US13/493,623 patent/US20120322690A1/en not_active Abandoned
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