JP2009519025A5 - - Google Patents
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- Publication number
- JP2009519025A5 JP2009519025A5 JP2008545009A JP2008545009A JP2009519025A5 JP 2009519025 A5 JP2009519025 A5 JP 2009519025A5 JP 2008545009 A JP2008545009 A JP 2008545009A JP 2008545009 A JP2008545009 A JP 2008545009A JP 2009519025 A5 JP2009519025 A5 JP 2009519025A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- heavy chain
- chain variable
- variable region
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 13
- 125000000539 amino acid group Chemical group 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 8
- 208000012902 Nervous system disease Diseases 0.000 claims 4
- 208000025966 Neurological disease Diseases 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 101000727472 Homo sapiens Reticulon-4 Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 102000049797 human RTN4 Human genes 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 210000001428 peripheral nervous system Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 238000012286 ELISA Assay Methods 0.000 claims 1
- 108010077641 Nogo Proteins Proteins 0.000 claims 1
- 102100029831 Reticulon-4 Human genes 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 102200029262 rs12065961 Human genes 0.000 claims 1
- 102220254749 rs143876748 Human genes 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0525662.3 | 2005-12-16 | ||
| GBGB0525662.3A GB0525662D0 (en) | 2005-12-16 | 2005-12-16 | Immunoglobulins |
| PCT/EP2006/069737 WO2007068750A2 (en) | 2005-12-16 | 2006-12-14 | Immunoglobulins directed against nogo |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009519025A JP2009519025A (ja) | 2009-05-14 |
| JP2009519025A5 true JP2009519025A5 (enExample) | 2011-11-10 |
| JP5015949B2 JP5015949B2 (ja) | 2012-09-05 |
Family
ID=35736284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545009A Expired - Fee Related JP5015949B2 (ja) | 2005-12-16 | 2006-12-14 | Ｎｏｇｏを標的とする免疫グロブリン |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8362208B2 (enExample) |
| EP (2) | EP2228391A3 (enExample) |
| JP (1) | JP5015949B2 (enExample) |
| KR (1) | KR101355118B1 (enExample) |
| CN (1) | CN101374863B (enExample) |
| AR (1) | AR057239A1 (enExample) |
| AU (1) | AU2006325228B2 (enExample) |
| BR (1) | BRPI0619855A2 (enExample) |
| CA (1) | CA2633501C (enExample) |
| CR (1) | CR10099A (enExample) |
| CY (1) | CY1113094T1 (enExample) |
| DK (1) | DK1960429T3 (enExample) |
| EA (1) | EA015536B1 (enExample) |
| ES (1) | ES2389380T3 (enExample) |
| GB (1) | GB0525662D0 (enExample) |
| HR (1) | HRP20120684T1 (enExample) |
| IL (1) | IL192086A0 (enExample) |
| JO (1) | JO2795B1 (enExample) |
| MA (1) | MA30041B1 (enExample) |
| MY (1) | MY149492A (enExample) |
| NO (1) | NO20082699L (enExample) |
| NZ (1) | NZ569143A (enExample) |
| PE (1) | PE20071099A1 (enExample) |
| PL (1) | PL1960429T3 (enExample) |
| PT (1) | PT1960429E (enExample) |
| SI (1) | SI1960429T1 (enExample) |
| TW (1) | TWI378940B (enExample) |
| UA (1) | UA96279C2 (enExample) |
| WO (1) | WO2007068750A2 (enExample) |
| ZA (2) | ZA200805111B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009151717A2 (en) | 2008-04-02 | 2009-12-17 | Macrogenics, Inc. | Bcr-complex-specific antibodies and methods of using same |
| PL2207808T3 (pl) * | 2007-11-02 | 2013-11-29 | Novartis Ag | Ulepszone cząsteczki wiążące się z Nogo-A i ich zastosowania farmaceutyczne |
| TW201012489A (en) | 2008-05-06 | 2010-04-01 | Glaxo Group Ltd | Encapsulation of biologically active agents |
| CA2730473A1 (en) * | 2008-07-11 | 2010-01-14 | Glaxo Group Limited | Novel treatment |
| US8828390B2 (en) | 2010-07-09 | 2014-09-09 | Universitat Zurich | Uses of NOGO-A inhibitors and related methods |
| BR112014032987A2 (pt) | 2012-07-05 | 2017-06-27 | Glaxo Group Ltd | método de tratamento ou profilaxia de um distúrbio neurológico |
| US20180362660A1 (en) * | 2016-05-09 | 2018-12-20 | Schickwann Tsai | Anti-penumbra monoclonal antibodies for detection and therapy of normal and abnormal B lymphocytes |
| US11013815B2 (en) | 2017-06-14 | 2021-05-25 | Monojul, Llc | High-affinity anti-human folate receptor beta antibodies and methods of use |
| MX2021015473A (es) * | 2019-06-13 | 2022-04-20 | Prestige Biopharma Pte Ltd | Nuevo anticuerpo específico para cthrc1 y su uso. |
| US20230399390A1 (en) | 2019-10-24 | 2023-12-14 | Novago Therapeutics Ag | Novel anti-nogo-a antibodies |
| GB202012331D0 (en) | 2020-08-07 | 2020-09-23 | Petmedix Ltd | Therapeutic antibodies |
| WO2022263864A1 (en) | 2021-06-17 | 2022-12-22 | Petmedix Ltd | Anti canine cd20 antibodies |
| WO2023067358A1 (en) | 2021-10-21 | 2023-04-27 | Petmedix Ltd | Proteins comprising the extracellular domain of p75ntr |
| CN116251181B (zh) * | 2021-12-02 | 2023-09-22 | 北京东方百泰生物科技股份有限公司 | 一种抗tslp单克隆抗体的注射制剂 |
| WO2023152486A1 (en) | 2022-02-09 | 2023-08-17 | Petmedix Ltd | Therapeutic antibodies |
| WO2024041450A1 (zh) * | 2022-08-22 | 2024-02-29 | 舒泰神（北京）生物制药股份有限公司 | 特异性识别Nogo-A的抗体及其应用 |
| GB202217993D0 (en) | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Therapeutic antibodies |
| WO2024165872A1 (en) | 2023-02-09 | 2024-08-15 | Petmedix Ltd | Therapeutic molecules comprising variants of the extracellular domain of p75 neurotrophin receptor (p75ntr) |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57106673A (en) | 1980-12-24 | 1982-07-02 | Chugai Pharmaceut Co Ltd | Dibenzo(b,f)(1,4)oxazepin derivative |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US5250414A (en) | 1988-11-04 | 1993-10-05 | Erziehungsdirektion Of The Canton Zurich | Diagnostic methods using neurite growth regulatory factors |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| CA2140280A1 (en) | 1992-08-17 | 1994-03-03 | Avi J. Ashkenazi | Bispecific immunoadhesins |
| GB9403250D0 (en) | 1994-02-21 | 1994-04-13 | Univ Mcgill | Therapeutic use of myelin-associated glycoprotein (mag) |
| US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
| DE69533408T2 (de) | 1994-05-27 | 2005-09-08 | Glaxosmithkline S.P.A. | Chinolinderivate als Tachykinin NK3 Rezeptor Antagonisten |
| GB9424449D0 (en) | 1994-12-02 | 1995-01-18 | Wellcome Found | Antibodies |
| DE69633336T2 (de) | 1995-06-27 | 2005-09-22 | Research Foundation Of Cuny | Zusamenzetzung enthaltend einen inhibitor des myelin assoziierten glycoproteins (mag), welcher einer veränderten oder mutierten form von mag enthält |
| US6420338B1 (en) * | 1997-06-13 | 2002-07-16 | New York University Medical Center | Inhibition of the Src kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma |
| GB9809839D0 (en) | 1998-05-09 | 1998-07-08 | Glaxo Group Ltd | Antibody |
| PT1098972E (pt) | 1998-07-22 | 2010-12-14 | Smithkline Beecham Ltd | Proteína semelhante a proteína especificamente neuroendócrina e adnc codificante |
| CN101684155A (zh) | 1998-11-06 | 2010-03-31 | 苏黎世大学 | Nogo基因的核苷酸序列和蛋白序列以及基于其的方法 |
| FR2792199B3 (fr) | 1999-04-13 | 2001-05-18 | Sanofi Sa | Utilisation de l'osanetant pour la preparation de medicaments utiles dans le traitement des troubles de l'humeur |
| JP2005538706A (ja) | 2001-07-12 | 2005-12-22 | ジェファーソン フーテ， | スーパーヒト化抗体 |
| GB0228832D0 (en) | 2002-12-10 | 2003-01-15 | Novartis Ag | Organic compound |
| GB0318727D0 (en) | 2003-08-08 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
| DE10338136A1 (de) | 2003-08-15 | 2005-03-24 | European Molecular Biology Laboratory | Zentrifuge und ein Träger zur Verwendung in einer Zentrifuge |
| GB0321997D0 (en) | 2003-09-19 | 2003-10-22 | Novartis Ag | Organic compound |
| CA2549956C (en) * | 2003-12-22 | 2016-04-12 | Glaxo Group Limited | Immunoglobulins |
| AU2005207003C1 (en) * | 2004-01-20 | 2013-06-13 | Humanigen, Inc. | Antibody specificity transfer using minimal essential binding determinants |
| US7973139B2 (en) * | 2004-03-26 | 2011-07-05 | Human Genome Sciences, Inc. | Antibodies against nogo receptor |
-
2005
- 2005-12-16 GB GBGB0525662.3A patent/GB0525662D0/en not_active Ceased
-
2006
- 2006-12-14 PE PE2006001607A patent/PE20071099A1/es not_active Application Discontinuation
- 2006-12-14 WO PCT/EP2006/069737 patent/WO2007068750A2/en not_active Ceased
- 2006-12-14 PL PL06830633T patent/PL1960429T3/pl unknown
- 2006-12-14 UA UAA200807663A patent/UA96279C2/ru unknown
- 2006-12-14 HR HRP20120684TT patent/HRP20120684T1/hr unknown
- 2006-12-14 ES ES06830633T patent/ES2389380T3/es active Active
- 2006-12-14 KR KR1020087017348A patent/KR101355118B1/ko not_active Expired - Fee Related
- 2006-12-14 US US12/097,279 patent/US8362208B2/en not_active Expired - Fee Related
- 2006-12-14 AU AU2006325228A patent/AU2006325228B2/en not_active Ceased
- 2006-12-14 JP JP2008545009A patent/JP5015949B2/ja not_active Expired - Fee Related
- 2006-12-14 EA EA200801343A patent/EA015536B1/ru not_active IP Right Cessation
- 2006-12-14 DK DK06830633.1T patent/DK1960429T3/da active
- 2006-12-14 EP EP20100162457 patent/EP2228391A3/en not_active Withdrawn
- 2006-12-14 MY MYPI20082130A patent/MY149492A/en unknown
- 2006-12-14 PT PT06830633T patent/PT1960429E/pt unknown
- 2006-12-14 NZ NZ569143A patent/NZ569143A/en not_active IP Right Cessation
- 2006-12-14 AR ARP060105524A patent/AR057239A1/es active IP Right Grant
- 2006-12-14 CN CN2006800529521A patent/CN101374863B/zh not_active Expired - Fee Related
- 2006-12-14 SI SI200631393T patent/SI1960429T1/sl unknown
- 2006-12-14 TW TW095146890A patent/TWI378940B/zh not_active IP Right Cessation
- 2006-12-14 EP EP06830633A patent/EP1960429B1/en active Active
- 2006-12-14 BR BRPI0619855-4A patent/BRPI0619855A2/pt not_active IP Right Cessation
- 2006-12-14 CA CA2633501A patent/CA2633501C/en not_active Expired - Fee Related
- 2006-12-24 JO JO2006457A patent/JO2795B1/en active
-
2008
- 2008-06-11 ZA ZA200805111A patent/ZA200805111B/xx unknown
- 2008-06-11 NO NO20082699A patent/NO20082699L/no not_active Application Discontinuation
- 2008-06-11 MA MA31018A patent/MA30041B1/fr unknown
- 2008-06-12 IL IL192086A patent/IL192086A0/en not_active IP Right Cessation
- 2008-06-20 CR CR10099A patent/CR10099A/es unknown
-
2009
- 2009-09-04 ZA ZA200906162A patent/ZA200906162B/en unknown
-
2012
- 2012-09-05 CY CY20121100801T patent/CY1113094T1/el unknown
-
2013
- 2013-01-28 US US13/751,588 patent/US20130287781A1/en not_active Abandoned
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