EA015536B1 - Антитело или его фрагменты, связывающиеся с nogo-a человека, и применение антитела и фрагментов - Google Patents
Антитело или его фрагменты, связывающиеся с nogo-a человека, и применение антитела и фрагментов Download PDFInfo
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- EA015536B1 EA015536B1 EA200801343A EA200801343A EA015536B1 EA 015536 B1 EA015536 B1 EA 015536B1 EA 200801343 A EA200801343 A EA 200801343A EA 200801343 A EA200801343 A EA 200801343A EA 015536 B1 EA015536 B1 EA 015536B1
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- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Mycology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0525662.3A GB0525662D0 (en) | 2005-12-16 | 2005-12-16 | Immunoglobulins |
| PCT/EP2006/069737 WO2007068750A2 (en) | 2005-12-16 | 2006-12-14 | Immunoglobulins directed against nogo |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200801343A1 EA200801343A1 (ru) | 2008-12-30 |
| EA015536B1 true EA015536B1 (ru) | 2011-08-30 |
Family
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Family Applications (1)
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|---|---|---|---|
| EA200801343A EA015536B1 (ru) | 2005-12-16 | 2006-12-14 | Антитело или его фрагменты, связывающиеся с nogo-a человека, и применение антитела и фрагментов |
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| HR (1) | HRP20120684T1 (enExample) |
| IL (1) | IL192086A0 (enExample) |
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| UA (1) | UA96279C2 (enExample) |
| WO (1) | WO2007068750A2 (enExample) |
| ZA (2) | ZA200805111B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2207808T3 (pl) * | 2007-11-02 | 2013-11-29 | Novartis Ag | Ulepszone cząsteczki wiążące się z Nogo-A i ich zastosowania farmaceutyczne |
| EP3045475B1 (en) | 2008-04-02 | 2017-10-04 | MacroGenics, Inc. | Bcr-complex-specific antibodies and methods of using same |
| UY31809A (es) | 2008-05-06 | 2009-12-14 | Glaxo Group Ltd | Encapsulación de agentes biológicamente activos |
| EP2323691A2 (en) * | 2008-07-11 | 2011-05-25 | Glaxo Group Limited | Treatment of amyotrophic lateral sclerosis by nogo-a-antagonist |
| US8828390B2 (en) | 2010-07-09 | 2014-09-09 | Universitat Zurich | Uses of NOGO-A inhibitors and related methods |
| CA2876284A1 (en) | 2012-07-05 | 2014-01-09 | Glaxo Group Limited | Optimum dose regime of an anti-nogo-a antibody in the treatment of amyotrophic lateral sclerosis |
| US20180362660A1 (en) * | 2016-05-09 | 2018-12-20 | Schickwann Tsai | Anti-penumbra monoclonal antibodies for detection and therapy of normal and abnormal B lymphocytes |
| WO2018232144A1 (en) * | 2017-06-14 | 2018-12-20 | Monojul, Llc | High-affinity anti-human folate receptor beta antibodies and methods of use |
| WO2020250204A1 (ko) * | 2019-06-13 | 2020-12-17 | 프레스티지 바이오파마 피티이. 엘티디. | 신규 cthrc1에 특이적 항체 및 이의 용도 |
| BR112022006534A2 (pt) | 2019-10-24 | 2022-07-05 | Novago Therapeutics Ag | Anticorpos anti-nogo-a |
| GB202012331D0 (en) | 2020-08-07 | 2020-09-23 | Petmedix Ltd | Therapeutic antibodies |
| CA3224517A1 (en) | 2021-06-17 | 2022-12-22 | Petmedix Ltd | Anti canine cd20 antibodies |
| JP2024542958A (ja) | 2021-10-21 | 2024-11-19 | ペットメディックス・リミテッド | Ｐ７５ｎｔｒの細胞外ドメインを含むタンパク質 |
| CN116251181B (zh) * | 2021-12-02 | 2023-09-22 | 北京东方百泰生物科技股份有限公司 | 一种抗tslp单克隆抗体的注射制剂 |
| IL314314A (en) | 2022-02-09 | 2024-09-01 | Petmedix Ltd | Therapeutic antibodies |
| WO2024041450A1 (zh) * | 2022-08-22 | 2024-02-29 | 舒泰神（北京）生物制药股份有限公司 | 特异性识别Nogo-A的抗体及其应用 |
| GB202217993D0 (en) | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Therapeutic antibodies |
| CN120712277A (zh) | 2023-02-09 | 2025-09-26 | 佩特迈迪有限公司 | 包含p75神经营养因子受体(p75ntr)胞外结构域变体的治疗分子 |
Citations (2)
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|---|---|---|---|---|
| WO2005061544A2 (en) * | 2003-12-22 | 2005-07-07 | Glaxo Group Limited | Nogo-a neutralising immunoglobulins for treatment of neurological diseases |
| US20050215770A1 (en) * | 2004-03-26 | 2005-09-29 | Human Genome Sciences, Inc. | Antibodies against Nogo receptor |
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| JPS57106673A (en) | 1980-12-24 | 1982-07-02 | Chugai Pharmaceut Co Ltd | Dibenzo(b,f)(1,4)oxazepin derivative |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US5250414A (en) | 1988-11-04 | 1993-10-05 | Erziehungsdirektion Of The Canton Zurich | Diagnostic methods using neurite growth regulatory factors |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| JPH08500017A (ja) | 1992-08-17 | 1996-01-09 | ジェネンテク，インコーポレイテッド | 二特異的免疫アドヘジン |
| GB9403250D0 (en) | 1994-02-21 | 1994-04-13 | Univ Mcgill | Therapeutic use of myelin-associated glycoprotein (mag) |
| US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
| SK282721B6 (sk) | 1994-05-27 | 2002-11-06 | Smithkline Beecham S.P.A. | Nepeptidové NK3 antagonistické látky, spôsob ich výroby, farmaceutické prostriedky s ich obsahom a ich použitie |
| GB9424449D0 (en) | 1994-12-02 | 1995-01-18 | Wellcome Found | Antibodies |
| CA2225691A1 (en) | 1995-06-27 | 1997-01-16 | Research Foundation Of Cuny, Hunter College | Compositions and methods using myelin-associated glycoprotein (mag) and inhibitors thereof |
| US6420338B1 (en) * | 1997-06-13 | 2002-07-16 | New York University Medical Center | Inhibition of the Src kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma |
| GB9809839D0 (en) | 1998-05-09 | 1998-07-08 | Glaxo Group Ltd | Antibody |
| DK1098972T3 (da) | 1998-07-22 | 2011-01-03 | Smithkline Beecham Ltd | Protein med lighed med neuroendokrinspecifikt protein samt cDNA kodende derfor |
| ES2529196T3 (es) | 1998-11-06 | 2015-02-17 | University Of Zurich | Secuencias de nucleótidos y proteínas de genes Nogo y métodos basados en estas |
| FR2792199B3 (fr) | 1999-04-13 | 2001-05-18 | Sanofi Sa | Utilisation de l'osanetant pour la preparation de medicaments utiles dans le traitement des troubles de l'humeur |
| US6881557B2 (en) | 2001-07-12 | 2005-04-19 | Arrowsmith Technologies Llp | Super humanized antibodies |
| GB0228832D0 (en) | 2002-12-10 | 2003-01-15 | Novartis Ag | Organic compound |
| GB0318727D0 (en) | 2003-08-08 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
| DE10338136A1 (de) | 2003-08-15 | 2005-03-24 | European Molecular Biology Laboratory | Zentrifuge und ein Träger zur Verwendung in einer Zentrifuge |
| GB0321997D0 (en) | 2003-09-19 | 2003-10-22 | Novartis Ag | Organic compound |
| AU2005207003C1 (en) * | 2004-01-20 | 2013-06-13 | Humanigen, Inc. | Antibody specificity transfer using minimal essential binding determinants |
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2005
- 2005-12-16 GB GBGB0525662.3A patent/GB0525662D0/en not_active Ceased
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2006
- 2006-12-14 EP EP06830633A patent/EP1960429B1/en active Active
- 2006-12-14 WO PCT/EP2006/069737 patent/WO2007068750A2/en not_active Ceased
- 2006-12-14 MY MYPI20082130A patent/MY149492A/en unknown
- 2006-12-14 HR HRP20120684TT patent/HRP20120684T1/hr unknown
- 2006-12-14 US US12/097,279 patent/US8362208B2/en not_active Expired - Fee Related
- 2006-12-14 CN CN2006800529521A patent/CN101374863B/zh not_active Expired - Fee Related
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- 2006-12-14 JP JP2008545009A patent/JP5015949B2/ja not_active Expired - Fee Related
- 2006-12-14 SI SI200631393T patent/SI1960429T1/sl unknown
- 2006-12-14 UA UAA200807663A patent/UA96279C2/ru unknown
- 2006-12-14 DK DK06830633.1T patent/DK1960429T3/da active
- 2006-12-14 CA CA2633501A patent/CA2633501C/en not_active Expired - Fee Related
- 2006-12-14 EA EA200801343A patent/EA015536B1/ru not_active IP Right Cessation
- 2006-12-14 NZ NZ569143A patent/NZ569143A/en not_active IP Right Cessation
- 2006-12-14 AU AU2006325228A patent/AU2006325228B2/en not_active Ceased
- 2006-12-14 KR KR1020087017348A patent/KR101355118B1/ko not_active Expired - Fee Related
- 2006-12-14 PT PT06830633T patent/PT1960429E/pt unknown
- 2006-12-14 BR BRPI0619855-4A patent/BRPI0619855A2/pt not_active IP Right Cessation
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- 2006-12-14 ES ES06830633T patent/ES2389380T3/es active Active
- 2006-12-14 AR ARP060105524A patent/AR057239A1/es active IP Right Grant
- 2006-12-14 PL PL06830633T patent/PL1960429T3/pl unknown
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- 2006-12-24 JO JO2006457A patent/JO2795B1/en active
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2008
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- 2008-06-11 MA MA31018A patent/MA30041B1/fr unknown
- 2008-06-11 ZA ZA200805111A patent/ZA200805111B/xx unknown
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- 2008-06-20 CR CR10099A patent/CR10099A/es unknown
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2009
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2012
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2013
- 2013-01-28 US US13/751,588 patent/US20130287781A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005061544A2 (en) * | 2003-12-22 | 2005-07-07 | Glaxo Group Limited | Nogo-a neutralising immunoglobulins for treatment of neurological diseases |
| US20050215770A1 (en) * | 2004-03-26 | 2005-09-29 | Human Genome Sciences, Inc. | Antibodies against Nogo receptor |
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| Title |
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| BANDTLOW CHRISTINE ET AL.: "The Escherichia coli-derived Fab fragment of the IgM/kappa antibody IN-1 recognizes and neutralizes myelin-associated inhibitors of neurite growth". EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 241, no. 2, 1996, pages 468-475, XP000991434, ISSN: 0014-2956, the whole document, especially figure 1 * |
| BROESAMLE C. ET AL.: "Regeneration of lesioned corticospinal tract fibers in the adult rat induced by a recombinant, humanized IN-1 antibody fragment". JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 20, no. 21, 1 November 2000 (2000-11-01), pages 8061-8068, XP002238449, ISSN: 0270-6474, the whole document * |
| PAPADOPOULOS C.M. ET AL.: "FUNCTIONAL RECOVERY ANF NEUROANATOMICAL PLASTICITY FOLLOWING MIDDLE CEREBRAL ARTERY OCCLUSION AND IN-1 ANTIBODY TREATMENT IN THE ADULT RAT". ANNALS OF NEUROLOGY, BOSTON, US, vol. 51, no. 4, April 2002 (2002-04), pages 433-441, XP008034394, ISSN: 0364-5134, the whole document * |
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