JP2009511449A5 - - Google Patents
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- Publication number
- JP2009511449A5 JP2009511449A5 JP2008534019A JP2008534019A JP2009511449A5 JP 2009511449 A5 JP2009511449 A5 JP 2009511449A5 JP 2008534019 A JP2008534019 A JP 2008534019A JP 2008534019 A JP2008534019 A JP 2008534019A JP 2009511449 A5 JP2009511449 A5 JP 2009511449A5
- Authority
- JP
- Japan
- Prior art keywords
- phosphoantigen
- salt
- peaks
- base
- crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims description 14
- YKAYCWPQDPILSA-UHFFFAOYSA-N bromohydrin pyrophosphate Chemical compound BrCC(O)(C)CCOP(O)(=O)OP(O)(O)=O YKAYCWPQDPILSA-UHFFFAOYSA-N 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 31
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 12
- 150000007530 organic bases Chemical class 0.000 claims 7
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 6
- 229930013930 alkaloid Natural products 0.000 claims 6
- 241000156724 Antirhea Species 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000007787 solid Substances 0.000 claims 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical compound C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 claims 4
- 235000019371 penicillin G benzathine Nutrition 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 150000003797 alkaloid derivatives Chemical class 0.000 claims 2
- 150000001450 anions Chemical class 0.000 claims 2
- KMPWYEUPVWOPIM-KODHJQJWSA-N cinchonidine Chemical compound C1=CC=C2C([C@H]([C@H]3[N@]4CC[C@H]([C@H](C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-KODHJQJWSA-N 0.000 claims 2
- KMPWYEUPVWOPIM-UHFFFAOYSA-N cinchonidine Natural products C1=CC=C2C(C(C3N4CCC(C(C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-UHFFFAOYSA-N 0.000 claims 2
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 claims 2
- 239000005725 8-Hydroxyquinoline Substances 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 239000012296 anti-solvent Substances 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- CTQMJYWDVABFRZ-UHFFFAOYSA-N cloxiquine Chemical compound C1=CN=C2C(O)=CC=C(Cl)C2=C1 CTQMJYWDVABFRZ-UHFFFAOYSA-N 0.000 claims 1
- 238000004320 controlled atmosphere Methods 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 229960003540 oxyquinoline Drugs 0.000 claims 1
- 150000004885 piperazines Chemical class 0.000 claims 1
- 229960001404 quinidine Drugs 0.000 claims 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- DEXHHOJZRQGTJO-DPZBITMOSA-N C/C(/CO)=C\CNP(O)(OP([O-])([U])=O)=O Chemical compound C/C(/CO)=C\CNP(O)(OP([O-])([U])=O)=O DEXHHOJZRQGTJO-DPZBITMOSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical group [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72430805P | 2005-10-06 | 2005-10-06 | |
| PCT/EP2006/067089 WO2007039635A2 (en) | 2005-10-06 | 2006-10-05 | Phosphoantigen salts of organic bases and methods for their crystallization |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009511449A JP2009511449A (ja) | 2009-03-19 |
| JP2009511449A5 true JP2009511449A5 (enExample) | 2009-11-26 |
Family
ID=37776880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008534019A Withdrawn JP2009511449A (ja) | 2005-10-06 | 2006-10-05 | 有機塩基のリン酸化抗原塩およびその結晶化方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080300222A1 (enExample) |
| EP (1) | EP1933848A2 (enExample) |
| JP (1) | JP2009511449A (enExample) |
| CN (1) | CN101282730A (enExample) |
| AU (1) | AU2006298677A1 (enExample) |
| CA (1) | CA2624533A1 (enExample) |
| EA (1) | EA200801028A1 (enExample) |
| WO (1) | WO2007039635A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8735624B2 (en) * | 2008-09-10 | 2014-05-27 | Innate Pharma | Polymorphic form of CHDMAPP, method of preparation thereof, and pharmaceutical composition comprising same |
| EP2669312A1 (en) | 2012-05-29 | 2013-12-04 | Huntsman International Llc | Process for the production of polyether polyols |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3056812A (en) * | 1958-08-08 | 1962-10-02 | Glaxo Lab Ltd | Steroid 21-pyrophosphate esters |
| DE1153373B (de) * | 1960-09-17 | 1963-08-29 | Shell Int Research | Verfahren zur Herstellung von Pyrophosphorsaeureestern, Phosphorsaeureestern, -amiden oder -carbonsaeureanhydriden |
| GB1395820A (en) * | 1971-06-05 | 1975-05-29 | Villax I | Preparation of 21-inorganic esters of corticosteroids and salts thereof |
| GB1580899A (en) * | 1976-07-27 | 1980-12-10 | Fujisawa Pharmaceutical Co | Hydroxyaminohydrocarbonphosphonic acid derivatives and production and use thereof |
| EP0350672A1 (en) * | 1988-06-28 | 1990-01-17 | MAGIS FARMACEUTICI S.p.A. | Salts of diacyl-glycero-(di)-phosphates of L-(acyl) carnitine and of L-acyl-carnitine esters |
| EP0541037A3 (en) * | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
| US5639653A (en) * | 1993-07-19 | 1997-06-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy | Method for proliferating Vγ2Vδ2 T cells |
| TW401276B (en) * | 1993-10-07 | 2000-08-11 | Zeneca Ltd | Novel compounds and a method of controlling growth of plants |
| FR2715660A1 (fr) * | 1994-01-28 | 1995-08-04 | Centre Nat Rech Scient | Composés organo-phosphorés activateurs des lymphocytes Tgammadelta, procédé pour préparer et/ou isoler et/ou caractériser ces composés, compositions et utilisations pharmaceutiques. |
| AU4815197A (en) * | 1996-10-09 | 1998-05-05 | Pharmasset, Ltd. | Tetraphosphonate bicyclic trisanhydrides |
| DE69942645D1 (en) * | 1998-01-09 | 2010-09-16 | Body Corporate Of The State Of | Synthese von combretastatin a-4 prodrugs |
| US6750340B2 (en) * | 1998-04-02 | 2004-06-15 | Mbc Research, Inc. | Bisphosphonate conjugates and methods of making and using the same |
| FR2782722B1 (fr) * | 1998-09-01 | 2001-01-12 | Inst Nat Sante Rech Med | Nouveaux composes phosphoepoxydes, procede de fabrication et applications |
| FR2782721B1 (fr) * | 1998-09-01 | 2000-11-03 | Inst Nat Sante Rech Med | Nouveaux composes phosphohalohydrines, procede de fabrication et applications |
| FR2791981B1 (fr) * | 1999-04-06 | 2001-07-20 | Inst Nat Sante Rech Med | Composes inhibant selectivement les lymphocytes tgamma9delta2, et leurs applications |
| SE9903345D0 (sv) * | 1999-09-17 | 1999-09-17 | Astra Pharma Prod | Novel process |
| US20020002140A1 (en) * | 2000-01-14 | 2002-01-03 | Holick Michael F. | Novel bisphosphonates and uses thereof |
| DE10201458A1 (de) * | 2001-04-11 | 2002-10-17 | Adelbert Bacher | Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg |
| AU2002339423B2 (en) * | 2001-07-20 | 2007-03-15 | Bioagency Ag | Organo-phosphorous compounds for activating gamma/delta T cells |
| FR2833266B1 (fr) * | 2001-12-11 | 2004-10-22 | Mayoly Spindler Lab | Nouveaux derives phosphonates, leur procede de preparation, leur utilisation comme modulateurs de l'activite des lymphocytes tgamma9 delta2 |
| RU2004128943A (ru) * | 2002-02-28 | 2005-04-20 | Байота, Инк. (Us) | Средства, имитирующие нуклеотиды, и их пролекарственные формы |
| CN1890252A (zh) * | 2003-12-02 | 2007-01-03 | 依奈特制药公司 | 新类型的γδT细胞活化剂及其应用 |
| WO2005066190A1 (en) * | 2004-01-02 | 2005-07-21 | Hexal A/S | New risedronate salts |
| CA2602223A1 (en) * | 2005-03-22 | 2006-10-05 | Christian Belmant | New class of yo t cells activators and use thereof |
-
2006
- 2006-10-05 EP EP06793975A patent/EP1933848A2/en not_active Withdrawn
- 2006-10-05 JP JP2008534019A patent/JP2009511449A/ja not_active Withdrawn
- 2006-10-05 US US12/088,477 patent/US20080300222A1/en not_active Abandoned
- 2006-10-05 EA EA200801028A patent/EA200801028A1/ru unknown
- 2006-10-05 CN CNA200680037327XA patent/CN101282730A/zh active Pending
- 2006-10-05 CA CA002624533A patent/CA2624533A1/en not_active Abandoned
- 2006-10-05 WO PCT/EP2006/067089 patent/WO2007039635A2/en not_active Ceased
- 2006-10-05 AU AU2006298677A patent/AU2006298677A1/en not_active Abandoned
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