EA200801028A1 - Соли фосфоантигенов с органическими основаниями и способы их кристаллизации - Google Patents

Соли фосфоантигенов с органическими основаниями и способы их кристаллизации

Info

Publication number
EA200801028A1
EA200801028A1 EA200801028A EA200801028A EA200801028A1 EA 200801028 A1 EA200801028 A1 EA 200801028A1 EA 200801028 A EA200801028 A EA 200801028A EA 200801028 A EA200801028 A EA 200801028A EA 200801028 A1 EA200801028 A1 EA 200801028A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phosphoantigens
methods
salts
phosphantigenes
crystallization
Prior art date
Application number
EA200801028A
Other languages
English (en)
Inventor
Жерар Кокрель
Эрик Обэн
Original Assignee
Иннейт Фарма
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Иннейт Фарма filed Critical Иннейт Фарма
Publication of EA200801028A1 publication Critical patent/EA200801028A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3895—Pyrophosphonic acids; phosphonic acid anhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/098—Esters of polyphosphoric acids or anhydrides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

В изобретении представлены новые соли фосфоантигенов и новые кристаллические фазы солей фосфоантигенов, причем последние включают несольватированные полиморфные формы и сольваты, применимые в качестве фармацевтических препаратов. В изобретении также представлены фармацевтические композиции, включающие новые кристаллические фазы фосфоантигенов, и способы получения последних. Также представлены способы применения таких композиций для лечения заболеваний, иммуностимулирующего или иммуномодулирующего применения. В изобретении также представлен способ получения кристаллов фосфоантигенов, а также композиций высокоочищенных фосфоантигенов.
EA200801028A 2005-10-06 2006-10-05 Соли фосфоантигенов с органическими основаниями и способы их кристаллизации EA200801028A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72430805P 2005-10-06 2005-10-06
PCT/EP2006/067089 WO2007039635A2 (en) 2005-10-06 2006-10-05 Phosphoantigen salts of organic bases and methods for their crystallization

Publications (1)

Publication Number Publication Date
EA200801028A1 true EA200801028A1 (ru) 2008-10-30

Family

ID=37776880

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801028A EA200801028A1 (ru) 2005-10-06 2006-10-05 Соли фосфоантигенов с органическими основаниями и способы их кристаллизации

Country Status (8)

Country Link
US (1) US20080300222A1 (ru)
EP (1) EP1933848A2 (ru)
JP (1) JP2009511449A (ru)
CN (1) CN101282730A (ru)
AU (1) AU2006298677A1 (ru)
CA (1) CA2624533A1 (ru)
EA (1) EA200801028A1 (ru)
WO (1) WO2007039635A2 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8735624B2 (en) * 2008-09-10 2014-05-27 Innate Pharma Polymorphic form of CHDMAPP, method of preparation thereof, and pharmaceutical composition comprising same
EP2669312A1 (en) 2012-05-29 2013-12-04 Huntsman International Llc Process for the production of polyether polyols

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3056812A (en) * 1958-08-08 1962-10-02 Glaxo Lab Ltd Steroid 21-pyrophosphate esters
DE1153373B (de) * 1960-09-17 1963-08-29 Shell Int Research Verfahren zur Herstellung von Pyrophosphorsaeureestern, Phosphorsaeureestern, -amiden oder -carbonsaeureanhydriden
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
GB1580899A (en) * 1976-07-27 1980-12-10 Fujisawa Pharmaceutical Co Hydroxyaminohydrocarbonphosphonic acid derivatives and production and use thereof
EP0350672A1 (en) * 1988-06-28 1990-01-17 MAGIS FARMACEUTICI S.p.A. Salts of diacyl-glycero-(di)-phosphates of L-(acyl) carnitine and of L-acyl-carnitine esters
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
US5639653A (en) * 1993-07-19 1997-06-17 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy Method for proliferating Vγ2Vδ2 T cells
TW401276B (en) * 1993-10-07 2000-08-11 Zeneca Ltd Novel compounds and a method of controlling growth of plants
FR2715660A1 (fr) * 1994-01-28 1995-08-04 Centre Nat Rech Scient Composés organo-phosphorés activateurs des lymphocytes Tgammadelta, procédé pour préparer et/ou isoler et/ou caractériser ces composés, compositions et utilisations pharmaceutiques.
CN1113888C (zh) * 1996-10-09 2003-07-09 法玛塞特有限公司 四膦酸酯二环三酸酐
US7018987B1 (en) * 1998-01-09 2006-03-28 Arizona Broad of Regents acting for and on behalf of Arizona State University Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof
US6750340B2 (en) * 1998-04-02 2004-06-15 Mbc Research, Inc. Bisphosphonate conjugates and methods of making and using the same
FR2782721B1 (fr) * 1998-09-01 2000-11-03 Inst Nat Sante Rech Med Nouveaux composes phosphohalohydrines, procede de fabrication et applications
FR2782722B1 (fr) * 1998-09-01 2001-01-12 Inst Nat Sante Rech Med Nouveaux composes phosphoepoxydes, procede de fabrication et applications
FR2791981B1 (fr) * 1999-04-06 2001-07-20 Inst Nat Sante Rech Med Composes inhibant selectivement les lymphocytes tgamma9delta2, et leurs applications
SE9903345D0 (sv) * 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
US20020002140A1 (en) * 2000-01-14 2002-01-03 Holick Michael F. Novel bisphosphonates and uses thereof
DE10201458A1 (de) * 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
DK1408984T3 (da) * 2001-07-20 2009-02-09 Bioagency Ag Organofosforforbindelser til aktivering af gamma/delta T celler
FR2833266B1 (fr) * 2001-12-11 2004-10-22 Mayoly Spindler Lab Nouveaux derives phosphonates, leur procede de preparation, leur utilisation comme modulateurs de l'activite des lymphocytes tgamma9 delta2
RU2004128943A (ru) * 2002-02-28 2005-04-20 Байота, Инк. (Us) Средства, имитирующие нуклеотиды, и их пролекарственные формы
EP1689758A2 (en) * 2003-12-02 2006-08-16 Innate Pharma New class of gamma delta t cells activators and use thereof
WO2005066190A1 (en) * 2004-01-02 2005-07-21 Hexal A/S New risedronate salts
EA200702029A1 (ru) * 2005-03-22 2008-02-28 Иннейт Фарма НОВЫЙ КЛАСС АКТИВАТОРОВ γ;δ Т-КЛЕТОК И ИХ ПРИМЕНЕНИЕ

Also Published As

Publication number Publication date
EP1933848A2 (en) 2008-06-25
CA2624533A1 (en) 2007-04-12
CN101282730A (zh) 2008-10-08
WO2007039635A2 (en) 2007-04-12
AU2006298677A1 (en) 2007-04-12
WO2007039635A3 (en) 2007-06-21
JP2009511449A (ja) 2009-03-19
US20080300222A1 (en) 2008-12-04

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