DK1408984T3 - Organofosforforbindelser til aktivering af gamma/delta T celler - Google Patents
Organofosforforbindelser til aktivering af gamma/delta T cellerInfo
- Publication number
- DK1408984T3 DK1408984T3 DK02776913T DK02776913T DK1408984T3 DK 1408984 T3 DK1408984 T3 DK 1408984T3 DK 02776913 T DK02776913 T DK 02776913T DK 02776913 T DK02776913 T DK 02776913T DK 1408984 T3 DK1408984 T3 DK 1408984T3
- Authority
- DK
- Denmark
- Prior art keywords
- delta
- cells
- organophosphorus compounds
- gamma
- activate gamma
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 150000002903 organophosphorus compounds Chemical class 0.000 title abstract 2
- 101100453077 Botryococcus braunii HDR gene Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65746—Esters of oxyacids of phosphorus the molecule containing more than one cyclic phosphorus atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/098—Esters of polyphosphoric acids or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3821—Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2001134705 DE10134705A1 (de) | 2001-07-20 | 2001-07-20 | Organo-Phosphorverbindungen zur Aktivierung von gamma/delta-T-Zellen |
DE2001135395 DE10135395A1 (de) | 2001-07-25 | 2001-07-25 | Organo-Phosphorverbindungen zur Aktivierung von gamma/delta-T-Zellen |
PCT/EP2002/007986 WO2003009855A2 (de) | 2001-07-20 | 2002-07-18 | Organo-phosphorverbindungen zur aktivierung von gamma/delta-t-zellen |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1408984T3 true DK1408984T3 (da) | 2009-02-09 |
Family
ID=26009714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02776913T DK1408984T3 (da) | 2001-07-20 | 2002-07-18 | Organofosforforbindelser til aktivering af gamma/delta T celler |
Country Status (13)
Country | Link |
---|---|
US (3) | US7399756B2 (da) |
EP (1) | EP1408984B1 (da) |
JP (1) | JP4607451B2 (da) |
KR (1) | KR100906018B1 (da) |
CN (1) | CN1533279A (da) |
AT (1) | ATE411805T1 (da) |
AU (1) | AU2002339423B2 (da) |
CA (1) | CA2453817C (da) |
DE (1) | DE50212935D1 (da) |
DK (1) | DK1408984T3 (da) |
ES (1) | ES2315411T3 (da) |
PT (1) | PT1408984E (da) |
WO (1) | WO2003009855A2 (da) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10201458A1 (de) * | 2001-04-11 | 2002-10-17 | Adelbert Bacher | Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg |
DK1408984T3 (da) * | 2001-07-20 | 2009-02-09 | Bioagency Ag | Organofosforforbindelser til aktivering af gamma/delta T celler |
FR2833266B1 (fr) * | 2001-12-11 | 2004-10-22 | Mayoly Spindler Lab | Nouveaux derives phosphonates, leur procede de preparation, leur utilisation comme modulateurs de l'activite des lymphocytes tgamma9 delta2 |
FR2836483B1 (fr) * | 2002-02-22 | 2006-09-15 | Innate Pharma | Procedes de production de lymphocytes gamma delta t |
GB0212666D0 (en) * | 2002-05-31 | 2002-07-10 | Secr Defence | Immunogenic sequences |
EP1426052B1 (en) * | 2002-12-02 | 2009-09-02 | Innate Pharma | Compositions comprising interleukin-2 and gamma-delta T cell activator and uses thereof |
WO2004096286A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
US20100291118A1 (en) * | 2003-12-02 | 2010-11-18 | Innate Pharma | Class of Gamma Delta T Cells Activators and Use Thereof |
CA2547008A1 (en) * | 2003-12-02 | 2005-06-16 | Innate Pharma | New class of gamma delta t cells activators and use thereof |
US20070134273A1 (en) * | 2004-02-10 | 2007-06-14 | Francois Romagne | Composition and method for the treatment of carcinoma |
DE602005012097D1 (de) * | 2004-04-26 | 2009-02-12 | Innate Pharma | Adjuvante zusammensetzung und anwendungsverfahren dafür |
ES2363160T3 (es) | 2004-07-27 | 2011-07-22 | Gilead Sciences, Inc. | Conjugados de fosfonato nucelosidico como agentes anti-vih. |
WO2006067635A2 (en) * | 2004-12-20 | 2006-06-29 | Innate Pharma S.A. | USE OF Ϝδ T LYMPHOCYTE ACTIVATORS AS VACCINE ADJUVANT |
MX2007011720A (es) * | 2005-03-22 | 2007-11-20 | Innate Pharma | Nueva clase de activadores de celulas t gamma-delta y usos de los mismos. |
EP1924279A2 (en) * | 2005-09-07 | 2008-05-28 | The Secretary of State for Defence | Adjuvanted vaccine |
JP2009511449A (ja) * | 2005-10-06 | 2009-03-19 | イナート・ファルマ | 有機塩基のリン酸化抗原塩およびその結晶化方法 |
GB2453475B (en) * | 2006-07-25 | 2011-01-19 | Secr Defence | Live vaccine strain |
EP2083830A1 (en) | 2006-11-17 | 2009-08-05 | Innate Pharma | Improved methods of using phosphoantigen for the treatment of cancer |
EP2123285A1 (en) | 2008-05-21 | 2009-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nucleosidic phosphoantigens for use in VGAMMA9DELTA2 T cell-mediated therapy |
AU2009268681B2 (en) | 2008-07-08 | 2014-10-02 | Gilead Sciences, Inc. | Salts of HIV inhibitor compounds |
EP2324040B1 (en) | 2008-09-10 | 2014-01-01 | Innate Pharma | Novel polymorphic form of chdmapp, method of preparation thereof, and pharmaceutical composition comprising same |
GB0901423D0 (en) * | 2009-01-29 | 2009-03-11 | Secr Defence | Treatment |
GB0901411D0 (en) * | 2009-01-29 | 2009-03-11 | Secr Defence | Treatment |
GB0906234D0 (en) | 2009-04-14 | 2009-05-20 | Secr Defence | Vaccine |
WO2017011686A1 (en) * | 2015-07-14 | 2017-01-19 | University Of Iowa Research Foundation | Fluorescent prodrugs |
WO2019027920A1 (en) | 2017-08-01 | 2019-02-07 | Gilead Sciences, Inc. | CRYSTALLINE FORMS OF ETHYL ((S) - (((((2R, 5R) -5- (6-AMINO-9H-PURIN-9-YL) -4-FLUORO-2,5-DIHYDROFURAN-2-YL) OXY ) METHYL) (PHENOXY) PHOSPHORYL) -L-ALANINATE (GS-9131) FOR THE TREATMENT OF VIRAL INFECTIONS |
CN109651429A (zh) * | 2017-10-11 | 2019-04-19 | 清华大学 | 高效稳定的Vγ9Vδ2 T细胞的小分子激动剂 |
WO2019118418A1 (en) | 2017-12-11 | 2019-06-20 | The Procter & Gamble Company | Method of making phosphono-phosphate containing compounds |
US11046817B2 (en) | 2017-12-11 | 2021-06-29 | The Procter & Gamble Company | Compositions comprising multi-valent cations and phosphono-phosphate containing polymers |
MX2020005972A (es) | 2017-12-11 | 2022-03-07 | Procter & Gamble | Composiciones para el cuidado bucal que comprenden polimeros que contienen grupos fosfonato y anionicos. |
US11008411B2 (en) | 2017-12-11 | 2021-05-18 | The Procter & Gamble Company | Phosphono-phosphate and anionic group containing polymers |
CN111372657A (zh) * | 2017-12-11 | 2020-07-03 | 宝洁公司 | 含有膦酰基-磷酸根的化合物和聚合物 |
CN111447974A (zh) | 2017-12-11 | 2020-07-24 | 宝洁公司 | 包括含有膦酰基-磷酸根基团和阴离子基团的聚合物的口腔护理组合物 |
WO2019182904A1 (en) | 2018-03-19 | 2019-09-26 | University Of Iowa Research Foundation | Phosphonamidate butyrophilin ligands |
KR20210069665A (ko) | 2018-09-27 | 2021-06-11 | 포스포감, 인크. | 동종이계 감마/델타-t 세포의 확장 및 사용을 위한 방법 및 조성물 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5639653A (en) | 1993-07-19 | 1997-06-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy | Method for proliferating Vγ2Vδ2 T cells |
FR2715660A1 (fr) | 1994-01-28 | 1995-08-04 | Centre Nat Rech Scient | Composés organo-phosphorés activateurs des lymphocytes Tgammadelta, procédé pour préparer et/ou isoler et/ou caractériser ces composés, compositions et utilisations pharmaceutiques. |
AU2783397A (en) * | 1996-05-15 | 1997-12-05 | University Of Sheffield, The | Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors |
DE19828450A1 (de) | 1998-06-26 | 1999-12-30 | Hassan Jomaa | Bisphosphonsäuren und deren Derivate enthaltende Arzneimittel zur Prophylaxe und zur Behandlung von Autoimmunkrankheiten sowie von Allergien |
FR2782721B1 (fr) | 1998-09-01 | 2000-11-03 | Inst Nat Sante Rech Med | Nouveaux composes phosphohalohydrines, procede de fabrication et applications |
DE59913101D1 (de) * | 1998-09-22 | 2006-04-13 | Bioagency Ag | Gene des 1-desoxy-d-xylulose-biosynthesewegs |
DE19854310A1 (de) | 1998-11-25 | 2000-06-29 | Hassan Jomaa | Verwendung von Phosphonoameisensäurederivaten zur therapeutischen und prophylaktischen Behandlung von Infektionen |
ATE313547T1 (de) * | 1999-01-21 | 2006-01-15 | Chugai Pharmaceutical Co Ltd | 2-methyl-3-butenyl-1-pyrophosphorsäuresalze und mittel zur behandlung von lymphozyten |
FR2791981B1 (fr) | 1999-04-06 | 2001-07-20 | Inst Nat Sante Rech Med | Composes inhibant selectivement les lymphocytes tgamma9delta2, et leurs applications |
HUP0201386A2 (en) * | 1999-05-21 | 2002-08-28 | Jomaa Pharmaka Gmbh | Use of genes of the deoxy-d-xylulose phosphate biosynthetic pathway for altering the concentration of isoprenoid |
EP1229790A4 (en) | 1999-09-30 | 2004-06-16 | Nat Jewish Med & Res Center | MODULATION OF -G (G) -G (D) T CELLS FOR REGULATING THE RESPIRATORY HYPERSENSITIVITY |
DE10027821A1 (de) | 2000-06-05 | 2001-12-06 | Adelbert Bacher | Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg |
AU9052201A (en) | 2000-08-07 | 2002-02-18 | Monsanto Technology Llc | Methyl-d-erythritol phosphate pathway genes |
DE10201458A1 (de) * | 2001-04-11 | 2002-10-17 | Adelbert Bacher | Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg |
DE10119905A1 (de) | 2001-04-23 | 2002-10-24 | Jomaa Pharmaka Gmbh | Inaktivierung von Genen des MEP-Wegs |
DK1408984T3 (da) * | 2001-07-20 | 2009-02-09 | Bioagency Ag | Organofosforforbindelser til aktivering af gamma/delta T celler |
US20050042751A1 (en) | 2001-10-31 | 2005-02-24 | Michel Goldman | Generation and use of new types of dendritic cells |
-
2002
- 2002-07-18 DK DK02776913T patent/DK1408984T3/da active
- 2002-07-18 DE DE50212935T patent/DE50212935D1/de not_active Expired - Lifetime
- 2002-07-18 CA CA2453817A patent/CA2453817C/en not_active Expired - Fee Related
- 2002-07-18 CN CNA028145585A patent/CN1533279A/zh active Pending
- 2002-07-18 PT PT02776913T patent/PT1408984E/pt unknown
- 2002-07-18 ES ES02776913T patent/ES2315411T3/es not_active Expired - Lifetime
- 2002-07-18 JP JP2003515247A patent/JP4607451B2/ja not_active Expired - Fee Related
- 2002-07-18 AU AU2002339423A patent/AU2002339423B2/en not_active Ceased
- 2002-07-18 US US10/484,143 patent/US7399756B2/en not_active Expired - Fee Related
- 2002-07-18 WO PCT/EP2002/007986 patent/WO2003009855A2/de active IP Right Grant
- 2002-07-18 KR KR1020047000770A patent/KR100906018B1/ko not_active IP Right Cessation
- 2002-07-18 EP EP02776913A patent/EP1408984B1/de not_active Expired - Lifetime
- 2002-07-18 AT AT02776913T patent/ATE411805T1/de active
-
2008
- 2008-06-11 US US12/137,241 patent/US7871992B2/en not_active Expired - Fee Related
-
2011
- 2011-01-17 US US13/007,852 patent/US20110112054A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20110112054A1 (en) | 2011-05-12 |
DE50212935D1 (de) | 2008-12-04 |
PT1408984E (pt) | 2008-12-26 |
US7399756B2 (en) | 2008-07-15 |
JP2005508305A (ja) | 2005-03-31 |
ATE411805T1 (de) | 2008-11-15 |
US20060030546A1 (en) | 2006-02-09 |
WO2003009855A3 (de) | 2003-11-06 |
AU2002339423B2 (en) | 2007-03-15 |
JP4607451B2 (ja) | 2011-01-05 |
CN1533279A (zh) | 2004-09-29 |
ES2315411T3 (es) | 2009-04-01 |
EP1408984A2 (de) | 2004-04-21 |
CA2453817A1 (en) | 2003-02-06 |
CA2453817C (en) | 2011-09-20 |
AU2002339423C1 (en) | 2003-02-17 |
KR100906018B1 (ko) | 2009-07-06 |
EP1408984B1 (de) | 2008-10-22 |
KR20040030814A (ko) | 2004-04-09 |
US20080249067A1 (en) | 2008-10-09 |
US7871992B2 (en) | 2011-01-18 |
WO2003009855A2 (de) | 2003-02-06 |
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