JP2009511449A - 有機塩基のリン酸化抗原塩およびその結晶化方法 - Google Patents

有機塩基のリン酸化抗原塩およびその結晶化方法 Download PDF

Info

Publication number
JP2009511449A
JP2009511449A JP2008534019A JP2008534019A JP2009511449A JP 2009511449 A JP2009511449 A JP 2009511449A JP 2008534019 A JP2008534019 A JP 2008534019A JP 2008534019 A JP2008534019 A JP 2008534019A JP 2009511449 A JP2009511449 A JP 2009511449A
Authority
JP
Japan
Prior art keywords
phosphoantigen
salt
organic base
group
salt according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2008534019A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009511449A5 (enExample
Inventor
ジェラール・コケレル
エリク・オーバン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innate Pharma SA
Original Assignee
Innate Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innate Pharma SA filed Critical Innate Pharma SA
Publication of JP2009511449A publication Critical patent/JP2009511449A/ja
Publication of JP2009511449A5 publication Critical patent/JP2009511449A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3895—Pyrophosphonic acids; phosphonic acid anhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/098—Esters of polyphosphoric acids or anhydrides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2008534019A 2005-10-06 2006-10-05 有機塩基のリン酸化抗原塩およびその結晶化方法 Withdrawn JP2009511449A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72430805P 2005-10-06 2005-10-06
PCT/EP2006/067089 WO2007039635A2 (en) 2005-10-06 2006-10-05 Phosphoantigen salts of organic bases and methods for their crystallization

Publications (2)

Publication Number Publication Date
JP2009511449A true JP2009511449A (ja) 2009-03-19
JP2009511449A5 JP2009511449A5 (enExample) 2009-11-26

Family

ID=37776880

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008534019A Withdrawn JP2009511449A (ja) 2005-10-06 2006-10-05 有機塩基のリン酸化抗原塩およびその結晶化方法

Country Status (8)

Country Link
US (1) US20080300222A1 (enExample)
EP (1) EP1933848A2 (enExample)
JP (1) JP2009511449A (enExample)
CN (1) CN101282730A (enExample)
AU (1) AU2006298677A1 (enExample)
CA (1) CA2624533A1 (enExample)
EA (1) EA200801028A1 (enExample)
WO (1) WO2007039635A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8735624B2 (en) * 2008-09-10 2014-05-27 Innate Pharma Polymorphic form of CHDMAPP, method of preparation thereof, and pharmaceutical composition comprising same
EP2669312A1 (en) 2012-05-29 2013-12-04 Huntsman International Llc Process for the production of polyether polyols

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3056812A (en) * 1958-08-08 1962-10-02 Glaxo Lab Ltd Steroid 21-pyrophosphate esters
DE1153373B (de) * 1960-09-17 1963-08-29 Shell Int Research Verfahren zur Herstellung von Pyrophosphorsaeureestern, Phosphorsaeureestern, -amiden oder -carbonsaeureanhydriden
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
GB1580899A (en) * 1976-07-27 1980-12-10 Fujisawa Pharmaceutical Co Hydroxyaminohydrocarbonphosphonic acid derivatives and production and use thereof
EP0350672A1 (en) * 1988-06-28 1990-01-17 MAGIS FARMACEUTICI S.p.A. Salts of diacyl-glycero-(di)-phosphates of L-(acyl) carnitine and of L-acyl-carnitine esters
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
US5639653A (en) * 1993-07-19 1997-06-17 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy Method for proliferating Vγ2Vδ2 T cells
TW401276B (en) * 1993-10-07 2000-08-11 Zeneca Ltd Novel compounds and a method of controlling growth of plants
FR2715660A1 (fr) * 1994-01-28 1995-08-04 Centre Nat Rech Scient Composés organo-phosphorés activateurs des lymphocytes Tgammadelta, procédé pour préparer et/ou isoler et/ou caractériser ces composés, compositions et utilisations pharmaceutiques.
AU4815197A (en) * 1996-10-09 1998-05-05 Pharmasset, Ltd. Tetraphosphonate bicyclic trisanhydrides
DE69942645D1 (en) * 1998-01-09 2010-09-16 Body Corporate Of The State Of Synthese von combretastatin a-4 prodrugs
US6750340B2 (en) * 1998-04-02 2004-06-15 Mbc Research, Inc. Bisphosphonate conjugates and methods of making and using the same
FR2782722B1 (fr) * 1998-09-01 2001-01-12 Inst Nat Sante Rech Med Nouveaux composes phosphoepoxydes, procede de fabrication et applications
FR2782721B1 (fr) * 1998-09-01 2000-11-03 Inst Nat Sante Rech Med Nouveaux composes phosphohalohydrines, procede de fabrication et applications
FR2791981B1 (fr) * 1999-04-06 2001-07-20 Inst Nat Sante Rech Med Composes inhibant selectivement les lymphocytes tgamma9delta2, et leurs applications
SE9903345D0 (sv) * 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
US20020002140A1 (en) * 2000-01-14 2002-01-03 Holick Michael F. Novel bisphosphonates and uses thereof
DE10201458A1 (de) * 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
AU2002339423B2 (en) * 2001-07-20 2007-03-15 Bioagency Ag Organo-phosphorous compounds for activating gamma/delta T cells
FR2833266B1 (fr) * 2001-12-11 2004-10-22 Mayoly Spindler Lab Nouveaux derives phosphonates, leur procede de preparation, leur utilisation comme modulateurs de l'activite des lymphocytes tgamma9 delta2
RU2004128943A (ru) * 2002-02-28 2005-04-20 Байота, Инк. (Us) Средства, имитирующие нуклеотиды, и их пролекарственные формы
CN1890252A (zh) * 2003-12-02 2007-01-03 依奈特制药公司 新类型的γδT细胞活化剂及其应用
WO2005066190A1 (en) * 2004-01-02 2005-07-21 Hexal A/S New risedronate salts
CA2602223A1 (en) * 2005-03-22 2006-10-05 Christian Belmant New class of yo t cells activators and use thereof

Also Published As

Publication number Publication date
US20080300222A1 (en) 2008-12-04
WO2007039635A2 (en) 2007-04-12
EA200801028A1 (ru) 2008-10-30
CA2624533A1 (en) 2007-04-12
AU2006298677A1 (en) 2007-04-12
CN101282730A (zh) 2008-10-08
EP1933848A2 (en) 2008-06-25
WO2007039635A3 (en) 2007-06-21

Similar Documents

Publication Publication Date Title
AU2021202967B2 (en) Phosphoramidates for the treatment of Hepatitis B virus
JP7703518B2 (ja) 抗ウイルスプロドラッグ及びその製剤
US6767900B2 (en) Phosphonate nucleotide compound
JP4033494B2 (ja) ヌクレオチドアナログ
AU747163B2 (en) Nucleotide analog compositions
JP5937073B2 (ja) ジアステレオマーとして純粋なホスホルアミデートプロドラッグの調製方法
DK170257B1 (da) Heterocyclisk biphosphonsyrederivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende et sådant derivat
CN103665043A (zh) 一种替诺福韦前药及其在医药上的应用
US20020045599A1 (en) Nucleotide analog compositions
KR20160007651A (ko) 인산/포스폰산 유도체 및 이의 의학적 용도
EP2160394A1 (en) Tenofovir disoproxil hemi-fumaric acid co-crystal
CA2890676A1 (en) Phosphonucleosides useful in the treatment of viral disorders
KR100619298B1 (ko) 뉴클레오타이드 동족체
JP5244917B2 (ja) C2−c5−アルキル−イミダゾール−ビスホスホネート類
KR20150130355A (ko) 비환식 뉴클레오사이드 포스포네이트 디에스테르
AU657018B2 (en) Guanidinoalkyl-1, 1-bisphosphonic acid derivatives, process for their preparation and their use
KR102476361B1 (ko) 테노포비르 프로드럭의 신규 다결정형 및 이의 제조방법 및 적용
JP7767151B2 (ja) プロドラッグ化合物
US20080300222A1 (en) Phosphoantigen Salts Of Organic Bases And Methods For Their Crystallization
CN114206841A (zh) Cd73抑制剂
WO2008131635A1 (fr) Dérivés phosphonates de nucléosides acycliques et leurs utilisation médicale
JP3148139B2 (ja) ホスホナートヌクレオチド化合物
HK40075688A (en) Antiviral prodrugs and formulations thereof
JPWO2001064693A1 (ja) ホスホナートヌクレオチド化合物
JPWO1998006726A1 (ja) ホスホナートヌクレオチド化合物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091005

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20091005

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20101122