JP2009510170A5 - - Google Patents

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Publication number
JP2009510170A5
JP2009510170A5 JP2008534664A JP2008534664A JP2009510170A5 JP 2009510170 A5 JP2009510170 A5 JP 2009510170A5 JP 2008534664 A JP2008534664 A JP 2008534664A JP 2008534664 A JP2008534664 A JP 2008534664A JP 2009510170 A5 JP2009510170 A5 JP 2009510170A5
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JP
Japan
Prior art keywords
phenyl
pyrimidine
carboxylic acid
benzylamide
fluoro
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JP2008534664A
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English (en)
Japanese (ja)
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JP2009510170A (ja
JP5452925B2 (ja
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Priority claimed from PCT/US2006/038841 external-priority patent/WO2007041634A1/en
Publication of JP2009510170A publication Critical patent/JP2009510170A/ja
Publication of JP2009510170A5 publication Critical patent/JP2009510170A5/ja
Application granted granted Critical
Publication of JP5452925B2 publication Critical patent/JP5452925B2/ja
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JP2008534664A 2005-10-04 2006-10-04 Ｐｇｄｓ阻害剤としてのピリミジンアミド化合物 Active JP5452925B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72357005P 2005-10-04 2005-10-04
US60/723,570 2005-10-04
PCT/US2006/038841 WO2007041634A1 (en) 2005-10-04 2006-10-04 Pyrimidine amide compounds as pgds inhibitors

Publications (3)

Publication Number Publication Date
JP2009510170A JP2009510170A (ja) 2009-03-12
JP2009510170A5 true JP2009510170A5 (enExample) 2009-11-19
JP5452925B2 JP5452925B2 (ja) 2014-03-26

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ID=37635758

Family Applications (1)

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JP2008534664A Active JP5452925B2 (ja) 2005-10-04 2006-10-04 Ｐｇｄｓ阻害剤としてのピリミジンアミド化合物

Country Status (27)

Country Link
US (1) US8202863B2 (enExample)
EP (1) EP1937652B1 (enExample)
JP (1) JP5452925B2 (enExample)
KR (1) KR101457966B1 (enExample)
CN (2) CN101282943A (enExample)
AR (1) AR056871A1 (enExample)
AU (1) AU2006299428B2 (enExample)
BR (1) BRPI0616815A2 (enExample)
CA (1) CA2624749C (enExample)
CR (1) CR9832A (enExample)
DO (1) DOP2006000210A (enExample)
EC (1) ECSP088335A (enExample)
ES (1) ES2514471T3 (enExample)
IL (1) IL190411A (enExample)
MA (1) MA29925B1 (enExample)
MY (1) MY151172A (enExample)
NO (1) NO20082000L (enExample)
NZ (1) NZ567208A (enExample)
PE (2) PE20110118A1 (enExample)
RU (1) RU2420519C2 (enExample)
SG (1) SG166121A1 (enExample)
TN (1) TNSN08104A1 (enExample)
TW (1) TWI415839B (enExample)
UA (1) UA93213C2 (enExample)
UY (1) UY29840A1 (enExample)
WO (1) WO2007041634A1 (enExample)
ZA (1) ZA200802222B (enExample)

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JP2010513458A (ja) 2006-12-19 2010-04-30 ファイザー・プロダクツ・インク Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体、およびプロスタグランジンｄ２の仲介による疾患を治療するためのその使用
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MX2010003864A (es) 2007-10-11 2010-06-01 Vertex Pharma Amidas utiles como inhibidores de canales de sodio dependientes de voltaje.
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AU2008310663A1 (en) 2007-10-11 2009-04-16 Vertex Pharmaceuticals Incorporated Aryl amides useful as inhibitors of voltage-gated sodium channels
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US20110306597A1 (en) 2008-06-18 2011-12-15 James Michael Crawforth Nicotinamide Derivatives
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BRPI0919004A2 (pt) 2008-09-22 2019-09-24 Cayman Chem Co composto de multiheteroarila como inibidores de h-pgds e sua utilização para o tratamento de doenças mediadas por prostaglandina d2
WO2010056044A2 (ko) * 2008-11-11 2010-05-20 (주)아모레퍼시픽 바닐로이드 수용체 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염 및 이를 포함하는 약학 조성물
KR101252335B1 (ko) 2009-07-16 2013-04-08 (주)아모레퍼시픽 피부 노화 방지용 조성물
KR101367057B1 (ko) 2009-03-17 2014-02-25 (주)아모레퍼시픽 피부 자극 완화용 조성물
AU2010222122B2 (en) 2009-03-09 2013-06-27 Taiho Pharmaceutical Co., Ltd. Piperazine compound capable of inhibiting prostaglandin D synthase
BR112012007635B1 (pt) * 2009-10-08 2019-07-09 Sanofi Compostos derivados de feniloxadiazol como inibidores de pgds, composição farmacêutica compreendendo os mesmos e seus processos de preparação
EP2527340B1 (en) * 2010-01-22 2016-08-17 Taiho Pharmaceutical Co., Ltd. Piperazine compound having a pgds inhibitory effect
US9320723B2 (en) * 2010-05-03 2016-04-26 University Of Rochester Methods of treating thyroid eye disease
US9199976B2 (en) 2010-06-01 2015-12-01 The University Of Queensland Haematopoietic-prostaglandin D2 synthase inhibitors
WO2012033069A1 (ja) 2010-09-07 2012-03-15 大鵬薬品工業株式会社 プロスタグランジンd合成酵素を阻害するピペリジン化合物
KR101271223B1 (ko) 2011-01-27 2013-06-07 한국과학기술연구원 아미노피리미딘 유도체 및 이를 포함하는 세포외 신호조절 키나제의 제해제
CN104159587A (zh) 2012-01-06 2014-11-19 南佛罗里达大学 组合物、使用方法、以及治疗方法
WO2014029193A1 (en) * 2012-08-24 2014-02-27 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
CN108430992A (zh) 2015-12-17 2018-08-21 阿斯特克斯医疗公司 作为h-pgds抑制剂的喹啉-3-甲酰胺
WO2017160832A1 (en) * 2016-03-14 2017-09-21 Emory University Amide-sulfamide derivatives, compositions, and uses related to cxcr4 inhibition
JOP20190072A1 (ar) 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
EP3638672A1 (en) 2017-06-13 2020-04-22 GlaxoSmithKline Intellectual Property Development Limited Chemical compounds as h-pgds inhibitors
US11357759B2 (en) 2017-10-29 2022-06-14 China Medical University Composition including ADAM9 inhibitor and the use thereof
EP3724197A1 (en) 2017-12-13 2020-10-21 GlaxoSmithKline Intellectual Property Development Ltd Fused pyridines which act as inhibitors of h-pgds
JP7428692B2 (ja) * 2018-03-23 2024-02-06 ステップ ファーマ エス．エー．エス Ｃｔｐｓ１阻害剤としてのアミノピリミジン誘導体
JP2022506850A (ja) 2018-11-08 2022-01-17 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド 化学化合物
CA3182912A1 (en) * 2020-05-13 2021-11-18 Chdi Foundation, Inc. Htt modulators for treating huntington's disease
US20230339937A1 (en) 2020-06-19 2023-10-26 Sato Pharmaceutical Co., Ltd. Condensed ring compounds that inhibit h-pgds
JP2023546996A (ja) * 2020-10-23 2023-11-08 ニンバス クロソー， インコーポレイテッド Ｃｔｐｓ１阻害剤およびその使用
CN113004208A (zh) * 2021-03-08 2021-06-22 沈阳药科大学 一种抑制黄嘌呤氧化酶活性的化合物及制备方法和应用
WO2023091456A1 (en) * 2021-11-17 2023-05-25 Chdi Foundation, Inc. N-(2h-indazol-5-yl)pyrazine-2-carboxamide derivatives and similar compounds as htt modulators for the treatment of huntington's disease
EP4450502A4 (en) * 2021-12-17 2025-06-11 Sato Pharmaceutical Co., Ltd. AZAINDOLE DERIVATIVE INHIBITING H-PGDS
JPWO2023163140A1 (enExample) * 2022-02-28 2023-08-31

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