JP2009510170A5 - - Google Patents

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Publication number
JP2009510170A5
JP2009510170A5 JP2008534664A JP2008534664A JP2009510170A5 JP 2009510170 A5 JP2009510170 A5 JP 2009510170A5 JP 2008534664 A JP2008534664 A JP 2008534664A JP 2008534664 A JP2008534664 A JP 2008534664A JP 2009510170 A5 JP2009510170 A5 JP 2009510170A5
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JP
Japan
Prior art keywords
phenyl
pyrimidine
carboxylic acid
benzylamide
fluoro
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JP2008534664A
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English (en)
Japanese (ja)
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JP2009510170A (ja
JP5452925B2 (ja
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Priority claimed from PCT/US2006/038841 external-priority patent/WO2007041634A1/en
Publication of JP2009510170A publication Critical patent/JP2009510170A/ja
Publication of JP2009510170A5 publication Critical patent/JP2009510170A5/ja
Application granted granted Critical
Publication of JP5452925B2 publication Critical patent/JP5452925B2/ja
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JP2008534664A 2005-10-04 2006-10-04 Ｐｇｄｓ阻害剤としてのピリミジンアミド化合物 Active JP5452925B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72357005P 2005-10-04 2005-10-04
US60/723,570 2005-10-04
PCT/US2006/038841 WO2007041634A1 (en) 2005-10-04 2006-10-04 Pyrimidine amide compounds as pgds inhibitors

Publications (3)

Publication Number Publication Date
JP2009510170A JP2009510170A (ja) 2009-03-12
JP2009510170A5 true JP2009510170A5 (enExample) 2009-11-19
JP5452925B2 JP5452925B2 (ja) 2014-03-26

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ID=37635758

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008534664A Active JP5452925B2 (ja) 2005-10-04 2006-10-04 Ｐｇｄｓ阻害剤としてのピリミジンアミド化合物

Country Status (27)

Country Link
US (1) US8202863B2 (enExample)
EP (1) EP1937652B1 (enExample)
JP (1) JP5452925B2 (enExample)
KR (1) KR101457966B1 (enExample)
CN (2) CN101538246B (enExample)
AR (1) AR056871A1 (enExample)
AU (1) AU2006299428B2 (enExample)
BR (1) BRPI0616815A2 (enExample)
CA (1) CA2624749C (enExample)
CR (1) CR9832A (enExample)
DO (1) DOP2006000210A (enExample)
EC (1) ECSP088335A (enExample)
ES (1) ES2514471T3 (enExample)
IL (1) IL190411A (enExample)
MA (1) MA29925B1 (enExample)
MY (1) MY151172A (enExample)
NO (1) NO20082000L (enExample)
NZ (1) NZ567208A (enExample)
PE (2) PE20110118A1 (enExample)
RU (1) RU2420519C2 (enExample)
SG (1) SG166121A1 (enExample)
TN (1) TNSN08104A1 (enExample)
TW (1) TWI415839B (enExample)
UA (1) UA93213C2 (enExample)
UY (1) UY29840A1 (enExample)
WO (1) WO2007041634A1 (enExample)
ZA (1) ZA200802222B (enExample)

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DOP2006000210A (es) 2005-10-04 2007-06-15 Aventis Pharma Inc Compuestos de pirimidina amida como inhibidores de pgds
KR20080109918A (ko) 2006-04-11 2008-12-17 버텍스 파마슈티칼스 인코포레이티드 전압 개폐 나트륨 채널의 억제제로서 유용한 조성물
CA2672373C (en) 2006-12-19 2011-08-30 Pfizer Products Inc. Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases
JP2010519328A (ja) * 2007-02-26 2010-06-03 ファイザー・プロダクツ・インク Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体およびプロスタグランジンｄ２が媒介する疾患の治療のためのそれらの使用
JP5718053B2 (ja) 2007-08-27 2015-05-13 ヘリコン・セラピューティクス・インコーポレーテッド 治療用イソオキサゾール化合物
MX2010003865A (es) 2007-10-11 2010-06-01 Vertex Pharma Aril amidas utiles como inhibidores de canales de sodio dependientes de voltaje.
NZ584475A (en) * 2007-10-11 2012-07-27 Vertex Pharma Heteroaryl amides useful as inhibitors of voltage-gated sodium channels
RU2010118481A (ru) 2007-10-11 2011-11-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) Амиды, применимые в качестве ингибиторов потенциалзависимых натриевых каналов
US8153651B2 (en) * 2007-11-13 2012-04-10 Evotec Ag Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
US8188280B2 (en) * 2008-02-06 2012-05-29 Msd K.K. 3-substituted sulfonyl piperidine derivative
EP2286221A4 (en) * 2008-05-13 2011-07-06 Cayman Chem Co METHOD FOR TESTING COMPOUNDS OR MEANS FOR THEIR POSSIBILITY TO DISPLACE STRONG LIGANDS OF THE HEMATOPOIETIC PROSTAGLANDIN D-SYNTHASE
TW201010997A (en) 2008-06-18 2010-03-16 Pfizer Ltd Nicotinamide derivatives
US20110306597A1 (en) 2008-06-18 2011-12-15 James Michael Crawforth Nicotinamide Derivatives
US8536185B2 (en) 2008-09-22 2013-09-17 Cayman Chemical Company, Incorporated Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases
KR101252335B1 (ko) 2009-07-16 2013-04-08 (주)아모레퍼시픽 피부 노화 방지용 조성물
WO2010056044A2 (ko) * 2008-11-11 2010-05-20 (주)아모레퍼시픽 바닐로이드 수용체 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염 및 이를 포함하는 약학 조성물
KR101367057B1 (ko) 2009-03-17 2014-02-25 (주)아모레퍼시픽 피부 자극 완화용 조성물
JP5111657B2 (ja) 2009-03-09 2013-01-09 大鵬薬品工業株式会社 プロスタグランジンｄ合成酵素を阻害するピペラジン化合物
MX2012003021A (es) * 2009-10-08 2012-04-10 Sanofi Sa Derivados de feniloxadiazol como agentes inhibidores de las pgds.
AU2011208139B2 (en) 2010-01-22 2014-10-23 Taiho Pharmaceutical Co., Ltd. Piperazine compound having a PGDS inhibitory effect
US9320723B2 (en) * 2010-05-03 2016-04-26 University Of Rochester Methods of treating thyroid eye disease
WO2011150457A2 (en) * 2010-06-01 2011-12-08 The University Of Queensland Haematopoietic-prostaglandin d2 synthase inhibitors
AU2011299904A1 (en) 2010-09-07 2013-05-02 Taiho Pharmaceutical Co., Ltd. Prostaglandin D synthase inhibitory piperidine compounds
KR101271223B1 (ko) 2011-01-27 2013-06-07 한국과학기술연구원 아미노피리미딘 유도체 및 이를 포함하는 세포외 신호조절 키나제의 제해제
CN104159587A (zh) 2012-01-06 2014-11-19 南佛罗里达大学 组合物、使用方法、以及治疗方法
RU2655914C9 (ru) * 2012-08-24 2018-07-24 Саншайн Лейк Фарма Ко., Лтд. Соединения дигидропиримидина и их применение в фармацевтических препаратах
WO2017103851A1 (en) 2015-12-17 2017-06-22 Astex Therapeutics Limited Quinoline-3-carboxamides as h-pgds inhibitors
WO2017160832A1 (en) * 2016-03-14 2017-09-21 Emory University Amide-sulfamide derivatives, compositions, and uses related to cxcr4 inhibition
JOP20190072A1 (ar) * 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
US11149035B2 (en) 2017-06-13 2021-10-19 Glaxosmithkline Intellectual Property Dfvelopment Limited Chemical compounds as H—PGDS inhibitors
EP3700521B1 (en) * 2017-10-29 2024-06-12 China Medical University Use of adam9 inhibitor compound and composition including adam9 inhibitor compound
CN111479814A (zh) 2017-12-13 2020-07-31 葛兰素史密斯克莱知识产权发展有限公司 作为h-pgds抑制剂的稠合的吡啶
CA3093050A1 (en) * 2018-03-23 2019-09-26 Step Pharma S.A.S. Aminopyrimidine derivatives as ctps1 inhibitors
WO2020095215A1 (en) 2018-11-08 2020-05-14 Glaxosmithkline Intellectual Property Development Limited Chemical compounds
AU2021272972A1 (en) * 2020-05-13 2022-12-08 Chdi Foundation, Inc. HTT modulators for treating Huntington's disease
EP4169575A4 (en) 2020-06-19 2023-10-25 Sato Pharmaceutical Co., Ltd. Condensed ring compounds that inhibit h-pgds
EP4232425A4 (en) * 2020-10-23 2024-07-24 Nimbus Clotho, Inc. Ctps1 inhibitors and uses thereof
CN113004208A (zh) * 2021-03-08 2021-06-22 沈阳药科大学 一种抑制黄嘌呤氧化酶活性的化合物及制备方法和应用
AU2022394333A1 (en) 2021-11-17 2024-06-27 Chdi Foundation, Inc. HTT modulators for treating Huntington’s disease
KR20240121786A (ko) 2021-12-17 2024-08-09 사토 세이야쿠 가부시키가이샤 H－pgds를 저해하는 아자인돌 유도체

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DOP2006000210A (es) 2005-10-04 2007-06-15 Aventis Pharma Inc Compuestos de pirimidina amida como inhibidores de pgds

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