JP2009507833A5 - - Google Patents
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- Publication number
- JP2009507833A5 JP2009507833A5 JP2008530008A JP2008530008A JP2009507833A5 JP 2009507833 A5 JP2009507833 A5 JP 2009507833A5 JP 2008530008 A JP2008530008 A JP 2008530008A JP 2008530008 A JP2008530008 A JP 2008530008A JP 2009507833 A5 JP2009507833 A5 JP 2009507833A5
- Authority
- JP
- Japan
- Prior art keywords
- complex
- prion
- alkyl
- pathogenic
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000029797 Prion Human genes 0.000 claims 98
- 108091000054 Prion Proteins 0.000 claims 97
- 230000001717 pathogenic effect Effects 0.000 claims 84
- 239000003153 chemical reaction reagent Substances 0.000 claims 81
- 108010043958 Peptoids Proteins 0.000 claims 77
- 239000000523 sample Substances 0.000 claims 44
- 238000000034 method Methods 0.000 claims 37
- 230000015572 biosynthetic process Effects 0.000 claims 17
- 201000010099 disease Diseases 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 9
- 108010049175 N-substituted Glycines Proteins 0.000 claims 8
- 230000000389 anti-prion effect Effects 0.000 claims 8
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- 150000001356 alkyl thiols Chemical class 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000004367 cycloalkylaryl group Chemical group 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000001041 indolyl group Chemical group 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000005936 piperidyl group Chemical group 0.000 claims 3
- 150000003573 thiols Chemical class 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 230000036770 blood supply Effects 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 230000001268 conjugating effect Effects 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 125000001326 naphthylalkyl group Chemical group 0.000 claims 2
- 230000003472 neutralizing effect Effects 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- -1 amidino, amidino Chemical group 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229920000831 ionic polymer Polymers 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71576105P | 2005-09-09 | 2005-09-09 | |
| US60/715,761 | 2005-09-09 | ||
| US72668605P | 2005-10-14 | 2005-10-14 | |
| US60/726,686 | 2005-10-14 | ||
| US75893406P | 2006-01-13 | 2006-01-13 | |
| US60/758,934 | 2006-01-13 | ||
| PCT/US2006/035226 WO2007030804A1 (en) | 2005-09-09 | 2006-09-08 | Prion-specific peptoid reagents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012126346A Division JP2012162571A (ja) | 2005-09-09 | 2012-06-01 | プリオンに特異的なペプトイド試薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009507833A JP2009507833A (ja) | 2009-02-26 |
| JP2009507833A5 true JP2009507833A5 (enExample) | 2009-10-22 |
| JP5209477B2 JP5209477B2 (ja) | 2013-06-12 |
Family
ID=37651167
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008530008A Expired - Fee Related JP5209477B2 (ja) | 2005-09-09 | 2006-09-08 | プリオンに特異的なペプトイド試薬 |
| JP2012126346A Withdrawn JP2012162571A (ja) | 2005-09-09 | 2012-06-01 | プリオンに特異的なペプトイド試薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012126346A Withdrawn JP2012162571A (ja) | 2005-09-09 | 2012-06-01 | プリオンに特異的なペプトイド試薬 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7834144B2 (enExample) |
| EP (2) | EP2383281A3 (enExample) |
| JP (2) | JP5209477B2 (enExample) |
| KR (1) | KR20080048527A (enExample) |
| CN (1) | CN101356186A (enExample) |
| AU (1) | AU2006287299B2 (enExample) |
| BR (1) | BRPI0615618A2 (enExample) |
| CA (1) | CA2621767A1 (enExample) |
| DK (1) | DK1931695T3 (enExample) |
| ES (1) | ES2404940T3 (enExample) |
| IL (1) | IL189992A0 (enExample) |
| NZ (2) | NZ566020A (enExample) |
| WO (1) | WO2007030804A1 (enExample) |
| ZA (1) | ZA200802186B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060035242A1 (en) * | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
| WO2006076497A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Osplation of pathogenic prions |
| WO2006076683A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Isolation and detection of pathogenic prions |
| EP2383281A3 (en) | 2005-09-09 | 2012-01-04 | Novartis AG | Prion-specific peptoid reagents |
| FR2892820B1 (fr) * | 2005-11-03 | 2008-02-01 | Diagast Soc Par Actions Simpli | Procede magnetique d'immunodiagnostic pour la mise en evidence de complexe anticorps/antigene, en particulier de groupe sanguin |
| AU2008218939B2 (en) * | 2007-02-23 | 2014-05-08 | The Research Foundation Of State University Of New York | RNA targeting compounds and methods for making and using same |
| US9260476B2 (en) | 2007-02-23 | 2016-02-16 | The Research Foundation For The State University Of New York | RNA targeting compounds and methods for making and using same |
| CA2684798A1 (en) * | 2007-04-04 | 2008-10-16 | Novartis Ag | Prion elisa |
| JP2010523977A (ja) * | 2007-04-04 | 2010-07-15 | ノバルティス アーゲー | プリオンアッセイ |
| AU2008307144B2 (en) * | 2007-10-02 | 2012-12-20 | Csl Limited | Therapeutic antibody purification method and method of use |
| US8445632B2 (en) * | 2008-02-08 | 2013-05-21 | The Regents Of The University Of California | Selective poly-N-substituted glycine antibiotics |
| EP2282753A1 (en) * | 2008-04-30 | 2011-02-16 | Novartis AG | Assay for pathogenic conformers |
| WO2010017412A1 (en) * | 2008-08-06 | 2010-02-11 | The Regents Of The University Of California | Novel biomimetic peptoid polymers |
| US8828413B2 (en) | 2009-02-24 | 2014-09-09 | New York University | Peptoid oligomers, pharmaceutical compositions and methods of using the same |
| EP2438444A1 (en) | 2009-06-02 | 2012-04-11 | The Board of Regents of The University of Texas System | Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases |
| US20130109581A1 (en) * | 2009-11-04 | 2013-05-02 | David Peretz | Positively charged species as binding reagents in the separation of protein aggregates from monomers |
| US8952127B2 (en) | 2010-06-04 | 2015-02-10 | The Regents Of The University Of California | Peptoids useful for catalyzing the mineralization of calcium carbonate |
| WO2013043669A1 (en) * | 2011-09-21 | 2013-03-28 | The Board Of Regents Of The University Of Texas System | Peptoid compositions for the treatment of alzheimer's disease and polyglutamine expansion disorder |
| US10391068B2 (en) * | 2012-08-06 | 2019-08-27 | Trustees Of Boston University | Prion protein ligands as therapeutic agents for neurodegenerative disorders |
| US9764953B2 (en) | 2013-03-20 | 2017-09-19 | The Regents Of The University Of California | Peptoids useful for the mineralization of apatite |
| HK1245015A1 (zh) * | 2015-03-11 | 2018-08-24 | 卢莫斯制药公司 | 环肌酸及其类似物的合成 |
| EP3370518B1 (en) | 2015-10-14 | 2023-08-23 | X-Therma, Inc. | Compositions and methods for reducing ice crystal formation |
| EP3426673B1 (en) | 2016-03-09 | 2021-05-05 | Mike-Ann, LLC | Peptoid affinity ligands |
| JP7212373B2 (ja) * | 2017-04-12 | 2023-01-25 | エックス－サーマ インコーポレイテッド | 新規ペプトイドポリマーおよび使用方法 |
| WO2020123534A1 (en) | 2018-12-10 | 2020-06-18 | Provivi, Inc. | Synthesis of conjugated diene pheromones and related compounds |
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-
2006
- 2006-09-08 EP EP20110171585 patent/EP2383281A3/en not_active Withdrawn
- 2006-09-08 ES ES06814415T patent/ES2404940T3/es active Active
- 2006-09-08 JP JP2008530008A patent/JP5209477B2/ja not_active Expired - Fee Related
- 2006-09-08 NZ NZ566020A patent/NZ566020A/xx not_active IP Right Cessation
- 2006-09-08 AU AU2006287299A patent/AU2006287299B2/en not_active Ceased
- 2006-09-08 EP EP06814415.3A patent/EP1931695B1/en not_active Not-in-force
- 2006-09-08 CA CA002621767A patent/CA2621767A1/en not_active Abandoned
- 2006-09-08 WO PCT/US2006/035226 patent/WO2007030804A1/en not_active Ceased
- 2006-09-08 KR KR1020087008427A patent/KR20080048527A/ko not_active Abandoned
- 2006-09-08 NZ NZ594844A patent/NZ594844A/xx not_active IP Right Cessation
- 2006-09-08 BR BRPI0615618-5A patent/BRPI0615618A2/pt not_active IP Right Cessation
- 2006-09-08 CN CNA2006800331296A patent/CN101356186A/zh active Pending
- 2006-09-08 DK DK06814415.3T patent/DK1931695T3/da active
- 2006-09-08 US US11/518,091 patent/US7834144B2/en not_active Expired - Fee Related
-
2008
- 2008-03-06 IL IL189992A patent/IL189992A0/en unknown
- 2008-03-07 ZA ZA200802186A patent/ZA200802186B/xx unknown
-
2010
- 2010-10-07 US US12/924,872 patent/US20120027677A1/en not_active Abandoned
-
2012
- 2012-06-01 JP JP2012126346A patent/JP2012162571A/ja not_active Withdrawn
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