HK1245015A1 - 環肌酸及其類似物的合成 - Google Patents

環肌酸及其類似物的合成

Info

Publication number
HK1245015A1
HK1245015A1 HK18104657.6A HK18104657A HK1245015A1 HK 1245015 A1 HK1245015 A1 HK 1245015A1 HK 18104657 A HK18104657 A HK 18104657A HK 1245015 A1 HK1245015 A1 HK 1245015A1
Authority
HK
Hong Kong
Prior art keywords
cyclocreatine
analogs
synthesis
Prior art date
Application number
HK18104657.6A
Other languages
English (en)
Inventor
William R Cantrell
William E Bauta
Original Assignee
盧莫斯製藥公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 盧莫斯製藥公司 filed Critical 盧莫斯製藥公司
Publication of HK1245015A1 publication Critical patent/HK1245015A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/02—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of guanidine from cyanamide, calcium cyanamide or dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK18104657.6A 2015-03-11 2018-04-10 環肌酸及其類似物的合成 HK1245015A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562131321P 2015-03-11 2015-03-11
PCT/US2016/021947 WO2016145286A1 (en) 2015-03-11 2016-03-11 Synthesis of cyclocreatine and analogs thereof

Publications (1)

Publication Number Publication Date
HK1245015A1 true HK1245015A1 (zh) 2018-08-24

Family

ID=56879112

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18104657.6A HK1245015A1 (zh) 2015-03-11 2018-04-10 環肌酸及其類似物的合成

Country Status (8)

Country Link
US (2) US10081605B2 (zh)
EP (1) EP3267795A4 (zh)
JP (1) JP2018513122A (zh)
CN (1) CN107529753A (zh)
AU (1) AU2016228785A1 (zh)
CA (1) CA2979224A1 (zh)
HK (1) HK1245015A1 (zh)
WO (1) WO2016145286A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020123581A1 (en) 2018-12-11 2020-06-18 Sirrus, Inc. Emulsion polymers of 1,1-dicarbonyl 1-alkenes of controlled particle size

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5321030A (en) * 1989-02-14 1994-06-14 Amira, Inc. Creatine analogs having antiviral activity
CA2235350C (en) * 1994-11-08 2009-01-06 Avicena Group, Inc. Use of creatine or creatine analogs for the treatment of diseases of the nervous system
AU2003232254A1 (en) * 2003-05-02 2004-11-23 Polyphor Ag Template-fixed peptidomimetics as medicaments against hiv and cancer
US7964736B2 (en) * 2004-12-30 2011-06-21 Nour Heart, Inc. Phosphagen synthesis
KR20080048527A (ko) * 2005-09-09 2008-06-02 노파르티스 아게 프리온-특이적 펩토이드 시약
CN105308021B (zh) * 2013-06-17 2018-05-04 3M创新有限公司 用于制备胍基官能化单体的方法
CN103923014A (zh) * 2014-05-05 2014-07-16 宁夏宝马药业有限公司 环肌酸制备方法
CN107001280A (zh) * 2014-09-03 2017-08-01 卢莫斯制药公司 环肌酸及其类似物的合成

Also Published As

Publication number Publication date
US10377721B2 (en) 2019-08-13
WO2016145286A1 (en) 2016-09-15
US20180044299A1 (en) 2018-02-15
US10081605B2 (en) 2018-09-25
US20180354910A1 (en) 2018-12-13
AU2016228785A1 (en) 2017-09-28
EP3267795A4 (en) 2018-11-21
EP3267795A1 (en) 2018-01-17
JP2018513122A (ja) 2018-05-24
CN107529753A (zh) 2018-01-02
CA2979224A1 (en) 2016-09-15

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