HK1246299A1 - 製備塞內可瑞偉洛克(cenicriviroc)和相關類似物的方法 - Google Patents

製備塞內可瑞偉洛克(cenicriviroc)和相關類似物的方法

Info

Publication number
HK1246299A1
HK1246299A1 HK18105554.7A HK18105554A HK1246299A1 HK 1246299 A1 HK1246299 A1 HK 1246299A1 HK 18105554 A HK18105554 A HK 18105554A HK 1246299 A1 HK1246299 A1 HK 1246299A1
Authority
HK
Hong Kong
Prior art keywords
related analogs
cenicriviroc
making
making cenicriviroc
analogs
Prior art date
Application number
HK18105554.7A
Other languages
English (en)
Inventor
Nicholas Morra
Original Assignee
Tobira Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tobira Therapeutics Inc filed Critical Tobira Therapeutics Inc
Publication of HK1246299A1 publication Critical patent/HK1246299A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D225/00Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
HK18105554.7A 2014-12-23 2018-04-28 製備塞內可瑞偉洛克(cenicriviroc)和相關類似物的方法 HK1246299A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462096286P 2014-12-23 2014-12-23
PCT/US2015/000289 WO2016105527A1 (en) 2014-12-23 2015-12-23 Process of making cenicriviroc and related analogs

Publications (1)

Publication Number Publication Date
HK1246299A1 true HK1246299A1 (zh) 2018-09-07

Family

ID=56151264

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18105554.7A HK1246299A1 (zh) 2014-12-23 2018-04-28 製備塞內可瑞偉洛克(cenicriviroc)和相關類似物的方法

Country Status (14)

Country Link
US (2) US10526349B2 (zh)
EP (1) EP3237424A4 (zh)
JP (2) JP6716568B2 (zh)
KR (1) KR20170097735A (zh)
CN (2) CN112266392A (zh)
AU (1) AU2015371250B2 (zh)
BR (1) BR112017013130A2 (zh)
CA (1) CA2971093A1 (zh)
HK (1) HK1246299A1 (zh)
IL (2) IL252985B (zh)
MX (1) MX2017008280A (zh)
RU (2) RU2020121461A (zh)
SG (1) SG11201704837VA (zh)
WO (1) WO2016105527A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4316203B2 (ja) 2001-08-08 2009-08-19 トビラ セラピューティクス インク 二環性化合物、その製造法および用途
AU2015371250B2 (en) 2014-12-23 2021-01-28 Tobira Therapeutics, Inc. Process of making cenicriviroc and related analogs
RU2019101242A (ru) 2016-06-21 2020-07-21 Тобира Терапьютикс, Инк. Очищенный ценикривирок и очищенные промежуточные соединения для получения ценикривирока
AU2017321594A1 (en) * 2016-08-31 2019-04-18 Tobira Therapeutics, Inc. Solid forms of cenicriviroc mesylate and processes of making solid forms of cenicriviroc mesylate
US11292785B2 (en) 2018-02-02 2022-04-05 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Nitrogen-containing benzoheterocycle compound comprising carboxylic acid group, preparation method and use thereof
WO2021133811A1 (en) 2019-12-26 2021-07-01 Teva Pharmaceuticals International Gmbh Solid state forms of cenicriviroc and process for preparation thereof
JPWO2022065070A1 (zh) 2020-09-23 2022-03-31

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62265270A (ja) 1986-05-13 1987-11-18 Zeria Shinyaku Kogyo Kk 新規イミダゾ−ル誘導体およびそれらを有効成分とする抗潰瘍剤
US5716944A (en) 1994-07-04 1998-02-10 Takeda Chemical Industries, Ltd. Phosphonic acid compounds, their production and use
BR9813691A (pt) 1997-12-19 2000-10-10 Takeda Chemical Industries Ltd Composição farmacêutica para antagonizar o ccr5, uso do composto ou um sal deste em combinação com um inibidor de protease e/ou um inibidor da transcriptase reversa, e, processo para antagonizar o ccr5.
CA2337307A1 (en) 1998-08-20 2000-03-02 Osamu Nishimura Quaternary ammonium salts and their use
CA2384145A1 (en) 1999-09-06 2001-03-15 Takeda Chemical Industries, Ltd. Process for the preparation of 2,3-dihydroazepine compounds
JP4316203B2 (ja) 2001-08-08 2009-08-19 トビラ セラピューティクス インク 二環性化合物、その製造法および用途
CA2479071A1 (en) * 2002-03-12 2003-09-18 Hiroyuki Tawada Process for producing optically active sulfoxide derivative
JPWO2005089716A1 (ja) 2004-03-24 2008-01-31 武田薬品工業株式会社 高含量化製剤
US20080249147A1 (en) 2004-03-24 2008-10-09 Takeda Pharmaceutical Company Limited Emulsion-Stabilized Preparation
JP2007269628A (ja) * 2004-05-28 2007-10-18 Takeda Chem Ind Ltd 医薬化合物の結晶
WO2006059716A1 (ja) 2004-12-03 2006-06-08 Takeda Pharmaceutical Company Limited 固形製剤
SG10201510402WA (en) * 2010-11-18 2016-01-28 Univ Yale Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
WO2014085808A1 (en) * 2012-11-30 2014-06-05 The Trustees Of The University Of Pennsylvania Methods for improving thymic recovery and preventing and treating graft versus host disease using ccr2 and ccr5 antagonists
CN105263498B (zh) 2013-05-15 2019-04-26 妥必徕疗治公司 赛尼克韦罗组合物及其制备和使用方法
CA2941411A1 (en) 2014-03-21 2015-09-24 Tobira Therapeutics, Inc. Cenicriviroc for the treatment of fibrosis
AU2015371250B2 (en) 2014-12-23 2021-01-28 Tobira Therapeutics, Inc. Process of making cenicriviroc and related analogs
RU2722641C2 (ru) 2015-02-10 2020-06-02 Тобира Терапьютикс, Инк. Ценикривирок для лечения заболеваний печени и перитонита

Also Published As

Publication number Publication date
WO2016105527A1 (en) 2016-06-30
CN107207538A (zh) 2017-09-26
EP3237424A4 (en) 2018-07-04
JP6716568B2 (ja) 2020-07-01
CN112266392A (zh) 2021-01-26
AU2015371250A1 (en) 2017-07-06
IL274142A (en) 2020-06-30
CA2971093A1 (en) 2016-06-30
US20200216476A1 (en) 2020-07-09
MX2017008280A (es) 2017-12-07
RU2725888C2 (ru) 2020-07-07
AU2015371250B2 (en) 2021-01-28
US20180327428A1 (en) 2018-11-15
RU2017126215A (ru) 2019-01-24
JP2020158516A (ja) 2020-10-01
IL252985A0 (en) 2017-08-31
KR20170097735A (ko) 2017-08-28
SG11201704837VA (en) 2017-07-28
IL252985B (en) 2020-05-31
US10526349B2 (en) 2020-01-07
RU2020121461A (ru) 2020-08-03
EP3237424A1 (en) 2017-11-01
BR112017013130A2 (pt) 2017-12-26
JP2018505148A (ja) 2018-02-22
RU2017126215A3 (zh) 2019-06-06

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