HK1251580B - 製造膜聯蛋白v的方法 - Google Patents

製造膜聯蛋白v的方法

Info

Publication number
HK1251580B
HK1251580B HK18107461.5A HK18107461A HK1251580B HK 1251580 B HK1251580 B HK 1251580B HK 18107461 A HK18107461 A HK 18107461A HK 1251580 B HK1251580 B HK 1251580B
Authority
HK
Hong Kong
Prior art keywords
annexin
manufacture
Prior art date
Application number
HK18107461.5A
Other languages
English (en)
Inventor
Toomas Moks
Jan Christoph Reich
Original Assignee
Annexin Pharmaceuticals Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Annexin Pharmaceuticals Ab filed Critical Annexin Pharmaceuticals Ab
Publication of HK1251580B publication Critical patent/HK1251580B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Pain & Pain Management (AREA)
HK18107461.5A 2015-09-17 2018-06-07 製造膜聯蛋白v的方法 HK1251580B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1516516.0A GB2542391A (en) 2015-09-17 2015-09-17 Process of manufacture
PCT/EP2016/072066 WO2017046391A2 (en) 2015-09-17 2016-09-16 Process of manufacture

Publications (1)

Publication Number Publication Date
HK1251580B true HK1251580B (zh) 2019-10-18

Family

ID=54544424

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18107461.5A HK1251580B (zh) 2015-09-17 2018-06-07 製造膜聯蛋白v的方法

Country Status (11)

Country Link
US (3) US11773134B2 (zh)
EP (3) EP3453721B1 (zh)
JP (4) JP6689371B2 (zh)
CN (3) CN116333031A (zh)
CA (2) CA3036298A1 (zh)
DK (2) DK3453721T3 (zh)
ES (2) ES2699155T3 (zh)
GB (1) GB2542391A (zh)
HK (1) HK1251580B (zh)
PL (2) PL3453721T3 (zh)
WO (1) WO2017046391A2 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3495376A1 (en) * 2017-12-05 2019-06-12 ChromaCon AG Improved chromatographic process for cell culture harvest
EP3560945A1 (en) * 2018-04-27 2019-10-30 F. Hoffmann-La Roche AG Methods for purification of polypeptides using polysorbates
WO2020045290A1 (ja) * 2018-08-31 2020-03-05 株式会社カネカ 抗体または抗体様分子の精製方法
CN110669141A (zh) * 2019-09-29 2020-01-10 杭州联科生物技术股份有限公司 一种别藻蓝蛋白(APC)与Annexin V蛋白偶联方法
TW202146042A (zh) * 2020-03-06 2021-12-16 瑞典商阿斯特捷利康公司 用於治療動脈和靜脈血栓形成的協同且靶向的組成物
CN111378005B (zh) * 2020-04-03 2021-08-17 安徽环球基因科技有限公司 一种可调式纯化蛋白装置
TW202323269A (zh) * 2021-12-08 2023-06-16 荷蘭商菲林公司 方法
CN114539383B (zh) * 2022-02-24 2024-03-26 南京大学 一种人源膜联蛋白人源膜联蛋白a5突变体二聚体的晶体结构的制备方法和应用
GB202207263D0 (en) * 2022-05-18 2022-06-29 Annexin Pharmaceuticals Ab Therapeutic compositions

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3689977T2 (de) 1985-01-10 1994-10-27 Biogen Inc Dns-sequenzen, rekombinante dns-moleküle und verfahren zur herstellung menschlicher lipocortinähnlicher polypeptide.
DE3643182A1 (de) 1986-12-18 1988-06-30 Behringwerke Ag Arzneimittel enthaltend das gewebeprotein pp4, verfahren zur herstellung von pp4 und zu seiner pasteurisierung sowie die verwendung von pp4
DE3939169A1 (de) 1989-11-27 1991-05-29 Behringwerke Ag Verfahren zur reinigung von lipocortinen
DE4003773A1 (de) 1990-02-08 1991-08-14 Behringwerke Ag Verfahren zur reinigung von lipocortinen
DE4012341A1 (de) 1990-04-18 1991-10-24 Behringwerke Ag Monoklonale antikoerper gegen pp4, verfahren zu ihrer herstellung und ihre verwendung
US5968477A (en) * 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
JP2000239299A (ja) 1999-02-15 2000-09-05 Snow Brand Milk Prod Co Ltd 新規蛋白質及びその製造方法
US6492327B2 (en) * 2000-12-19 2002-12-10 Sulzer Biologics Inc. Isolation of purified TGF- β1 and TGF -β2 from bone tissue
GB0101300D0 (en) * 2001-01-18 2001-02-28 Univ Cambridge Tech Primordial germ cell genes
EP1379266B1 (en) 2001-02-21 2007-04-18 SurroMed, Inc. Modified annexin proteins and prevention and treatment of thrombosis
US7635680B2 (en) * 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
US7645739B2 (en) 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
EP1389090A2 (en) * 2001-04-26 2004-02-18 Board of Regents, The University of Texas System Diagnostic imaging compositions, their methods of synthesis and use
US6825027B2 (en) * 2001-12-10 2004-11-30 Baxter Healthcare S.A. Method of production of purified hepatitis a virus particles and vaccine preparation
CH696701A5 (de) * 2001-12-18 2007-10-15 Hoffmann La Roche Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen.
US7148049B2 (en) * 2002-04-02 2006-12-12 Roche Molecular Systems, Inc. Thermostable or thermoactive DNA polymerase molecules with attenuated 3′-5′ exonuclease activity
TW200504218A (en) 2003-03-04 2005-02-01 Smithkline Beecham Corp Methods for preventing gluconoylation of proteins
AU2005221195B2 (en) 2004-03-11 2011-05-19 Alavita Pharmaceuticals, Inc. Modified annexin proteins and methods for preventing thrombosis
DE602005018914D1 (de) * 2004-04-15 2010-03-04 Athera Biotechnologies Ab Annexin zur prävention von der ruptur des plaques
CA2573259A1 (en) * 2004-07-06 2006-02-09 Bioren Inc. High affinity anti-tnf-alpha antibodies and method
US7511016B2 (en) * 2004-07-07 2009-03-31 Mosamedix B.V. Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof
WO2006081320A2 (en) * 2005-01-27 2006-08-03 Human Genome Sciences, Inc. Pharmaceutical formulation
WO2009077764A1 (en) * 2007-12-18 2009-06-25 Athera Biotechnologies Ab Compounds and methods for the treatment of vascular disease
GB0905348D0 (en) 2009-03-27 2009-05-13 Ucl Business Plc Carrier
ES2733902T3 (es) * 2008-02-22 2019-12-03 Annexin Pharmaceuticals Ab Compuestos y procedimientos para la prevención o tratamiento de reestenosis
ITCZ20080004A1 (it) * 2008-02-26 2009-08-27 Univ Bari Anticorpo monospecifico e metodo di produzione mediante l utilizzo come antigene di un isoforma della fad sintetasi umana
EP2381958A1 (en) * 2008-10-17 2011-11-02 Tallinn University Of Technology Potato virus a coat protein-based vaccine for treating melanoma and its use
CA2740557C (en) 2008-10-17 2020-04-14 London Health Sciences Centre Research Inc. Annexin and its use to treat inflammatory disorders
AU2009328507A1 (en) * 2008-12-19 2011-07-14 Medirista Biotechnologies Ab Oxidized cardiolipin as a novel pro-inflammatory factor
AU2010254681B2 (en) * 2009-06-03 2016-08-11 Mosamedix B.V. Method for enhancing phagocytosis of phosphatidylserine-exposing cells
US20120219538A1 (en) * 2009-11-02 2012-08-30 Therapeomic Ag Stabilized protein formulations and use thereof
BR112012027793B1 (pt) * 2010-04-29 2022-10-11 Takeda Pharmaceutical Company Limited Método para a purificação de uma proteína de ligação de cátion divalente
ES2674567T3 (es) * 2010-05-21 2018-07-02 Merrimack Pharmaceuticals, Inc. Proteínas de fusión biespecíficas
CN102690345B (zh) 2011-03-24 2014-03-19 江苏靶标生物医药研究所有限公司 人膜联蛋白v变体及其表达、制备和应用
WO2012136819A1 (en) * 2011-04-05 2012-10-11 Athera Biotechnologies Ab Therapeutic and prophylactic methods, uses and compositions comprising anexin a5
ES2700933T3 (es) * 2011-10-14 2019-02-20 Baxalta GmbH Purificación de proteínas mediante cromatografía de intercambio aniónico
WO2013170272A2 (en) 2012-05-11 2013-11-14 Alexander Krantz Site-specific labeling and targeted delivery of proteins for the treatment of cancer
SI2917195T1 (en) * 2012-11-05 2018-04-30 Pfizer Inc. Spliceostatin analogues
CA2895869C (en) * 2012-12-21 2020-09-22 Glenmark Pharmaceuticals S.A. Anti her2 antibody formulation
WO2016115431A1 (en) * 2015-01-16 2016-07-21 The Johns Hopkins University Methods for enhancing antigen-specific immune responses

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