HK1254923A1 - Shishijimicin a及其類似物的全合成 - Google Patents
Shishijimicin a及其類似物的全合成Info
- Publication number
- HK1254923A1 HK1254923A1 HK18114023.2A HK18114023A HK1254923A1 HK 1254923 A1 HK1254923 A1 HK 1254923A1 HK 18114023 A HK18114023 A HK 18114023A HK 1254923 A1 HK1254923 A1 HK 1254923A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- shishijimicin
- analogs
- total synthesis
- synthesis
- total
- Prior art date
Links
- FVNYJZKDBPDHIP-UHFFFAOYSA-N shishijimicin A Natural products O1CC(NC(C)C)C(OC)CC1OC1C(O)C(SC)(C(=O)C=2C=3NC4=CC=C(O)C=C4C=3C=CN=2)C(C)OC1OC1C(C2=CCSSSC)=C(NC(=O)OC)C(=O)CC2(O)C#CC=CC#C1 FVNYJZKDBPDHIP-UHFFFAOYSA-N 0.000 title 1
- 238000006257 total synthesis reaction Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562186191P | 2015-06-29 | 2015-06-29 | |
| PCT/US2016/040047 WO2017004172A1 (en) | 2015-06-29 | 2016-06-29 | Total synthesis of shishijimicin a and analogs thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1254923A1 true HK1254923A1 (zh) | 2019-08-02 |
Family
ID=57609044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18114023.2A HK1254923A1 (zh) | 2015-06-29 | 2018-11-02 | Shishijimicin a及其類似物的全合成 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10590158B2 (zh) |
| EP (1) | EP3313389A1 (zh) |
| JP (1) | JP2018525346A (zh) |
| KR (1) | KR20180053294A (zh) |
| CN (1) | CN108348489A (zh) |
| AR (1) | AR105193A1 (zh) |
| AU (1) | AU2016286071A1 (zh) |
| BR (1) | BR112017028557A2 (zh) |
| CA (1) | CA2990206A1 (zh) |
| CL (1) | CL2017003500A1 (zh) |
| HK (1) | HK1254923A1 (zh) |
| IL (1) | IL256345A (zh) |
| MA (1) | MA42273A (zh) |
| MX (1) | MX2017016885A (zh) |
| PE (1) | PE20180658A1 (zh) |
| PH (1) | PH12018500014A1 (zh) |
| RU (1) | RU2018102808A (zh) |
| TW (1) | TW201713634A (zh) |
| WO (1) | WO2017004172A1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110357785B (zh) * | 2019-07-26 | 2020-03-24 | 东莞市领创环保材料科技有限公司 | 一种氰酸酯树脂增塑剂的制备方法 |
| CN115197188B (zh) * | 2021-04-12 | 2023-12-26 | 南开大学 | 一类具有五环骨架的倍半萜氢醌化合物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264586A (en) | 1991-07-17 | 1993-11-23 | The Scripps Research Institute | Analogs of calicheamicin gamma1I, method of making and using the same |
| US5261586A (en) * | 1992-03-26 | 1993-11-16 | Chen Jen Fu | Yarn feeding device with a guiding flange |
| US5550246A (en) * | 1994-09-07 | 1996-08-27 | The Scripps Research Institute | Calicheamicin mimics |
| JP2003238584A (ja) * | 2002-02-08 | 2003-08-27 | Yamanouchi Pharmaceut Co Ltd | 新規エンジイン化合物 |
| AR048098A1 (es) * | 2004-03-15 | 2006-03-29 | Wyeth Corp | Conjugados de caliqueamicina |
| WO2014080251A1 (en) * | 2012-11-24 | 2014-05-30 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
-
2016
- 2016-06-29 RU RU2018102808A patent/RU2018102808A/ru not_active Application Discontinuation
- 2016-06-29 JP JP2017568032A patent/JP2018525346A/ja active Pending
- 2016-06-29 MA MA042273A patent/MA42273A/fr unknown
- 2016-06-29 CN CN201680050079.6A patent/CN108348489A/zh active Pending
- 2016-06-29 AR ARP160101973A patent/AR105193A1/es unknown
- 2016-06-29 MX MX2017016885A patent/MX2017016885A/es unknown
- 2016-06-29 TW TW105120685A patent/TW201713634A/zh unknown
- 2016-06-29 BR BR112017028557A patent/BR112017028557A2/pt not_active IP Right Cessation
- 2016-06-29 KR KR1020187002549A patent/KR20180053294A/ko unknown
- 2016-06-29 WO PCT/US2016/040047 patent/WO2017004172A1/en active Application Filing
- 2016-06-29 CA CA2990206A patent/CA2990206A1/en not_active Abandoned
- 2016-06-29 US US15/740,656 patent/US10590158B2/en active Active
- 2016-06-29 EP EP16818662.5A patent/EP3313389A1/en not_active Withdrawn
- 2016-06-29 PE PE2017002877A patent/PE20180658A1/es unknown
- 2016-06-29 AU AU2016286071A patent/AU2016286071A1/en not_active Abandoned
-
2017
- 2017-12-17 IL IL256345A patent/IL256345A/en unknown
- 2017-12-29 CL CL2017003500A patent/CL2017003500A1/es unknown
-
2018
- 2018-01-03 PH PH12018500014A patent/PH12018500014A1/en unknown
- 2018-11-02 HK HK18114023.2A patent/HK1254923A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20180327439A1 (en) | 2018-11-15 |
| PE20180658A1 (es) | 2018-04-17 |
| BR112017028557A2 (pt) | 2018-09-04 |
| WO2017004172A8 (en) | 2018-01-11 |
| CN108348489A (zh) | 2018-07-31 |
| US10590158B2 (en) | 2020-03-17 |
| RU2018102808A3 (zh) | 2020-04-30 |
| AU2016286071A8 (en) | 2019-08-08 |
| AU2016286071A1 (en) | 2018-02-01 |
| TW201713634A (zh) | 2017-04-16 |
| IL256345A (en) | 2018-02-28 |
| EP3313389A1 (en) | 2018-05-02 |
| CA2990206A1 (en) | 2017-01-05 |
| MA42273A (fr) | 2018-05-02 |
| KR20180053294A (ko) | 2018-05-21 |
| WO2017004172A1 (en) | 2017-01-05 |
| JP2018525346A (ja) | 2018-09-06 |
| PH12018500014A1 (en) | 2018-07-09 |
| CL2017003500A1 (es) | 2018-04-27 |
| MX2017016885A (es) | 2018-09-06 |
| AR105193A1 (es) | 2017-09-13 |
| RU2018102808A (ru) | 2019-07-30 |
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