SG10202111790YA - Synthesis of omecamtiv mecarbil - Google Patents
Synthesis of omecamtiv mecarbilInfo
- Publication number
- SG10202111790YA SG10202111790YA SG10202111790YA SG10202111790YA SG10202111790YA SG 10202111790Y A SG10202111790Y A SG 10202111790YA SG 10202111790Y A SG10202111790Y A SG 10202111790YA SG 10202111790Y A SG10202111790Y A SG 10202111790YA SG 10202111790Y A SG10202111790Y A SG 10202111790YA
- Authority
- SG
- Singapore
- Prior art keywords
- synthesis
- omecamtiv mecarbil
- mecarbil
- omecamtiv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762527174P | 2017-06-30 | 2017-06-30 | |
| US201862664363P | 2018-04-30 | 2018-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10202111790YA true SG10202111790YA (en) | 2021-12-30 |
Family
ID=62976317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202111790YA SG10202111790YA (en) | 2017-06-30 | 2018-06-29 | Synthesis of omecamtiv mecarbil |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US11040956B2 (en) |
| EP (3) | EP4265597A3 (en) |
| JP (2) | JP7181896B2 (en) |
| KR (1) | KR102625774B1 (en) |
| CN (1) | CN110799503B (en) |
| AU (2) | AU2018294254C1 (en) |
| BR (1) | BR112019028205A2 (en) |
| CA (1) | CA3063102A1 (en) |
| CL (2) | CL2019003898A1 (en) |
| CY (1) | CY1124427T1 (en) |
| DK (1) | DK3645518T3 (en) |
| ES (1) | ES2882905T3 (en) |
| GE (1) | GEP20227340B (en) |
| HR (1) | HRP20211290T1 (en) |
| HU (1) | HUE055242T2 (en) |
| IL (2) | IL294834A (en) |
| LT (1) | LT3645518T (en) |
| MD (1) | MD3645518T2 (en) |
| MX (2) | MX2021013326A (en) |
| PL (1) | PL3645518T3 (en) |
| PT (1) | PT3645518T (en) |
| RS (1) | RS62328B1 (en) |
| SG (1) | SG10202111790YA (en) |
| SI (1) | SI3645518T1 (en) |
| TW (2) | TWI769272B (en) |
| UA (1) | UA127517C2 (en) |
| WO (1) | WO2019006231A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3821882A1 (en) | 2013-03-14 | 2021-05-19 | Amgen Inc. | Heterocyclic compounds and their uses |
| EP3645002A1 (en) | 2017-06-30 | 2020-05-06 | Amgen Inc. | Methods of treating heart failure with cardiac sarcomere activators |
| EP4265597A3 (en) | 2017-06-30 | 2023-11-22 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
| AR112804A1 (en) | 2017-09-13 | 2019-12-11 | Amgen Inc | BISAMIDE COMPOUNDS THAT ACTIVATE THE SARCOMER AND ITS USES |
| EP3837009A1 (en) | 2018-08-17 | 2021-06-23 | Amgen, Inc | Salts and crystal forms of omecamtiv mecarbil |
| US20220402874A1 (en) * | 2019-10-09 | 2022-12-22 | Dr. Reddy's Laboratories Limited | Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof |
| US20220411374A1 (en) * | 2019-10-09 | 2022-12-29 | Dr. Reddy's Laboratories Limited | Alternate processes for the preparation of omecamtiv mecarbil |
| TW202300479A (en) | 2021-03-10 | 2023-01-01 | 美商安進公司 | Synthesis of omecamtiv mecarbil |
| WO2023205291A2 (en) * | 2022-04-21 | 2023-10-26 | The Board Of Regents Of The University Of Oklahoma | Targeting myocardial tissue for delivery of therapeutic and imaging agents |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6492529B1 (en) * | 2000-01-18 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Bis pyrazole-1H-pyrazole intermediates and their synthesis |
| RU2410384C2 (en) | 2004-06-17 | 2011-01-27 | Цитокинетикс, Инк. | Compounds, compositions and methods of their application |
| AR058347A1 (en) | 2005-12-15 | 2008-01-30 | Cytokinetics Inc | ENTITIES CHEMIES COMPOSITIONS AND METHODS |
| US20070208000A1 (en) | 2005-12-15 | 2007-09-06 | Morgan Bradley P | Certain chemical entities, compositions and methods |
| JP5178526B2 (en) * | 2005-12-19 | 2013-04-10 | サイトキネティクス・インコーポレーテッド | Compounds, compositions and methods |
| CA2663984C (en) * | 2006-10-18 | 2012-02-21 | Pfizer Products Inc. | Biaryl ether urea compounds |
| US20090192168A1 (en) | 2008-01-04 | 2009-07-30 | Alex Muci | Compounds, Compositions and Methods |
| US20120083476A1 (en) * | 2009-06-05 | 2012-04-05 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
| US9895308B2 (en) | 2013-03-14 | 2018-02-20 | Amgen Inc. | Heterocyclic compounds and their uses |
| EP3821882A1 (en) * | 2013-03-14 | 2021-05-19 | Amgen Inc. | Heterocyclic compounds and their uses |
| KR101885448B1 (en) | 2014-03-31 | 2018-08-03 | 가부시키가이샤 메테크 | Blood purification device and fluid replacement/priming method for blood purification device |
| AU2015353073B2 (en) * | 2014-11-24 | 2018-04-19 | Medifron Dbt Inc. | Substituted oxazole- and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands II |
| EP3250557A4 (en) | 2015-01-29 | 2018-06-20 | Signal Pharmaceuticals, LLC | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| CA2988796A1 (en) | 2015-06-26 | 2016-12-29 | Amgen Inc. | Combination therapy of cardiac myosin activator and sinus node if current inhibitor |
| EP3645002A1 (en) | 2017-06-30 | 2020-05-06 | Amgen Inc. | Methods of treating heart failure with cardiac sarcomere activators |
| EP4265597A3 (en) | 2017-06-30 | 2023-11-22 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
| ES2815899T3 (en) | 2018-07-09 | 2021-03-31 | Fis Fabbrica Italiana Sintetici Spa | 2-Fluoro-3-crystalline nitrotoluene and procedure for its preparation |
| EP3837009A1 (en) | 2018-08-17 | 2021-06-23 | Amgen, Inc | Salts and crystal forms of omecamtiv mecarbil |
| US20220042055A1 (en) | 2018-12-18 | 2022-02-10 | Amgen Inc. | Method of reducing aromatic nitro compounds |
| US20220411374A1 (en) | 2019-10-09 | 2022-12-29 | Dr. Reddy's Laboratories Limited | Alternate processes for the preparation of omecamtiv mecarbil |
| EP4103159A1 (en) | 2020-02-10 | 2022-12-21 | Amgen Inc. | Omecamtiv mecarbil tablet |
| JP2024500616A (en) | 2020-11-12 | 2024-01-10 | アムジェン インコーポレイテッド | Method of treating heart failure by administering omecamtibumecarbil |
| TW202300479A (en) | 2021-03-10 | 2023-01-01 | 美商安進公司 | Synthesis of omecamtiv mecarbil |
-
2018
- 2018-06-29 EP EP23189293.6A patent/EP4265597A3/en active Pending
- 2018-06-29 SG SG10202111790YA patent/SG10202111790YA/en unknown
- 2018-06-29 HU HUE18743314A patent/HUE055242T2/en unknown
- 2018-06-29 ES ES18743314T patent/ES2882905T3/en active Active
- 2018-06-29 CA CA3063102A patent/CA3063102A1/en active Pending
- 2018-06-29 IL IL294834A patent/IL294834A/en unknown
- 2018-06-29 GE GEAP201815258A patent/GEP20227340B/en unknown
- 2018-06-29 MX MX2021013326A patent/MX2021013326A/en unknown
- 2018-06-29 AU AU2018294254A patent/AU2018294254C1/en active Active
- 2018-06-29 LT LTEP18743314.9T patent/LT3645518T/en unknown
- 2018-06-29 JP JP2019561794A patent/JP7181896B2/en active Active
- 2018-06-29 IL IL270663A patent/IL270663B/en unknown
- 2018-06-29 BR BR112019028205-0A patent/BR112019028205A2/en unknown
- 2018-06-29 EP EP21174262.2A patent/EP3925950B1/en active Active
- 2018-06-29 PT PT187433149T patent/PT3645518T/en unknown
- 2018-06-29 UA UAA202000509A patent/UA127517C2/en unknown
- 2018-06-29 MD MDE20200486T patent/MD3645518T2/en unknown
- 2018-06-29 CN CN201880043674.6A patent/CN110799503B/en active Active
- 2018-06-29 TW TW107122465A patent/TWI769272B/en active
- 2018-06-29 US US16/607,940 patent/US11040956B2/en active Active
- 2018-06-29 EP EP18743314.9A patent/EP3645518B1/en active Active
- 2018-06-29 DK DK18743314.9T patent/DK3645518T3/en active
- 2018-06-29 PL PL18743314T patent/PL3645518T3/en unknown
- 2018-06-29 MX MX2021009594A patent/MX2021009594A/en unknown
- 2018-06-29 TW TW111120441A patent/TW202235415A/en unknown
- 2018-06-29 WO PCT/US2018/040176 patent/WO2019006231A1/en active Application Filing
- 2018-06-29 SI SI201830350T patent/SI3645518T1/en unknown
- 2018-06-29 RS RS20210965A patent/RS62328B1/en unknown
- 2018-06-29 KR KR1020207001578A patent/KR102625774B1/en active IP Right Grant
-
2019
- 2019-12-30 CL CL2019003898A patent/CL2019003898A1/en unknown
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2021
- 2021-05-19 US US17/324,867 patent/US11753394B2/en active Active
- 2021-08-10 CY CY20211100714T patent/CY1124427T1/en unknown
- 2021-08-11 HR HRP20211290TT patent/HRP20211290T1/en unknown
- 2021-08-16 CL CL2021002167A patent/CL2021002167A1/en unknown
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2022
- 2022-06-29 AU AU2022204648A patent/AU2022204648A1/en active Pending
- 2022-08-19 JP JP2022130911A patent/JP2022166243A/en active Pending
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2023
- 2023-07-26 US US18/359,467 patent/US20230373955A1/en active Pending
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