JP2009504676A5 - - Google Patents
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- Publication number
- JP2009504676A5 JP2009504676A5 JP2008526279A JP2008526279A JP2009504676A5 JP 2009504676 A5 JP2009504676 A5 JP 2009504676A5 JP 2008526279 A JP2008526279 A JP 2008526279A JP 2008526279 A JP2008526279 A JP 2008526279A JP 2009504676 A5 JP2009504676 A5 JP 2009504676A5
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- JP
- Japan
- Prior art keywords
- compound
- ring
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- compound according
- size
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 12
- 125000003003 spiro group Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 208000020685 sleep-wake disease Diseases 0.000 claims 2
- YQOLEILXOBUDMU-KRWDZBQOSA-N (4R)-5-[(6-bromo-3-methyl-2-pyrrolidin-1-ylquinoline-4-carbonyl)amino]-4-(2-chlorophenyl)pentanoic acid Chemical compound CC1=C(C2=C(C=CC(=C2)Br)N=C1N3CCCC3)C(=O)NC[C@H](CCC(=O)O)C4=CC=CC=C4Cl YQOLEILXOBUDMU-KRWDZBQOSA-N 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 229940125844 compound 46 Drugs 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- MXZWCVKSYUXGOK-UHFFFAOYSA-N CC(C)(CN(CC1)CCN1C1=Nc(cccc2)c2Nc2c1cc(C)[s]2)C(O)=O Chemical compound CC(C)(CN(CC1)CCN1C1=Nc(cccc2)c2Nc2c1cc(C)[s]2)C(O)=O MXZWCVKSYUXGOK-UHFFFAOYSA-N 0.000 description 2
- 0 Cc1c(*)c(C(N2CCN(CC(*)(*)*)CC2)=Nc(cc(*)c(*)c2)c2N2)c2[s]1 Chemical compound Cc1c(*)c(C(N2CCN(CC(*)(*)*)CC2)=Nc(cc(*)c(*)c2)c2N2)c2[s]1 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70736805P | 2005-08-11 | 2005-08-11 | |
| US11/502,789 US7807828B2 (en) | 2005-08-11 | 2006-08-10 | Olanzapine analogs and methods of use thereof |
| PCT/US2006/031602 WO2007022068A1 (en) | 2005-08-11 | 2006-08-11 | Olanzapine analogs and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009504676A JP2009504676A (ja) | 2009-02-05 |
| JP2009504676A5 true JP2009504676A5 (enExample) | 2009-09-24 |
Family
ID=37460090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008526279A Pending JP2009504676A (ja) | 2005-08-11 | 2006-08-11 | オランザピンアナログ及びその使用法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7807828B2 (enExample) |
| EP (1) | EP1915379B1 (enExample) |
| JP (1) | JP2009504676A (enExample) |
| AT (1) | ATE448234T1 (enExample) |
| CA (1) | CA2617107C (enExample) |
| DE (1) | DE602006010400D1 (enExample) |
| ES (1) | ES2333983T3 (enExample) |
| WO (1) | WO2007022068A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200701065A1 (ru) * | 2004-11-16 | 2007-12-28 | Элан Фарма Интернэшнл Лтд. | Инъецируемые составы, содержащие нанодисперсный оланзапин |
| WO2007092333A1 (en) * | 2006-02-03 | 2007-08-16 | Hypnion, Inc. | Use of olopatadine for treating sleep disorders |
| WO2008050341A2 (en) * | 2006-10-25 | 2008-05-02 | Ramot At Tel-Aviv University Ltd | Novel psychotropic agents having glutamate nmda activity |
| JP2011506441A (ja) * | 2007-12-12 | 2011-03-03 | アムジエン・インコーポレーテツド | グリシン輸送体−１阻害薬 |
| AR084867A1 (es) * | 2011-02-07 | 2013-07-10 | Lilly Co Eli | Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual |
| PL395468A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego |
| DK2729474T3 (en) | 2011-07-08 | 2018-05-22 | Lilly Co Eli | (THIENO [2,3-b] [1,5] BENZOXAZEPIN-4-YL) PIPERAZIN-1-YL COMPOUNDS AS H1-INVERSE AGONISTS / 5-HT2A DOUBLE EFFECTS |
| AU2012300451B2 (en) * | 2011-08-30 | 2016-10-13 | Eli Lilly And Company | (thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity H1 inverse agonists/5-HT 2A antagonists |
| PL2943498T3 (pl) | 2013-01-14 | 2018-01-31 | Lilly Co Eli | Związki (tieno[2,3-b][1,5]benzoksazepin-4-ylo)piperazyn-1-ylowe jako odwrotni agoniści h1 / antagoniści 5-ht2a o podwójnej aktywności |
| TW201625644A (zh) | 2014-04-29 | 2016-07-16 | 美國禮來大藥廠 | 作為選擇性５－ＨＴＡ反向促效劑之（噻吩并［２，３－ｂ］［１，５］苯并氧氮呯－４－基）哌嗪－１－基化合物 |
| AU2019205329B2 (en) * | 2018-01-05 | 2023-04-20 | Impel Pharmaceuticals Inc. | Intranasal delivery of olanzapine by precision olfactory device |
| AU2020370063B2 (en) * | 2019-10-21 | 2025-10-23 | Alairion, Inc. | 3-(4-(11H-dibenzo[b,e][1,4]azepin-6-yl)piperazin-1-yl)- and 3-(4-(dibenzo[b,f][1,4]oxazepin/thiazepin/diazepin-11-yl)piperazin-1-yl)-propanoic acid derivatives as H1 and 5-HT2A-receptor modulators for the treatment of sleep disorders |
| CN114685527B (zh) * | 2020-12-25 | 2024-03-05 | 长沙博源医疗科技有限公司 | 一种奥氮平衍生物、免疫原、抗奥氮平特异性抗体及其制备方法与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04211071A (ja) * | 1990-03-05 | 1992-08-03 | Hokuriku Seiyaku Co Ltd | 多環式化合物 |
| US5602124A (en) | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | 5-HT2 receptor ligands |
| US5744470A (en) * | 1996-03-11 | 1998-04-28 | Eli Lilly And Company | Method for treating insomnia |
| US6271225B1 (en) | 1997-09-02 | 2001-08-07 | Welfide Corporation | Fused thiophene compounds and medicinal use thereof |
| US7355042B2 (en) | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
| JP2005529840A (ja) * | 2001-10-16 | 2005-10-06 | ヒプニオン， インコーポレイテッド | Ｃｎｓ標的モジュレータを使用するｃｎｓ障害の治療 |
| JP2007505106A (ja) | 2003-09-09 | 2007-03-08 | イーライ リリー アンド カンパニー | アゼピン、オキサゼピン、およびチアゼピンの置換ピペラジン |
-
2006
- 2006-08-10 US US11/502,789 patent/US7807828B2/en not_active Expired - Fee Related
- 2006-08-11 JP JP2008526279A patent/JP2009504676A/ja active Pending
- 2006-08-11 DE DE602006010400T patent/DE602006010400D1/de active Active
- 2006-08-11 AT AT06801404T patent/ATE448234T1/de not_active IP Right Cessation
- 2006-08-11 CA CA2617107A patent/CA2617107C/en not_active Expired - Fee Related
- 2006-08-11 ES ES06801404T patent/ES2333983T3/es active Active
- 2006-08-11 WO PCT/US2006/031602 patent/WO2007022068A1/en not_active Ceased
- 2006-08-11 EP EP06801404A patent/EP1915379B1/en not_active Not-in-force
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