CA2617107C - Olanzapine analogs and methods of use thereof - Google Patents
Olanzapine analogs and methods of use thereof Download PDFInfo
- Publication number
- CA2617107C CA2617107C CA2617107A CA2617107A CA2617107C CA 2617107 C CA2617107 C CA 2617107C CA 2617107 A CA2617107 A CA 2617107A CA 2617107 A CA2617107 A CA 2617107A CA 2617107 C CA2617107 C CA 2617107C
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- Prior art keywords
- thieno
- piperazin
- benzodiazepin
- compound
- dimethyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70736805P | 2005-08-11 | 2005-08-11 | |
| US60/707,368 | 2005-08-11 | ||
| US11/502,789 | 2006-08-10 | ||
| US11/502,789 US7807828B2 (en) | 2005-08-11 | 2006-08-10 | Olanzapine analogs and methods of use thereof |
| PCT/US2006/031602 WO2007022068A1 (en) | 2005-08-11 | 2006-08-11 | Olanzapine analogs and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2617107A1 CA2617107A1 (en) | 2007-02-22 |
| CA2617107C true CA2617107C (en) | 2014-07-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2617107A Expired - Fee Related CA2617107C (en) | 2005-08-11 | 2006-08-11 | Olanzapine analogs and methods of use thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7807828B2 (enExample) |
| EP (1) | EP1915379B1 (enExample) |
| JP (1) | JP2009504676A (enExample) |
| AT (1) | ATE448234T1 (enExample) |
| CA (1) | CA2617107C (enExample) |
| DE (1) | DE602006010400D1 (enExample) |
| ES (1) | ES2333983T3 (enExample) |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2623095A1 (en) * | 2004-11-16 | 2013-08-07 | Elan Pharma International Limited | Injectable nanoparticulate olanzapine formulations |
| WO2007092333A1 (en) * | 2006-02-03 | 2007-08-16 | Hypnion, Inc. | Use of olopatadine for treating sleep disorders |
| EP2077860B1 (en) | 2006-10-25 | 2014-04-09 | Ramot at Tel-Aviv University Ltd | Psychotropic agents having glutamate nmda activity |
| AU2008335788B2 (en) * | 2007-12-12 | 2012-11-29 | Amgen Inc. | Glycine transporter-1 inhibitors |
| AR084867A1 (es) * | 2011-02-07 | 2013-07-10 | Lilly Co Eli | Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual |
| PL395468A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego |
| NO2729474T3 (enExample) * | 2011-07-08 | 2018-08-11 | ||
| BR112014004557A2 (pt) * | 2011-08-30 | 2017-05-30 | Lilly Co Eli | compostos (tieno[2,3-b][1,5]benzoxazepin-4-il)piperazin-1-ila como agonistas inversos de h1/antagonistas de 5-ht2a de dupla atividade |
| HUE037363T2 (hu) | 2013-01-14 | 2018-08-28 | Lilly Co Eli | Kettõs aktivitású H1 inverz agonista/5-HT2A antagonista (tieno[2,3-b][1,5]-benzoxazepin-4-il)piperazin-1-il vegyületek |
| TW201625644A (zh) | 2014-04-29 | 2016-07-16 | 美國禮來大藥廠 | 作為選擇性５－ＨＴＡ反向促效劑之（噻吩并［２，３－ｂ］［１，５］苯并氧氮呯－４－基）哌嗪－１－基化合物 |
| EP3735223A4 (en) * | 2018-01-05 | 2021-10-13 | Impel Neuropharma Inc. | INTRANASAL ADMINISTRATION OF OLANZAPINE BY A PRECISION OLFACTORY DEVICE |
| CN114929688B (zh) * | 2019-10-21 | 2024-11-01 | 阿莱瑞恩公司 | 作为H1和5-HT2A-受体调节剂、用于治疗睡眠障碍的3-(4-(11H-二苯并[b,e][1,4]吖庚英-6-基)哌嗪-1-基)-和3-(4-(二苯并[b,f][1,4]氧杂吖庚英/硫杂吖庚英/二吖庚英-11-基)哌嗪-1-基)-丙酸衍生物 |
| CN114685527B (zh) * | 2020-12-25 | 2024-03-05 | 长沙博源医疗科技有限公司 | 一种奥氮平衍生物、免疫原、抗奥氮平特异性抗体及其制备方法与应用 |
Family Cites Families (7)
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| JPH04211071A (ja) * | 1990-03-05 | 1992-08-03 | Hokuriku Seiyaku Co Ltd | 多環式化合物 |
| US5602124A (en) | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | 5-HT2 receptor ligands |
| US5744470A (en) * | 1996-03-11 | 1998-04-28 | Eli Lilly And Company | Method for treating insomnia |
| AU739385B2 (en) | 1997-09-02 | 2001-10-11 | Mitsubishi Pharma Corporation | Condensed thiophene compounds and pharmaceutical use thereof |
| US7355042B2 (en) | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
| US20050009730A1 (en) * | 2001-10-16 | 2005-01-13 | Dale Edgar | Treatment of cns disorders using cns target modulators |
| CA2536107A1 (en) | 2003-09-09 | 2005-03-24 | Eli Lilly And Company | Substituted piperazines of azepines, oxazepines, and thiazepines |
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- 2006-08-11 EP EP06801404A patent/EP1915379B1/en not_active Expired - Lifetime
- 2006-08-11 WO PCT/US2006/031602 patent/WO2007022068A1/en not_active Ceased
- 2006-08-11 CA CA2617107A patent/CA2617107C/en not_active Expired - Fee Related
- 2006-08-11 JP JP2008526279A patent/JP2009504676A/ja active Pending
- 2006-08-11 AT AT06801404T patent/ATE448234T1/de not_active IP Right Cessation
- 2006-08-11 ES ES06801404T patent/ES2333983T3/es not_active Expired - Lifetime
- 2006-08-11 DE DE602006010400T patent/DE602006010400D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2333983T3 (es) | 2010-03-03 |
| WO2007022068A1 (en) | 2007-02-22 |
| JP2009504676A (ja) | 2009-02-05 |
| EP1915379B1 (en) | 2009-11-11 |
| DE602006010400D1 (de) | 2009-12-24 |
| US7807828B2 (en) | 2010-10-05 |
| US20070043021A1 (en) | 2007-02-22 |
| CA2617107A1 (en) | 2007-02-22 |
| EP1915379A1 (en) | 2008-04-30 |
| ATE448234T1 (de) | 2009-11-15 |
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