ES2333983T3 - Analogos de olanzapina y procedimientos de uso de los mismos. - Google Patents

Analogos de olanzapina y procedimientos de uso de los mismos. Download PDF

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Publication number
ES2333983T3
ES2333983T3 ES06801404T ES06801404T ES2333983T3 ES 2333983 T3 ES2333983 T3 ES 2333983T3 ES 06801404 T ES06801404 T ES 06801404T ES 06801404 T ES06801404 T ES 06801404T ES 2333983 T3 ES2333983 T3 ES 2333983T3
Authority
ES
Spain
Prior art keywords
sleep
compound
compounds
baselineskip
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES06801404T
Other languages
English (en)
Spanish (es)
Inventor
James F. White
Kazumi Shiosaki
David G. Hangauer
Michael Solomon
Dale M. Edgar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hypnion Inc
Original Assignee
Hypnion Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hypnion Inc filed Critical Hypnion Inc
Application granted granted Critical
Publication of ES2333983T3 publication Critical patent/ES2333983T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES06801404T 2005-08-11 2006-08-11 Analogos de olanzapina y procedimientos de uso de los mismos. Expired - Lifetime ES2333983T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70736805P 2005-08-11 2005-08-11
US707368P 2005-08-11
US502789 2006-08-10
US11/502,789 US7807828B2 (en) 2005-08-11 2006-08-10 Olanzapine analogs and methods of use thereof

Publications (1)

Publication Number Publication Date
ES2333983T3 true ES2333983T3 (es) 2010-03-03

Family

ID=37460090

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06801404T Expired - Lifetime ES2333983T3 (es) 2005-08-11 2006-08-11 Analogos de olanzapina y procedimientos de uso de los mismos.

Country Status (8)

Country Link
US (1) US7807828B2 (enExample)
EP (1) EP1915379B1 (enExample)
JP (1) JP2009504676A (enExample)
AT (1) ATE448234T1 (enExample)
CA (1) CA2617107C (enExample)
DE (1) DE602006010400D1 (enExample)
ES (1) ES2333983T3 (enExample)
WO (1) WO2007022068A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2623095A1 (en) * 2004-11-16 2013-08-07 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
WO2007092333A1 (en) * 2006-02-03 2007-08-16 Hypnion, Inc. Use of olopatadine for treating sleep disorders
EP2077860B1 (en) 2006-10-25 2014-04-09 Ramot at Tel-Aviv University Ltd Psychotropic agents having glutamate nmda activity
AU2008335788B2 (en) * 2007-12-12 2012-11-29 Amgen Inc. Glycine transporter-1 inhibitors
AR084867A1 (es) * 2011-02-07 2013-07-10 Lilly Co Eli Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual
PL395468A1 (pl) 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego
NO2729474T3 (enExample) * 2011-07-08 2018-08-11
BR112014004557A2 (pt) * 2011-08-30 2017-05-30 Lilly Co Eli compostos (tieno[2,3-b][1,5]benzoxazepin-4-il)piperazin-1-ila como agonistas inversos de h1/antagonistas de 5-ht2a de dupla atividade
HUE037363T2 (hu) 2013-01-14 2018-08-28 Lilly Co Eli Kettõs aktivitású H1 inverz agonista/5-HT2A antagonista (tieno[2,3-b][1,5]-benzoxazepin-4-il)piperazin-1-il vegyületek
TW201625644A (zh) 2014-04-29 2016-07-16 美國禮來大藥廠 作為選擇性５－ＨＴＡ反向促效劑之（噻吩并［２，３－ｂ］［１，５］苯并氧氮呯－４－基）哌嗪－１－基化合物
EP3735223A4 (en) * 2018-01-05 2021-10-13 Impel Neuropharma Inc. INTRANASAL ADMINISTRATION OF OLANZAPINE BY A PRECISION OLFACTORY DEVICE
CN114929688B (zh) * 2019-10-21 2024-11-01 阿莱瑞恩公司 作为H1和5-HT2A-受体调节剂、用于治疗睡眠障碍的3-(4-(11H-二苯并[b,e][1,4]吖庚英-6-基)哌嗪-1-基)-和3-(4-(二苯并[b,f][1,4]氧杂吖庚英/硫杂吖庚英/二吖庚英-11-基)哌嗪-1-基)-丙酸衍生物
CN114685527B (zh) * 2020-12-25 2024-03-05 长沙博源医疗科技有限公司 一种奥氮平衍生物、免疫原、抗奥氮平特异性抗体及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04211071A (ja) * 1990-03-05 1992-08-03 Hokuriku Seiyaku Co Ltd 多環式化合物
US5602124A (en) 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
US5744470A (en) * 1996-03-11 1998-04-28 Eli Lilly And Company Method for treating insomnia
AU739385B2 (en) 1997-09-02 2001-10-11 Mitsubishi Pharma Corporation Condensed thiophene compounds and pharmaceutical use thereof
US7355042B2 (en) 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
US20050009730A1 (en) * 2001-10-16 2005-01-13 Dale Edgar Treatment of cns disorders using cns target modulators
CA2536107A1 (en) 2003-09-09 2005-03-24 Eli Lilly And Company Substituted piperazines of azepines, oxazepines, and thiazepines

Also Published As

Publication number Publication date
CA2617107C (en) 2014-07-08
WO2007022068A1 (en) 2007-02-22
JP2009504676A (ja) 2009-02-05
EP1915379B1 (en) 2009-11-11
DE602006010400D1 (de) 2009-12-24
US7807828B2 (en) 2010-10-05
US20070043021A1 (en) 2007-02-22
CA2617107A1 (en) 2007-02-22
EP1915379A1 (en) 2008-04-30
ATE448234T1 (de) 2009-11-15

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