|
GB753166A
(en)
|
1953-05-22 |
1956-07-18 |
Miles Lab |
Improvements in or relating to substituted piperazines
|
|
US2993899A
(en)
*
|
1958-03-31 |
1961-07-25 |
Miles Lab |
Acetylenically unsaturated piperazine derivatives
|
|
US3309370A
(en)
*
|
1964-07-16 |
1967-03-14 |
Miles Lab |
Bicycloalkyl piperazine derivatives and process
|
|
GB1293565A
(en)
*
|
1969-05-03 |
1972-10-18 |
Aspro Nicholas Ltd |
Aminophthalazines and pharmaceutical compositions thereof
|
|
US3886161A
(en)
|
1970-12-14 |
1975-05-27 |
Sandoz Ag |
2-Piperazino-3-cyano-5-phenyl-pyridines
|
|
GB1345880A
(en)
|
1971-06-18 |
1974-02-06 |
Cepbepe |
Pyridazine derivatives
|
|
DE2516040C2
(de)
*
|
1974-06-10 |
1984-12-20 |
Dr. Karl Thomae Gmbh, 7950 Biberach |
Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
|
|
FR2306694A1
(fr)
|
1975-04-07 |
1976-11-05 |
Parcor |
Derives de la piperazine
|
|
US3986161A
(en)
*
|
1975-04-07 |
1976-10-12 |
Sea-Scan, Inc. |
Underwater directional guidance apparatus
|
|
GB1545094A
(en)
*
|
1976-12-14 |
1979-05-02 |
Gist Brocades Nv |
Piperazine derivatives
|
|
US4144346A
(en)
*
|
1977-01-31 |
1979-03-13 |
Janssen Pharmaceutica N.V. |
Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
|
|
HU175471B
(hu)
*
|
1977-06-13 |
1980-08-28 |
Gyogyszerkutato Intezet |
Sposob poluchenija novykh proizvodnykh 3-skobka-1-pirazolil-skobka zakryta-piridazina
|
|
US4163849A
(en)
*
|
1978-03-17 |
1979-08-07 |
Merck & Co., Inc. |
Piperazinylpyrazines
|
|
DE2824764A1
(de)
|
1978-06-06 |
1979-12-20 |
Hoechst Ag |
Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung
|
|
EP0034752B1
(en)
|
1980-02-22 |
1983-06-08 |
Tanabe Seiyaku Co., Ltd. |
Phenoxyalkane derivative and processes for preparing same
|
|
US4339579A
(en)
*
|
1980-12-29 |
1982-07-13 |
American Home Products Corporation |
2,6-Bis-(pyrrolopyrazinyl)pyrazines
|
|
US4616014A
(en)
*
|
1981-10-22 |
1986-10-07 |
Fujisawa Pharmaceutical Co., Ltd. |
Triazine derivatives, and pharmaceutical compositions comprising the same
|
|
US5001125A
(en)
*
|
1984-03-26 |
1991-03-19 |
Janssen Pharmaceutica N.V. |
Anti-virally active pyridazinamines
|
|
FR2573075B1
(fr)
*
|
1984-09-14 |
1987-03-20 |
Innothera Lab Sa |
Nouvelles (pyridyl-2)-1 piperazines, leur procede de preparation et leur application en therapeutique
|
|
WO1986003198A1
(fr)
*
|
1984-11-27 |
1986-06-05 |
Dainippon Pharmaceutical Co., Ltd. |
Derives de 2-(1-piperazinyle)-4-substitue phenylquinoline, procede de preparation et composition medicinale les contenant
|
|
PH25772A
(en)
|
1985-08-30 |
1991-10-18 |
Novo Industri As |
Insulin analogues, process for their preparation
|
|
DK111387A
(da)
|
1986-03-05 |
1987-09-06 |
Otsuka Pharma Co Ltd |
Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne
|
|
DE3609596A1
(de)
*
|
1986-03-21 |
1987-10-01 |
Hoechst Ag |
2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
|
|
MY104343A
(en)
|
1987-11-23 |
1994-03-31 |
Janssen Pharmaceutica Nv |
Novel pyridizinamine deravatives
|
|
DE3803860A1
(de)
|
1988-02-09 |
1989-08-17 |
Basf Ag |
N,n'-disubstituierte piperazine
|
|
DE3837825A1
(de)
|
1988-11-08 |
1990-05-10 |
Hoechst Ag |
Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
|
|
EP0385237B1
(en)
|
1989-03-03 |
1994-06-29 |
Dainippon Pharmaceutical Co., Ltd. |
2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same
|
|
GB9012316D0
(en)
|
1990-06-01 |
1990-07-18 |
Wellcome Found |
Pharmacologically active cns compounds
|
|
JPH08504798A
(ja)
|
1992-12-18 |
1996-05-21 |
ザ ウエルカム ファウンデーション リミテッド |
酵素阻害薬としての,ピリミジン,ピリジン,プテリジノンおよびインダゾール誘導体
|
|
WO1994022846A1
(en)
|
1993-03-30 |
1994-10-13 |
Pfizer Inc. |
Compounds enhancing antitumor activity of other cytotoxic agents
|
|
JP2837956B2
(ja)
|
1993-06-21 |
1998-12-16 |
ノボ ノルディスク アクティーゼルスカブ |
Asp▲上B28▼インスリン結晶
|
|
SI0792290T1
(en)
|
1993-09-17 |
2001-12-31 |
Novo Nordisk As |
Acylated insulin
|
|
IL111730A
(en)
*
|
1993-11-29 |
1998-12-06 |
Fujisawa Pharmaceutical Co |
Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
|
|
US5504188A
(en)
|
1994-06-16 |
1996-04-02 |
Eli Lilly And Company |
Preparation of stable zinc insulin analog crystals
|
|
AU6318896A
(en)
|
1995-07-06 |
1997-02-05 |
Japan Tobacco Inc. |
Benzamidoxime derivatives and medicinal use thereof
|
|
US6130217A
(en)
*
|
1995-09-20 |
2000-10-10 |
Pfizer Inc |
Compounds enhancing antitumor activity of other cytotoxic agents
|
|
BR9611311A
(pt)
*
|
1995-11-09 |
1999-06-29 |
Synthelabo |
Derivados de 5-fenil-3-(piperidin-4-il)-1,3,4-oxadiazol-2(3h)-ona úteis como ligantes dos receptores 5-ht4 ou h3
|
|
EP0876379A1
(en)
|
1996-01-17 |
1998-11-11 |
Novo Nordisk A/S |
Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use
|
|
WO1997041120A1
(en)
|
1996-07-26 |
1997-11-06 |
Dr. Reddy's Research Foundation |
Thiazolidinedione compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions thereof
|
|
IL128332A0
(en)
|
1996-08-30 |
2000-01-31 |
Novo Nordisk As |
GLP-1 derivatives
|
|
DZ2376A1
(fr)
|
1996-12-19 |
2002-12-28 |
Smithkline Beecham Plc |
Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
|
|
RU2200161C2
(ru)
|
1996-12-31 |
2003-03-10 |
Др. Редди'З Рисерч Фаундейшн |
Новые производные азолидиндиона, способ их получения (варианты), фармацевтические композиции на их основе, способ предупреждения или лечения, способ снижения глюкозы и промежуточное соединение
|
|
JP2001518069A
(ja)
|
1997-05-02 |
2001-10-09 |
ドクター・レディーズ・リサーチ・ファウンデーション |
低脂質性、抗高血圧性特性を有する新規な抗糖尿病化合物、それらの製造方法及びそれらを含有する薬学的組成物
|
|
WO1999001423A1
(en)
|
1997-07-01 |
1999-01-14 |
Novo Nordisk A/S |
Glucagon antagonists/inverse agonists
|
|
US6613942B1
(en)
|
1997-07-01 |
2003-09-02 |
Novo Nordisk A/S |
Glucagon antagonists/inverse agonists
|
|
JP2001510195A
(ja)
|
1997-07-16 |
2001-07-31 |
ノボ ノルディスク アクティーゼルスカブ |
縮合化1,2,4−チアジアジン誘導体、その調製及び使用
|
|
WO1999018077A1
(en)
|
1997-10-02 |
1999-04-15 |
Eisai Co., Ltd. |
Fused pyridine derivatives
|
|
US6569878B1
(en)
|
1997-10-27 |
2003-05-27 |
Agouron Pharmaceuticals Inc. |
Substituted 4-amino-thiazol-2-yl compounds as cyclin-dependent kinase inhibitors
|
|
WO1999019313A1
(en)
|
1997-10-27 |
1999-04-22 |
Dr. Reddy's Research Foundation |
Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
|
|
US6440961B1
(en)
|
1997-10-27 |
2002-08-27 |
Dr. Reddy's Research Foundation |
Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
|
|
AU6966498A
(en)
|
1997-12-02 |
1998-10-30 |
Dr. Reddy's Research Foundation |
Thiazolidinedione and oxazolidinedione derivatives having antidiabetic, hypol ipidaemic and antihypertensive properties
|
|
GB9803536D0
(en)
|
1998-02-19 |
1998-04-15 |
Black James Foundation |
Histamine H,receptor ligands
|
|
EP0978512A1
(en)
|
1998-07-29 |
2000-02-09 |
Societe Civile Bioprojet |
Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications
|
|
AU6190299A
(en)
|
1998-10-21 |
2000-05-08 |
Dr. Reddy's Research Foundation |
New compounds, their preparation and use
|
|
WO2000023451A1
(en)
|
1998-10-21 |
2000-04-27 |
Novo Nordisk A/S |
New compounds, their preparation and use
|
|
JP2002527502A
(ja)
|
1998-10-21 |
2002-08-27 |
ノボ ノルディスク アクティーゼルスカブ |
新規化合物、それらの調製及び使用
|
|
AU6325599A
(en)
|
1998-10-21 |
2000-05-08 |
Dr. Reddy's Research Foundation |
New compounds, their preparation and use
|
|
EP1123269A1
(en)
|
1998-10-21 |
2001-08-16 |
Novo Nordisk A/S |
New compounds, their preparation and use
|
|
WO2000023415A1
(en)
|
1998-10-21 |
2000-04-27 |
Novo Nordisk A/S |
New compounds, their preparation and use
|
|
ES2200575T3
(es)
|
1998-12-18 |
2004-03-01 |
Novo Nordisk A/S |
Derivados de 1,2,4-tiadiazina fusionados, su preparacion y uso.
|
|
WO2000041121A1
(en)
|
1999-01-07 |
2000-07-13 |
Ccrewards.Com |
Method and arrangement for issuance and management of digital coupons and sales offers
|
|
WO2000042026A1
(en)
|
1999-01-15 |
2000-07-20 |
Novo Nordisk A/S |
Non-peptide glp-1 agonists
|
|
HRP20010748A2
(en)
|
1999-04-16 |
2003-02-28 |
Reddys Lab Ltd Dr |
Novel polymorphic forms of an antidiabetic agent: process for their preparation and pharmaceutical compositions containing them
|
|
AU2953699A
(en)
|
1999-04-16 |
2000-11-02 |
Dr. Reddy's Research Foundation |
Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them
|
|
WO2000063189A1
(en)
|
1999-04-16 |
2000-10-26 |
Novo Nordisk A/S |
Crystalline r- guanidines, arginine or (l) -arginine (2s) -2- ethoxy -3-{4- [2-(10h -phenoxazin -10-yl)ethoxy]phenyl}propanoate
|
|
CN1348439A
(zh)
|
1999-04-20 |
2002-05-08 |
诺沃挪第克公司 |
新化合物及其制备和用途
|
|
WO2000063196A1
(en)
|
1999-04-20 |
2000-10-26 |
Novo Nordisk A/S |
New compounds, their preparation and use
|
|
EP1171431A1
(en)
|
1999-04-20 |
2002-01-16 |
Novo Nordisk A/S |
Compounds, their preparation and use
|
|
EP1171438A1
(en)
|
1999-04-20 |
2002-01-16 |
Novo Nordisk A/S |
Compounds, their preparation and use
|
|
AU2935200A
(en)
|
1999-04-30 |
2000-11-17 |
Pfizer Products Inc. |
Compounds for the treatment of obesity
|
|
GB9926302D0
(en)
|
1999-11-05 |
2000-01-12 |
Smithkline Beecham Plc |
Novel compounds
|
|
GB9926303D0
(en)
|
1999-11-05 |
2000-01-12 |
Smithkline Beecham Plc |
Novel compounds
|
|
US6602872B1
(en)
|
1999-12-13 |
2003-08-05 |
Merck & Co., Inc. |
Substituted pyridazines having cytokine inhibitory activity
|
|
FR2802206B1
(fr)
|
1999-12-14 |
2005-04-22 |
Sod Conseils Rech Applic |
Derives de 4-aminopiperidine et leur utilisation en tant que medicament
|
|
AR032292A1
(es)
|
1999-12-16 |
2003-11-05 |
Schering Corp |
Imidazoles sustituidos, composiciones farmaceuticas y el uso de dichos imidazoles para la manufactura de un medicamento para los tratamientos de desordenes en la alimentacion
|
|
FI20000480A0
(fi)
|
2000-03-01 |
2000-03-01 |
Orion Yhtymae Oyj |
Kinoliini- ja naftaleenijohdannaisia alfa-2 antagonisteina
|
|
WO2001066534A2
(en)
|
2000-03-09 |
2001-09-13 |
Abbott Laboratories |
Cyclic and bicyclic diamino histamine-3 receptor antagonists
|
|
AU2001249672A1
(en)
|
2000-03-31 |
2001-10-15 |
Ortho-Mcneil Pharmaceutical, Inc. |
Method for using 2- or 3-aryl substituted imidazo(1,2-a) pyridines as h3 antagonists
|
|
ES2325477T3
(es)
|
2000-03-31 |
2009-09-07 |
Ortho-Mcneil-Janssen Pharmaceuticals, Inc. |
Indoles sustituidos por fenilo como antagonistas del receptor de histamina h3.
|
|
ATE361297T1
(de)
|
2000-03-31 |
2007-05-15 |
Ortho Mcneil Pharm Inc |
Phenyl-substituierte imidazopyridine
|
|
PT1268479E
(pt)
|
2000-03-31 |
2004-06-30 |
Ortho Mcneil Pharm Inc |
Derivados de indolizina fenil-substituidos e sua utilizacao como ligandos h3 de histamina
|
|
US6436939B2
(en)
|
2000-03-31 |
2002-08-20 |
Ortho-Mcneil Pharmaceutical, Inc. |
Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as H3 antagonists
|
|
AU8112101A
(en)
|
2000-08-08 |
2002-02-18 |
Ortho Mcneil Pharm Inc |
Non-imidazole aryloxypiperidines
|
|
US6316475B1
(en)
|
2000-11-17 |
2001-11-13 |
Abbott Laboratories |
Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications
|
|
WO2002060392A2
(en)
|
2001-01-31 |
2002-08-08 |
Synaptic Pharmaceutical Corporation |
Use of gal3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
|
|
US20030073672A1
(en)
*
|
2001-09-05 |
2003-04-17 |
Breitenbucher J. Guy |
Method for treating allergies using substituted pyrazoles
|
|
US20030236259A1
(en)
*
|
2002-02-05 |
2003-12-25 |
Rolf Hohlweg |
Novel aryl- and heteroarylpiperazines
|
|
CN1628109A
(zh)
*
|
2002-02-05 |
2005-06-15 |
诺沃挪第克公司 |
新颖的芳基-与杂芳基-哌嗪
|
|
US6864261B2
(en)
*
|
2002-05-02 |
2005-03-08 |
Euro-Celtique S.A. |
Therapeutic agents useful for treating pain
|
|
SE0201544D0
(sv)
*
|
2002-05-17 |
2002-05-17 |
Biovitrum Ab |
Novel compounds and thier use
|
|
US6906060B2
(en)
*
|
2002-06-06 |
2005-06-14 |
Novo Nordisk A/S |
Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines
|
|
EP1513842B1
(en)
|
2002-06-06 |
2007-03-07 |
Novo Nordisk A/S |
Substituted hexahydropyrrolo (1,2-a)pyrazines, octahydropyrido(1,2-a)pyrazines and decahydropyrazino(1,2-a)azepines
|
|
US7332508B2
(en)
*
|
2002-12-18 |
2008-02-19 |
Novo Nordisk A/S |
Substituted homopiperidine, piperidine or pyrrolidine derivatives
|
|
AU2004259263B2
(en)
|
2003-07-29 |
2010-12-16 |
High Point Pharmaceuticals, Llc |
Pyridazinyl- piperazines and their use as histamine H3 receptor ligands
|
|
WO2005028438A1
(ja)
*
|
2003-09-22 |
2005-03-31 |
Banyu Pharmaceutical Co., Ltd. |
新規ピペリジン誘導体
|
|
FR2864080B1
(fr)
*
|
2003-12-23 |
2006-02-03 |
Sanofi Synthelabo |
Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique
|
|
DE602005026509D1
(de)
|
2004-04-09 |
2011-04-07 |
Merck Sharp & Dohme |
Hemmer der akt aktivität
|
|
US8338591B2
(en)
|
2004-05-08 |
2012-12-25 |
Novartis International Pharmaceutical Ltd. |
3-aryl-5,6-disubstituted pyridazines
|
|
WO2006050389A2
(en)
|
2004-11-02 |
2006-05-11 |
Northwestern University |
Pyridazine compounds, compositions and methods
|
|
JP2008521847A
(ja)
|
2004-12-03 |
2008-06-26 |
エフ.ホフマン−ラ ロシュ アーゲー |
H3拮抗剤としての3−置換ピリジン誘導体
|
|
GB0501146D0
(en)
|
2005-01-20 |
2005-02-23 |
Astrazeneca Ab |
Novel benzamide derivatives
|
|
EP1871762A2
(en)
|
2005-04-18 |
2008-01-02 |
Neurogen Corporation |
Subtituted heteroaryl cb1 antagonists
|
|
FR2885615B1
(fr)
*
|
2005-05-12 |
2007-06-22 |
Servier Lab |
Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
FR2885616B1
(fr)
|
2005-05-12 |
2007-06-22 |
Servier Lab |
Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
MX2007015675A
(es)
|
2005-07-04 |
2008-02-20 |
Novo Nordisk As |
Antagonistas del receptor de histamina h3.
|
|
ZA200800440B
(en)
|
2005-07-15 |
2009-12-30 |
Amr Technology Inc |
Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
|
|
EP1909797A4
(en)
|
2005-08-02 |
2013-02-27 |
Neurogen Corp |
DIPIPERAZINYL KETONE AND RELATED ANALOG
|
|
CN101410385B
(zh)
*
|
2006-03-28 |
2011-08-24 |
高点制药有限责任公司 |
具有组胺h3受体活性的苯并噻唑类
|
|
CA2653062A1
(en)
*
|
2006-05-23 |
2007-11-29 |
Transtech Pharma, Inc. |
6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ' ] -bipyridine and its use as a medicament
|
|
KR20090040259A
(ko)
|
2006-05-29 |
2009-04-23 |
하이 포인트 파마슈티칼스, 엘엘씨 |
3-(1,3-벤조디옥솔-5-일)-6-(4-시클로프로필피페라진-1-일)-피리다진, 그것의 염과 용매화합물 및 그것의 히스타민 h3 수용체 안타고니스트로서의 용도
|
|
EP2014656A3
(en)
*
|
2007-06-11 |
2011-08-24 |
High Point Pharmaceuticals, LLC |
New heteocyclic h3 antagonists
|