CY1112455T1 - 3-(1,3-βενζοδiοξολ-5-υλο)-6-(4-κυκλοπροπυλοπιπεραζιν-1-υλο)-πυριδαζινη, τα αλατα αυτης και τα επιδιαλυτωμενα χημικα σωματιδια αυτης και η χρηση της ως ανταγωνιστη του η3 υποδοχεα της ισταμινης - Google Patents
3-(1,3-βενζοδiοξολ-5-υλο)-6-(4-κυκλοπροπυλοπιπεραζιν-1-υλο)-πυριδαζινη, τα αλατα αυτης και τα επιδιαλυτωμενα χημικα σωματιδια αυτης και η χρηση της ως ανταγωνιστη του η3 υποδοχεα της ισταμινηςInfo
- Publication number
- CY1112455T1 CY1112455T1 CY20121100230T CY121100230T CY1112455T1 CY 1112455 T1 CY1112455 T1 CY 1112455T1 CY 20121100230 T CY20121100230 T CY 20121100230T CY 121100230 T CY121100230 T CY 121100230T CY 1112455 T1 CY1112455 T1 CY 1112455T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pyridazine
- benzodioxol
- istaminis
- cyclopropylpiperazino
- solvates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η 3-(1,3-βενζοδιοξολ-5-υλο)-6-(4-κυκλοπροπυλοπιπεραζιν-1-υλο)πυριδαζίνη και τα άλατα και τα επιδιαλυτωμένα χημικά σωματίδια αυτής, η (Ι) που έχει ανταγωνιστική δράση στον Η3 της ισταμίνης μπορεί να χρησιμοποιηθεί σε φαρμακευτικές συνθέσεις.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06114615 | 2006-05-29 | ||
EP06120117 | 2006-09-05 | ||
EP07729379A EP2079732B9 (en) | 2006-05-29 | 2007-05-22 | 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112455T1 true CY1112455T1 (el) | 2015-12-09 |
Family
ID=38458030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100230T CY1112455T1 (el) | 2006-05-29 | 2012-03-07 | 3-(1,3-βενζοδiοξολ-5-υλο)-6-(4-κυκλοπροπυλοπιπεραζιν-1-υλο)-πυριδαζινη, τα αλατα αυτης και τα επιδιαλυτωμενα χημικα σωματιδια αυτης και η χρηση της ως ανταγωνιστη του η3 υποδοχεα της ισταμινης |
Country Status (24)
Country | Link |
---|---|
US (1) | US8378097B2 (el) |
EP (2) | EP2402324A1 (el) |
JP (1) | JP5694661B2 (el) |
KR (1) | KR20090040259A (el) |
CN (2) | CN102295606A (el) |
AT (1) | ATE538116T1 (el) |
AU (1) | AU2007267197B2 (el) |
BR (1) | BRPI0711370A2 (el) |
CA (1) | CA2659570C (el) |
CY (1) | CY1112455T1 (el) |
DK (1) | DK2079732T3 (el) |
EA (1) | EA016026B1 (el) |
ES (1) | ES2375872T3 (el) |
HR (1) | HRP20120227T1 (el) |
IL (1) | IL194681A (el) |
MX (1) | MX2008014766A (el) |
NZ (1) | NZ571972A (el) |
PL (1) | PL2079732T3 (el) |
PT (1) | PT2079732E (el) |
RS (1) | RS52234B (el) |
SG (1) | SG163547A1 (el) |
SI (1) | SI2079732T1 (el) |
WO (1) | WO2007137968A1 (el) |
ZA (1) | ZA200808730B (el) |
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WO2007071023A1 (en) * | 2005-12-20 | 2007-06-28 | Merck Frosst Canada Ltd. | Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
JP2009537596A (ja) * | 2006-05-23 | 2009-10-29 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 6−(4−シクロプロピルピペリジン−1−イル)−2’−メチル−[3,4’]−ビピリジン及びその医薬としての使用 |
KR20090040259A (ko) | 2006-05-29 | 2009-04-23 | 하이 포인트 파마슈티칼스, 엘엘씨 | 3-(1,3-벤조디옥솔-5-일)-6-(4-시클로프로필피페라진-1-일)-피리다진, 그것의 염과 용매화합물 및 그것의 히스타민 h3 수용체 안타고니스트로서의 용도 |
US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
AU2007260836B2 (en) | 2006-06-23 | 2012-11-15 | Abbvie Bahamas Ltd. | Cyclopropyl amine derivatives as histamin H3 receptor modulators |
EP2014656A3 (en) * | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
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JP6884102B2 (ja) | 2015-02-09 | 2021-06-09 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | がんの治療のための化合物 |
US20210355114A1 (en) * | 2018-10-24 | 2021-11-18 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
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-
2007
- 2007-05-22 KR KR1020087028536A patent/KR20090040259A/ko active Search and Examination
- 2007-05-22 US US12/302,132 patent/US8378097B2/en not_active Expired - Fee Related
- 2007-05-22 RS RS20120078A patent/RS52234B/en unknown
- 2007-05-22 JP JP2009512547A patent/JP5694661B2/ja not_active Expired - Fee Related
- 2007-05-22 DK DK07729379.3T patent/DK2079732T3/da active
- 2007-05-22 BR BRPI0711370-6A patent/BRPI0711370A2/pt not_active IP Right Cessation
- 2007-05-22 CN CN2011101822989A patent/CN102295606A/zh active Pending
- 2007-05-22 EP EP11182795A patent/EP2402324A1/en not_active Withdrawn
- 2007-05-22 WO PCT/EP2007/054940 patent/WO2007137968A1/en active Application Filing
- 2007-05-22 CA CA2659570A patent/CA2659570C/en not_active Expired - Fee Related
- 2007-05-22 ES ES07729379T patent/ES2375872T3/es active Active
- 2007-05-22 EA EA200870586A patent/EA016026B1/ru not_active IP Right Cessation
- 2007-05-22 NZ NZ571972A patent/NZ571972A/en not_active IP Right Cessation
- 2007-05-22 SG SG201004699-3A patent/SG163547A1/en unknown
- 2007-05-22 EP EP07729379A patent/EP2079732B9/en active Active
- 2007-05-22 CN CNA2007800197395A patent/CN101460487A/zh active Pending
- 2007-05-22 AT AT07729379T patent/ATE538116T1/de active
- 2007-05-22 MX MX2008014766A patent/MX2008014766A/es active IP Right Grant
- 2007-05-22 PL PL07729379T patent/PL2079732T3/pl unknown
- 2007-05-22 PT PT07729379T patent/PT2079732E/pt unknown
- 2007-05-22 SI SI200730845T patent/SI2079732T1/sl unknown
- 2007-05-22 AU AU2007267197A patent/AU2007267197B2/en not_active Ceased
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- 2008-10-12 IL IL194681A patent/IL194681A/en not_active IP Right Cessation
- 2008-10-13 ZA ZA2008/08730A patent/ZA200808730B/en unknown
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Also Published As
Publication number | Publication date |
---|---|
HRP20120227T1 (hr) | 2012-04-30 |
PL2079732T3 (pl) | 2012-05-31 |
EA200870586A1 (ru) | 2009-10-30 |
US20090176793A1 (en) | 2009-07-09 |
AU2007267197A1 (en) | 2007-12-06 |
BRPI0711370A2 (pt) | 2011-11-01 |
EA016026B1 (ru) | 2012-01-30 |
IL194681A (en) | 2013-09-30 |
JP5694661B2 (ja) | 2015-04-01 |
EP2079732A1 (en) | 2009-07-22 |
SI2079732T1 (sl) | 2012-03-30 |
SG163547A1 (en) | 2010-08-30 |
CA2659570A1 (en) | 2007-12-06 |
NZ571972A (en) | 2011-09-30 |
PT2079732E (pt) | 2012-02-02 |
EP2079732B1 (en) | 2011-12-21 |
EP2079732B9 (en) | 2012-03-21 |
ES2375872T9 (es) | 2012-07-19 |
AU2007267197B2 (en) | 2011-12-01 |
CN102295606A (zh) | 2011-12-28 |
CN101460487A (zh) | 2009-06-17 |
MX2008014766A (es) | 2009-03-06 |
RS52234B (en) | 2012-10-31 |
ZA200808730B (en) | 2010-02-24 |
US8378097B2 (en) | 2013-02-19 |
DK2079732T3 (da) | 2012-01-23 |
ES2375872T3 (es) | 2012-03-07 |
JP2009538861A (ja) | 2009-11-12 |
WO2007137968A1 (en) | 2007-12-06 |
KR20090040259A (ko) | 2009-04-23 |
ATE538116T1 (de) | 2012-01-15 |
EP2402324A1 (en) | 2012-01-04 |
CA2659570C (en) | 2015-10-06 |
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