DK1268479T3 - Phenylsubstituerede indolizinderivater og deres anvendelse som histamin H3-ligander - Google Patents

Phenylsubstituerede indolizinderivater og deres anvendelse som histamin H3-ligander

Info

Publication number
DK1268479T3
DK1268479T3 DK01928331T DK01928331T DK1268479T3 DK 1268479 T3 DK1268479 T3 DK 1268479T3 DK 01928331 T DK01928331 T DK 01928331T DK 01928331 T DK01928331 T DK 01928331T DK 1268479 T3 DK1268479 T3 DK 1268479T3
Authority
DK
Denmark
Prior art keywords
phenyl
histamine
ligands
indolizine derivatives
substituted indolizine
Prior art date
Application number
DK01928331T
Other languages
English (en)
Inventor
Xiaobing Li
Wenying Chai
Annette K Kwok
Dale A Rudolph
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of DK1268479T3 publication Critical patent/DK1268479T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/423Oxazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
DK01928331T 2000-03-31 2001-03-29 Phenylsubstituerede indolizinderivater og deres anvendelse som histamin H3-ligander DK1268479T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19407100P 2000-03-31 2000-03-31
US27213701P 2001-02-28 2001-02-28

Publications (1)

Publication Number Publication Date
DK1268479T3 true DK1268479T3 (da) 2004-04-19

Family

ID=26889667

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01928331T DK1268479T3 (da) 2000-03-31 2001-03-29 Phenylsubstituerede indolizinderivater og deres anvendelse som histamin H3-ligander

Country Status (9)

Country Link
EP (1) EP1268479B1 (da)
AT (1) ATE258553T1 (da)
AU (1) AU2001255202A1 (da)
DE (1) DE60101906T2 (da)
DK (1) DK1268479T3 (da)
ES (1) ES2213693T3 (da)
PT (1) PT1268479E (da)
TR (1) TR200400354T4 (da)
WO (1) WO2001074814A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208497B2 (en) 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
EP1430027B1 (en) 2001-09-14 2010-09-01 High Point Pharmaceuticals, LLC Novel aminoazetidine, -pyrrolidine and -piperidine derivatives
US6673829B2 (en) 2001-09-14 2004-01-06 Novo Nordisk A/S Aminoazetidine,-pyrrolidine and -piperidine derivatives
WO2005077953A1 (ja) * 2004-02-18 2005-08-25 Banyu Pharmaceutical Co., Ltd. 含窒素縮合へテロ芳香環誘導体
EP1807427A2 (en) * 2004-11-01 2007-07-18 Wyeth Substituted indolizines and derivatives as cns agents
WO2006077024A2 (en) 2005-01-19 2006-07-27 F. Hoffmann-La Roche Ag 5-aminoindole derivatives
EP1717235A3 (en) * 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
EP2233470B1 (en) 2005-07-04 2011-12-07 High Point Pharmaceuticals, LLC Histamine H3 receptor antagonists
US7432255B2 (en) 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
MX2008014766A (es) 2006-05-29 2009-03-06 High Point Pharmaceuticals Llc 3-(1,3-benzodioxol-5-il)-6-(4-ciclopropilpiperazin-1-il)-piperazi na, sus sales y solvatos y su uso como antagonista del receptor de h3 histamina.
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0978512A1 (en) * 1998-07-29 2000-02-09 Societe Civile Bioprojet Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications

Also Published As

Publication number Publication date
ATE258553T1 (de) 2004-02-15
WO2001074814A1 (en) 2001-10-11
EP1268479B1 (en) 2004-01-28
AU2001255202A1 (en) 2001-10-15
ES2213693T3 (es) 2004-09-01
TR200400354T4 (tr) 2004-04-21
DE60101906D1 (de) 2004-03-04
PT1268479E (pt) 2004-06-30
EP1268479A1 (en) 2003-01-02
DE60101906T2 (de) 2004-11-04

Similar Documents

Publication Publication Date Title
WO2001074815A3 (en) Phenyl-substituted imidazopyridines
ATE465181T1 (de) Humanisierte anti-cmet-antagonisten
DK1385825T3 (da) Substituerede 2-pyridincyclohexan-1,4-diaminderivater
EE200300243A (et) Püridiinasendatud pürasolopüridiini derivaadid
NO20034648D0 (no) Hydroksycyklyloksy-, tioksy- og -aminobenzazol-derivater som 5-hydroksytryptamin-6-ligander
NO20053600D0 (no) Pyrazolo (3,4-b)pyridinforbindelser og anvendelse derav som fosfodiesterase inhibitorer.
DE60225563D1 (de) 4-amino-6-phenyl-pyrroloä2,3-düpyrimidin derivate
RS50660B (sr) Dihidrotetrabenazini i farmaceutske kompozicije koje ih sadrže
TR200202194T2 (tr) Poliglütamik asit-kamptotesin birleşikleri ve hazırlama yöntemleri
WO2001074773A3 (en) Phenyl-substituted indoles as histamine h3-receptor antagonists
DE602005011780D1 (de) Triazinderivate mit carbamatfunktion
NO20063393L (no) Farmasoytiske preparater
DK1456206T3 (da) Azaindolylalkylaminderivater som 5-hydroxytryptamin-6-ligander
NO20043100L (no) Indolylalkylaminderivater som 5-hydroksytryptamin-6-ligander
DK1268479T3 (da) Phenylsubstituerede indolizinderivater og deres anvendelse som histamin H3-ligander
DK1643984T3 (da) Anvendelse af parthenolidderivater som antileukæmiske og cytotoksske midler
NO20034647D0 (no) Hydroksyclylalkoksy-, alkyloksy- og -alkylaminobenzazol- derivater som 5-hydroksytryptamin-6-ligander
NO20053588D0 (no) Acylaminotiazol-derivater, fremstilling og anvendelse derav som beta-amyloidpeptid-produksjonsinhibitorer.
NO20052478D0 (no) Vitamin D-analoger, sammensetninger omfattende analogene og deres anvendelse.
ITRM20030363A0 (it) Composizioni comprendenti la 3, 5diiodotironina e uso farmaceutico diesse.
DE50310323D1 (de) Wässrige polyurethanzubereitungen
DE50003566D1 (de) Haftvermittler
DK1390351T3 (da) Pyrimidinderivater, der er nyttige som selektive COX-2-inhibitorer
IT1313592B1 (it) Derivati di 1h-pirido 3,4-b indol-1-one.
DK1322161T3 (da) Anvendelse af riboflavin og flavinderivater som chitanaseinhibitorer