ATE258553T1 - Phenyl-substituierte indolizinderivate und deren verwendung als histamin h3 liganden - Google Patents

Phenyl-substituierte indolizinderivate und deren verwendung als histamin h3 liganden

Info

Publication number
ATE258553T1
ATE258553T1 AT01928331T AT01928331T ATE258553T1 AT E258553 T1 ATE258553 T1 AT E258553T1 AT 01928331 T AT01928331 T AT 01928331T AT 01928331 T AT01928331 T AT 01928331T AT E258553 T1 ATE258553 T1 AT E258553T1
Authority
AT
Austria
Prior art keywords
phenyl
substituted
histamine
ligands
indolicine
Prior art date
Application number
AT01928331T
Other languages
English (en)
Inventor
Wenying Chai
Annette K Kwok
Xiaobing Li
Dale A Rudolph
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of ATE258553T1 publication Critical patent/ATE258553T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
AT01928331T 2000-03-31 2001-03-29 Phenyl-substituierte indolizinderivate und deren verwendung als histamin h3 liganden ATE258553T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19407100P 2000-03-31 2000-03-31
US27213701P 2001-02-28 2001-02-28
PCT/US2001/010049 WO2001074814A1 (en) 2000-03-31 2001-03-29 Phenyl-substituted indolizine derivatives and their use as histamine h3 ligands

Publications (1)

Publication Number Publication Date
ATE258553T1 true ATE258553T1 (de) 2004-02-15

Family

ID=26889667

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01928331T ATE258553T1 (de) 2000-03-31 2001-03-29 Phenyl-substituierte indolizinderivate und deren verwendung als histamin h3 liganden

Country Status (9)

Country Link
EP (1) EP1268479B1 (de)
AT (1) ATE258553T1 (de)
AU (1) AU2001255202A1 (de)
DE (1) DE60101906T2 (de)
DK (1) DK1268479T3 (de)
ES (1) ES2213693T3 (de)
PT (1) PT1268479E (de)
TR (1) TR200400354T4 (de)
WO (1) WO2001074814A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208497B2 (en) 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
US6673829B2 (en) 2001-09-14 2004-01-06 Novo Nordisk A/S Aminoazetidine,-pyrrolidine and -piperidine derivatives
JP4619655B2 (ja) 2001-09-14 2011-01-26 ハイ・ポイント・ファーマスーティカルズ、エルエルシー 新規アミノアゼチジン、−ピロリジンおよび−ピペリジン誘導体
JPWO2005077953A1 (ja) * 2004-02-18 2007-10-18 萬有製薬株式会社 含窒素縮合ヘテロ芳香環誘導体
BRPI0517955A (pt) * 2004-11-01 2008-10-21 Wyeth Corp indolizinas substituìdas e derivados como agentes de snc
WO2006077024A2 (en) * 2005-01-19 2006-07-27 F. Hoffmann-La Roche Ag 5-aminoindole derivatives
EP1717235A3 (de) 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor
ES2375929T3 (es) 2005-07-04 2012-03-07 High Point Pharmaceuticals, Llc Antagonistas del receptor histamina h3.
US7432255B2 (en) * 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
ATE538116T1 (de) 2006-05-29 2012-01-15 High Point Pharmaceuticals Llc 3-(1,3-benyodioxol-5-yl)-6- (4- cyclopropylpiperazin-1-yl)-pyridazin, dessen salze und solvate und dessen verwendung als histamin-h3-rezeptorantagonist
EP2014656A3 (de) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC Neue heterocyclische H3-Antagonisten
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0978512A1 (de) * 1998-07-29 2000-02-09 Societe Civile Bioprojet Aryloxy- (oder Arylthio)alkylamine ohne Imidazolring als Histamin-H3-Antagonisten und deren therapeutische Anwendung

Also Published As

Publication number Publication date
DK1268479T3 (da) 2004-04-19
ES2213693T3 (es) 2004-09-01
TR200400354T4 (tr) 2004-04-21
DE60101906T2 (de) 2004-11-04
EP1268479A1 (de) 2003-01-02
WO2001074814A1 (en) 2001-10-11
PT1268479E (pt) 2004-06-30
AU2001255202A1 (en) 2001-10-15
EP1268479B1 (de) 2004-01-28
DE60101906D1 (de) 2004-03-04

Similar Documents

Publication Publication Date Title
WO2001074815A3 (en) Phenyl-substituted imidazopyridines
ATE465181T1 (de) Humanisierte anti-cmet-antagonisten
ATE248175T1 (de) Epothilonderivate und ihre verwendung als antitumormittel
DE60314500D1 (de) Diaminopyrimidine und deren verwendung als angiogenesehemmer
WO2001074773A3 (en) Phenyl-substituted indoles as histamine h3-receptor antagonists
DK1385825T3 (da) Substituerede 2-pyridincyclohexan-1,4-diaminderivater
ATE350409T1 (de) Ampholytisches copolymer und dessen verwendung
RS50660B (sr) Dihidrotetrabenazini i farmaceutske kompozicije koje ih sadrže
IS7782A (is) Setin píperasín, (1,4) díassepín og 2,5-díasabísýkló (2.2.1) heptön sem histamín H1 og/eða H3 mótlyf eða histamín H3 gagnmótlyf
DE60107221D1 (de) Indolin-2-on derivate und deren verwendung als liganden der ocytocin rezeptoren
ATE474828T1 (de) Aryl substituierte pyridinen, pyrimidinen, pyrazinen und triazinen und deren verwendung
DE602005011780D1 (de) Triazinderivate mit carbamatfunktion
ATE258553T1 (de) Phenyl-substituierte indolizinderivate und deren verwendung als histamin h3 liganden
ATE515262T1 (de) Verwendung von parthenolid-derivaten als antileukämische und zytotoxische mittel
ATE327237T1 (de) Imidazol derivate, ihre herstellung und ihre verwendung
ATE343582T1 (de) Derivate von (6, 7-dihydro -5h-imidazo(1,2 - a)imidazol -3 -sulfonylamino)-propionamid und deren verwendung als inhibitoren der interaktion von cams und leukointreginen
DE50003566D1 (de) Haftvermittler
SE0301654D0 (sv) Novel compounds
ATE329908T1 (de) Arylethene-sulfonamid derivate, deren herstellung und deren verwendung als endothelin-antagonisten
TR200402030T4 (tr) İkame edilen I-aminobutan-3-ol-türevleri
DE60229414D1 (de) Verwendung von aplidine in der behandlung von pankreaskrebs
DE10108995A1 (de) Substituierte Pyrimidinon-Derivate als Liganden von Integrinrezeptoren
DE60304360D1 (de) N-aryl-2-oxazolidinone und deren derivate
PL430985A1 (pl) Schody segmentowe
ITRM20010648A0 (it) Linee cellulari per l'incapsidazione di vettori sv40 derivati loro usi e kit che le comprendono.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1268479

Country of ref document: EP

REN Ceased due to non-payment of the annual fee