DE60304360D1 - N-aryl-2-oxazolidinone und deren derivate - Google Patents

N-aryl-2-oxazolidinone und deren derivate

Info

Publication number
DE60304360D1
DE60304360D1 DE60304360T DE60304360T DE60304360D1 DE 60304360 D1 DE60304360 D1 DE 60304360D1 DE 60304360 T DE60304360 T DE 60304360T DE 60304360 T DE60304360 T DE 60304360T DE 60304360 D1 DE60304360 D1 DE 60304360D1
Authority
DE
Germany
Prior art keywords
oxazolidinone
aryl
derivatives
formula
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60304360T
Other languages
English (en)
Other versions
DE60304360T2 (de
Inventor
C Gadwood
M Ochoada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Application granted granted Critical
Publication of DE60304360D1 publication Critical patent/DE60304360D1/de
Publication of DE60304360T2 publication Critical patent/DE60304360T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Structure Of Belt Conveyors (AREA)
DE60304360T 2002-08-12 2003-08-01 N-aryl-2-oxazolidinone und deren derivate Expired - Fee Related DE60304360T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40278302P 2002-08-12 2002-08-12
US402783P 2002-08-12
PCT/US2003/022486 WO2004014897A1 (en) 2002-08-12 2003-08-01 N-aryl-2-oxazolidinones and their derivatives

Publications (2)

Publication Number Publication Date
DE60304360D1 true DE60304360D1 (de) 2006-05-18
DE60304360T2 DE60304360T2 (de) 2006-11-16

Family

ID=31715900

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60304360T Expired - Fee Related DE60304360T2 (de) 2002-08-12 2003-08-01 N-aryl-2-oxazolidinone und deren derivate

Country Status (11)

Country Link
US (1) US7094900B2 (de)
EP (1) EP1539745B1 (de)
JP (1) JP2005537301A (de)
AT (1) ATE321760T1 (de)
AU (1) AU2003259159A1 (de)
BR (1) BR0313400A (de)
CA (1) CA2491287A1 (de)
DE (1) DE60304360T2 (de)
ES (1) ES2258234T3 (de)
MX (1) MXPA05001558A (de)
WO (1) WO2004014897A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0413744A (pt) * 2003-08-22 2006-10-24 Pharmacia & Upjohn Co Llc n-aril-2-ciano-oxazolidinonas e seus derivados
US7186844B2 (en) * 2004-01-13 2007-03-06 Mitsubishi Gas Chemical Co., Inc. Method for producing cyclic carbamate ester
WO2005113520A1 (en) * 2004-05-20 2005-12-01 Pharmacia & Upjohn Company Llc Substituted 2,3,5-trifluorphenyl oxazolidinones for use as antibacterial agents
WO2016061772A1 (en) 2014-10-22 2016-04-28 Merck Sharp & Dohme Corp. Nargenicin compounds and uses thereof as antibacterial agents
WO2017066964A1 (en) 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705799A (en) 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
US5043443A (en) 1988-07-29 1991-08-27 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives
US5225565A (en) 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5164510A (en) 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
US5182403A (en) 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
US5231188A (en) 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
AU667198B2 (en) 1991-11-01 1996-03-14 Pharmacia & Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
SK283420B6 (sk) 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
EP0648119A1 (de) 1992-07-08 1995-04-19 The Upjohn Company Gegen mycobacterium tuberculosis verwendbare 5'-indolinyloxazolidinone
ATE161833T1 (de) 1992-12-08 1998-01-15 Upjohn Co Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel
US5688792A (en) 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
ATE182142T1 (de) 1993-11-22 1999-07-15 Upjohn Co Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester
JPH0873455A (ja) 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物
DE4425609A1 (de) 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE4425612A1 (de) 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE4425613A1 (de) 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE19514313A1 (de) 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
ATE204277T1 (de) 1994-10-26 2001-09-15 Upjohn Co Phenyloxazolidinone mit antimikrobieller wirkung
DE69529838T2 (de) 1994-11-15 2003-11-13 Upjohn Co Antibakterielle bizyklische oxazin und thiazin-oxazolidinone
WO1996023788A1 (en) 1995-02-03 1996-08-08 Pharmacia + Upjohn Company Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
HRP960159A2 (en) 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
NZ306310A (en) 1995-05-11 2001-05-25 Upjohn Co Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones
NZ315469A (en) 1995-09-01 2000-01-28 Upjohn Co Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings
AU6964096A (en) 1995-09-15 1997-04-01 Pharmacia & Upjohn Company Aminoaryl oxazolidinone n-oxides
ZA968661B (en) 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
DE19601265A1 (de) 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19601627A1 (de) 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
GB9601666D0 (en) 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
MY116093A (en) 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
JP2002501530A (ja) 1997-05-30 2002-01-15 ファルマシア・アンド・アップジョン・カンパニー チオカルボニル官能基を有するオキサゾリジノン抗菌剤
DE19730847A1 (de) 1997-07-18 1999-01-28 Bayer Ag Tricyclisch substituierte Oxazolidinone
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
US5998406A (en) 1997-11-12 1999-12-07 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions
US6083967A (en) 1997-12-05 2000-07-04 Pharmacia & Upjohn Company S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones
DE19802235A1 (de) 1998-01-22 1999-07-29 Bayer Ag Mit tricyclischen Indolen substituierte Oxazolidinone
DE19802239A1 (de) 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
AU764184B2 (en) 1998-01-23 2003-08-14 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
DE19805117A1 (de) 1998-02-09 1999-08-12 Bayer Ag Neue Oxazolidinone mit azolhaltigen Tricyclen
GB9821938D0 (en) 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
GB9928499D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical processes and intermediates
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
EP1289984A4 (de) 2000-06-05 2004-11-24 Dong A Pharm Co Ltd Neue oxazolidinderivate und ein verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
CA2491287A1 (en) 2004-02-19
JP2005537301A (ja) 2005-12-08
AU2003259159A1 (en) 2004-02-25
MXPA05001558A (es) 2005-09-08
BR0313400A (pt) 2005-07-12
EP1539745B1 (de) 2006-03-29
US20040072873A1 (en) 2004-04-15
US7094900B2 (en) 2006-08-22
WO2004014897A1 (en) 2004-02-19
EP1539745A1 (de) 2005-06-15
DE60304360T2 (de) 2006-11-16
ES2258234T3 (es) 2006-08-16
ATE321760T1 (de) 2006-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee