IS7782A - Setin píperasín, (1,4) díassepín og 2,5-díasabísýkló (2.2.1) heptön sem histamín H1 og/eða H3 mótlyf eða histamín H3 gagnmótlyf - Google Patents
Setin píperasín, (1,4) díassepín og 2,5-díasabísýkló (2.2.1) heptön sem histamín H1 og/eða H3 mótlyf eða histamín H3 gagnmótlyfInfo
- Publication number
- IS7782A IS7782A IS7782A IS7782A IS7782A IS 7782 A IS7782 A IS 7782A IS 7782 A IS7782 A IS 7782A IS 7782 A IS7782 A IS 7782A IS 7782 A IS7782 A IS 7782A
- Authority
- IS
- Iceland
- Prior art keywords
- histamine
- antagonists
- diazepines
- heptanes
- diazabicyclo
- Prior art date
Links
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 title 2
- POXWDTQUDZUOGP-UHFFFAOYSA-N 1h-1,4-diazepine Chemical class N1C=CC=NC=C1 POXWDTQUDZUOGP-UHFFFAOYSA-N 0.000 title 1
- UKHJNJFJCGBKSF-UHFFFAOYSA-N 2,5-diazabicyclo[2.2.1]heptane Chemical class C1NC2CNC1C2 UKHJNJFJCGBKSF-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 229960001340 histamine Drugs 0.000 title 1
- 239000003395 histamine H3 receptor antagonist Substances 0.000 title 1
- 150000004885 piperazines Chemical class 0.000 title 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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GBGB0224084.4A GB0224084D0 (en) | 2002-10-16 | 2002-10-16 | Novel compounds |
PCT/EP2003/011423 WO2004035556A1 (en) | 2002-10-16 | 2003-10-14 | Substituted piperazines, (1,4) diaszepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine h1 and/or h3 antagonists or histamine h3 reverse antagonists |
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AU2001273384A1 (en) * | 2000-07-13 | 2002-01-30 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
US6620839B2 (en) | 2000-07-13 | 2003-09-16 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
US20030216257A1 (en) | 2000-07-18 | 2003-11-20 | Ingo Sagasser | 1-aryl-4-alkyl halide-2(1h)-pyridones and their use as herbicides |
DK1313721T3 (da) * | 2000-08-08 | 2006-06-26 | Ortho Mcneil Pharm Inc | Ikke-imidazol-aryloxyalkylaminer som H3-receptorligander |
ATE354568T1 (de) * | 2000-08-08 | 2007-03-15 | Ortho Mcneil Pharm Inc | Nicht-imidazol aryloxypiperidine als h3 rezeptor liganden |
JP2002173426A (ja) | 2000-12-05 | 2002-06-21 | Ss Pharmaceut Co Ltd | 血糖低下剤 |
US20040077654A1 (en) | 2001-01-15 | 2004-04-22 | Bouillot Anne Marie Jeanne | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression |
WO2002076925A2 (en) * | 2001-03-23 | 2002-10-03 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
JP4186518B2 (ja) * | 2001-06-15 | 2008-11-26 | アステラス製薬株式会社 | フェニルピリジン誘導体 |
US7459461B2 (en) | 2001-10-19 | 2008-12-02 | Ortho-Mcneil Pharmaceutical, Inc. | Phosphonic acid compounds as inhibitors of serine proteases |
IL162859A0 (en) | 2002-02-05 | 2005-11-20 | Novo Nordisk As | Novel aryl-and heteroarylpiperazines |
US20060019964A1 (en) | 2002-10-16 | 2006-01-26 | Ancliff Ranchael A | Compounds |
GB0224084D0 (en) * | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
GB0609897D0 (en) * | 2006-05-18 | 2006-06-28 | Glaxo Group Ltd | Compounds |
-
2002
- 2002-10-16 GB GBGB0224084.4A patent/GB0224084D0/en not_active Ceased
-
2003
- 2003-10-14 CA CA002502249A patent/CA2502249A1/en not_active Abandoned
- 2003-10-14 RU RU2005110061/04A patent/RU2328494C2/ru not_active IP Right Cessation
- 2003-10-14 AU AU2003280380A patent/AU2003280380A1/en not_active Abandoned
- 2003-10-14 MX MXPA05004078A patent/MXPA05004078A/es unknown
- 2003-10-14 NZ NZ549963A patent/NZ549963A/en unknown
- 2003-10-14 BR BR0315283-9A patent/BR0315283A/pt not_active IP Right Cessation
- 2003-10-14 US US10/531,758 patent/US7615550B2/en not_active Expired - Fee Related
- 2003-10-14 NZ NZ539446A patent/NZ539446A/en unknown
- 2003-10-14 CN CNA2006101086109A patent/CN101070309A/zh active Pending
- 2003-10-14 EP EP03772221A patent/EP1567511A1/en not_active Withdrawn
- 2003-10-14 CN CNB2003801060141A patent/CN100400523C/zh not_active Expired - Fee Related
- 2003-10-14 JP JP2004544241A patent/JP2006508935A/ja active Pending
- 2003-10-14 PL PL03376477A patent/PL376477A1/xx unknown
- 2003-10-14 KR KR1020057006621A patent/KR20050049553A/ko not_active Withdrawn
- 2003-10-14 WO PCT/EP2003/011423 patent/WO2004035556A1/en active Application Filing
-
2005
- 2005-03-31 IS IS7782A patent/IS7782A/is unknown
- 2005-04-05 NO NO20051689A patent/NO20051689L/no not_active Application Discontinuation
- 2005-04-08 ZA ZA200502873A patent/ZA200502873B/en unknown
- 2005-04-29 MA MA28246A patent/MA27482A1/fr unknown
-
2006
- 2006-05-05 ZA ZA200603604A patent/ZA200603604B/en unknown
- 2006-08-28 JP JP2006231163A patent/JP2007016041A/ja active Pending
-
2009
- 2009-09-18 US US12/562,285 patent/US20100075953A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
GB0224084D0 (en) | 2002-11-27 |
KR20050049553A (ko) | 2005-05-25 |
BR0315283A (pt) | 2005-08-30 |
CN100400523C (zh) | 2008-07-09 |
EP1567511A1 (en) | 2005-08-31 |
PL376477A1 (en) | 2005-12-27 |
CN1726201A (zh) | 2006-01-25 |
MA27482A1 (fr) | 2005-08-01 |
RU2005110061A (ru) | 2006-01-20 |
CA2502249A1 (en) | 2004-04-29 |
US7615550B2 (en) | 2009-11-10 |
RU2328494C2 (ru) | 2008-07-10 |
NZ549963A (en) | 2008-03-28 |
AU2003280380A1 (en) | 2004-05-04 |
ZA200502873B (en) | 2006-07-26 |
JP2007016041A (ja) | 2007-01-25 |
NO20051689D0 (no) | 2005-04-05 |
CN101070309A (zh) | 2007-11-14 |
NZ539446A (en) | 2006-11-30 |
JP2006508935A (ja) | 2006-03-16 |
US20100075953A1 (en) | 2010-03-25 |
ZA200603604B (en) | 2007-04-25 |
MXPA05004078A (es) | 2005-06-08 |
US20060025404A1 (en) | 2006-02-02 |
WO2004035556A1 (en) | 2004-04-29 |
NO20051689L (no) | 2005-07-07 |
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